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Volumn 94, Issue 1, 2015, Pages 183-191

TLR2 promoter hypermethylation creates innate immune dysbiosis

Author keywords

chronic in vitro infection; CpG island; DNA methylation; gingival epithelial cells; oral gavage; P. gingivalis

Indexed keywords

AUTACOID; AZACITIDINE; DECITABINE; DNA METHYLTRANSFERASE; INTERLEUKIN 1BETA; TLR2 PROTEIN, HUMAN; TLR2 PROTEIN, MOUSE; TOLL LIKE RECEPTOR 2;

EID: 84919486892     PISSN: 00220345     EISSN: 15440591     Source Type: Journal    
DOI: 10.1177/0022034514557545     Document Type: Article
Times cited : (73)

References (39)
  • 2
    • 84889684183 scopus 로고    scopus 로고
    • Modifiable risk factors in periodontal disease: Epigenetic regulation of gene expression in the inflammatory response
    • Barros SP, Offenbacher S. Modifiable risk factors in periodontal disease: epigenetic regulation of gene expression in the inflammatory response. Periodontol. 2014 2000 ; 64 (1). 95-110
    • (2000) Periodontol , vol.64 , Issue.1 , pp. 95-110
    • Barros, S.P.1    Offenbacher, S.2
  • 5
    • 27744577751 scopus 로고    scopus 로고
    • BiQ Analyzer: Visualization and quality control for DNA methylation data from bisulfite sequencing
    • Bock C, Reither S, Mikeska T, Paulsen M, Walter J, Lengauer T. BiQ Analyzer: visualization and quality control for DNA methylation data from bisulfite sequencing. Bioinformatics. 2005 ; 21 (21). 4067-4068
    • (2005) Bioinformatics , vol.21 , Issue.21 , pp. 4067-4068
    • Bock, C.1    Reither, S.2    Mikeska, T.3    Paulsen, M.4    Walter, J.5    Lengauer, T.6
  • 6
    • 33845462504 scopus 로고    scopus 로고
    • Cutting edge: TLR2 is required for the innate response to Porphyromonas gingivalis: Activation leads to bacterial persistence and TLR2 deficiency attenuates induced alveolar bone resorption
    • Burns E, Bachrach G, Shapira L, Nussbaum G. Cutting edge: TLR2 is required for the innate response to Porphyromonas gingivalis: activation leads to bacterial persistence and TLR2 deficiency attenuates induced alveolar bone resorption. J Immunol. 2006 ; 177 (12). 8296-8300
    • (2006) J Immunol , vol.177 , Issue.12 , pp. 8296-8300
    • Burns, E.1    Bachrach, G.2    Shapira, L.3    Nussbaum, G.4
  • 7
    • 4544337512 scopus 로고    scopus 로고
    • Porphyromonas gingivalis lipopolysaccharide contains multiple lipid A species that functionally interact with both toll-like receptors 2 and 4
    • Darveau RP, Pham TT, Lemley K, Reife RA, Bainbridge BW, Coats SR, Howald WN, Way SS, Hajjar AM. Porphyromonas gingivalis lipopolysaccharide contains multiple lipid A species that functionally interact with both toll-like receptors 2 and 4. Infect Immun. 2004 ; 72 (9). 5041-5051
    • (2004) Infect Immun , vol.72 , Issue.9 , pp. 5041-5051
    • Darveau, R.P.1    Pham, T.T.2    Lemley, K.3    Reife, R.A.4    Bainbridge, B.W.5    Coats, S.R.6    Howald, W.N.7    Way, S.S.8    Hajjar, A.M.9
  • 10
    • 40849139208 scopus 로고    scopus 로고
    • Epigenetics in cancer
    • Esteller M. Epigenetics in cancer. N Engl J Med. 2008 ; 358 (11). 1148-1159
    • (2008) N Engl J Med , vol.358 , Issue.11 , pp. 1148-1159
    • Esteller, M.1
  • 11
    • 57149107350 scopus 로고    scopus 로고
    • Gene-specific control of the TLR-induced inflammatory response
    • Foster SL, Medzhitov R. Gene-specific control of the TLR-induced inflammatory response. Clin Immunol. 2009 ; 130 (1). 7-15
    • (2009) Clin Immunol , vol.130 , Issue.1 , pp. 7-15
    • Foster, S.L.1    Medzhitov, R.2
  • 12
    • 70349284481 scopus 로고    scopus 로고
    • Epigenetics and periodontal disease: Future perspectives
    • Gomez RS, Dutra WO, Moreira PR. Epigenetics and periodontal disease: future perspectives. Inflamm Res. 2009 ; 58 (10). 625-629
    • (2009) Inflamm Res , vol.58 , Issue.10 , pp. 625-629
    • Gomez, R.S.1    Dutra, W.O.2    Moreira, P.R.3
  • 13
    • 84863341461 scopus 로고    scopus 로고
    • Epigenetic modification of TLRs in leukocytes is associated with increased susceptibility to Salmonella enteritidis in chickens
    • Gou Z, Liu R, Zhao G, Zheng M, Li P, Wang H, Zhu Y, Chen J, Wen J. Epigenetic modification of TLRs in leukocytes is associated with increased susceptibility to Salmonella enteritidis in chickens. PLoS One. 2012 ; 7 (3). e33627
    • (2012) PLoS One , vol.7 , Issue.3 , pp. 33627
    • Gou, Z.1    Liu, R.2    Zhao, G.3    Zheng, M.4    Li, P.5    Wang, H.6    Zhu, Y.7    Chen, J.8    Wen, J.9
  • 14
    • 38149006156 scopus 로고    scopus 로고
    • The use of rodent models to investigate host-bacteria interactions related to periodontal diseases
    • Graves DT, Fine D, Teng YT, Van Dyke TE, Hajishengallis G. The use of rodent models to investigate host-bacteria interactions related to periodontal diseases. J Clin Periodontol. 2008 ; 35 (2). 89-105
    • (2008) J Clin Periodontol , vol.35 , Issue.2 , pp. 89-105
    • Graves, D.T.1    Fine, D.2    Teng, Y.T.3    Van Dyke, T.E.4    Hajishengallis, G.5
  • 15
    • 0021506680 scopus 로고
    • Clinical, microbiological and immunological features associated with the treatment of active periodontosis lesions
    • Haffajee AD, Socransky SS, Ebersole JL, Smith DJ. Clinical, microbiological and immunological features associated with the treatment of active periodontosis lesions. J Clin Periodontol. 1984 ; 11 (9). 600-618
    • (1984) J Clin Periodontol , vol.11 , Issue.9 , pp. 600-618
    • Haffajee, A.D.1    Socransky, S.S.2    Ebersole, J.L.3    Smith, D.J.4
  • 16
    • 84872004568 scopus 로고    scopus 로고
    • Editorial: A toll gate to escape T cells
    • Hajishengallis G. Editorial: a toll gate to escape T cells. J Leukoc Biol. 2013 ; 93 (1). 3-5
    • (2013) J Leukoc Biol , vol.93 , Issue.1 , pp. 3-5
    • Hajishengallis, G.1
  • 18
    • 67449116290 scopus 로고    scopus 로고
    • Induction of distinct TLR2-mediated proinflammatory and proadhesive signaling pathways in response to Porphyromonas gingivalis fimbriae
    • Hajishengallis G, Wang M, Liang S. Induction of distinct TLR2-mediated proinflammatory and proadhesive signaling pathways in response to Porphyromonas gingivalis fimbriae. J Immunol. 2009 ; 182 (11). 6690-6696
    • (2009) J Immunol , vol.182 , Issue.11 , pp. 6690-6696
    • Hajishengallis, G.1    Wang, M.2    Liang, S.3
  • 20
    • 0142185046 scopus 로고    scopus 로고
    • Age-related epigenetic changes and the immune system
    • Issa JP. Age-related epigenetic changes and the immune system. Clin Immunol. 2003 ; 109 (1). 103-108
    • (2003) Clin Immunol , vol.109 , Issue.1 , pp. 103-108
    • Issa, J.P.1
  • 21
    • 79960912486 scopus 로고    scopus 로고
    • Epigenetic variation and cellular Darwinism
    • Issa JP. Epigenetic variation and cellular Darwinism. Nat Genet. 2011 ; 43 (8). 724-726
    • (2011) Nat Genet , vol.43 , Issue.8 , pp. 724-726
    • Issa, J.P.1
  • 22
    • 0035328527 scopus 로고    scopus 로고
    • Accelerated age-related CpG island methylation in ulcerative colitis
    • Issa JP, Ahuja N, Toyota M, Bronner MP, Brentnall TA. Accelerated age-related CpG island methylation in ulcerative colitis. Cancer Res. 2001 ; 61 (9). 3573-3577
    • (2001) Cancer Res , vol.61 , Issue.9 , pp. 3573-3577
    • Issa, J.P.1    Ahuja, N.2    Toyota, M.3    Bronner, M.P.4    Brentnall, T.A.5
  • 23
    • 0028001087 scopus 로고
    • Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon
    • Issa JP, Ottaviano YL, Celano P, Hamilton SR, Davidson NE, Baylin SB. Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon. Nat Genet. 1994 ; 7 (4). 536-540
    • (1994) Nat Genet , vol.7 , Issue.4 , pp. 536-540
    • Issa, J.P.1    Ottaviano, Y.L.2    Celano, P.3    Hamilton, S.R.4    Davidson, N.E.5    Baylin, S.B.6
  • 24
    • 0036274359 scopus 로고    scopus 로고
    • The fundamental role of epigenetic events in cancer
    • Jones PA, Baylin SB. The fundamental role of epigenetic events in cancer. Nat Rev Genet. 2002 ; 3 (6). 415-428
    • (2002) Nat Rev Genet , vol.3 , Issue.6 , pp. 415-428
    • Jones, P.A.1    Baylin, S.B.2
  • 26
    • 33646148510 scopus 로고    scopus 로고
    • Gingival epithelial cells heterozygous for Toll-like receptor 4 polymorphisms Asp299Gly and Thr399ile are hypo-responsive to Porphyromonas gingivalis
    • Kinane DF, Shiba H, Stathopoulou PG, Zhao H, Lappin DF, Singh A, Eskan MA, Beckers S, Waigel S, Alpert B, et al. Gingival epithelial cells heterozygous for Toll-like receptor 4 polymorphisms Asp299Gly and Thr399ile are hypo-responsive to Porphyromonas gingivalis. Genes Immun. 2006 ; 7 (3). 190-200
    • (2006) Genes Immun , vol.7 , Issue.3 , pp. 190-200
    • Kinane, D.F.1    Shiba, H.2    Stathopoulou, P.G.3    Zhao, H.4    Lappin, D.F.5    Singh, A.6    Eskan, M.A.7    Beckers, S.8    Waigel, S.9    Alpert, B.10
  • 28
    • 33745945755 scopus 로고    scopus 로고
    • Tolerance to microbial TLR ligands: Molecular mechanisms and relevance to disease
    • Medvedev AE, Sabroe I, Hasday JD, Vogel SN. Tolerance to microbial TLR ligands: molecular mechanisms and relevance to disease. J Endotoxin Res. 2006 ; 12 (3). 133-150
    • (2006) J Endotoxin Res , vol.12 , Issue.3 , pp. 133-150
    • Medvedev, A.E.1    Sabroe, I.2    Hasday, J.D.3    Vogel, S.N.4
  • 31
    • 33646237805 scopus 로고    scopus 로고
    • Promoter hypomethylation of Toll-like receptor-2 gene is associated with increased proinflammatory response toward bacterial peptidoglycan in cystic fibrosis bronchial epithelial cells
    • Shuto T, Furuta T, Oba M, Xu H, Li JD, Cheung J, Gruenert DC, Uehara A, Suico MA, Okiyoneda T, et al. Promoter hypomethylation of Toll-like receptor-2 gene is associated with increased proinflammatory response toward bacterial peptidoglycan in cystic fibrosis bronchial epithelial cells. FASEB J. 2006 ; 20 (6). 782-784
    • (2006) FASEB J , vol.20 , Issue.6 , pp. 782-784
    • Shuto, T.1    Furuta, T.2    Oba, M.3    Xu, H.4    Li, J.D.5    Cheung, J.6    Gruenert, D.C.7    Uehara, A.8    Suico, M.A.9    Okiyoneda, T.10
  • 32
    • 72549086297 scopus 로고    scopus 로고
    • Epithelial cell pro-inflammatory cytokine response differs across dental plaque bacterial species
    • Stathopoulou PG, Benakanakere MR, Galicia JC, Kinane DF. Epithelial cell pro-inflammatory cytokine response differs across dental plaque bacterial species. J Clin Periodontol. 2010 ; 37 (1). 24-29
    • (2010) J Clin Periodontol , vol.37 , Issue.1 , pp. 24-29
    • Stathopoulou, P.G.1    Benakanakere, M.R.2    Galicia, J.C.3    Kinane, D.F.4
  • 33
  • 36
    • 80052385986 scopus 로고    scopus 로고
    • Targets in epigenetics: Inhibiting the methyl writers of the histone code
    • Yost JM, Korboukh I, Liu F, Gao C, Jin J. Targets in epigenetics: inhibiting the methyl writers of the histone code. Curr Chem Genomics. 2011 ; 5: 72-84
    • (2011) Curr Chem Genomics , vol.5 , pp. 72-84
    • Yost, J.M.1    Korboukh, I.2    Liu, F.3    Gao, C.4    Jin, J.5
  • 39
    • 78649511964 scopus 로고    scopus 로고
    • Mammalian target of rapamycin (mTOR) regulates TLR3 induced cytokines in human oral keratinocytes
    • Zhao J, Benakanakere MR, Hosur KB, Galicia JC, Martin M, Kinane DF. Mammalian target of rapamycin (mTOR) regulates TLR3 induced cytokines in human oral keratinocytes. Mol Immunol. 2010 ; 48 (1-3). 294-304
    • (2010) Mol Immunol , vol.48 , Issue.13 , pp. 294-304
    • Zhao, J.1    Benakanakere, M.R.2    Hosur, K.B.3    Galicia, J.C.4    Martin, M.5    Kinane, D.F.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.