Amelioration by the natural polyamine spermine of cartilage and bone destruction in rats with collagen-induced arthritis

Journal of Pharmacological Sciences

Volumn 119, Issue 1, 2012, Pages 107-111

  Iezaki, Takashi ^a   Hinoi, Eiichi ^a   Yamamoto, Tomomi ^a   Ishiura, Ryo ^a   Ogawa, Shinya ^a   Yoneda, Yukio ^a  

^a KANAZAWA UNIVERSITY   (Japan)

Author keywords

Arthritis; Cartilage; Spermine

Indexed keywords

MESSENGER RNA; OSTEOCLAST DIFFERENTIATION FACTOR; SPERMIDINE; SPERMINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE DESTRUCTION; CARTILAGE DEGENERATION; CHEMOPROPHYLAXIS; DRUG EFFICACY; HISTOPATHOLOGY; IN VIVO STUDY; MALE; NONHUMAN; PROTEIN EXPRESSION; RAT; RHEUMATOID ARTHRITIS; SUPPLEMENTATION; SYNOVIUM;

EID: 84861467213     PISSN: 13478613     EISSN: 13478648     Source Type: Journal    
DOI: 10.1254/jphs.11241SC     Document Type: Article

References (14)

1. Hinoi E, Ohashi R, Miyata S, Kato Y, Iemata M, Hojo H, et al. Excitatory amino acid transporters expressed by synovial fibroblasts in rats with collagen-induced arthritis. Biochem Pharmacol. 2005;70:1744-1755. (Pubitemid 41612005)
2. Waldburger JM, Firestein GS. Garden of therapeutic delights: new targets in rheumatic diseases. Arthritis Res Ther. 2009;11:206.
3. Igarashi K, Kashiwagi K. Modulation of cellular function by polyamines. Int J Biochem Cell Biol. 2010;42:39-51.
4. Morrison LD, Kish SJ. Brain polyamine levels are altered in Alzheimer's disease. Neurosci Lett. 1995;197:5-8.
5. Turchanowa L, Rogozkin VA, Milovic V, Feldkoren BI, Caspary WF, Stein J. Influence of physical exercise on polyamine synthesis in the rat skeletal muscle. Eur J Clin Invest. 2000;30:72-78. (Pubitemid 30071860)
6. Yamamoto T, Hinoi E, Fujita H, Iezaki T, Takahata Y, Takamori M, et al. Natural polyamines spermidine and spermine prevent bone loss through preferential disturbance of osteoclastic activation in ovariectomized mice. Br J Pharmacol. 2012;DOI:10.1111/j.1476-5381.
7. Butz DE, Li G, Huebner SM, Cook ME. A mechanistic approach to understanding conjugated linoleic acid's role in inflammation using murine models of rheumatoid arthritis. Am J Physiol Regul Integr Comp Physiol. 2007;293:R669-R676. (Pubitemid 47205049)
8. Zhang M, Caragine T, Wang H, Cohen PS, Botchkina G, Soda K, et al. Spermine inhibits proinflammatory cytokine synthesis in human mononuclear cells: a counter regulatory mechanism that restrains the immune response. J Exp Med. 1997;185:1759-1768. (Pubitemid 27242197)
9. Soda K, Kano Y, Nakamura T, Kasono K, Kawakami M, Konishi F. Spermine, a natural polyamine, suppresses LFA-1 expression on human lymphocyte. J Immunol. 2005;175:237-245. (Pubitemid 40884324)
10. Okamoto A, Sugi E, Koizumi Y, Yanagida F, Udaka S. Polyamine content of ordinary foodstuffs and various fermented foods. Biosci Biotechnol Biochem. 1997;61:1582-1584.
11. Soda K, Kano Y, Sakuragi M, Takao K, Lefor A, Konishi F. Long-term oral polyamine intake increases blood polyamine concentrations. J Nutr Sci Vitaminol (Tokyo). 2009;55:361-366.
12. Williams R, Feldmann M, Maini R. Anti-tumor necrosis factor ameliorates joint disease in murine collagen-induced arthritis. Proc Natl Acad Sci U S A. 1992;89:9784-9788.
13. Asagiri M, Hirai T, Kunigami T, Kamano S, Gober HJ, Okamoto K, et al. Cathepsin K-dependent toll-like receptor 9 signaling revealed in experimental arthritis. Science. 2008;319:624-627. (Pubitemid 351197065)
14. Mohammad Shahi M, Rashidi MR, Mahboob S, Haidari F, Rashidi B, Hanaee J. Protective effect of soy protein on collageninduced arthritis in rat. Rheumatol Int. 2011;DOI:10.1007/s00296-011-1979-7.