An alpha-adrenergic agonist protects hearts by inducing Akt1-mediated autophagy

Biochemical and Biophysical Research Communications

Volumn 456, Issue 1, 2015, Pages 250-256

  Nakaoka, Mikihiko ^a   Iwai Kanai, Eri ^a,b   Katamura, Maki ^a   Okawa, Yoshifumi ^a   Mita, Yuichiro ^a   Matoba, Satoaki ^a  

^a KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

^b TENRI HEALTH CARE UNIVERSITY   (Japan)

Author keywords

Adrenergic overload; Apoptosis; Autophagy; Cardioprotection

Indexed keywords

AUTOPHAGY PROTEIN 5; GREEN FLUORESCENT PROTEIN; ISOPRENALINE; MITOGEN ACTIVATED PROTEIN KINASE; NORADRENALIN; PHENYLEPHRINE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; AKT1 PROTEIN, RAT; ALPHA ADRENERGIC RECEPTOR STIMULATING AGENT; CARDIOTONIC AGENT; TARGET OF RAPAMYCIN KINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CELL STIMULATION; CONTROLLED STUDY; DRUG EFFECT; GENE OVEREXPRESSION; GENE SILENCING; HEART FAILURE; HEART MUSCLE; HEART MUSCLE CELL; HEART PROTECTION; HEART STRESS; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NEWBORN; NONHUMAN; RAT; SIGNAL TRANSDUCTION; ANIMAL; C57BL MOUSE; DRUG EFFECTS; HEART; METABOLISM; TRANSGENIC MOUSE;

RATTUS;

ADRENERGIC ALPHA-AGONISTS; ANIMALS; ANIMALS, NEWBORN; APOPTOSIS; AUTOPHAGY; CARDIOTONIC AGENTS; GREEN FLUORESCENT PROTEINS; HEART; HEART FAILURE; ISOPROTERENOL; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; NOREPINEPHRINE; PHENYLEPHRINE; PROTO-ONCOGENE PROTEINS C-AKT; RATS; TOR SERINE-THREONINE KINASES;

EID: 84919635720     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2014.11.067     Document Type: Article

References (26)

1. T. Vago, M. Bevilacqua, and G. Norbiato Identification of alpha 1-adrenergic receptors on sarcolemma from normal subjects and patients with idiopathic dilated cardiomyopathy: characteristics and linkage to GTP-binding protein Circ. Res. 64 1989 474 481
2. E. Iwai-Kanai, K. Hasegawa, and M. Araki α- and β-adrenergic pathways differentially regulate cell type-specific apoptosis in rat cardiac myocytes Circulation 100 1999 305 311
3. S.A. Hunt, W.T. Abraham, and M.H. Chin Focused update incorporated into the ACC/AHA 2005 guidelines for the diagnosis and management of heart failure in adults. A report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines Circulation 119 2009 2009 e391 e479
4. B. Ravikumar, C. Vacher, and Z. Berger Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease Nat. Genet. 36 2004 585 595
5. N. Mizushima Autophagy: process and function Genes Dev. 21 2007 2861 2873
6. R.A. Gottlieb, and A.B. Gustafsson Mitochondrial turnover in the heart Biochem. Biophys. Acta 2011 1813 1295 1301
7. A. Nakai, O. Yamaguchi, and T. Takeda The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress Nat. Med. 13 2007 619 624
8. A. Hoshino, Y. Mita, and Y. Okawa Cytosolic p53 inhibits Parkin-mediated mitophagy and promotes mitochondrial dysfunction in the mouse heart Nat. Commun. 4 2013 2208
9. A. Hamacher-Brady, N.R. Brady, and R.A. Gottlieb Enhancing macroautophagy protects against ischemia/reperfusion injury in cardiac myocytes J. Biol. Chem. 281 2006 29776 29787
10. Y. Matsui, H. Takagi, and X. Qu Distinct roles of autophagy in the heart during ischemia and reperfusion: roles of AMP-activated protein kinase and Beclin 1 in mediating autophagy Circ. Res. 100 2007 914 922
11. Y. Tanaka, G. Guhde, and A. Suter Accumulation of autophagic vacuoles and cardiomyopathy in LAMP-2-deficient mice Nature 406 2000 902 906
12. H. Zhu, P. Tannous, and J.L. Johnstone Cardiac autophagy is a maladaptive response to hemodynamic stress J. Clin. Invest. 117 2007 1782 1793
13. S. Kostin, L. Pool, and A. Elsasser Myocytes die by multiple mechanisms in failing human hearts Circ. Res. 92 2003 715 724
14. E. Iwai-Kanai, and K. Hasegawa Intracellular signaling pathways for norepinephrine- and endothelin-1-mediated regulation of myocardial cell apoptosis Mol. Cell. Biochem. 59 2004 163 168
15. K. Nishida, S. Kyoi, and O. Yamaguchi The role of autophagy in the heart Cell Death Differ. 16 2009 31 38
16. S. Shimizu, T. Kanaseki, and N. Mizushima Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes Nat. Cell Biol. 6 2004 1221 1228
17. M.C. Maiuri, E. Zalckvar, and A. Kimchi Self-eating and self-killing: crosstalk between autophagy and apoptosis Nat. Rev. Mol. Cell Biol. 8 2007 741 752
18. E. Iwai-Kanai, H. Yuan, and C. Huang A method to measure cardiac autophagic flux in vivo Autophagy 4 2008 322 329
19. S.P. Kunuthur, M.M. Mocanu, and B.A. Hemmings The Akt1 isoform is an essential mediator of ischaemic preconditioning J. Cell Mol. Med. 16 2012 1739 1749
20. U. Pfeifer, J. Four, and W. Wilhelm Short-term inhibition of cardiac cellular autophagy by isoproterenol J. Mol. Cell. Cardiol. 19 1987 1179 1184
21. T. Kanazawa, I. Taneike, and R. Akaishi Amino acids and insulin control autophagic proteolysis through different signaling pathways in relation to mTOR in isolated rat hepatocytes J. Biol. Chem. 279 2004 8452 8459
22. S. Sarkar, E.O. Perlstein, and S. Imarisio Small molecules enhance autophagy and reduce toxicity in Huntington's disease models Nat. Chem. Biol. 3 2007 331 338
23. M. Inoko, Y. Kihara, and I. Morii Transition from compensatory hypertrophy to dilated, failing left ventricles in Dahl salt-sensitive rats Am. J. Physiol. 267 1994 H2471 H2482
24. J.A. Kuzman, T.D. O'Connell, and A.M. Gerdes Rapamycin prevents thyroid hormone-induced cardiac hypertrophy Endocrinology 148 2007 3477 3484
25. B. DeBosch, N. Sambandam, and C. Weinheimer AKT2 regulates cardiac metabolism and cardiomyocyte survival J. Biol. Chem. 281 2006 32841 32851
26. H. Takeuchi, Y. Kondo, and K. Fujiwara Synergistic augmentation of rapamycin-induced autophagy in malignant glioma cells by phosphatidylinositol 3-kinase/protein kinase B inhibitors Cancer Res. 65 2005 3336 3346