메뉴 건너뛰기




Volumn 5, Issue 6, 2015, Pages 4083-4091

Biopharmaceutical profiling of sesamol: Physiochemical characterization, gastrointestinal permeability and pharmacokinetic evaluation

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANTS; BIOCHEMISTRY; MOLECULES; RATS; SOLUBILITY; TISSUE;

EID: 84919667255     PISSN: None     EISSN: 20462069     Source Type: Journal    
DOI: 10.1039/c4ra10926k     Document Type: Article
Times cited : (37)

References (38)
  • 1
    • 84864889856 scopus 로고
    • Sesame oil, III antioxidant properties of sesamol
    • P. Budowski, Sesame oil, III antioxidant properties of sesamol, J. Am. Oil Chem. Soc., 1950, 27, 2647-2649.
    • (1950) J. Am. Oil Chem. Soc. , vol.27 , pp. 2647-2649
    • Budowski, P.1
  • 2
    • 1242314212 scopus 로고    scopus 로고
    • Free radical scavenging behavior of antioxidant compounds of sesame (Sesamum indicum L.) in DPPH system
    • K. P. Suja, A. Jayalekshmy and C. Arumughan, Free radical scavenging behavior of antioxidant compounds of sesame (Sesamum indicum L.) in DPPH system, J. Agric. Food Chem., 2004, 52, 912-915.
    • (2004) J. Agric. Food Chem. , vol.52 , pp. 912-915
    • Suja, K.P.1    Jayalekshmy, A.2    Arumughan, C.3
  • 3
    • 0029801149 scopus 로고    scopus 로고
    • Formation of the mutagenic/carcinogenic imidazoquinoxaline-type heterocyclic amines through the unstable free radical Maillard intermediates and its inhibition by phenolic antioxidants
    • T. Kato, T. Harashima, N. Moriya, K. Kikugawa and K. Hiramoto, Formation of the mutagenic/carcinogenic imidazoquinoxaline-type heterocyclic amines through the unstable free radical Maillard intermediates and its inhibition by phenolic antioxidants, Carcinogenesis , 1996, 17, 2469-2476.
    • (1996) Carcinogenesis , vol.17 , pp. 2469-2476
    • Kato, T.1    Harashima, T.2    Moriya, N.3    Kikugawa, K.4    Hiramoto, K.5
  • 5
    • 16344376551 scopus 로고    scopus 로고
    • Free radical reactions and antioxidant activities of sesamol: Pulse radiolytic and biochemical studies
    • R. Joshi, M. S. Kumar, K. Satyamoorthy, M. K. Unnikrisnan and T. Mukherjee, Free radical reactions and antioxidant activities of sesamol: pulse radiolytic and biochemical studies, J. Agric. Food Chem., 2005, 53, 2696-2703.
    • (2005) J. Agric. Food Chem. , vol.53 , pp. 2696-2703
    • Joshi, R.1    Kumar, M.S.2    Satyamoorthy, K.3    Unnikrisnan, M.K.4    Mukherjee, T.5
  • 6
    • 0029931801 scopus 로고    scopus 로고
    • Effect of plant phenolics on the formation of the spin-adduct of hydroxyl radical and the DNA strand breaking by hydroxyl radical
    • K. Hiramoto, N. Ojima, K. Sako and K. Kikugawa, Effect of plant phenolics on the formation of the spin-adduct of hydroxyl radical and the DNA strand breaking by hydroxyl radical, Biol. Pharm. Bull., 1996, 19, 558-563.
    • (1996) Biol. Pharm. Bull. , vol.19 , pp. 558-563
    • Hiramoto, K.1    Ojima, N.2    Sako, K.3    Kikugawa, K.4
  • 7
    • 70249125069 scopus 로고    scopus 로고
    • Sesamol: An efficient antioxidant with potential therapeutic benefits
    • T. Geetha, R. Bhandari and I. P. Kaur, Sesamol: An efficient antioxidant with potential therapeutic benefits, J. Med. Chem., 2009, 5, 367-371.
    • (2009) J. Med. Chem. , vol.5 , pp. 367-371
    • Geetha, T.1    Bhandari, R.2    Kaur, I.P.3
  • 8
    • 84887470184 scopus 로고    scopus 로고
    • Neuroprotective effect of sesamol in glioma induced in rats
    • R. Narasimhan, M. Vaithiyanathan and V. Janardanam, Neuroprotective effect of sesamol in glioma induced in rats, Biomed. Int., 2011, 2, 22-27.
    • (2011) Biomed. Int. , vol.2 , pp. 22-27
    • Narasimhan, R.1    Vaithiyanathan, M.2    Janardanam, V.3
  • 9
    • 83755225768 scopus 로고    scopus 로고
    • Delivery of sesamol loaded solid lipid nanoparticles to brain for menopause related emotional and cognitive central nervous system derangements
    • V. Kakkar, A. K. Mishra, K. Chuttani, K. Chopra and I. P. Kaur, Delivery of sesamol loaded solid lipid nanoparticles to brain for menopause related emotional and cognitive central nervous system derangements, Rejuvenation Res., 2011, 14, 597-604.
    • (2011) Rejuvenation Res. , vol.14 , pp. 597-604
    • Kakkar, V.1    Mishra, A.K.2    Chuttani, K.3    Chopra, K.4    Kaur, I.P.5
  • 10
    • 0034633899 scopus 로고    scopus 로고
    • Sesamol exhibits antimutagenic activity against oxygen species mediated mutagenicity
    • I. P. Kaur and A. Saini, Sesamol exhibits antimutagenic activity against oxygen species mediated mutagenicity, Mutat. Res., 2000, 470, 71-76.
    • (2000) Mutat. Res. , vol.470 , pp. 71-76
    • Kaur, I.P.1    Saini, A.2
  • 13
    • 62549098543 scopus 로고    scopus 로고
    • Renoprotective effects of sesamol in ferric nitrilotriacetate-induced oxidative renal injury in rats
    • A. Gupta, S. Sharma, I. Kaur and K. Chopra, Renoprotective effects of sesamol in ferric nitrilotriacetate-induced oxidative renal injury in rats, Basic Clin. Pharmacol. Toxicol., 2009, 104, 316-321.
    • (2009) Basic Clin. Pharmacol. Toxicol. , vol.104 , pp. 316-321
    • Gupta, A.1    Sharma, S.2    Kaur, I.3    Chopra, K.4
  • 14
    • 80155141103 scopus 로고    scopus 로고
    • Sesamol as a potential radioprotective agent: In vitro studies
    • K. Mishra, P. S. Srivastava and N. K. Chaudhury, Sesamol as a potential radioprotective agent: in vitro studies, Radiat. Res., 2011, 176 , 613-623.
    • (2011) Radiat. Res. , vol.176 , pp. 613-623
    • Mishra, K.1    Srivastava, P.S.2    Chaudhury, N.K.3
  • 15
    • 78649323827 scopus 로고    scopus 로고
    • Sesamol inhibits UVB-induced ROS generation and subsequent oxidative damage in cultured human skin dermal fibroblasts
    • S. Ramachandran, R. N. Prasad and S. Karthikeyan, Sesamol inhibits UVB-induced ROS generation and subsequent oxidative damage in cultured human skin dermal fibroblasts, Arch. Dermatol. Res., 2010, 302, 733-744.
    • (2010) Arch. Dermatol. Res. , vol.302 , pp. 733-744
    • Ramachandran, S.1    Prasad, R.N.2    Karthikeyan, S.3
  • 16
    • 33644747334 scopus 로고    scopus 로고
    • Development and evaluation of sesamol as an antiaging agent
    • S. Sharma and I. P. Kaur, Development and evaluation of sesamol as an antiaging agent, Int. J. Dermatol., 2006, 45, 200-208.
    • (2006) Int. J. Dermatol. , vol.45 , pp. 200-208
    • Sharma, S.1    Kaur, I.P.2
  • 17
    • 78649673058 scopus 로고    scopus 로고
    • Sesamol downregulates the lipopolysaccharide-induced inflammatory response by inhibiting nuclear factor-kappa B activation
    • P. Y. Chu, D. Z. Hsu, P. Y. Hsu and M. Y. Liu, Sesamol downregulates the lipopolysaccharide-induced inflammatory response by inhibiting nuclear factor-kappa B activation, Innate Immun., 2010, 16, 333-339.
    • (2010) Innate Immun. , vol.16 , pp. 333-339
    • Chu, P.Y.1    Hsu, D.Z.2    Hsu, P.Y.3    Liu, M.Y.4
  • 18
    • 74549190015 scopus 로고    scopus 로고
    • The non-peptide chemical 3,4-methylenedioxyphenol blocked lipopolysaccharide (LPS) from binding to LPS-binding protein and inhibited proin flammatory cytokines
    • D. Z. Hsu, P. Y. Chu and M. Y. Liu, The non-peptide chemical 3,4-methylenedioxyphenol blocked lipopolysaccharide (LPS) from binding to LPS-binding protein and inhibited proin flammatory cytokines, Innate Immun., 2009, 15, 380-385.
    • (2009) Innate Immun. , vol.15 , pp. 380-385
    • Hsu, D.Z.1    Chu, P.Y.2    Liu, M.Y.3
  • 19
    • 0014254256 scopus 로고
    • A note on the absorption of 3-methoxy-N-methyl-morphinan hydrochloride from the rat stomach
    • G. Fiese and J. H. Perrin, A note on the absorption of 3-methoxy-N-methyl-morphinan hydrochloride from the rat stomach, J. Pharmacokinet. Pharmacodyn., 1968, 20 , 98-101.
    • (1968) J. Pharmacokinet. Pharmacodyn. , vol.20 , pp. 98-101
    • Fiese, G.1    Perrin, J.H.2
  • 20
    • 0042447852 scopus 로고
    • Influence of experimental procedures and dose on the intestinal absorption of an onium compound, benzomethamine
    • R. R. Levine and E. W. Perikan, Influence of experimental procedures and dose on the intestinal absorption of an onium compound, benzomethamine, J. Pharmacol. Exp. Ther., 1961, 131, 319-327.
    • (1961) J. Pharmacol. Exp. Ther. , vol.131 , pp. 319-327
    • Levine, R.R.1    Perikan, E.W.2
  • 21
    • 67650002409 scopus 로고    scopus 로고
    • Elimination and metabolism of sesamol, a bioactive compound in sesame oil, in rats
    • K. C. Jan, C. T. Ho and L. S. Hwang, Elimination and metabolism of sesamol, a bioactive compound in sesame oil, in rats, Mol. Nutr. Food Res. , 2009, 53, 36-43.
    • (2009) Mol. Nutr. Food Res. , vol.53 , pp. 36-43
    • Jan, K.C.1    Ho, C.T.2    Hwang, L.S.3
  • 22
    • 51649094378 scopus 로고    scopus 로고
    • Bioavailability and tissue distribution of sesamol in rat
    • K. C. Jan, C. T. Ho and L. S. Hwang, Bioavailability and tissue distribution of sesamol in rat, J. Agric. Food Chem., 2008, 56, 7032-7037.
    • (2008) J. Agric. Food Chem. , vol.56 , pp. 7032-7037
    • Jan, K.C.1    Ho, C.T.2    Hwang, L.S.3
  • 23
    • 0027093470 scopus 로고
    • Forestomach neoplasm induction in F344/DuCrj rats and B6C3F1 mice exposed to sesamol
    • S. Tamano, M. Hirose, H. Tanaka, E. Asakawa, K. Ogawa and N. Ito, Forestomach neoplasm induction in F344/DuCrj rats and B6C3F1 mice exposed to sesamol, Jpn. J. Cancer Res., 1992, 83, 1279-1285.
    • (1992) Jpn. J. Cancer Res. , vol.83 , pp. 1279-1285
    • Tamano, S.1    Hirose, M.2    Tanaka, H.3    Asakawa, E.4    Ogawa, K.5    Ito, N.6
  • 25
    • 0024214130 scopus 로고
    • A carcinogenesis reversibility study of the effects of butylated hydroxyanisole on the forestomach and urinary bladder in male Fischer 344 rats
    • E. A. Nera, F. Iverson, E. Lok, C. L. Armstrong, K. Karpinski and D. B. Clayson, A carcinogenesis reversibility study of the effects of butylated hydroxyanisole on the forestomach and urinary bladder in male Fischer 344 rats, Toxicology, 1988, 53, 251-268.
    • (1988) Toxicology , vol.53 , pp. 251-268
    • Nera, E.A.1    Iverson, F.2    Lok, E.3    Armstrong, C.L.4    Karpinski, K.5    Clayson, D.B.6
  • 26
    • 0027372444 scopus 로고
    • Comparison of reversibility of rat forestomach lesions induced by genotoxic and non-genotoxic carcinogens
    • M. Kagawa, K. Hakoi, A. Yamamoto, M. Futakuchi and M. Hirose, Comparison of reversibility of rat forestomach lesions induced by genotoxic and non-genotoxic carcinogens, Jpn. J. Cancer Res., 1993, 84, 1120-1129.
    • (1993) Jpn. J. Cancer Res. , vol.84 , pp. 1120-1129
    • Kagawa, M.1    Hakoi, K.2    Yamamoto, A.3    Futakuchi, M.4    Hirose, M.5
  • 28
    • 0023203191 scopus 로고
    • Regression of simple hyperplasia and papillomas and persistence of basal cell hyperplasia in the forestomach of F344 rats treated with butylated hydroxyanisole
    • T. Masui, M. Asamoto, M. Hisose, S. Fukushima and N. Ito, Regression of simple hyperplasia and papillomas and persistence of basal cell hyperplasia in the forestomach of F344 rats treated with butylated hydroxyanisole, Cancer Res., 1987, 47, 5171-5174.
    • (1987) Cancer Res. , vol.47 , pp. 5171-5174
    • Masui, T.1    Asamoto, M.2    Hisose, M.3    Fukushima, S.4    Ito, N.5
  • 29
    • 36049041164 scopus 로고
    • Dissociation constant, solubility and the pH value of the solvent
    • H. A. Krebs and J. C. Speakman, Dissociation constant, solubility and the pH value of the solvent, J. Chem. Soc., 1945, 593-595.
    • (1945) J. Chem. Soc. , pp. 593-595
    • Krebs, H.A.1    Speakman, J.C.2
  • 30
    • 0032927254 scopus 로고    scopus 로고
    • Drug, meal and formulation interactions influencing drug absorption after oral administration-clinical implications
    • D. Fleisher, C. Li, Y. Zhou, L. H. Pao and A. Karim, Drug, meal and formulation interactions influencing drug absorption after oral administration-clinical implications, Clin. Pharmacokinet., 1999, 36, 233-254.
    • (1999) Clin. Pharmacokinet. , vol.36 , pp. 233-254
    • Fleisher, D.1    Li, C.2    Zhou, Y.3    Pao, L.H.4    Karim, A.5
  • 31
    • 0011911167 scopus 로고
    • Absorption and excretion of drugs. XIX Some pharmacokinetic aspects of absorption and excretion of sulphonamides. (1) Absorption from rat stomach
    • T. Koizumi, T. Arita and K. Kakemi, Absorption and excretion of drugs. XIX Some pharmacokinetic aspects of absorption and excretion of sulphonamides. (1) Absorption from rat stomach, Chem. Pharm. Bull., 1964, 12(4), 413-420.
    • (1964) Chem. Pharm. Bull. , vol.12 , Issue.4 , pp. 413-420
    • Koizumi, T.1    Arita, T.2    Kakemi, K.3
  • 32
    • 8444223066 scopus 로고    scopus 로고
    • Drug permeation in biomembranes: In vitro and in silico prediction and influence of physicochemical properties
    • A. Malkia, L. Murtomaki, A. Urtti and K. Kontturi, Drug permeation in biomembranes: in vitro and in silico prediction and influence of physicochemical properties, Eur. J. Pharm. Sci., 2004, 23, 13-47.
    • (2004) Eur. J. Pharm. Sci. , vol.23 , pp. 13-47
    • Malkia, A.1    Murtomaki, L.2    Urtti, A.3    Kontturi, K.4
  • 33
    • 0028912168 scopus 로고
    • Glycol amide esters of 6- methoxy-2-naphthyl acetic acid as potential prodrugs-physicochemical properties, chemical stability and enzymatic hydrolysis
    • L. K. Wadhawa and P. D. Sharma, Glycol amide esters of 6- methoxy-2-naphthyl acetic acid as potential prodrugs-physicochemical properties, chemical stability and enzymatic hydrolysis, Int. J. Pharm., 1995, 118, 31-39.
    • (1995) Int. J. Pharm. , vol.118 , pp. 31-39
    • Wadhawa, L.K.1    Sharma, P.D.2
  • 34
    • 0022889696 scopus 로고
    • A method for calculation of the aqueous solubility of organic compounds by using new fragment solubility constants
    • K. Wakita, M. Yoshimoto, S. Miyamoto and H. Watanabe, A method for calculation of the aqueous solubility of organic compounds by using new fragment solubility constants, Chem. Pharm. Bull., 1986, 34 , 4663-4681.
    • (1986) Chem. Pharm. Bull. , vol.34 , pp. 4663-4681
    • Wakita, K.1    Yoshimoto, M.2    Miyamoto, S.3    Watanabe, H.4
  • 37
    • 8644243613 scopus 로고
    • Partition coefficients and their uses
    • A. Leo, C. Hanch and D. Elkins, Partition coefficients and their uses, Chem. Rev. , 1971, 71, 6.
    • (1971) Chem. Rev. , vol.71 , pp. 6
    • Leo, A.1    Hanch, C.2    Elkins, D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.