Rational design of hyper-glycosylated interferon beta analogs: A computational strategy for glycoengineering

Journal of Molecular Graphics and Modelling

Volumn 56, Issue , 2015, Pages 31-42

  Samoudi, Mojtaba ^a   Tabandeh, Fatemeh ^a   Minuchehr, Zarrin ^a   Ahangari Cohan, Reza ^b   Nouri Inanlou, Davoud ^b   Khodabandeh, Mahvash ^a   Sabery Anvar, Mohammad ^a  

^a NATIONAL INSTITUTE OF GENETIC ENGINEERING AND BIOTECHNOLOGY   (Iran)

^b PASTEUR INSTITUTE OF IRAN   (Iran)

Author keywords

Comparative modeling; Glycoengineering; In silico design; Interferon beta; Molecular dynamics

Indexed keywords

AMINO ACIDS; ANTIBIOTICS; ESTERIFICATION; GLYCOPROTEINS; GLYCOSYLATION; MOLECULAR DYNAMICS; PROTEINS;

COMPARATIVE MODELING; GLYCOENGINEERING; IN-SILICO; INTERFERON BETAS; MOLECULAR DYNAMICS SIMULATIONS; N-LINKED GLYCOSYLATION; STRUCTURAL DISTORTIONS; THREE DIMENSIONAL (3D) STRUCTURES;

STRUCTURAL DESIGN;

BETA INTERFERON; SIALIC ACID DERIVATIVE;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; CONFORMATIONAL TRANSITION; CONSENSUS SEQUENCE; CRYSTAL STRUCTURE; GLYCOENGINEERING; MOLECULAR DYNAMICS; MOLECULAR STABILITY; PROTEIN CONFORMATION; PROTEIN ENGINEERING; PROTEIN FUNCTION; PROTEIN GLYCOSYLATION; PROTEIN STRUCTURE; SEQUENCE ALIGNMENT; ANIMAL; CHEMISTRY; GLYCOSYLATION; HUMAN; MOLECULAR GENETICS; PROTEIN SECONDARY STRUCTURE; PROTEIN STABILITY; PROTEIN TERTIARY STRUCTURE; SEQUENCE HOMOLOGY; STRUCTURAL HOMOLOGY; THERMODYNAMICS;

AMINO ACID SEQUENCE; ANIMALS; GLYCOSYLATION; HUMANS; INTERFERON-BETA; MOLECULAR DYNAMICS SIMULATION; MOLECULAR SEQUENCE DATA; PROTEIN ENGINEERING; PROTEIN STABILITY; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; SIALIC ACIDS; STRUCTURAL HOMOLOGY, PROTEIN; THERMODYNAMICS;

EID: 84919622567     PISSN: 10933263     EISSN: 18734243     Source Type: Journal    
DOI: 10.1016/j.jmgm.2014.12.001     Document Type: Article

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