메뉴 건너뛰기




Volumn 2012, Issue 7, 2012, Pages

Tiotropium versus placebo for chronic obstructive pulmonary disease

Author keywords

[No Author keywords available]

Indexed keywords

BETA ADRENERGIC RECEPTOR STIMULATING AGENT; CORTICOSTEROID; LONG ACTING DRUG; PLACEBO; TIOTROPIUM BROMIDE; BRONCHODILATING AGENT; CHOLINERGIC RECEPTOR BLOCKING AGENT; SCOPOLAMINE DERIVATIVE;

EID: 84866439937     PISSN: None     EISSN: 1469493X     Source Type: Journal    
DOI: 10.1002/14651858.CD009285.pub2     Document Type: Review
Times cited : (125)

References (235)
  • 1
    • 85041503976 scopus 로고    scopus 로고
    • A randomised, double-blind, placebo-controlled, parallel-group study to assess long term (one-year) efficacy and safety of tiotropium inhalation solution 5 mcg (2 puffs of 2.5 mcg) delivered by the Respimat® inhaler in patients with chronic obstructive pulmonary disease (COPD)
    • [trial number: 205.372]
    • Bateman ED. A randomised, double-blind, placebo-controlled, parallel-group study to assess long term (one-year) efficacy and safety of tiotropium inhalation solution 5 mcg (2 puffs of 2.5 mcg) delivered by the Respimat® inhaler in patients with chronic obstructive pulmonary disease (COPD). www.trials.boehringer-ingelheim.com. [trial number: 205.372].
    • Bateman, E.D.1
  • 2
    • 77956338422 scopus 로고    scopus 로고
    • A one-year trial of tiotropium Respimat plus usual therapy in COPD patients
    • CTG: NCT00387088]
    • Bateman ED, Tashkin D, Siafakas N, Dahl R, Towse L, Massey D, et al.A one-year trial of tiotropium Respimat plus usual therapy in COPD patients. Respiratory Medicine 2010;104(10):1460-72. [CTG: NCT00387088].
    • (2010) Respiratory Medicine , vol.104 , Issue.10 , pp. 1460-1472
    • Bateman, E.D.1    Tashkin, D.2    Siafakas, N.3    Dahl, R.4    Towse, L.5    Massey, D.6
  • 4
    • 85041501302 scopus 로고    scopus 로고
    • A retrospective collection of vital status and pulmonary medication usage data for patients with chronic obstructive pulmonary disease (COPD) who withdrew prematurely from either of two one-year trials (205.254, 205.255) of tiotropium inhalation solution delivered by the Respimat® inhaler
    • (accessed 05 March 2008). [trial number: 205.392]
    • Cooper, C. A retrospective collection of vital status and pulmonary medication usage data for patients with chronic obstructive pulmonary disease (COPD) who withdrew prematurely from either of two one-year trials (205.254, 205.255) of tiotropium inhalation solution delivered by the Respimat® inhaler. www.trials.boehringer-ingelheim.com (accessed 05 March 2008). [trial number: 205.392].
    • Cooper, C.1
  • 6
    • 85041532996 scopus 로고    scopus 로고
    • A randomised, double-blind, placebo-controlled, parallel group efficacy and safety comparison of one-year treatment of two doses (5 μg [2 actuations of 2.5 μg] and 10 μg [2 actuations of 5 μg]) of tiotropium inhalation solution delivered by the Respimat® inhaler in patients with chronic obstructive pulmonary disease (COPD)
    • [trial number: 205.255]
    • Singh SD. A randomised, double-blind, placebo-controlled, parallel group efficacy and safety comparison of one-year treatment of two doses (5 μg [2 actuations of 2.5 μg] and 10 μg [2 actuations of 5 μg]) of tiotropium inhalation solution delivered by the Respimat® inhaler in patients with chronic obstructive pulmonary disease (COPD). www.trials.boehringer-ingelheim.com. [trial number: 205.255].
    • Singh, S.D.1
  • 7
    • 85041550389 scopus 로고    scopus 로고
    • A Randomised, Double-Blind Placebo Controlled, Parallel Group Efficacy and Safety Comparison of One-year Treatment of Two Doses (5 μg [2 actuations of 2.5 μg] and 10 μg [2 actuations of 5 μg]) of Tiotropium Inhalation Solution Delivered by the Respimat® Inhaler in Patients with Chronic Obstructive Pulmonary Disease (COPD)
    • [trial number: 205.254]
    • Smith D. A Randomised, Double-Blind Placebo Controlled, Parallel Group Efficacy and Safety Comparison of One-year Treatment of Two Doses (5 μg [2 actuations of 2.5 μg] and 10 μg [2 actuations of 5 μg]) of Tiotropium Inhalation Solution Delivered by the Respimat® Inhaler in Patients with Chronic Obstructive Pulmonary Disease (COPD). www.trials.boehringer-ingelheim.com. [trial number: 205.254].
    • Smith, D.1
  • 8
    • 85041510993 scopus 로고    scopus 로고
    • Efficacy of tiotropium (spriva) in patients with COPD switched from previous treatment with short-acting anticholinergics [Abstract]. Proceedings of the American Thoracic Society; 2006 May 19-24; San Diego. :
    • Beeh KM, Beier J, Buhl R, Gerken FMN. Efficacy of tiotropium (spriva) in patients with COPD switched from previous treatment with short-acting anticholinergics [Abstract]. Proceedings of the American Thoracic Society; 2006 May 19-24; San Diego. 2006:A113 [Poster J27].
    • (2006)
    • Beeh, K.M.1    Beier, J.2    Buhl, R.3    Gerken, F.M.N.4
  • 9
    • 33745885342 scopus 로고    scopus 로고
    • Efficacy of tiotropium bromide (Spiriva) in patients with chronic-obstructive pulmonary disease (COPD) of different severities
    • Wirksamkeit von Tiotropiumbromid (Spiriva)bei verschiedenen Schweregraden derchronisch-obstruktiven Lungenerkrankung (COPD)][CTG: NCT00274573]
    • Beeh KM, Beier J, Buhl R, Stark-Lorenzen P, Gerken F, Metzdorf N, et al.Efficacy of tiotropium bromide (Spiriva) in patients with chronic-obstructive pulmonary disease (COPD) of different severities [Wirksamkeit von Tiotropiumbromid (Spiriva)bei verschiedenen Schweregraden derchronisch-obstruktiven Lungenerkrankung (COPD)]. Pneumologie 2006;60(6):341-6. [CTG: NCT00274573].
    • (2006) Pneumologie , vol.60 , Issue.6 , pp. 341-346
    • Beeh, K.M.1    Beier, J.2    Buhl, R.3    Stark-Lorenzen, P.4    Gerken, F.5    Metzdorf, N.6
  • 10
    • 85041550185 scopus 로고    scopus 로고
    • Efficacy of tiotropium in patients with mild to moderate COPD [Abstract]
    • 2004 May 21-26; Florida, USA. :
    • Beeh KM, Beier J, Buhl R, Strak-Lorenzen P, Gerken F, Metzdorf N. Efficacy of tiotropium in patients with mild to moderate COPD [Abstract]. American Thoracic Society 2004 International Conference; 2004 May 21-26; Florida, USA. 2004:P513.
    • (2004)
    • Beeh, K.M.1    Beier, J.2    Buhl, R.3    Strak-Lorenzen, P.4    Gerken, F.5    Metzdorf, N.6
  • 11
    • 85041505497 scopus 로고    scopus 로고
    • Acute and long-term effects of once daily oral inhalation of tiotropium 18 mcg dry powder inhalation capsules in a placebo controlled parallel group design study in patients with chronic obstructive pulmonary disease (COPD) of different severity
    • [trial number: 205.257]
    • Boehringer Ingelheim. Acute and long-term effects of once daily oral inhalation of tiotropium 18 mcg dry powder inhalation capsules in a placebo controlled parallel group design study in patients with chronic obstructive pulmonary disease (COPD) of different severity. www.trials.boehringer-ingelheim.com. [trial number: 205.257].
    • Boehringer, I.1
  • 14
    • 0038366897 scopus 로고    scopus 로고
    • Health outcomes following treatment for six months with once daily tiotropium compared with twice daily salmeterol in patients with COPD
    • Brusasco V, Hodder R, Miravitlles M, Korducki L, Towse L, Kesten S. Health outcomes following treatment for six months with once daily tiotropium compared with twice daily salmeterol in patients with COPD. Thorax 2003;58(5):399-404.
    • (2003) Thorax , vol.58 , Issue.5 , pp. 399-404
    • Brusasco, V.1    Hodder, R.2    Miravitlles, M.3    Korducki, L.4    Towse, L.5    Kesten, S.6
  • 15
    • 85041528323 scopus 로고    scopus 로고
    • American Thoracic Society 99th International Conference; 2003; May 16 - 21; Seattle. :
    • Brusasco V, Menjoge SS, Kesten S. Flow and volume responders following treatment with tiotropium and salmeterol in patients with COPD [Abstract]. American Thoracic Society 99th International Conference; 2003; May 16 - 21; Seattle. 2003:B024 Poster 420.
    • (2003)
    • Brusasco, V.1    Menjoge, S.S.2    Kesten, S.3
  • 16
    • 85041521269 scopus 로고    scopus 로고
    • Flow and volume responders over 12 hours following treatment with tiotropium or salmeterol in patients with COPD [Abstract]. American Thoracic Society Annual Meeting; 2006; May 19-24; San Diego. :
    • Brusasco V, Menjoge SS, Kesten S. Flow and volume responders over 12 hours following treatment with tiotropium or salmeterol in patients with COPD [Abstract]. American Thoracic Society Annual Meeting; 2006; May 19-24; San Diego. 2006:A110 [Poster J10].
    • (2006)
    • Brusasco, V.1    Menjoge, S.S.2    Kesten, S.3
  • 17
    • 0002857075 scopus 로고    scopus 로고
    • Improvement of dyspnea following of six months treatment with tiotropium but not with salmeterol in patients with COPD
    • Brusasco V, Thompson P, Vincken W, Lee A, Towse L, Witek TJ. Improvement of dyspnea following of six months treatment with tiotropium but not with salmeterol in patients with COPD. European Respiratory Journal 2001;18(Suppl 33):26.
    • (2001) European Respiratory Journal , vol.18 , pp. 26
    • Brusasco, V.1    Thompson, P.2    Vincken, W.3    Lee, A.4    Towse, L.5    Witek, T.J.6
  • 18
    • 84878703140 scopus 로고    scopus 로고
    • Alterations in bronchodilator effectiveness over six months with tiotropium and salmeterol
    • Donohue JF. Alterations in bronchodilator effectiveness over six months with tiotropium and salmeterol. American Journal of Respiratory and Critical Care Medicine 2002;165(Suppl 8):A227.
    • (2002) American Journal of Respiratory and Critical Care Medicine , vol.165
    • Donohue, J.F.1
  • 19
    • 0042882845 scopus 로고    scopus 로고
    • Tolerance to bronchodilating effects of salmeterol in COPD
    • Donohue JF, Menjoge S, Kesten S. Tolerance to bronchodilating effects of salmeterol in COPD. Respiratory Medicine 2003;97(9):1014-20.
    • (2003) Respiratory Medicine , vol.97 , Issue.9 , pp. 1014-1020
    • Donohue, J.F.1    Menjoge, S.2    Kesten, S.3
  • 20
    • 0036305399 scopus 로고    scopus 로고
    • A 6-month, placebo-controlled study comparing lung function and health status changes in COPD patients treated with tiotropium or salmeterol
    • Donohue JF, Van Noord JA, Bateman ED, Langley SJ, Lee A, Witek TJ, et al.A 6-month, placebo-controlled study comparing lung function and health status changes in COPD patients treated with tiotropium or salmeterol. Chest 2002;122(1):47-55.
    • (2002) Chest , vol.122 , Issue.1 , pp. 47-55
    • Donohue, J.F.1    Van Noord, J.A.2    Bateman, E.D.3    Langley, S.J.4    Lee, A.5    Witek, T.J.6
  • 23
    • 85040450082 scopus 로고    scopus 로고
    • Superior bronchodilation of once daily tiotropium compared with twice daily salmeterol in patients with COPD [Abstract]
    • International Primary Care Respiratory Group Congress; 2002; June 7-9; Amsterdam. :
    • Gunther K, Lee A, Kesten S, Towse L. Superior bronchodilation of once daily tiotropium compared with twice daily salmeterol in patients with COPD [Abstract]. International Primary Care Respiratory Group Congress; 2002; June 7-9; Amsterdam. 2002:112.
    • (2002) , pp. 112
    • Gunther, K.1    Lee, A.2    Kesten, S.3    Towse, L.4
  • 24
    • 34547624362 scopus 로고    scopus 로고
    • Outcomes in COPD patients receiving tiotropium or salmeterol plus treatment with inhaled corticosteroids
    • Hodder R, Kesten S, Menjoge S, Viel K. Outcomes in COPD patients receiving tiotropium or salmeterol plus treatment with inhaled corticosteroids. International Journal of COPD 2007;2(2):157-67.
    • (2007) International Journal of COPD , vol.2 , Issue.2 , pp. 157-167
    • Hodder, R.1    Kesten, S.2    Menjoge, S.3    Viel, K.4
  • 25
    • 85041517194 scopus 로고    scopus 로고
    • Spirometric outcomes of COPD patients with tiotropium compared with salmeterol according to previous maintenance long acting beta-agonist use [Abstract]
    • Langley J, Briggs Jr D, Bhattacharya S, Kesten S, Cassino C. Spirometric outcomes of COPD patients with tiotropium compared with salmeterol according to previous maintenance long acting beta-agonist use [Abstract]. European Respiratory Journal 2004;24(Suppl 48):289.
    • (2004) European Respiratory Journal , vol.24 , pp. 289
    • Langley, J.1    Briggs, D.2    Bhattacharya, S.3    Kesten, S.4    Cassino, C.5
  • 26
    • 33746804545 scopus 로고    scopus 로고
    • Tiotropium in COPD patients not previously receiving maintenance respiratory medications
    • Adams SG, Anzueto A, Briggs DD, Menjoge SS, Kesten S. Tiotropium in COPD patients not previously receiving maintenance respiratory medications. Respiratory Medicine 2006;100(9):1495-503.
    • (2006) Respiratory Medicine , vol.100 , Issue.9 , pp. 1495-1503
    • Adams, S.G.1    Anzueto, A.2    Briggs, D.D.3    Menjoge, S.S.4    Kesten, S.5
  • 27
    • 85041494982 scopus 로고    scopus 로고
    • Effects of tiotropium in COPD patients only treated with PRN albuterol [Abstract]
    • American Thoracic Society 100th International Conference; 2004 May 21-26; Orlando. :
    • Anzueto A, Kesten S. Effects of tiotropium in COPD patients only treated with PRN albuterol [Abstract]. American Thoracic Society 100th International Conference; 2004 May 21-26; Orlando. 2004:C47 Poster F81.
    • (2004)
    • Anzueto, A.1    Kesten, S.2
  • 28
    • 11844265905 scopus 로고    scopus 로고
    • One-year analysis of longitudinal changes in spirometry in patients with COPD receiving tiotropium
    • Anzueto A, Tashkin D, Menjoge S, Kesten S. One-year analysis of longitudinal changes in spirometry in patients with COPD receiving tiotropium. Pulmonary Pharmacology and Therapeutics 2005;18(2):75-81.
    • (2005) Pulmonary Pharmacology and Therapeutics , vol.18 , Issue.2 , pp. 75-81
    • Anzueto, A.1    Tashkin, D.2    Menjoge, S.3    Kesten, S.4
  • 29
    • 0033748430 scopus 로고    scopus 로고
    • The spirometric efficacy of once-daily dosing with tiotropium in stable COPD: a 13-week multicenter trial
    • Casaburi R, Briggs DD Jr, Donohue JF, Serby CW, Menjoge SS, The US Tiotropium Study Group. The spirometric efficacy of once-daily dosing with tiotropium in stable COPD: a 13-week multicenter trial. Chest 2000;118(5):1294-302.
    • (2000) Chest , vol.118 , Issue.5 , pp. 1294-1302
    • Casaburi, R.1    Briggs, D.D.2    Donohue, J.F.3    Serby, C.W.4    Menjoge, S.S.5
  • 31
    • 0011060670 scopus 로고    scopus 로고
    • Cost consequences of tiotropium plus existing therapy versus existing therapy alone following one year of treatment in patients with COPD
    • Friedman M, Bell T, Menjoge SS, Anton S, Koch P. Cost consequences of tiotropium plus existing therapy versus existing therapy alone following one year of treatment in patients with COPD. European Respiratory Journal 2001;18(Suppl 33):5.
    • (2001) European Respiratory Journal , vol.18 , pp. 5
    • Friedman, M.1    Bell, T.2    Menjoge, S.S.3    Anton, S.4    Koch, P.5
  • 32
    • 3242888951 scopus 로고    scopus 로고
    • Healthcare costs with tiotropium plus usual care versus usual care alone following 1 year of treatment in patients with chronic obstructive pulmonary disorder (COPD)
    • Friedman M, Menjoge SS, Anton SF, Kesten S. Healthcare costs with tiotropium plus usual care versus usual care alone following 1 year of treatment in patients with chronic obstructive pulmonary disorder (COPD). Pharmacoeconomics 2004;22(11):741-9.
    • (2004) Pharmacoeconomics , vol.22 , Issue.11 , pp. 741-749
    • Friedman, M.1    Menjoge, S.S.2    Anton, S.F.3    Kesten, S.4
  • 33
    • 85041517971 scopus 로고    scopus 로고
    • Maintenance of bronchodilation following tiotropium in patients with mild, moderate and severe COPD in one-year placebo-controlled clinical trials [Abstract]. International Primary Care Respiratory Group Congress; 2002; June 7-9; Amsterdam. :
    • Kesten S, Flanders J, Menjoge SS, Serby C. Maintenance of bronchodilation following tiotropium in patients with mild, moderate and severe COPD in one-year placebo-controlled clinical trials [Abstract]. International Primary Care Respiratory Group Congress; 2002; June 7-9; Amsterdam. 2002:24.
    • (2002) , pp. 24
    • Kesten, S.1    Flanders, J.2    Menjoge, S.S.3    Serby, C.4
  • 34
    • 85041554326 scopus 로고    scopus 로고
    • Can patient demographics be used to predict future choices for antibiotics, steroids, or both for exacerbations of COPD? [Abstract]. National COPD Conference; 2003; November 14-15, 2003; Arlington, Virginia. :
    • Kesten S, Menjoge S. Can patient demographics be used to predict future choices for antibiotics, steroids, or both for exacerbations of COPD? [Abstract]. National COPD Conference; 2003; November 14-15, 2003; Arlington, Virginia. 2003:Abstract no: 1189.
    • (2003)
    • Kesten, S.1    Menjoge, S.2
  • 35
    • 85041529803 scopus 로고    scopus 로고
    • The impact of COPD exacerbations (EXAC) on health related quality of life (HRQL) is attenuated by tiotropium [Abstract]. International Primary Care Respiratory Group Congress; 2002; June 7-9; Amsterdam. :
    • Kesten S, Menjoge SS, Witek T. The impact of COPD exacerbations (EXAC) on health related quality of life (HRQL) is attenuated by tiotropium [Abstract]. International Primary Care Respiratory Group Congress; 2002; June 7-9; Amsterdam. 2002:23.
    • (2002) , pp. 23
    • Kesten, S.1    Menjoge, S.S.2    Witek, T.3
  • 38
    • 0036701328 scopus 로고    scopus 로고
    • Impact of tiotropium on COPD exacerbations: 1-Yr studies versus placebo or ipratropium
    • Serby CW. Impact of tiotropium on COPD exacerbations: 1-Yr studies versus placebo or ipratropium. European Respiratory Review 2002;12(82):16-7.
    • (2002) European Respiratory Review , vol.12 , Issue.82 , pp. 16-17
    • Serby, C.W.1
  • 41
    • 85041539396 scopus 로고    scopus 로고
    • Short-term changes in health status with tiotropium predict long-term changes in health status [Abstract]. European Respiratory Society Annual Congress; 2002; September 14-18; Stockholm. :
    • Spencer S, Jones PW. Short-term changes in health status with tiotropium predict long-term changes in health status [Abstract]. European Respiratory Society Annual Congress; 2002; September 14-18; Stockholm. 2002:P1611.
    • (2002) , pp. P1611
    • Spencer, S.1    Jones, P.W.2
  • 42
    • 0037879081 scopus 로고    scopus 로고
    • Long-term treatment benefits with tiotropium in COPD patients with and without short-term bronchodilator responses
    • Tashkin D, Kesten S. Long-term treatment benefits with tiotropium in COPD patients with and without short-term bronchodilator responses. Chest 2003;123(5):1441-9.
    • (2003) Chest , vol.123 , Issue.5 , pp. 1441-1449
    • Tashkin, D.1    Kesten, S.2
  • 43
    • 0037368520 scopus 로고    scopus 로고
    • Meaningful effect size and patterns of response of the transition dyspnea index
    • Witek TJ Jr, Mahler DA. Meaningful effect size and patterns of response of the transition dyspnea index. Journal of Clinical Epidemiology 2003;56(3):248-55.
    • (2003) Journal of Clinical Epidemiology , vol.56 , Issue.3 , pp. 248-255
    • Witek, T.J.1    Mahler, D.A.2
  • 45
    • 85041493577 scopus 로고    scopus 로고
    • Electrocardiographic evaluations in COPD patients treated with tiotropium in one-year clinical trials [Abstract]. American Thoracic Society 99th International Conference; 2003 May 16-21; Seattle. :
    • Zuwallack R, Morganroth J, Lanes S, Kesten S. Electrocardiographic evaluations in COPD patients treated with tiotropium in one-year clinical trials [Abstract]. American Thoracic Society 99th International Conference; 2003 May 16-21; Seattle. 2003:A035 Poster D78.
    • (2003)
    • Zuwallack, R.1    Morganroth, J.2    Lanes, S.3    Kesten, S.4
  • 46
    • 85041532697 scopus 로고    scopus 로고
    • Spiriva assessment of FEV1 (SAFE). The effect of inhaled tiotropium bromide (18 mcg once daily) on the change in FEV1 during long-term treatment in patients with COPD. A one-year parallel group, double-blind, randomised, placebo-controlled study
    • [trial number: 205.259]
    • Chan C. Spiriva assessment of FEV1 (SAFE). The effect of inhaled tiotropium bromide (18 mcg once daily) on the change in FEV1 during long-term treatment in patients with COPD. A one-year parallel group, double-blind, randomised, placebo-controlled study. Boehringer Ingelheim Clinical Trial Register 2005. [trial number: 205.259].
    • (2005) Boehringer Ingelheim Clinical Trial Register
    • Chan, C.1
  • 47
    • 39149134323 scopus 로고    scopus 로고
    • A randomized controlled trial to assess the efficacy of tiotropium in Canadian patients with chronic obstructive pulmonary disease
    • Group SS.. ;():-. [CTG: NCT00277264]
    • Chan CK, Maltais F, Sigouin C, Haddon JM, Ford GT, Group SS. A randomized controlled trial to assess the efficacy of tiotropium in Canadian patients with chronic obstructive pulmonary disease. Canadian Respiratory Journal 2007;14(8):465-72. [CTG: NCT00277264].
    • (2007) Canadian Respiratory Journal , vol.14 , Issue.8 , pp. 465-472
    • Chan, C.K.1    Maltais, F.2    Sigouin, C.3    Haddon, J.M.4    Ford, G.T.5
  • 48
    • 85041500100 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled two-year trial to examine the changes in exercise endurance and COPD patients treated with tiotropium (Spiriva® HandiHaler®) 18 μg once daily (EXACTT trial)
    • [trial number: 205.368]
    • Cooper C. A randomized, double-blind, placebo-controlled two-year trial to examine the changes in exercise endurance and COPD patients treated with tiotropium (Spiriva® HandiHaler®) 18 μg once daily (EXACTT trial). www.trials.boehringer-ingelheim.com. [trial number: 205.368].
    • Cooper, C.1
  • 49
    • 79952279089 scopus 로고    scopus 로고
    • Development and implementation of treadmill exercise testing protocols in COPD
    • CTG: NCT00525512]
    • Cooper CB, Abrazado M, Legg D, Kesten S. Development and implementation of treadmill exercise testing protocols in COPD. International Journal of COPD 2010;5:375-85. [CTG: NCT00525512].
    • (2010) International Journal of COPD , vol.5 , pp. 375-385
    • Cooper, C.B.1    Abrazado, M.2    Legg, D.3    Kesten, S.4
  • 51
    • 85041552472 scopus 로고    scopus 로고
    • Efficacy and safety (including 24-hour holter monitoring) of tiotropium inhalation capsules in patients with chronic obstructive pulmonary disease (a 12-week, parallel group, randomized, placebo-controlled, double-blind study)
    • [trial number: 205.284]
    • Boehringer Ingelheim. Efficacy and safety (including 24-hour holter monitoring) of tiotropium inhalation capsules in patients with chronic obstructive pulmonary disease (a 12-week, parallel group, randomized, placebo-controlled, double-blind study). www.trials.boehringer-ingelheim.com. [trial number: 205.284].
    • Boehringer, I.1
  • 52
    • 29044441927 scopus 로고    scopus 로고
    • Absence of electrocardiographic findings and improved function with once-daily tiotropium in patients with chronic obstructive pulmonary disease
    • Vol. 25, issue 12:-. [CTG: NCT00239460]
    • Covelli H, Bhattacharya S, Cassino C, Conoscenti C, Kesten S. Absence of electrocardiographic findings and improved function with once-daily tiotropium in patients with chronic obstructive pulmonary disease. Pharmacotherapy 2005; Vol. 25, issue 12:1708-18. [CTG: NCT00239460].
    • (2005) Pharmacotherapy , pp. 1708-1718
    • Covelli, H.1    Bhattacharya, S.2    Cassino, C.3    Conoscenti, C.4    Kesten, S.5
  • 53
    • 85041550549 scopus 로고    scopus 로고
    • Absence of electrocardiographic findings with daily tiotropium in patients with chronic obstructive pulmonary disease [Abstract]
    • Kesten S, Cassino C, Conoscenti C. Absence of electrocardiographic findings with daily tiotropium in patients with chronic obstructive pulmonary disease [Abstract]. Chest 2004;126(4 Suppl):837S.
    • (2004) Chest , vol.126 , Issue.4 , pp. 837S
    • Kesten, S.1    Cassino, C.2    Conoscenti, C.3
  • 54
    • 85041510513 scopus 로고    scopus 로고
    • Effect of inhaled tiotropium bromide (18 mcg once daily) on the severity of airflow obstruction during long-term treatment in patients with moderately severe COPD. Impact on severity and incidence of exacerbations. A one-year parallel-group, double-blind, randomized, placebo-controlled study
    • [trial number: 205.214]
    • Dusser D. Effect of inhaled tiotropium bromide (18 mcg once daily) on the severity of airflow obstruction during long-term treatment in patients with moderately severe COPD. Impact on severity and incidence of exacerbations. A one-year parallel-group, double-blind, randomized, placebo-controlled study. www.trials.boehringer-ingelheim.com. [trial number: 205.214].
    • Dusser, D.1
  • 55
    • 33644859913 scopus 로고    scopus 로고
    • The effect of tiotropium on exacerbations and airflow in patients with COPD
    • CTG: NCT00274014]
    • Dusser D, Bravo ML, Lacono P. The effect of tiotropium on exacerbations and airflow in patients with COPD. European Respiratory Journal 2006;27(3):547-55. [CTG: NCT00274014].
    • (2006) European Respiratory Journal , vol.27 , Issue.3 , pp. 547-555
    • Dusser, D.1    Bravo, M.L.2    Lacono, P.3
  • 56
    • 85041529889 scopus 로고    scopus 로고
    • Tiotropium reduces health resource utilization associated with COPD exacerbations [Abstract]
    • Dusser D, Bravo ML, Lacono P. Tiotropium reduces health resource utilization associated with COPD exacerbations [Abstract]. European Respiratory Journal 2004;24(Suppl 48):513.
    • (2004) European Respiratory Journal , vol.24 , pp. 513
    • Dusser, D.1    Bravo, M.L.2    Lacono, P.3
  • 57
    • 85041529889 scopus 로고    scopus 로고
    • Tiotropium COPD exacerbations the MISTRAL study [Abstract]
    • Dusser D, Bravo ML, Lanono P. Tiotropium COPD exacerbations the MISTRAL study [Abstract]. European Respiratory Journal 2004;24(Suppl 48):513.
    • (2004) European Respiratory Journal , vol.24 , pp. 513
    • Dusser, D.1    Bravo, M.L.2    Lanono, P.3
  • 58
    • 85041528912 scopus 로고    scopus 로고
    • Tiotropium reduces moderate-to-severe exacerbations in COPD patients irrespective of concomitant use of inhaled corticosteroids (ICS) [Abstract]. Proceedings of the American Thoracic Society; 2006 May 19-24; San Diego. :
    • Dusser D, Viel K, Bravo ML, Lacono P. Tiotropium reduces moderate-to-severe exacerbations in COPD patients irrespective of concomitant use of inhaled corticosteroids (ICS) [Abstract]. Proceedings of the American Thoracic Society; 2006 May 19-24; San Diego. 2006:A603 [Poster H6].
    • (2006)
    • Dusser, D.1    Viel, K.2    Bravo, M.L.3    Lacono, P.4
  • 59
    • 85041544797 scopus 로고    scopus 로고
    • Tiotropium reduces COPD exacerbations requiring treatment with systemic corticosteroids, antibiotics, or hospitalizations [Abstract]. Proceedings of the American Thoracic Society; 2006 May 19-24; San Diego. :
    • Dusser D, Viel K, Rouyrre N, Lancono P. Tiotropium reduces COPD exacerbations requiring treatment with systemic corticosteroids, antibiotics, or hospitalizations [Abstract]. Proceedings of the American Thoracic Society; 2006 May 19-24; San Diego. 2006:A603 [Poster H5].
    • (2006)
    • Dusser, D.1    Viel, K.2    Rouyrre, N.3    Lancono, P.4
  • 60
    • 85041501815 scopus 로고    scopus 로고
    • A randomised, double-blind, parallel group, 12 week study, comparing the effect of once daily tiotropium lactose capsule with placebo in patients with chronic obstructive pulmonary disease (COPD), naive to anticholinergic agents in addition to receiving their usual COPD care
    • [trial number: 205.276]
    • Freeman D. A randomised, double-blind, parallel group, 12 week study, comparing the effect of once daily tiotropium lactose capsule with placebo in patients with chronic obstructive pulmonary disease (COPD), naive to anticholinergic agents in addition to receiving their usual COPD care. www.trials.boehringer-ingelheim.com. [trial number: 205.276].
    • Freeman, D.1
  • 61
    • 34547618224 scopus 로고    scopus 로고
    • Efficacy and safety of tiotropium in COPD patients in primary care-the SPiRiva Usual CarE (SPRUCE) study
    • CTG: NCT00274079]
    • Freeman D, Lee A, Price D. Efficacy and safety of tiotropium in COPD patients in primary care-the SPiRiva Usual CarE (SPRUCE) study. Respiratory Research 2007;8:45. [CTG: NCT00274079].
    • (2007) Respiratory Research , vol.8 , pp. 45
    • Freeman, D.1    Lee, A.2    Price, D.3
  • 62
    • 85041545995 scopus 로고    scopus 로고
    • Spruce: tiotropium in UK primary care [Abstract]
    • Freeman D, Sarno M, White L, Lee A, Price D. Spruce: tiotropium in UK primary care [Abstract]. Thorax 2004;59(Suppl II):ii100.
    • (2004) Thorax , vol.59
    • Freeman, D.1    Sarno, M.2    White, L.3    Lee, A.4    Price, D.5
  • 63
    • 85041516493 scopus 로고    scopus 로고
    • SPiRiva usual carE- SPRUCE - tiotropium in a UK primary care COPD population other regular inhaled treatment [Abstract]. American Thoracic Society 2005 International Conference; 2005 May 20-25; San Diego. :
    • Price D, Sarno M, Lee A, Freeman D. SPiRiva usual carE- SPRUCE - tiotropium in a UK primary care COPD population other regular inhaled treatment [Abstract]. American Thoracic Society 2005 International Conference; 2005 May 20-25; San Diego. 2005:[A43] [Poster: F26].
    • (2005)
    • Price, D.1    Sarno, M.2    Lee, A.3    Freeman, D.4
  • 64
    • 85041551238 scopus 로고    scopus 로고
    • A 12-week, double-blind, randomised, parallel-group, multi-centre study evaluating the efficacy of tiotropium versus placebo in patients with mild COPD according to Swedish guidelines (SPIRIMILD)
    • [trial number: 205.281]
    • Johansson G. A 12-week, double-blind, randomised, parallel-group, multi-centre study evaluating the efficacy of tiotropium versus placebo in patients with mild COPD according to Swedish guidelines (SPIRIMILD). www.trials.boehringer-ingelheim.com. [trial number: 205.281].
    • Johansson, G.1
  • 67
    • 85041538796 scopus 로고    scopus 로고
    • A trial evaluating the efficacy and safety of inhaled tiotropium 18 g qd in patients with COPD and a concomitant diagnosis of asthma
    • Boehringer Ingelheim. A trial evaluating the efficacy and safety of inhaled tiotropium 18 g qd in patients with COPD and a concomitant diagnosis of asthma. www.clinicaltrials.gov 2005.
    • (2005)
    • Boehringer, I.1
  • 68
    • 85041514842 scopus 로고    scopus 로고
    • A 12-week randomised, double blind, placebo-controlled, parallel group trial evaluating the efficacy and safety of inhaled tiotropium 18 μg q.d. in patients with COPD and a concomitant diagnosis of asthma
    • [trial number: 205.301]
    • Magnussen H. A 12-week randomised, double blind, placebo-controlled, parallel group trial evaluating the efficacy and safety of inhaled tiotropium 18 μg q.d. in patients with COPD and a concomitant diagnosis of asthma. www.trials.boehringer-ingelheim.com. [trial number: 205.301].
    • Magnussen, H.1
  • 70
    • 85041509335 scopus 로고    scopus 로고
    • Spirometric improvements with tiotropium in COPD patients with concomitant asthma [Abstract]. American Thoracic Society International Conference; 2007 May 18-23; San Francisco. :
    • Magnussen H, Bugnas B, Van Noord J, Schmidt P, Gerken F, Kesten S, et al.Spirometric improvements with tiotropium in COPD patients with concomitant asthma [Abstract]. American Thoracic Society International Conference; 2007 May 18-23; San Francisco. 2007:Poster #A5.
    • (2007)
    • Magnussen, H.1    Bugnas, B.2    Van Noord, J.3    Schmidt, P.4    Gerken, F.5    Kesten, S.6
  • 71
    • 85041551056 scopus 로고    scopus 로고
    • Spiriva® assessment of FEV1 - (SAFE-Portugal). The effect of inhaled tiotropium bromide (18 mcg once daily) on the change in FEV1 during treatment in patients with COPD. A three-month parallel group, double-blind, randomised, placebo-controlled study
    • [trial number: 205.282]
    • Boehringer Ingelheim. Spiriva® assessment of FEV1 - (SAFE-Portugal). The effect of inhaled tiotropium bromide (18 mcg once daily) on the change in FEV1 during treatment in patients with COPD. A three-month parallel group, double-blind, randomised, placebo-controlled study. www.trials.boehringer-ingelheim.com. [trial number: 205.282].
    • Boehringer, I.1
  • 73
    • 85041523883 scopus 로고    scopus 로고
    • The effect of tiotropium bromide in a stable cohort of COPD patients in Portugal [Abstract]
    • Moita J, Costa R, Barbara C, Cardosa J, Rulz J, Sousa M. The effect of tiotropium bromide in a stable cohort of COPD patients in Portugal [Abstract]. European Respiratory Journal 2005;26(Suppl 49):Abstract No. 1955.
    • (2005) European Respiratory Journal , vol.26
    • Moita, J.1    Costa, R.2    Barbara, C.3    Cardosa, J.4    Rulz, J.5    Sousa, M.6
  • 74
    • 84941197416 scopus 로고    scopus 로고
    • A randomised, double-blind, placebo-controlled, 12 week trial to evaluate the effect of tiotropium inhalation capsules on the magnitude of exercise, measured using an accelerometer, in patients with chronic obstructive pulmonary disease (COPD)
    • (accessed 15 Oct 2007). [CTG: NCT00144326; trial number: 205.269]
    • García Río, F. A randomised, double-blind, placebo-controlled, 12 week trial to evaluate the effect of tiotropium inhalation capsules on the magnitude of exercise, measured using an accelerometer, in patients with chronic obstructive pulmonary disease (COPD). www.trials.boehringer-ingelheim.com (accessed 15 Oct 2007). [CTG: NCT00144326; trial number: 205.269].
    • García, R.F.1
  • 75
    • 85083929353 scopus 로고    scopus 로고
    • Tiotropium reduces exacerbations in COPD
    • Anonymous. Tiotropium reduces exacerbations in COPD. Pharmaceutical Journal 2004;272(7302):696.
    • (2004) Pharmaceutical Journal , vol.272 , Issue.7302 , pp. 696
  • 77
    • 85041503521 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled, parallel group trial assessing the proportion of patients experiencing an exacerbation and proportion of patients hospitalized for an exacerbation over 6 months during treatment with tiotropium 18 mcg capsule once daily in patients with COPD in a Veterans Affairs setting
    • [trial number: 205.266]
    • Niewoehner D. A randomized, double-blind, placebo-controlled, parallel group trial assessing the proportion of patients experiencing an exacerbation and proportion of patients hospitalized for an exacerbation over 6 months during treatment with tiotropium 18 mcg capsule once daily in patients with COPD in a Veterans Affairs setting. www.trials.boehringer-ingelheim.com. [trial number: 205.266].
    • Niewoehner, D.1
  • 78
    • 85041536801 scopus 로고    scopus 로고
    • Reduced COPD exacerbations in patients without first-dose peak FEV increases 15% with tiotropium [Abstract] American Thoracic Society 2005 International Conference; 2005 May 20-25; San Diego, California. San Diego
    • Niewoehner D, Gonzalez-Rothi R, Shigeoka J, Korducki L, Cassino C, Kesten S, et al.Reduced COPD exacerbations in patients without first-dose peak FEV increases 15% with tiotropium [Abstract] American Thoracic Society 2005 International Conference; 2005 May 20-25; San Diego, California. San Diego, 2005:[B93] [Poster: 319].
    • (2005)
    • Niewoehner, D.1    Gonzalez-Rothi, R.2    Shigeoka, J.3    Korducki, L.4    Cassino, C.5    Kesten, S.6
  • 79
    • 85041509014 scopus 로고    scopus 로고
    • Characteristics of COPD and response to once-daily tiotropium in African-Americans in the VA medical system [Abstract]. American Thoracic Society 2005 International Conference; 2005 May 20-25; San Diego. San Diego
    • Niewoehner D, Rice K, Cote C, Korducki L, Cassino C, Kesten S. Characteristics of COPD and response to once-daily tiotropium in African-Americans in the VA medical system [Abstract]. American Thoracic Society 2005 International Conference; 2005 May 20-25; San Diego. San Diego, 2005:[A43] [Poster: F41].
    • (2005)
    • Niewoehner, D.1    Rice, K.2    Cote, C.3    Korducki, L.4    Cassino, C.5    Kesten, S.6
  • 80
    • 85041546356 scopus 로고    scopus 로고
    • Reduced COPD exacerbations and associated health care utilization with once-daily tiotropium (TIO) in the VA medical system [Abstract]. American Thoracic Society 100th International Conference; 2004 May 21-26; Orlando. :
    • Niewoehner D, Rice K, Cote C, Paulson D, Cooper JA, Korducki L, et al.Reduced COPD exacerbations and associated health care utilization with once-daily tiotropium (TIO) in the VA medical system [Abstract]. American Thoracic Society 100th International Conference; 2004 May 21-26; Orlando. 2004:A84.
    • (2004)
    • Niewoehner, D.1    Rice, K.2    Cote, C.3    Paulson, D.4    Cooper, J.A.5    Korducki, L.6
  • 81
    • 85041502346 scopus 로고    scopus 로고
    • Reductions in COPD exacerbations with tiotropium in African-Americans in the VA medical system [Abstract]. American Thoracic Society International Conference; 2007 May 18-23; San Francisco. :
    • Niewoehner DE, Rice K, Cassino C, Leimer I, Kesten S. Reductions in COPD exacerbations with tiotropium in African-Americans in the VA medical system [Abstract]. American Thoracic Society International Conference; 2007 May 18-23; San Francisco. 2007:Poster #A51.
    • (2007)
    • Niewoehner, D.E.1    Rice, K.2    Cassino, C.3    Leimer, I.4    Kesten, S.5
  • 82
    • 24644492301 scopus 로고    scopus 로고
    • Prevention of exacerbations of chronic obstructive pulmonary disease with tiotropium, a once-daily inhaled anticholinergic bronchodilator: A randomized trial
    • CTG: NCT00274547]
    • Niewoehner DE, Rice K, Cote C, Paulson D, Cooper Jr JAD, Korducki L, et al.Prevention of exacerbations of chronic obstructive pulmonary disease with tiotropium, a once-daily inhaled anticholinergic bronchodilator: A randomized trial. Annals of Internal Medicine 2005;143(5):317-326. [CTG: NCT00274547].
    • (2005) Annals of Internal Medicine , vol.143 , Issue.5 , pp. 317-326
    • Niewoehner, D.E.1    Rice, K.2    Cote, C.3    Paulson, D.4    Cooper, J.A.D.5    Korducki, L.6
  • 83
    • 50949132697 scopus 로고    scopus 로고
    • Responses to tiotropium in African-American and Caucasian patients with chronic obstructive pulmonary disease
    • Rice KL, Leimer I, Kesten S, Niewoehner DE. Responses to tiotropium in African-American and Caucasian patients with chronic obstructive pulmonary disease. Translational Research 2008;152(2):88-94.
    • (2008) Translational Research , vol.152 , Issue.2 , pp. 88-94
    • Rice, K.L.1    Leimer, I.2    Kesten, S.3    Niewoehner, D.E.4
  • 84
    • 85041542592 scopus 로고    scopus 로고
    • The effect of tiotropium on diary based exacerbation frequency in COPD [Abstract]. American Thoracic Society Annual Meeting; 2006 May 19-24 2006; San Diego. :
    • Powrie D, Wilkinson T, Donaldson G, Viel K, Jones P, Scrine K, et al.The effect of tiotropium on diary based exacerbation frequency in COPD [Abstract]. American Thoracic Society Annual Meeting; 2006 May 19-24 2006; San Diego. 2006:A604 [Poster H11].
    • (2006)
    • Powrie, D.1    Wilkinson, T.2    Donaldson, G.3    Viel, K.4    Jones, P.5    Scrine, K.6
  • 85
    • 85041515445 scopus 로고    scopus 로고
    • Tiotropium reduces exacerbations and common colds in patients with COPD [Abstract]
    • American Thoracic Society International Conference; 2007 May 18-23; San Francisco, California, USA. :
    • Powrie DJ, Donaldson GC, Wilkinson TM, Jones P, Viel K, Kesten S, et al.Tiotropium reduces exacerbations and common colds in patients with COPD [Abstract]. American Thoracic Society International Conference; 2007 May 18-23; San Francisco, California, USA. 2007:Poster #A50.
    • (2007)
    • Powrie, D.J.1    Donaldson, G.C.2    Wilkinson, T.M.3    Jones, P.4    Viel, K.5    Kesten, S.6
  • 88
    • 85041521973 scopus 로고    scopus 로고
    • A randomised, double-blind, parallel-group, placebo-controlled study to evaluate the changes in inflammatory markers and in induced sputum following treatment with tiotropium inhalation capsules 18 μg once daily in patients with chronic obstructive pulmonary disease (COPD)
    • [trial number: 205.270]
    • Wedzicha JA. A randomised, double-blind, parallel-group, placebo-controlled study to evaluate the changes in inflammatory markers and in induced sputum following treatment with tiotropium inhalation capsules 18 μg once daily in patients with chronic obstructive pulmonary disease (COPD). www.trials.boehringer-ingelheim.com. [trial number: 205.270].
    • Wedzicha, J.A.1
  • 89
    • 84926285617 scopus 로고    scopus 로고
    • Evaluation of clinical effect and safety of tiotropium bromide in treating stable chronic obstructive pulmonary disease
    • Sun LH, Tan Y, Qiao Y, Fang SR, Xie H. Evaluation of clinical effect and safety of tiotropium bromide in treating stable chronic obstructive pulmonary disease. Zhongguo Xinyao yu Linchuang Zazhi 2007;26(5):328-31.
    • (2007) Zhongguo Xinyao yu Linchuang Zazhi , vol.26 , Issue.5 , pp. 328-331
    • Sun, L.H.1    Tan, Y.2    Qiao, Y.3    Fang, S.R.4    Xie, H.5
  • 90
    • 79953036135 scopus 로고    scopus 로고
    • Effect of domestic tiotropium bromide inhalation in patients with COPD at stable stage
    • Yan L, Lu YK. Effect of domestic tiotropium bromide inhalation in patients with COPD at stable stage. Chinese Journal of New Drugs 2010;19(2):127-129, 138.
    • (2010) Chinese Journal of New Drugs , vol.19 , Issue.2
    • Yan, L.1    Lu, Y.K.2
  • 91
    • 67649303112 scopus 로고    scopus 로고
    • UPLIFT Study: The effects of long-term therapy with inhaled tiotropium in chronic obstructive pulmonary disease
    • Antoniu SA. UPLIFT Study: The effects of long-term therapy with inhaled tiotropium in chronic obstructive pulmonary disease. Expert Opinion on Pharmacotherapy 2009;10(4):719-22.
    • (2009) Expert Opinion on Pharmacotherapy , vol.10 , Issue.4 , pp. 719-722
    • Antoniu, S.A.1
  • 92
    • 77949762407 scopus 로고    scopus 로고
    • UPLIFT study: The results and their implications
    • Braido F. UPLIFT study: The results and their implications. Multidisciplinary Respiratory Medicine. 2009; Vol. 4, issue Suppl 1:6s-12s.
    • (2009) Multidisciplinary Respiratory Medicine , vol.4 , pp. 6s-12s
    • Braido, F.1
  • 94
    • 85041543636 scopus 로고    scopus 로고
    • Long-term changes in inspiratory capacity: an analysis from the UPLIFT(R) trial [Abstract]American Thoracic Society (ATS) International Conference; 2010 May 14-19; New Orleans., issue Meeting Abstracts:
    • Celli B, Kesten S, Lystig T, Tashkin DP, Decramer M. Long-term changes in inspiratory capacity: an analysis from the UPLIFT(R) trial [Abstract]American Thoracic Society (ATS) International Conference; 2010 May 14-19; New Orleans. 2010, issue Meeting Abstracts:A4482.
    • (2010)
    • Celli, B.1    Kesten, S.2    Lystig, T.3    Tashkin, D.P.4    Decramer, M.5
  • 96
    • 85041508384 scopus 로고    scopus 로고
    • The effect of tiotropium on COPD GOLD stage II during the four-year UPLIFT trial [Abstract]. American Thoracic Society International Conference; 2008 May 16-21; Toronto. :
    • Decramer M, Celli B, Burkhart D, Kesten S, Mehra S, Liu D, et al.The effect of tiotropium on COPD GOLD stage II during the four-year UPLIFT trial [Abstract]. American Thoracic Society International Conference; 2008 May 16-21; Toronto. 2009:A2466.
    • (2009)
    • Decramer, M.1    Celli, B.2    Burkhart, D.3    Kesten, S.4    Mehra, S.5    Liu, D.6
  • 97
    • 85041532387 scopus 로고    scopus 로고
    • Statistical approaches to analysis of exacerbations in the UPLIFT(R) trial [Abstract]. American Thoracic Society (ATS) International Conference; 2010 May 14-19; New Orleans., issue Meeting Abstracts:
    • Decramer M, Celli B, Kesten S, Liu D, Menjoge S, Senn S, et al.Statistical approaches to analysis of exacerbations in the UPLIFT(R) trial [Abstract]. American Thoracic Society (ATS) International Conference; 2010 May 14-19; New Orleans. 2010, issue Meeting Abstracts:A1527.
    • (2010)
    • Decramer, M.1    Celli, B.2    Kesten, S.3    Liu, D.4    Menjoge, S.5    Senn, S.6
  • 98
    • 70349547108 scopus 로고    scopus 로고
    • Effect of tiotropium on outcomes in patients with moderate chronic obstructive pulmonary disease (UPLIFT): a prespecified subgroup analysis of a randomised controlled trial
    • Decramer M, Celli B, Kesten S, Lystig T, Mehra S, Tashkin DP, et al.Effect of tiotropium on outcomes in patients with moderate chronic obstructive pulmonary disease (UPLIFT): a prespecified subgroup analysis of a randomised controlled trial. Lancet 2009;374(9696):1171-8.
    • (2009) Lancet , vol.374 , Issue.9696 , pp. 1171-1178
    • Decramer, M.1    Celli, B.2    Kesten, S.3    Lystig, T.4    Mehra, S.5    Tashkin, D.P.6
  • 100
    • 73949132196 scopus 로고    scopus 로고
    • How much lift to the UPLIFT study? - Authors' reply
    • Decramer M, Kesten S, Celli B, Tashkin DP. How much lift to the UPLIFT study? - Authors' reply. The Lancet 2010;375(9710):198.
    • (2010) The Lancet , vol.375 , Issue.9710 , pp. 198
    • Decramer, M.1    Kesten, S.2    Celli, B.3    Tashkin, D.P.4
  • 102
    • 85041535048 scopus 로고    scopus 로고
    • Efficacy of tiotropium in COPD patients from Asia: A subgroup analysis from the uplift trial [Abstract]. 15th Congress of the Asian Pacific Society of Respirology; 2010 November 22-25; Manila.
    • Fernandez L, Kesten S, Liu D, Decramer M, Tashkin D, Celli B, et al.Efficacy of tiotropium in COPD patients from Asia: A subgroup analysis from the uplift trial [Abstract]. 15th Congress of the Asian Pacific Society of Respirology; 2010 November 22-25; Manila. 2010.
    • (2010)
    • Fernandez, L.1    Kesten, S.2    Liu, D.3    Decramer, M.4    Tashkin, D.5    Celli, B.6
  • 103
    • 79959898445 scopus 로고    scopus 로고
    • Efficacy of tiotropium in COPD patients from Asia: A subgroup analysis from the UPLIFT trial
    • Fukuchi Y, Fernandez L, Kuo HP, Mahayiddin A, Celli B, Decramer M, et al.Efficacy of tiotropium in COPD patients from Asia: A subgroup analysis from the UPLIFT trial. Respirology 2011;16:825-35.
    • (2011) Respirology , vol.16 , pp. 825-835
    • Fukuchi, Y.1    Fernandez, L.2    Kuo, H.P.3    Mahayiddin, A.4    Celli, B.5    Decramer, M.6
  • 104
    • 79961209764 scopus 로고    scopus 로고
    • Risk of nonlower respiratory serious adverse events following COPD exacerbations in the 4-year UPLIFT trial
    • Halpin DM, Decramer M, Celli B, Kesten S, Leimer I, Tashkin DP. Risk of nonlower respiratory serious adverse events following COPD exacerbations in the 4-year UPLIFT trial. Lung 2011;189(4):261-8.
    • (2011) Lung , vol.189 , Issue.4 , pp. 261-268
    • Halpin, D.M.1    Decramer, M.2    Celli, B.3    Kesten, S.4    Leimer, I.5    Tashkin, D.P.6
  • 105
    • 85041534444 scopus 로고    scopus 로고
    • Acute bronchodilator response does not predict health outcomes in patients with COPD treated with tiotropium [Abstract]. European Respiratory Society Annual Congress; 2009 September 12-16; Vienna. :
    • Hanania N, Kesten S, Celli B, Decramer M, Sharafkhaneh A, Lystig T, et al.Acute bronchodilator response does not predict health outcomes in patients with COPD treated with tiotropium [Abstract]. European Respiratory Society Annual Congress; 2009 September 12-16; Vienna. 2009:[E4353].
    • (2009)
    • Hanania, N.1    Kesten, S.2    Celli, B.3    Decramer, M.4    Sharafkhaneh, A.5    Lystig, T.6
  • 107
    • 69749120963 scopus 로고    scopus 로고
    • UPLIFT (understanding potential long-term impacts on function with tiotropium) study
    • Inoue H, Asai Y. UPLIFT (understanding potential long-term impacts on function with tiotropium) study. Respiration and Circulation 2009;57(8):813-8.
    • (2009) Respiration and Circulation , vol.57 , Issue.8 , pp. 813-818
    • Inoue, H.1    Asai, Y.2
  • 108
    • 80053367951 scopus 로고    scopus 로고
    • Adverse health consequences in COPD patients with rapid decline in FEV1 - evidence from the UPLIFT trial
    • Kesten S, Celli B, Decramer M, Liu D, Tashkin D. Adverse health consequences in COPD patients with rapid decline in FEV1 - evidence from the UPLIFT trial. Respiratory Research 2011;12:129.
    • (2011) Respiratory Research , vol.12 , pp. 129
    • Kesten, S.1    Celli, B.2    Decramer, M.3    Liu, D.4    Tashkin, D.5
  • 109
    • 85041533284 scopus 로고    scopus 로고
    • A comparison of the classification of cause of death between site investigators and a mortality adjudication committee in the UPLIFT(R) trial [Abstract]
    • American Thoracic Society (ATS) International Conference; 2010 May 14-19; New Orleans.
    • McGarvey L, Magder SA, Liu D, Kesten S, Manuel R, Niewoehner DE. A comparison of the classification of cause of death between site investigators and a mortality adjudication committee in the UPLIFT(R) trial [Abstract]. American Thoracic Society (ATS) International Conference; 2010 May 14-19; New Orleans. 2010.
    • (2010)
    • McGarvey, L.1    Magder, S.A.2    Liu, D.3    Kesten, S.4    Manuel, R.5    Niewoehner, D.E.6
  • 110
    • 77957157119 scopus 로고    scopus 로고
    • COPD in young patients: A pre-specified analysis of the four-year trial of tiotropium (UPLIFT)
    • Morice AH, Celli B, Kesten S, Lystig T, Tashkin D, Decramer M. COPD in young patients: A pre-specified analysis of the four-year trial of tiotropium (UPLIFT). Respiratory Medicine 2010;104(11):1659-67.
    • (2010) Respiratory Medicine , vol.104 , Issue.11 , pp. 1659-1667
    • Morice, A.H.1    Celli, B.2    Kesten, S.3    Lystig, T.4    Tashkin, D.5    Decramer, M.6
  • 111
    • 77951636419 scopus 로고    scopus 로고
    • Safety of tiotropium therapy in chronic obstructive lung diseases (COPD)
    • [A tiotropiumterápia cardiovascularis biztonságossága krónikus obstruktív tüdobetegségben (COPD)]. ;():-
    • Osztovits J, Feher J. Safety of tiotropium therapy in chronic obstructive lung diseases (COPD) [A tiotropiumterápia cardiovascularis biztonságossága krónikus obstruktív tüdobetegségben (COPD)]. Orvosi Hetilap 2010;151(18):749-50.
    • (2010) Orvosi Hetilap , vol.151 , Issue.18 , pp. 749-750
    • Osztovits, J.1    Feher, J.2
  • 112
    • 74549145053 scopus 로고    scopus 로고
    • "Prince Charming"? Some considerations about the decline of FEV1 and on data from UPLIFT study
    • Paggiaro P, Rossi A. "Prince Charming"? Some considerations about the decline of FEV1 and on data from UPLIFT study. Rassegna di Patologia dell'Apparato Respiratorio 2009;24(5):278-86.
    • (2009) Rassegna di Patologia dell'Apparato Respiratorio , vol.24 , Issue.5 , pp. 278-286
    • Paggiaro, P.1    Rossi, A.2
  • 114
    • 85041550766 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled, parallel group trial assessing the rate of decline of lung function with tiotropium 18 mcg inhalation capsule once daily in patients with chronic obstructive pulmonary disease (COPD)
    • [trial number: 205.235]
    • Tashkin D. A randomized, double-blind, placebo-controlled, parallel group trial assessing the rate of decline of lung function with tiotropium 18 mcg inhalation capsule once daily in patients with chronic obstructive pulmonary disease (COPD). www.trials.boehringer-ingelheim.com. [trial number: 205.235].
    • Tashkin, D.1
  • 115
    • 85041523248 scopus 로고    scopus 로고
    • Comorbid conditions reported in patients with COPD recruited into a global clinical trial (UPLIFT) [Abstract]. European Respiratory Society 15th Annual Congress; 2005 September 17 - 21; Copenhagen.; Vol. 26, issue Suppl 49:
    • Tashkin D, Celli B, Decramer M, Burkhart D, Kesten S, Cassino C. Comorbid conditions reported in patients with COPD recruited into a global clinical trial (UPLIFT) [Abstract]. European Respiratory Society 15th Annual Congress; 2005 September 17 - 21; Copenhagen. 2005; Vol. 26, issue Suppl 49:Abstract No. 4203.
    • (2005)
    • Tashkin, D.1    Celli, B.2    Decramer, M.3    Burkhart, D.4    Kesten, S.5    Cassino, C.6
  • 116
    • 77956341838 scopus 로고    scopus 로고
    • Effect of tiotropium in men and women with COPD: Results of the 4-year UPLIFT trial
    • Tashkin D, Celli B, Kesten S, Lystig T, Decramer M. Effect of tiotropium in men and women with COPD: Results of the 4-year UPLIFT trial. Respiratory Medicine 2010;104(10):1495-504.
    • (2010) Respiratory Medicine , vol.104 , Issue.10 , pp. 1495-1504
    • Tashkin, D.1    Celli, B.2    Kesten, S.3    Lystig, T.4    Decramer, M.5
  • 117
    • 85041505595 scopus 로고    scopus 로고
    • Efficacy of tiotropium in COPD patients with FEV1? 60% participating in the UPLIFT trial [Abstract]. European Respiratory Society Annual Congress; 2010 September 18-22; Barcelona, Spain. :
    • Tashkin D, Celli B, Lystig T, Kesten S, Decramer M. Efficacy of tiotropium in COPD patients with FEV1? 60% participating in the UPLIFT trial [Abstract]. European Respiratory Society Annual Congress; 2010 September 18-22; Barcelona, Spain. 2010:[P1186].
    • (2010)
    • Tashkin, D.1    Celli, B.2    Lystig, T.3    Kesten, S.4    Decramer, M.5
  • 119
    • 77953234288 scopus 로고    scopus 로고
    • Impact of tiotropium on the course of moderate-to-very severe chronic obstructive pulmonary disease: The UPLIFT trial
    • Tashkin DP. Impact of tiotropium on the course of moderate-to-very severe chronic obstructive pulmonary disease: The UPLIFT trial. Expert Review of Respiratory Medicine 2010;4(3):279-89.
    • (2010) Expert Review of Respiratory Medicine , vol.4 , Issue.3 , pp. 279-289
    • Tashkin, D.P.1
  • 120
    • 85041549214 scopus 로고    scopus 로고
    • Long-term efficacy of tiotropium in continuing smokers vs sustained ex-smokers in the UPLIFT trial [Abstract]
    • American Thoracic Society International Conference; 2009 May 15-20; San Diego. :
    • Tashkin DP, Celli B, Burkhart D, Kesten S, Liu D, Mehra S, et al.Long-term efficacy of tiotropium in continuing smokers vs sustained ex-smokers in the UPLIFT trial [Abstract]. American Thoracic Society International Conference; 2009 May 15-20; San Diego. 2009:A6175 [Poster #201].
    • (2009)
    • Tashkin, D.P.1    Celli, B.2    Burkhart, D.3    Kesten, S.4    Liu, D.5    Mehra, S.6
  • 122
    • 85041503877 scopus 로고    scopus 로고
    • Reduced reporting of respiratory failure in the UPLIFT(R) trial [Abstract]. American Thoracic Society International Conference; 2010 May 14-19; New Orleans.
    • Tashkin DP, Celli B, Kesten S, Liu D, Decramer M. Reduced reporting of respiratory failure in the UPLIFT(R) trial [Abstract]. American Thoracic Society International Conference; 2010 May 14-19; New Orleans. 2010.
    • (2010)
    • Tashkin, D.P.1    Celli, B.2    Kesten, S.3    Liu, D.4    Decramer, M.5
  • 124
    • 53749102775 scopus 로고    scopus 로고
    • A 4-year trial of tiotropium in chronic obstructive pulmonary disease
    • Vol. 359, issue 15:-. [CTG: NCT00144339]
    • Tashkin DP, Celli B, Senn S, Burkhart D, Kesten S, Menjoge S, et al.A 4-year trial of tiotropium in chronic obstructive pulmonary disease. New England Journal of Medicine 2008; Vol. 359, issue 15:1543-54. [CTG: NCT00144339].
    • (2008) New England Journal of Medicine , pp. 1543-1554
    • Tashkin, D.P.1    Celli, B.2    Senn, S.3    Burkhart, D.4    Kesten, S.5    Menjoge, S.6
  • 125
    • 85041555384 scopus 로고    scopus 로고
    • Cardiovascular adverse events according to GOLD stage in the UPLIFT trial
    • Tashkin DP, Celli BR, Kesten S, Liu D, Decramer M. Cardiovascular adverse events according to GOLD stage in the UPLIFT trial. Chest 2009;136(4):52.
    • (2009) Chest , vol.136 , Issue.4 , pp. 52
    • Tashkin, D.P.1    Celli, B.R.2    Kesten, S.3    Liu, D.4    Decramer, M.5
  • 126
    • 85041509775 scopus 로고    scopus 로고
    • Efficacy of tiotropium in men and women: 4-year follow-up in the UPLIFT trial
    • Tashkin DP, Celli BR, Kesten S, Lystig T, Mehra S, Decramer M. Efficacy of tiotropium in men and women: 4-year follow-up in the UPLIFT trial. Chest 2009;136(4):24-25.
    • (2009) Chest , vol.136 , Issue.4 , pp. 24-25
    • Tashkin, D.P.1    Celli, B.R.2    Kesten, S.3    Lystig, T.4    Mehra, S.5    Decramer, M.6
  • 127
    • 85041548797 scopus 로고    scopus 로고
    • Baseline characteristics according to gender in a global respiratory trial [Abstract]. American Thoracic Society International Conference; 2007 May 18-23; San Francisco. :
    • Tashkin DP, Decramer M, Celli B, Burkhart D, Cassino C, Kesten S. Baseline characteristics according to gender in a global respiratory trial [Abstract]. American Thoracic Society International Conference; 2007 May 18-23; San Francisco. 2007:Poster #924.
    • (2007)
    • Tashkin, D.P.1    Decramer, M.2    Celli, B.3    Burkhart, D.4    Cassino, C.5    Kesten, S.6
  • 128
    • 85041523647 scopus 로고    scopus 로고
    • Effectiveness of combination therapy with tiotropium in COPD. A secondary analysis of the uplift trial [Abstract]. European Respiratory Society Annual Congress; 2009 September 12-16; Vienna. :
    • Troosters T, Celli B, Kesten S, Liu D, Mehra S, Tashkin D, et al.Effectiveness of combination therapy with tiotropium in COPD. A secondary analysis of the uplift trial [Abstract]. European Respiratory Society Annual Congress; 2009 September 12-16; Vienna. 2009:[P3808].
    • (2009)
    • Troosters, T.1    Celli, B.2    Kesten, S.3    Liu, D.4    Mehra, S.5    Tashkin, D.6
  • 129
    • 85041509879 scopus 로고    scopus 로고
    • Effectiveness of combination therapy with tiotropium in COPD. A secondary analysis of the UPLIFT trial [Abstract]
    • Troosters T, Celli B, Kesten S, Liu D, Tashkin D, Decramer M. Effectiveness of combination therapy with tiotropium in COPD. A secondary analysis of the UPLIFT trial [Abstract]. Primary Care Respiratory Journal 2010;19(2):A13.
    • (2010) Primary Care Respiratory Journal , vol.19 , Issue.2
    • Troosters, T.1    Celli, B.2    Kesten, S.3    Liu, D.4    Tashkin, D.5    Decramer, M.6
  • 131
    • 85041542155 scopus 로고    scopus 로고
    • Effectiveness of tiotropium as first maintenance drug in patients with COPD. Secondary analysis of the UPLIFT Trial [Abstract]. American Thoracic Society International Conference; 2009 May 15-20; San Diego.
    • Troosters T, Kesten S, Burkhart D, Celli B, Liu D, Mehra S, et al.Effectiveness of tiotropium as first maintenance drug in patients with COPD. Secondary analysis of the UPLIFT Trial [Abstract]. American Thoracic Society International Conference; 2009 May 15-20; San Diego. 2009.
    • (2009)
    • Troosters, T.1    Kesten, S.2    Burkhart, D.3    Celli, B.4    Liu, D.5    Mehra, S.6
  • 132
    • 85041514827 scopus 로고    scopus 로고
    • Effect of a 9-month treatment of SPIRIVA® on health related quality of life in patients with chronic obstructive pulmonary disease. Validation of a new HRQoL questionnaire appropriate to common daily practice. (TIPHON Study)
    • [trial number: 205.256]
    • Tonnel AB. Effect of a 9-month treatment of SPIRIVA® on health related quality of life in patients with chronic obstructive pulmonary disease. Validation of a new HRQoL questionnaire appropriate to common daily practice. (TIPHON Study). www.trials.boehringer-ingelheim.com. [trial number: 205.256].
    • Tonnel, A.B.1
  • 133
    • 85041552328 scopus 로고    scopus 로고
    • Clinically significant improvements of health status of COPD patients after 9 months treatment with tiotropium bromide: the TIPHON study [Abstract]
    • Poster: 302]American Thoracic Society International Conference; May 20-25; San Diego. :
    • Tonnel AB, Bravo ML, Brun M. Clinically significant improvements of health status of COPD patients after 9 months treatment with tiotropium bromide: the TIPHON study [Abstract]. American Thoracic Society International Conference; May 20-25; San Diego. 2005:[B93] [Poster: 302].
    • (2005)
    • Tonnel, A.B.1    Bravo, M.L.2    Brun, M.3
  • 134
    • 85041554528 scopus 로고    scopus 로고
    • Improvement in HRQoL of COPD patients after 9 months treatment with tiotropium bromide: use of a new scale for daily medical practice [Abstract]. European Respiratory Society 15th Annual Congress; 2005 September 17 - 21; Copenhagen.
    • Tonnel AB, Perez T, Grosbois JM, Bravo ML, Brun M. Improvement in HRQoL of COPD patients after 9 months treatment with tiotropium bromide: use of a new scale for daily medical practice [Abstract]. European Respiratory Society 15th Annual Congress; 2005 September 17 - 21; Copenhagen. 2005.
    • (2005)
    • Tonnel, A.B.1    Perez, T.2    Grosbois, J.M.3    Bravo, M.L.4    Brun, M.5
  • 135
    • 47849123646 scopus 로고    scopus 로고
    • Effect of tiotropium on health-related quality of life as a primary efficacy endpoint in COPD
    • CTG: NCT00274053]
    • Tonnel AB, Perez T, Grosbois JM, Verkindre C, Bravo ML, Brun M. Effect of tiotropium on health-related quality of life as a primary efficacy endpoint in COPD. International Journal of COPD 2008;3(2):301-10. [CTG: NCT00274053].
    • (2008) International Journal of COPD , vol.3 , Issue.2 , pp. 301-310
    • Tonnel, A.B.1    Perez, T.2    Grosbois, J.M.3    Verkindre, C.4    Bravo, M.L.5    Brun, M.6
  • 136
    • 85041542219 scopus 로고    scopus 로고
    • A 24 week, randomized, double-blind, placebo-controlled, multicenter study to evaluate the efficacy and safety of 18 mcg of tiotropium inhalation capsules administered by handihaler® once-daily plus prn albuterol (salbutamol) vs. placebo plusprn albuterol (salbutamol) in chronic obstructive pulmonary disease subjects naive to maintenance therapy
    • [trial number: 205.365]
    • Carron K. A 24 week, randomized, double-blind, placebo-controlled, multicenter study to evaluate the efficacy and safety of 18 mcg of tiotropium inhalation capsules administered by handihaler® once-daily plus prn albuterol (salbutamol) vs. placebo plusprn albuterol (salbutamol) in chronic obstructive pulmonary disease subjects naive to maintenance therapy. www.trials.boehringer-ingelheim.com. [trial number: 205.365].
    • Carron, K.1
  • 137
    • 85041510833 scopus 로고    scopus 로고
    • The efficacy and safety of tiotropium Handihaler, 18 g, once daily plus PRN salbutamol versus placebo plus prn salbutamol in COPD subjects naive to maintenance therapy [Abstract]. American Thoracic Society 2011 International Conference; 2011 May 13-18; Denver.; Vol. 183:
    • Sciurba FC, Siafakas N, Troosters T, Klioze SS, Sutradhar S, Weisman I, et al.The efficacy and safety of tiotropium Handihaler, 18 g, once daily plus PRN salbutamol versus placebo plus prn salbutamol in COPD subjects naive to maintenance therapy [Abstract]. American Thoracic Society 2011 International Conference; 2011 May 13-18; Denver. 2011; Vol. 183:A1589.
    • (2011)
    • Sciurba, F.C.1    Siafakas, N.2    Troosters, T.3    Klioze, S.S.4    Sutradhar, S.5    Weisman, I.6
  • 138
    • 80053524708 scopus 로고    scopus 로고
    • Assessing the impact of tiotropium on lung function and physical activity in GOLD Stage II COPD patients who are naive to maintenance respiratory therapy: a study protocol
    • CTG: NCT00523991]
    • Troosters T, Weisman I, Dobbels F, Giardino N, Valluri SR. Assessing the impact of tiotropium on lung function and physical activity in GOLD Stage II COPD patients who are naive to maintenance respiratory therapy: a study protocol. The Open Respiratory Medicine Journal 2011;5:1-9. [CTG: NCT00523991].
    • (2011) The Open Respiratory Medicine Journal , vol.5 , pp. 1-9
    • Troosters, T.1    Weisman, I.2    Dobbels, F.3    Giardino, N.4    Valluri, S.R.5
  • 139
    • 85041533920 scopus 로고    scopus 로고
    • Effect of a 12-week treatment with inhaled tiotropium (18 mcg once daily) on lung function and static lung volumes in stable, moderate to severe COPD patients. Correlation to dyspnoea scales: a double-blind, placebo-controlled, randomized, parallel group study
    • [trial number: 205.215]
    • Huchon G. Effect of a 12-week treatment with inhaled tiotropium (18 mcg once daily) on lung function and static lung volumes in stable, moderate to severe COPD patients. Correlation to dyspnoea scales: a double-blind, placebo-controlled, randomized, parallel group study. www.trials.boehringer-ingelheim.com. [trial number: 205.215].
    • Huchon, G.1
  • 140
    • 85041517153 scopus 로고    scopus 로고
    • Improvements with tiotropium on endurance measure by the shuttle walking test (SWT) and on health related quality of life (HRQoL) in COPD patients. European Respiratory Society Congress; 2002 September 14-18; Stockholm.
    • Huchon G, Verkindre C, Bart F, Aguilaniu B, Guerin JC, Lemerre C, et al.Improvements with tiotropium on endurance measure by the shuttle walking test (SWT) and on health related quality of life (HRQoL) in COPD patients. European Respiratory Society Congress; 2002 September 14-18; Stockholm. 2002.
    • (2002)
    • Huchon, G.1    Verkindre, C.2    Bart, F.3    Aguilaniu, B.4    Guerin, J.C.5    Lemerre, C.6
  • 141
    • 33745202663 scopus 로고    scopus 로고
    • The effect of tiotropium on hyperinflation and exercise capacity in chronic obstructive pulmonary disease
    • Verkindre C, Bart F, Aguilaniu B, Fortin F, Guerin JC, Le Merre C, et al.The effect of tiotropium on hyperinflation and exercise capacity in chronic obstructive pulmonary disease. Respiration 2006;73(4):420-7.
    • (2006) Respiration , vol.73 , Issue.4 , pp. 420-427
    • Verkindre, C.1    Bart, F.2    Aguilaniu, B.3    Fortin, F.4    Guerin, J.C.5    Le Merre, C.6
  • 142
    • 85041531437 scopus 로고    scopus 로고
    • A randomised, double-blind, double-dummy, placebo- and active-controlled, parallel group efficacy and safety comparison of 12-week treatment of two doses [5 mcg (2 actuations of 2.5 mcg) and 10 mcg (2 actuations of 5 mcg)] of tiotropium inhalation solution delivered by the Respimat inhaler, placebo and ipratropium bromide inhalation aerosol (MDI) in patients with chronic obstructive pulmonary disease (COPD)
    • [trial number: 205.251]
    • Boehringer Ingelheim. A randomised, double-blind, double-dummy, placebo- and active-controlled, parallel group efficacy and safety comparison of 12-week treatment of two doses [5 mcg (2 actuations of 2.5 mcg) and 10 mcg (2 actuations of 5 mcg)] of tiotropium inhalation solution delivered by the Respimat inhaler, placebo and ipratropium bromide inhalation aerosol (MDI) in patients with chronic obstructive pulmonary disease (COPD). www.trials.boehringer-ingelheim.com. [trial number: 205.251].
    • Boehringer, I.1
  • 143
    • 85041493812 scopus 로고    scopus 로고
    • A randomized, double-blind, double-dummy, placebo- and active-controlled, parallel group efficacy and safety comparison of 12-week treatment of two doses (5 Mcg and 10 Mcg) of tiotropium inhalation solution delivered by the Respimat inhaler, placebo and ipratropium bromide inhalation aerosol (MDI) in patients with chronic obstructive pulmonary disease (COPD)
    • Vol. Sept 2004 End Date. [trial number: 205.252]
    • Boehringer Ingelheim. A randomized, double-blind, double-dummy, placebo- and active-controlled, parallel group efficacy and safety comparison of 12-week treatment of two doses (5 Mcg and 10 Mcg) of tiotropium inhalation solution delivered by the Respimat inhaler, placebo and ipratropium bromide inhalation aerosol (MDI) in patients with chronic obstructive pulmonary disease (COPD). www.clinicaltrials.gov 2002; Vol. Sept 2004 End Date. [trial number: 205.252].
    • (2002)
    • Boehringer, I.1
  • 144
    • 85041547884 scopus 로고    scopus 로고
    • A randomised study of tiotropium Respimat soft mist inhaler versus ipratropium PMDI in chronic obstructive pulmonary disease [Abstract]
    • Voshaar T, Lapidus R, Maleki-Yazdi R, Timmer W, Rubin E, Lowe L, et al.A randomised study of tiotropium Respimat soft mist inhaler versus ipratropium PMDI in chronic obstructive pulmonary disease [Abstract]. Thorax 2006;61(Suppl 2):ii40 [S112].
    • (2006) Thorax , vol.61
    • Voshaar, T.1    Lapidus, R.2    Maleki-Yazdi, R.3    Timmer, W.4    Rubin, E.5    Lowe, L.6
  • 145
    • 36448952390 scopus 로고    scopus 로고
    • A randomized study of tiotropium Respimat Soft Mist inhaler vs. ipratropium pMDI in COPD
    • CTG: NCT00239473; CTG: NCT00240435]
    • Voshaar T, Lapidus R, Maleki-Yazdi R, Timmer W, Rubin E, Lowe L, et al.A randomized study of tiotropium Respimat Soft Mist inhaler vs. ipratropium pMDI in COPD. Respiratory Medicine 2008;102(1):32-41. [CTG: NCT00239473; CTG: NCT00240435].
    • (2008) Respiratory Medicine , vol.102 , Issue.1 , pp. 32-41
    • Voshaar, T.1    Lapidus, R.2    Maleki-Yazdi, R.3    Timmer, W.4    Rubin, E.5    Lowe, L.6
  • 147
    • 85041505399 scopus 로고    scopus 로고
    • Effects of tiotropium bromide in exercise tolerance in patients with chronic obstructive pulmonary disease [Abstract]. European Respiratory Society Congress; 2005 September 17-21; Copenhagen.; Vol. 26, issue Suppl 49:
    • Baloira A, Vilarino C. Effects of tiotropium bromide in exercise tolerance in patients with chronic obstructive pulmonary disease [Abstract]. European Respiratory Society Congress; 2005 September 17-21; Copenhagen. 2005; Vol. 26, issue Suppl 49:Abstract No. 1929.
    • (2005)
    • Baloira, A.1    Vilarino, C.2
  • 148
    • 85041503626 scopus 로고    scopus 로고
    • Tiotropium improves walking endurance in chronic obstructive pulmonary disease patients
    • American Journal of Respiratory and Critical Care Medicine.; Vol. 183:
    • Bedard ME, Brouillard C, Pepin V, Milot J, Lacasse Y, Leblanc P, et al.Tiotropium improves walking endurance in chronic obstructive pulmonary disease patients. American Journal of Respiratory and Critical Care Medicine. 2011; Vol. 183:A1590.
    • (2011)
    • Bedard, M.E.1    Brouillard, C.2    Pepin, V.3    Milot, J.4    Lacasse, Y.5    Leblanc, P.6
  • 149
    • 4243961318 scopus 로고    scopus 로고
    • The timing of dose and pattern of bronchodilatation of tiotropium (TIO) in stable COPD
    • Calverley PMA, Towse LJ, Lee A. The timing of dose and pattern of bronchodilatation of tiotropium (TIO) in stable COPD. European Respiratory Journal 2000;16(Suppl 31):56s.
    • (2000) European Respiratory Journal , vol.16 , pp. 56s
    • Calverley, P.M.A.1    Towse, L.J.2    Lee, A.3
  • 150
    • 85041517032 scopus 로고    scopus 로고
    • Improvement in exercise endurance with the combination of tiotropium and rehabilitative exercise training in COPD patients [Abstract]
    • American Thoracic Society 100th International Conference; 2004 May 21-26; Orlando. :
    • Casaburi R, Kukafka D, Cooper CB, Kesten S. Improvement in exercise endurance with the combination of tiotropium and rehabilitative exercise training in COPD patients [Abstract]. American Thoracic Society 100th International Conference; 2004 May 21-26; Orlando. 2004:D14.
    • (2004) , pp. D14
    • Casaburi, R.1    Kukafka, D.2    Cooper, C.B.3    Kesten, S.4
  • 151
    • 15844429415 scopus 로고    scopus 로고
    • Improvement in exercise tolerance with the combination of tiotropium and pulmonary rehabilitation in patients with COPD
    • Casaburi R, Kukafka D, Cooper CB, Witek TJ Jr, Kesten S. Improvement in exercise tolerance with the combination of tiotropium and pulmonary rehabilitation in patients with COPD. Chest 2005;127(3):809-17.
    • (2005) Chest , vol.127 , Issue.3 , pp. 809-817
    • Casaburi, R.1    Kukafka, D.2    Cooper, C.B.3    Witek, T.J.4    Kesten, S.5
  • 152
    • 85041493906 scopus 로고    scopus 로고
    • Tiotropium augments improvements in dyspnea and health-related quality of life following pulmonary rehabilitation in COPD patients [Abstract]
    • American Thoracic Society 100th International Conference; 2004 May 21-26; Orlando. :
    • Cooper CB, Kukafka D, Casburi R, Kesten S. Tiotropium augments improvements in dyspnea and health-related quality of life following pulmonary rehabilitation in COPD patients [Abstract]. American Thoracic Society 100th International Conference; 2004 May 21-26; Orlando. 2004:C22 Poster 507.
    • (2004)
    • Cooper, C.B.1    Kukafka, D.2    Casburi, R.3    Kesten, S.4
  • 153
    • 42149136242 scopus 로고    scopus 로고
    • Improvement in self-reported exercise participation with the combination of tiotropium and rehabilitative exercise training in COPD patients
    • Kesten S, Casaburi R, Kukafka D, Cooper CB. Improvement in self-reported exercise participation with the combination of tiotropium and rehabilitative exercise training in COPD patients. International Journal of COPD 2008;3(1):127-36.
    • (2008) International Journal of COPD , vol.3 , Issue.1 , pp. 127-136
    • Kesten, S.1    Casaburi, R.2    Kukafka, D.3    Cooper, C.B.4
  • 154
    • 85041517877 scopus 로고    scopus 로고
    • Improvements in inspiratory capacity with tiotropium in patients with COPD [Abstract]
    • European Respiratory Society Annual Congress 2002. :
    • Celli BR, Zuwallack RL, Wang S, Kesten S. Improvements in inspiratory capacity with tiotropium in patients with COPD [Abstract]. European Respiratory Society Annual Congress 2002. 2002:abstract nr: P3079.
    • (2002)
    • Celli, B.R.1    Zuwallack, R.L.2    Wang, S.3    Kesten, S.4
  • 155
    • 85041518580 scopus 로고    scopus 로고
    • A role of tiotropium in patients with severe COPD subject to a supervised program of exercises [Abstract]
    • European Respiratory Society Annual Congress; 2010 September 18-22; Barcelona, Spain. :
    • Da Fonseca Reis LF, Ventura TG, Jayme S, Bispo P, Cantanhede LA. A role of tiotropium in patients with severe COPD subject to a supervised program of exercises [Abstract]. European Respiratory Society Annual Congress; 2010 September 18-22; Barcelona, Spain. 2010:[P4872].
    • (2010)
    • Da Fonseca Reis, L.F.1    Ventura, T.G.2    Jayme, S.3    Bispo, P.4    Cantanhede, L.A.5
  • 156
    • 85041552295 scopus 로고    scopus 로고
    • Evaluation of the response of Filipino COPD patients to Tiotropium (EVEREST STUDY) [Abstract]
    • American Thoracic Society 100th International Conference; 2004 May 21-26; Orlando. :
    • De Guia T, Punzal P, Canizares L, Sy-Naval S, Salonga R, Tan D, et al.Evaluation of the response of Filipino COPD patients to Tiotropium (EVEREST STUDY) [Abstract]. American Thoracic Society 100th International Conference; 2004 May 21-26; Orlando. 2004:C47 Poster F78.
    • (2004)
    • De Guia, T.1    Punzal, P.2    Canizares, L.3    Sy-Naval, S.4    Salonga, R.5    Tan, D.6
  • 158
    • 79960463228 scopus 로고    scopus 로고
    • Improved respiratory system conductance following bronchodilator predicts reduced exertional dyspnoea
    • Diba C, King GG, Berend N, Salome CM. Improved respiratory system conductance following bronchodilator predicts reduced exertional dyspnoea. Respiratory Medicine 2011; Vol. 105, issue 9:1345-51.
    • (2011) Respiratory Medicine , vol.105 , Issue.9 , pp. 1345-1351
    • Diba, C.1    King, G.G.2    Berend, N.3    Salome, C.M.4
  • 160
    • 85041546530 scopus 로고    scopus 로고
    • Efficacy and safety of twice-daily aclidinium bromide 400 g compared with placebo and tiotropium 18 g qd in moderate to severe COPD patients [Abstract]
    • Fuhr R, Magnussen H, Ribera A, Kirsten AM, Falques M, Caracta C, et al.Efficacy and safety of twice-daily aclidinium bromide 400 g compared with placebo and tiotropium 18 g qd in moderate to severe COPD patients [Abstract]. Chest 2010;138(4):465A.
    • (2010) Chest , vol.138 , Issue.4 , pp. 465A
    • Fuhr, R.1    Magnussen, H.2    Ribera, A.3    Kirsten, A.M.4    Falques, M.5    Caracta, C.6
  • 161
    • 85041492999 scopus 로고    scopus 로고
    • Efficacy and safety of twice-daily aclidinium bromide compared with tiotropium and placebo in patients with moderate to severe COPD [Abstract]
    • European Respiratory Society Annual Congress; 2010 September 18-22; Barcelona, Spain. :
    • Fuhr R, Magnussen H, Ribera Llovera A, Kirsten A, Falques M, Caracta C, et al.Efficacy and safety of twice-daily aclidinium bromide compared with tiotropium and placebo in patients with moderate to severe COPD [Abstract]. European Respiratory Society Annual Congress; 2010 September 18-22; Barcelona, Spain. 2010:[P1236].
    • (2010)
    • Fuhr, R.1    Magnussen, H.2    Ribera Llovera, A.3    Kirsten, A.4    Falques, M.5    Caracta, C.6
  • 162
    • 79953025909 scopus 로고    scopus 로고
    • Lack of protective effect of tiotropium vs induced dynamic hyperinflation in moderate COPD
    • Gelb AF, Fraser C, Zamel N. Lack of protective effect of tiotropium vs induced dynamic hyperinflation in moderate COPD. Respiratory Medicine 2011;105:755-60.
    • (2011) Respiratory Medicine , vol.105 , pp. 755-760
    • Gelb, A.F.1    Fraser, C.2    Zamel, N.3
  • 163
    • 85041548812 scopus 로고    scopus 로고
    • Evaluation of mucociliary clearance 's (MCC) condition in patients with COPD influence of tiotropium bromide (TB) on MCC [Abstract]
    • Gurzhiy O, Pertseva T, Lykholat O. Evaluation of mucociliary clearance 's (MCC) condition in patients with COPD influence of tiotropium bromide (TB) on MCC [Abstract]. European Respiratory Journal 2007;30(Suppl 51):73s [P582].
    • (2007) European Respiratory Journal , vol.30 , pp. 73s
    • Gurzhiy, O.1    Pertseva, T.2    Lykholat, O.3
  • 164
    • 85041541204 scopus 로고    scopus 로고
    • Tiotropium reduces the risk of COPD exacerbation irrespective of its characterization by the treatment intervention [Abstract]
    • Halpin DMG, Menjoge S, Viel K. Tiotropium reduces the risk of COPD exacerbation irrespective of its characterization by the treatment intervention [Abstract]. European Respiratory Journal 2006;28(Suppl 50):764s [4397].
    • (2006) European Respiratory Journal , vol.28 , pp. 764s4397
    • Halpin, D.M.G.1    Menjoge, S.2    Viel, K.3
  • 168
    • 85041498417 scopus 로고    scopus 로고
    • Tiotropium once daily improves health status in Japanese patients with COPD [Abstract]. American Thoracic Society 99th International Conference; 2003 May 16-21; Seattle. :
    • Hirata K, Nishimura M, Ichinose M, Nishimura K, Nagai A, Yoshida M, et al.Tiotropium once daily improves health status in Japanese patients with COPD [Abstract]. American Thoracic Society 99th International Conference; 2003 May 16-21; Seattle. 2003:A035 Poster D79.
    • (2003)
    • Hirata, K.1    Nishimura, M.2    Ichinose, M.3    Nishimura, K.4    Nagai, A.5    Yoshida, M.6
  • 169
    • 85041553178 scopus 로고    scopus 로고
    • Tiotropium once daily improves spirometry over 24 hours in Japanese patient with COPD [Abstract]. American Thoracic Society Meeting; 2003 May 16-21; Seattle. :
    • Ichinose M, Nishimura M, Hirata K, Nagai A, Yoshida M, Fukuchi Y. Tiotropium once daily improves spirometry over 24 hours in Japanese patient with COPD [Abstract]. American Thoracic Society Meeting; 2003 May 16-21; Seattle. 2003:A035 Poster D80.
    • (2003)
    • Ichinose, M.1    Nishimura, M.2    Hirata, K.3    Nagai, A.4    Yoshida, M.5    Fukuchi, Y.6
  • 170
    • 85041492887 scopus 로고    scopus 로고
    • Tiotropium maintainence therapy and the additive effects of a single dose of ipratropium bromide or fenoterol in patient with COPD [Abstract]
    • Poster 514 American Thoracic Society 100th International Conference 2004 May 21-26 Orlando. :
    • Kerstjens HAM, Bantje TA, Luursema PB, Damste HEJS, De Jong JW, Lee A, et al.Tiotropium maintainence therapy and the additive effects of a single dose of ipratropium bromide or fenoterol in patient with COPD [Abstract]. American Thoracic Society 100th International Conference 2004 May 21-26 Orlando. 2004:C22 Poster 514.
    • (2004)
    • Kerstjens, H.A.M.1    Bantje, T.A.2    Luursema, P.B.3    Damste, H.E.J.S.4    De Jong, J.W.5    Lee, A.6
  • 173
    • 85041554885 scopus 로고    scopus 로고
    • The role of tiotropium bromide in physical training for patients with COPD [Abstract]
    • Meshcheriakova N, Belevskiy A, Cherniak A. The role of tiotropium bromide in physical training for patients with COPD [Abstract]. European Respiratory Journal 2007;30(Suppl 51):516s [E3091].
    • (2007) European Respiratory Journal , vol.30 , pp. 516s
    • Meshcheriakova, N.1    Belevskiy, A.2    Cherniak, A.3
  • 175
    • 33845680518 scopus 로고    scopus 로고
    • Reproducibility of measurements of inspiratory capacity dyspnea intensity and exercise endurance in multicentre trials in COPD [Abstract]
    • O'Donnell D, He Z, Lam M, Webb K, Flüge T, Hamilton A. Reproducibility of measurements of inspiratory capacity dyspnea intensity and exercise endurance in multicentre trials in COPD [Abstract]. European Respiratory Journal 2004;24(Suppl 48):323s.
    • (2004) European Respiratory Journal , vol.24 , pp. 323s
    • O'Donnell, D.1    He, Z.2    Lam, M.3    Webb, K.4    Flüge, T.5    Hamilton, A.6
  • 176
    • 85041513330 scopus 로고    scopus 로고
    • Spiriva (tiotropium) improves exercise tolerance in COPD [Abstract]. First National COPD Conference; 2003 November 14-15; Arlington, Virginia. :
    • O'Donnell DE, Magnussen H, Aguilaniu B, Gerken F, Hamilton A, Flüge T. Spiriva (tiotropium) improves exercise tolerance in COPD [Abstract]. First National COPD Conference; 2003 November 14-15; Arlington, Virginia. 2003:Abstract no: 1192.
    • (2003)
    • O'Donnell, D.E.1    Magnussen, H.2    Aguilaniu, B.3    Gerken, F.4    Hamilton, A.5    Flüge, T.6
  • 179
    • 85041497863 scopus 로고    scopus 로고
    • Mechanisms of improved exercise tolerance in COPD in response to tiotropium [Abstract]. European Respiratory Society Annual Congress; 2002 September 14-18; Stockholm. :
    • O'Donnell DE, Magnussen H, Gerken F, Kesten S, Flüge T. Mechanisms of improved exercise tolerance in COPD in response to tiotropium [Abstract]. European Respiratory Society Annual Congress; 2002 September 14-18; Stockholm. 2002:abstract nr: P1826.
    • (2002)
    • O'Donnell, D.E.1    Magnussen, H.2    Gerken, F.3    Kesten, S.4    Flüge, T.5
  • 180
    • 85041543379 scopus 로고    scopus 로고
    • Cardiovascular evaluation of tiotropium during constant-work rate exercise in COPD [Abstract]
    • O'Donnell DE, Magnussen H, Gerken F, Kesten S, Flüge T. Cardiovascular evaluation of tiotropium during constant-work rate exercise in COPD [Abstract]. European Respiratory Journal 2003;22(Suppl 45):Abstract No: [P430].
    • (2003) European Respiratory Journal , vol.22
    • O'Donnell, D.E.1    Magnussen, H.2    Gerken, F.3    Kesten, S.4    Flüge, T.5
  • 183
    • 85041494423 scopus 로고    scopus 로고
    • SPIRIVA® (Tiotropium) improves symptom-limited exercise tolerance in COPD patients [Abstract]
    • American Thoracic Society 100th International Conference; 2004 May 21-26; Orlando. :
    • O'Donnell D, Maltais F, Sciurba F, Kesten S, Hamilton A. SPIRIVA® (Tiotropium) improves symptom-limited exercise tolerance in COPD patients [Abstract]. American Thoracic Society 100th International Conference; 2004 May 21-26; Orlando. 2004:D23 Poster 207.
    • (2004)
    • O'Donnell, D.1    Maltais, F.2    Sciurba, F.3    Kesten, S.4    Hamilton, A.5
  • 184
    • 85041542571 scopus 로고    scopus 로고
    • Spiriva® (Tiotropium) reduces lung hyperinflation at rest and during exercise in COPD patients [Abstract]
    • American Thoracic Society 100th International Conference; 2004 May 21-26 2004; Orlando. :
    • O'Donnell D, Marciniuk D, Hernandez P, Richter K, Kesten S, Hamilton A. Spiriva® (Tiotropium) reduces lung hyperinflation at rest and during exercise in COPD patients [Abstract]. American Thoracic Society 100th International Conference; 2004 May 21-26 2004; Orlando. 2004:D23 Poster 210.
    • (2004)
    • O'Donnell, D.1    Marciniuk, D.2    Hernandez, P.3    Richter, K.4    Kesten, S.5    Hamilton, A.6
  • 185
    • 24744435050 scopus 로고    scopus 로고
    • Inspiratory capacity (IC) and dyspnea during recovery from symptom-limited exercise in COPD patients treated with tiotropium [Abstract]
    • O'Donnell DE, Johnson B, Richter K, Kesten S, Hamilton A. Inspiratory capacity (IC) and dyspnea during recovery from symptom-limited exercise in COPD patients treated with tiotropium [Abstract]. European Respiratory Journal 2004;24(Suppl 48):214s.
    • (2004) European Respiratory Journal , vol.24 , pp. 214s
    • O'Donnell, D.E.1    Johnson, B.2    Richter, K.3    Kesten, S.4    Hamilton, A.5
  • 186
    • 85041505288 scopus 로고    scopus 로고
    • Influence of the exercise-limiting symptom on the relationship between lung hyperinflation and endurance time in COPD patients treated with tiotropium [Abstract]
    • American Thoracic Society 2005 International Conference; 2005 May 20-25; San Diego, California. :
    • O'Donnell D, Hamilton A, Kesten S. Influence of the exercise-limiting symptom on the relationship between lung hyperinflation and endurance time in COPD patients treated with tiotropium [Abstract]. American Thoracic Society 2005 International Conference; 2005 May 20-25; San Diego, California. 2005:[B23] [Poster: 502].
    • (2005)
    • O'Donnell, D.1    Hamilton, A.2    Kesten, S.3
  • 187
    • 85041515231 scopus 로고    scopus 로고
    • The effect of tiotropium on ventilatory mechanics during exercise in COPD [Abstract]
    • Poster: A51] American Thoracic Society 2005 International Conference; 2005 May 20-25; San Diego, California. :
    • O'Donnell D, Webb KA. The effect of tiotropium on ventilatory mechanics during exercise in COPD [Abstract]. American Thoracic Society 2005 International Conference; 2005 May 20-25; San Diego, California. 2005:[B65] [Poster: A51].
    • (2005)
    • O'Donnell, D.1    Webb, K.A.2
  • 188
    • 85041527897 scopus 로고    scopus 로고
    • Cardiac consequences of obstruction during exercise: benefits of bronchodilation [Abstract]
    • Poster #J84] American Thoracic Society International Conference; 2009 May 15-20; San Diego. :
    • Olson T, Baldi J, Afessa B, Scanlon P, Hulsebus M, Miller A, et al.Cardiac consequences of obstruction during exercise: benefits of bronchodilation [Abstract]. American Thoracic Society International Conference; 2009 May 15-20; San Diego. 2009:A4571 [Poster #J84].
    • (2009)
    • Olson, T.1    Baldi, J.2    Afessa, B.3    Scanlon, P.4    Hulsebus, M.5    Miller, A.6
  • 190
    • 80053193731 scopus 로고    scopus 로고
    • Novel combination of glycopyrrolate and formoterol MDI (GFF-MDI) provides superior bronchodilation compared to its components administered alone, tiotropium DPI, and formoterol DPI in a randomized, double-blind, placebo-controlled phase 2b study in patients with COPD [Abstract]
    • Reisner C, Fogarty C, Spangenthal S, Dunn L, Kerwin EM, Quinn D, et al.Novel combination of glycopyrrolate and formoterol MDI (GFF-MDI) provides superior bronchodilation compared to its components administered alone, tiotropium DPI, and formoterol DPI in a randomized, double-blind, placebo-controlled phase 2b study in patients with COPD [Abstract]. American Journal of Respiratory and Critical Care Medicine. 2011; Vol. 183:A6435.
    • (2011) , vol.183
    • Reisner, C.1    Fogarty, C.2    Spangenthal, S.3    Dunn, L.4    Kerwin, E.M.5    Quinn, D.6
  • 191
    • 85041516191 scopus 로고    scopus 로고
    • Fixed combination of glycopyrrolate and formoterol MDI (GFF-MDI) demonstrates superior inspiratory capacity (IC) compared to tiotropium DPI (Tio) following 7 days dosing, in a randomized, double-blind, placebo-controlled phase 2b study in patients with COPD [Abstract]
    • [P879]
    • Reisner C, St. Rose E, Strom S, Fischer T, Golden M, Thomas M, et al.Fixed combination of glycopyrrolate and formoterol MDI (GFF-MDI) demonstrates superior inspiratory capacity (IC) compared to tiotropium DPI (Tio) following 7 days dosing, in a randomized, double-blind, placebo-controlled phase 2b study in patients with COPD [Abstract]. European Respiratory Society Annual Congress; 2011 September 24-28; Amsterdam, The Netherlands 2011;38(55):150s [P879].
    • (2011) European Respiratory Society Annual Congress; 2011 September 24-28; Amsterdam, The Netherlands , vol.38 , Issue.55 , pp. 150s
    • Reisner, C.1    St Rose, E.2    Strom, S.3    Fischer, T.4    Golden, M.5    Thomas, M.6
  • 192
    • 85041494006 scopus 로고    scopus 로고
    • COPD patients who respond to tiotropium with dyspnea relief: A proof of efficacy? [Abstract]
    • American Thoracic Society International Conference 2008 May 16-21; Toronto. :
    • Rossi S, Gladly C, Baril J, Perrault H, Bourbeau J. COPD patients who respond to tiotropium with dyspnea relief: A proof of efficacy? [Abstract]. American Thoracic Society International Conference 2008 May 16-21; Toronto. 2008:A648[#F15].
    • (2008)
    • Rossi, S.1    Gladly, C.2    Baril, J.3    Perrault, H.4    Bourbeau, J.5
  • 196
    • 85041516496 scopus 로고    scopus 로고
    • Bronchodilation improves endurance but not muscular efficiency in COPD [Abstract]
    • American Thoracic Society International Conference; 2007 May 18-23; San Francisco, California, USA. :
    • Ten Hacken NH, Van der Haart H, Grevink R, Thompson S, Roemer W, Postma DS. Bronchodilation improves endurance but not muscular efficiency in COPD [Abstract]. American Thoracic Society International Conference; 2007 May 18-23; San Francisco, California, USA. 2007:Poster #M72.
    • (2007)
    • Ten Hacken, N.H.1    Van der Haart, H.2    Grevink, R.3    Thompson, S.4    Roemer, W.5    Postma, D.S.6
  • 197
    • 36448943227 scopus 로고    scopus 로고
    • Efficacy in COPD patients of tiotropium administered via the Respimat soft mist inhaler (SMI) compared to handihaler (HH) [Abstract]
    • Van Noord JA, Cornelissen G, Aumann JL, Platz J, Mueller A, Fogarty C. Efficacy in COPD patients of tiotropium administered via the Respimat soft mist inhaler (SMI) compared to handihaler (HH) [Abstract]. European Respiratory Journal 2006;28(Suppl 50):431s [P2516].
    • (2006) European Respiratory Journal , vol.28 , pp. 431s
    • Van Noord, J.A.1    Cornelissen, G.2    Aumann, J.L.3    Platz, J.4    Mueller, A.5    Fogarty, C.6
  • 198
    • 0009405672 scopus 로고    scopus 로고
    • Maintenance of bronchodilation following tiotropium in patients with mild, moderate and severe COPD in one year clinical trials
    • Vincken WG, Vermiere P, Menjoge SS, Keston S, Cornelissen PJG. Maintenance of bronchodilation following tiotropium in patients with mild, moderate and severe COPD in one year clinical trials. European Respiratory Journal 2001;18(Supp 33):331s.
    • (2001) European Respiratory Journal , vol.18 , pp. 331s
    • Vincken, W.G.1    Vermiere, P.2    Menjoge, S.S.3    Keston, S.4    Cornelissen, P.J.G.5
  • 199
  • 201
    • 85041537989 scopus 로고    scopus 로고
    • Tiotropium (SPIRIVA®) RESPIMAT®: Evaluation of fatal events - February 2010
    • (accessed 12 July 2010). [CTG: NCT00528996; trial number: 1205.14]
    • Boehringer Ingelheim. Tiotropium (SPIRIVA®) RESPIMAT®: Evaluation of fatal events - February 2010. www.trials.boehringer-ingelheim.com (accessed 12 July 2010). [CTG: NCT00528996; trial number: 1205.14].
    • Boehringer, I.1
  • 203
    • 84855167661 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-control study of once-daily inhaled tiotropium in chronic obstructive pulmonary disease
    • Yin KS, Zhang DP, Shi Y, Sun LH, Min R, Xiao YL, et al.A randomized, double-blind, placebo-control study of once-daily inhaled tiotropium in chronic obstructive pulmonary disease. Zhonghua Jie He He Hu Xi Za Zhi 2010;33(7):519-23.
    • (2010) Zhonghua Jie He He Hu Xi Za Zhi , vol.33 , Issue.7 , pp. 519-523
    • Yin, K.S.1    Zhang, D.P.2    Shi, Y.3    Sun, L.H.4    Min, R.5    Xiao, Y.L.6
  • 205
    • 77953028976 scopus 로고    scopus 로고
    • The short, the long, and the "ultra-long": why duration of bronchodilator action matters in chronic obstructive pulmonary disease
    • Beeh KM, Beier J. The short, the long, and the "ultra-long": why duration of bronchodilator action matters in chronic obstructive pulmonary disease. Advances in Therapy 2010;27(3):150-59.
    • (2010) Advances in Therapy , vol.27 , Issue.3 , pp. 150-159
    • Beeh, K.M.1    Beier, J.2
  • 206
    • 85041498161 scopus 로고    scopus 로고
    • Tiotropium (SPIRIVA®) RESPIMAT®: Evaluation of fatal events
    • Boehringer Ingelheim. Tiotropium (SPIRIVA®) RESPIMAT®: Evaluation of fatal events. www.trials.boehringer-ingelheim.com/res/trial/data/pdf/Pooled_Analysis_U10-3255-01.pdf 2010.
    • (2010)
    • Boehringer, I.1
  • 207
    • 85041515275 scopus 로고    scopus 로고
    • Global Clinical Trials Website of Boehringer Ingelheim
    • Global Clinical Trials Website of Boehringer Ingelheim. http://trials.boehringer-ingelheim.com/.
    • http://trials.boehringer-ingelheim.com/
  • 208
    • 79959317765 scopus 로고    scopus 로고
    • Safety of tiotropium
    • Cates CJ. Safety of tiotropium. BMJ 2011;342:d2970.
    • (2011) BMJ , vol.342
    • Cates, C.J.1
  • 210
    • 74949134191 scopus 로고    scopus 로고
    • Cardiovascular safety of tiotropium in patients with COPD
    • Celli B, Decramer M, Leimer I, Vogel U, Kesten S, Tashkin DP. Cardiovascular safety of tiotropium in patients with COPD. Chest 2010; Vol. 137, issue 1:20-30.
    • (2010) Chest , vol.137 , Issue.1 , pp. 20-30
    • Celli, B.1    Decramer, M.2    Leimer, I.3    Vogel, U.4    Kesten, S.5    Tashkin, D.P.6
  • 213
    • 0030922816 scopus 로고    scopus 로고
    • Bias in meta-analysis detected by a simple, graphical test
    • Egger M, Davey Smith G, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ 1997; Vol. 315, issue 7109:629-34.
    • (1997) BMJ , vol.315 , Issue.7109 , pp. 629-634
    • Egger, M.1    Davey Smith, G.2    Schneider, M.3    Minder, C.4
  • 214
    • 79959898445 scopus 로고    scopus 로고
    • Efficacy of tiotropium in COPD patients from Asia: A subgroup analysis from the UPLIFT trial
    • Fukuchi Y, Fernandez L, Kuo HP, Mahayiddin A, Celli B, Decramer M, et al.Efficacy of tiotropium in COPD patients from Asia: A subgroup analysis from the UPLIFT trial. Respirology 2011;16:825-35.
    • (2011) Respirology , vol.16 , pp. 825-835
    • Fukuchi, Y.1    Fernandez, L.2    Kuo, H.P.3    Mahayiddin, A.4    Celli, B.5    Decramer, M.6
  • 215
    • 84943656481 scopus 로고    scopus 로고
    • Global Initiative for Chronic Obstructive Lung Disease
    • (accessed 14th December 2009)
    • Global Initiative for Chronic Obstructive Lung Disease. www.goldcopd.com (accessed 14th December 2009).
  • 216
    • 84872417999 scopus 로고    scopus 로고
    • Cochrane Handbook for Systematic Reviews of Interventions Version 5.1 [updated March 2011]. The Cochrane Collaboration, 2011
    • Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1 [updated March 2011]. The Cochrane Collaboration, 2011. Available from www.cochrane-handbook.org.
    • Higgins, J.P.T.1    Green, S.2
  • 217
    • 77952739978 scopus 로고    scopus 로고
    • Acute care costs of patients admitted for management of chronic obstructive pulmonary disease exacerbations: contribution of disease severity, infection and chronic heart failure
    • Hutchinson A, Brand C, Irving L, Roberts C, Thompson P, Campbell D. Acute care costs of patients admitted for management of chronic obstructive pulmonary disease exacerbations: contribution of disease severity, infection and chronic heart failure. Internal Medicine Journal 2010;40(5):364-71.
    • (2010) Internal Medicine Journal , vol.40 , Issue.5 , pp. 364-371
    • Hutchinson, A.1    Brand, C.2    Irving, L.3    Roberts, C.4    Thompson, P.5    Campbell, D.6
  • 218
    • 79551650342 scopus 로고    scopus 로고
    • Effect of tiotropium on quality of life in COPD: a systematic review
    • Kaplan A. Effect of tiotropium on quality of life in COPD: a systematic review. Primary Care Respiratory Journal 2010;19(4):315-25.
    • (2010) Primary Care Respiratory Journal , vol.19 , Issue.4 , pp. 315-325
    • Kaplan, A.1
  • 222
    • 77956675843 scopus 로고    scopus 로고
    • Cost effectiveness of tiotropium for chronic obstructive pulmonary disease: a systematic review of the evidence
    • Mauskopf JA, Baker CL, Monz BU, Juniper MD. Cost effectiveness of tiotropium for chronic obstructive pulmonary disease: a systematic review of the evidence. Journal of Medical Economics 2010;13(3):403-17.
    • (2010) Journal of Medical Economics , vol.13 , Issue.3 , pp. 403-417
    • Mauskopf, J.A.1    Baker, C.L.2    Monz, B.U.3    Juniper, M.D.4
  • 223
    • 77956498722 scopus 로고    scopus 로고
    • Tiotropium's cost-effectiveness for the treatment of COPD: a cost-utility analysis under real-world conditions
    • Neyt M, Devriese S, Thiry N, Van den Bruel A. Tiotropium's cost-effectiveness for the treatment of COPD: a cost-utility analysis under real-world conditions. BMC Pulmonary Medicine 2010;10:47.
    • (2010) BMC Pulmonary Medicine , vol.10 , pp. 47
    • Neyt, M.1    Devriese, S.2    Thiry, N.3    Van den Bruel, A.4
  • 224
    • 85040462272 scopus 로고    scopus 로고
    • Chronic obstructive pulmonary disease, costing report, implementing NICE guidance
    • National Institute for Health and Clinical Excellence. Chronic obstructive pulmonary disease, costing report, implementing NICE guidance. www.guidance.nice.org.uk/CG101/CostingReport/pdf/English.
  • 226
    • 27644482811 scopus 로고    scopus 로고
    • Beta2-agonist and anticholinergic drugs in the treatment of lung disease
    • discussion 311-2
    • Proskocil BJ, Fryer AD. Beta2-agonist and anticholinergic drugs in the treatment of lung disease. Proceedings of the American Thoracic Society 2005;2(4):305-10; discussion 311-2.
    • (2005) Proceedings of the American Thoracic Society , vol.2 , Issue.4 , pp. 305-310
    • Proskocil, B.J.1    Fryer, A.D.2
  • 227
    • 79959812842 scopus 로고    scopus 로고
    • Clinical effectiveness of the Respimat inhaler device in managing chronic obstructive pulmonary disease: evidence when compared with other handheld inhaler devices
    • Ram FS, Carvallho CR, White J. Clinical effectiveness of the Respimat inhaler device in managing chronic obstructive pulmonary disease: evidence when compared with other handheld inhaler devices. International Journal of Chronic Obstructive Pulmonary Disease 2011; Vol. 6:129-39.
    • (2011) International Journal of Chronic Obstructive Pulmonary Disease , vol.6 , pp. 129-139
    • Ram, F.S.1    Carvallho, C.R.2    White, J.3
  • 228
    • 79960705415 scopus 로고    scopus 로고
    • Review Manager (RevMan)
    • The Cochrane Collaboration.. 5.1. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration
    • The Nordic Cochrane Centre, The Cochrane Collaboration. Review Manager (RevMan). 5.1. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2011.
    • (2011)
  • 229
    • 50949132697 scopus 로고    scopus 로고
    • Responses to tiotropium in African-American and Caucasian patients with chronic obstructive pulmonary disease
    • Rice KL, Leimer I, Kesten S, Niewoehner DE. Responses to tiotropium in African-American and Caucasian patients with chronic obstructive pulmonary disease. Translational Research 2008;152(2):88-94.
    • (2008) Translational Research , vol.152 , Issue.2 , pp. 88-94
    • Rice, K.L.1    Leimer, I.2    Kesten, S.3    Niewoehner, D.E.4
  • 230
    • 84907809009 scopus 로고    scopus 로고
    • St George's Respiratory Questionnaire for COPD Patients (SGRQ-C)
    • Jones P. St George's Respiratory Questionnaire for COPD Patients (SGRQ-C). www.healthstatus.sgul.ac.uk/SGRQ_download/SGRQ-C%20Manual%202008.pdf 2008.
    • (2008)
    • Jones, P.1
  • 231
    • 64849117859 scopus 로고    scopus 로고
    • Review: inhaled anticholinergics increase risk of major cardiovascular events in COPD
    • Singh S. Review: inhaled anticholinergics increase risk of major cardiovascular events in COPD. Evidence Based Medicine 2009;14(2):42-3.
    • (2009) Evidence Based Medicine , vol.14 , Issue.2 , pp. 42-43
    • Singh, S.1
  • 232
    • 84859008802 scopus 로고    scopus 로고
    • Mortality associated with tiotropium mist inhaler in patients with chronic obstructive pulmonary disease: systematic review and meta-analysis of randomised controlled trials
    • Singh S, Loke YK, Enright PL, Furberg CD. Mortality associated with tiotropium mist inhaler in patients with chronic obstructive pulmonary disease: systematic review and meta-analysis of randomised controlled trials. BMJ 2011;342:d3215.
    • (2011) BMJ , vol.342
    • Singh, S.1    Loke, Y.K.2    Enright, P.L.3    Furberg, C.D.4
  • 234
    • 33846207657 scopus 로고    scopus 로고
    • Chronic respiratory diseases
    • World Health Organization. Chronic respiratory diseases. www.who.int.
  • 235
    • 79955664791 scopus 로고    scopus 로고
    • Tiotropium for treatment of stable COPD: a meta-analysis of clinically relevant outcomes
    • Yohannes AM, Willgoss TG, Vestbo J. Tiotropium for treatment of stable COPD: a meta-analysis of clinically relevant outcomes. Respiratory Care 2011;56(4):477-87.
    • (2011) Respiratory Care , vol.56 , Issue.4 , pp. 477-487
    • Yohannes, A.M.1    Willgoss, T.G.2    Vestbo, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.