Natural polyamines inhibit the migration of preosteoclasts by attenuating Ca2+-PYK2-Src-NFATc1 signaling pathways

Amino Acids

Volumn 46, Issue 11, 2014, Pages 2605-2614

  Yeon, Jeong Tae ^a   Ryu, Byung Jun ^b   Choi, Sik Won ^b   Heo, Jin Chul ^b   Kim, Kwang Jin ^a   Son, Young Jin ^a   Kim, Seong Hwan ^b  

^a Sunchon National University   (South Korea)

^b Korea Research Institute of Chemical Technology   (South Korea)

Author keywords

Calcium; Fusion; Migration; NFATc1; Polyamines; Preosteoclast; PYK2

Indexed keywords

ADENOSINE TRIPHOSPHATE; CALCIUM ION; CATHEPSIN K; FOCAL ADHESION KINASE 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; OSTEOCLAST DIFFERENTIATION FACTOR; PROTEIN TYROSINE KINASE; PUTRESCINE; SPERMIDINE; SPERMINE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR NFATC1; UNCLASSIFIED DRUG; CALCIUM; NFATC1 PROTEIN, MOUSE; POLYAMINE; TRANSCRIPTION FACTOR NFAT;

ANIMAL CELL; ARTICLE; BONE MARROW DERIVED MACROPHAGE; C SRC GENE; CALCIUM CELL LEVEL; CATHEPSIN K GENE; CELL DIFFERENTIATION; CELL FUSION; CELL MIGRATION; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; GENE; GENE EXPRESSION; MALE; MIGRATION INHIBITION; MOUSE; NONHUMAN; OSCAR GENE; OSTEOCLAST; OSTEOCLASTOGENESIS; PREOSTEOCLAST; SIGNAL TRANSDUCTION; TRAP GENE; ANIMAL; CELL MOTION; CYTOLOGY; DOSE RESPONSE; INSTITUTE FOR CANCER RESEARCH MOUSE; METABOLISM; OSTEOLYSIS; PHENOTYPE;

ADENOSINE TRIPHOSPHATE; ANIMALS; BONE RESORPTION; CALCIUM; CELL DIFFERENTIATION; CELL MOVEMENT; DOSE-RESPONSE RELATIONSHIP, DRUG; FOCAL ADHESION KINASE 2; MALE; MICE; MICE, INBRED ICR; NF-KAPPA B; NFATC TRANSCRIPTION FACTORS; OSTEOCLASTS; PHENOTYPE; POLYAMINES; RANK LIGAND; SIGNAL TRANSDUCTION; SPERMINE;

EID: 84919678326     PISSN: 09394451     EISSN: 14382199     Source Type: Journal    
DOI: 10.1007/s00726-014-1797-9     Document Type: Article

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