Congenital and postnatal CMV and EBV acquisition in HIV-infected Zimbabwean infants

PLoS ONE

Volumn 9, Issue 12, 2014, Pages

  Gumbo, Hlanai ^a   Chasekwa, Bernard ^a   Church, James A ^a,b   Ntozini, Robert ^a   Mutasa, Kuda ^a   Humphrey, Jean H ^a,c   Prendergast, Andrew J ^a,b,c  

^a Zvitambo Institute for Maternal and Child Health Research   (Zimbabwe)

^b QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^c JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CONGENITAL INFECTION; CROSS-SECTIONAL STUDY; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTION; EPSTEIN BARR VIRUS; EPSTEIN BARR VIRUS INFECTION; FEMALE; HAZARD RATIO; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INFANT; INFANT MORTALITY; KAPLAN MEIER METHOD; LIMIT OF DETECTION; LIMIT OF QUANTITATION; MAJOR CLINICAL STUDY; MALE; MIXED INFECTION; PERINATAL PERIOD; PREVALENCE; PROPORTIONAL HAZARDS MODEL; REAL TIME POLYMERASE CHAIN REACTION; VIRUS LOAD; ZIMBABWEAN; ADULT; AIDS-RELATED OPPORTUNISTIC INFECTIONS; CYTOMEGALOVIRUS INFECTIONS; EPSTEIN-BARR VIRUS INFECTIONS; TRANSMISSION; VERTICAL TRANSMISSION; ZIMBABWE;

CYTOMEGALOVIRUS; HUMAN HERPESVIRUS 4;

ADULT; AIDS-RELATED OPPORTUNISTIC INFECTIONS; COINFECTION; CYTOMEGALOVIRUS INFECTIONS; EPSTEIN-BARR VIRUS INFECTIONS; FEMALE; HUMANS; INFANT; INFANT MORTALITY; INFECTIOUS DISEASE TRANSMISSION, VERTICAL; MALE; ZIMBABWE;

EID: 84919485297     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0114870     Document Type: Article

References (53)

1. Global report: UNAIDS report on the global AIDS epidemic 2013. Joint United Nations Programme on HIV/AIDS (UNAIDS). Available: http://www.unaids.org/en/resources/campaigns/globalreport2013/globalreport Accessed 2014 December 1.
2. Marinda E, Humphrey JH, Iliff PJ, Mutasa K, Nathoo KJ, et al. (2007) Child mortality according to maternal and infant HIV status in Zimbabwe. Pediatr Infect Dis J 26: 519-526.
3. Newell ML, Coovadia H, Cortina-Borja M, Rollins N, Gaillard P, et al. (2004) Mortality of infected and uninfected infants born to HIV-infected mothers in Africa: a pooled analysis. Lancet 364: 1236-1243.
4. Dickover RE, Dillon M, Leung KM, Krogstad P, Plaeger S, et al. (1998) Early prognostic indicators in primary perinatal human immunodeficiency virus type 1 infection: importance of viral RNA and the timing of transmission on long-term outcome. J Infect Dis 178: 375-387.
5. Rouet F, Sakarovitch C, Msellati P, Elenga N, Montcho C, et al. (2003) Pediatric viral human immunodeficiency virus type 1 RNA levels, timing of infection, and disease progression in African HIV-1-infected children. Pediatrics 112: e289.
6. Shearer WT, Quinn TC, LaRussa P, Lew JF, Mofenson L, et al. (1997) Viral load and disease progression in infants infected with human immunodeficiency virus type 1. Women and Infants Transmission Study Group. N Engl J Med 336: 1337-1342.
7. Doyle M, Atkins JT, Rivera-Matos IR (1996) Congenital cytomegalovirus infection in infants infected with human immunodeficiency virus type 1. Pediatr Infect Dis J 15: 1102-1106.
8. Kovacs A, Schluchter M, Easley K, Demmler G, Shearer W, et al. (1999) Cytomegalovirus infection and HIV-1 disease progression in infants born to HIV-1-infected women. Pediatric Pulmonary and Cardiovascular Complications of Vertically Transmitted HIV Infection Study Group. N Engl J Med 341: 77-84.
9. Bowser CS, Kaye J, Leier TU, Chorney V, Nathawad R, et al. (2006) Prevalence of viral and mycobacterial co-infections in perinatally HIV-infected children. Fetal Pediatr Pathol 25: 321-331.
10. Long SS, Pickering LK, Prober CG (2009) DNA Viruses: Herpesviridae. Principles and Practice of Paediatric Infectious Diseases. 3rd Edition ed: Saunders. pp. 1029-1036.
11. Rodier MH, Berthonneau J, Bourgoin A, Giraudeau G, Agius G, et al. (1995) Seroprevalences of Toxoplasma, malaria, rubella, cytomegalovirus, HIV and treponemal infections among pregnant women in Cotonou, Republic of Benin. Acta Trop 59: 271-277.
12. Schoub BD, Johnson S, McAnerney JM, Blackburn NK, Guidozzi F, et al. (1993) Is antenatal screening for rubella and cytomegalovirus justified? S Afr Med J 83: 108-110.
13. Cannon MJ, Schmid DS, Hyde TB (2010) Review of cytomegalovirus seroprevalence and demographic characteristics associated with infection. Rev Med Virol 20: 202-213.
14. Pedneault L, Lapointe N, Alfieri C, Ghadirian P, Carpentier L, et al. (1998) Natural history of Epstein-Barr virus infection in a prospective pediatric cohort born to human immunodeficiency virus-infected mothers. J Infect Dis 177: 1087-1090.
15. Slyker JA, Casper C, Tapia K, Richardson B, Bunts L, et al. (2013) Clinical and virologic manifestations of primary Epstein-Barr virus (EBV) infection in Kenyan infants born to HIV-infected women. J Infect Dis 207: 1798-1806.
16. Petrara MR, Penazzato M, Massavon W, Nabachwa S, Nannyonga M, et al. (2014) Epstein-Barr Virus load in children infected with Human Immunodeficiency Virus type 1 in Uganda. J Infect Dis 210: 392-9.
17. Humphrey JH, Iliff PJ, Marinda ET, Mutasa K, Moulton LH, et al. (2006) Effects of a single large dose of vitamin A, given during the postpartum period to HIV-positive women and their infants, on child HIV infection, HIV-free survival, and mortality. J Infect Dis 193: 860-871.
18. Gibson RS (1990) Principles of Nutritional Assessment: Oxford University Press.
19. Mutasa K, Ntozini R, Prendergast A, Iliff P, Rukobo S, et al. (2012) Impact of six-week viral load on mortality in HIV-infected Zimbabwean infants. Pediatr Infect Dis J 31: 948-950.
20. Kraft CS, Armstrong WS, Caliendo AM (2012) Interpreting quantitative cytomegalovirus DNA testing: understanding the laboratory perspective. Clin Infect Dis 54: 1793-1797.
21. Bates M, Monze M, Bima H, Kapambwe M, Kasolo FC, et al. (2008) High human cytomegalovirus loads and diverse linked variable genotypes in both HIV-1 infected and exposed, but uninfected, children in Africa. Virology 382: 28-36.
22. Bello C, Whittle H (1991) Cytomegalovirus infection in Gambian mothers and their babies. J Clin Pathol 44: 366-369.
23. Slyker JA, Lohman-Payne BL, John-Stewart GC, Maleche-Obimbo E, Emery S, et al. (2009) Acute cytomegalovirus infection in Kenyan HIV-infected infants. AIDS 23: 2173-2181.
24. Guibert G, Warszawski J, Le Chenadec J, Blanche S, Benmebarek Y, et al. (2009) Decreased risk of congenital cytomegalovirus infection in children born to HIV-1-infected mothers in the era of highly active antiretroviral therapy. Clin Infect Dis 48: 1516-1525.
25. Slyker J, Farquhar C, Atkinson C, Asbjornsdottir K, Roxby A, et al. (2014) Compartmentalized cytomegalovirus replication and transmission in the setting of maternal HIV-1 infection. Clin Infect Dis 58: 564-572.
26. Mwaanza N, Chilukutu L, Tembo J, Kabwe M, Musonda K, et al. (2014) High Rates of Congenital Cytomegalovirus Infection Linked With Maternal HIV Infection Among Neonatal Admissions at a Large Referral Center in Sub-Saharan Africa. Clin Infect Dis 58: 728-735.
27. Lanzieri TM, Dollard SC, Bialek SR, Grosse SD (2014) Systematic review of the birth prevalence of congenital cytomegalovirus infection in developing countries. Int J Infect Dis 22: 44-48.
28. Toth FD, Mosborg-Petersen P, Kiss J, Aboagye-Mathiesen G, Hager H, et al. (1995) Interactions between human immunodeficiency virus type 1 and human cytomegalovirus in human term syncytiotrophoblast cells coinfected with both viruses. J Virol 69: 2223-2232.
29. Gompels UA, Larke N, Sanz-Ramos M, Bates M, Musonda K, et al. (2012) Human cytomegalovirus infant infection adversely affects growth and development in maternally HIV-exposed and unexposed infants in Zambia. Clin Infect Dis 54: 434-442.
30. Peterson PK, Gekker G, Chao CC, Hu SX, Edelman C, et al. (1992) Human cytomegalovirus-stimulated peripheral blood mononuclear cells induce HIV-1 replication via a tumor necrosis factor-alpha-mediated mechanism. J Clin Invest 89: 574-580.
31. Koval V, Clark C, Vaishnav M, Spector SA, Spector DH (1991) Human cytomegalovirus inhibits human immunodeficiency virus replication in cells productively infected by both viruses. J Virol 65: 6969-6978.
32. Sever JL, Rakusan TA, Ellaurie M, Frenkel N, Wyatt LS, et al. (1995) Coinfection with herpesviruses in young children of HIV-infected women. Pediatr AIDS HIV Infect 6: 75-82.
33. Spector SA, Hsia K, Crager M, Pilcher M, Cabral S, et al. (1999) Cytomegalovirus (CMV) DNA load is an independent predictor of CMV disease and survival in advanced AIDS. J Virol 73: 7027-7030.
34. Deayton JR, Prof Sabin CA, Johnson MA, Emery VC, Wilson P, et al. (2004) Importance of cytomegalovirus viraemia in risk of disease progression and death in HIV-infected patients receiving highly active antiretroviral therapy. Lancet 363: 2116-2121.
35. Marin Gabriel MA, Ramos Amador JT, Gonzalez Tome M, Rojo Conejo P, Saavedra Lozano J, et al. (2007) Cytomegalovirus infection in the first year of life in human immunodeficiency virus-infected children: impact on survival and progression of the HIV disease. Med Sci Monit 13: CR177-181.
36. Balfour HH, Jr., Sifakis F, Sliman JA, Knight JA, Schmeling DO, et al. (2013) Age-specific prevalence of Epstein-Barr virus infection among individuals aged 6-19 years in the United States and factors affecting its acquisition. J Infect Dis 208: 1286-1293.
37. Kafuko GW, Henderson BE, Kirya BG, Munube GM, Tukei PM, et al. (1972) Epstein-Barr virus antibody levels in children from the West Nile District of Uganda. Report of a field study. Lancet 1: 706-709.
38. Piriou E, Asito AS, Sumba PO, Fiore N, Middeldorp JM, et al. (2012) Early age at time of primary Epstein-Barr virus infection results in poorly controlled viral infection in infants from Western Kenya: clues to the etiology of endemic Burkitt lymphoma. J Infect Dis 205: 906-913.
39. Slyker JA, Casper C, Tapia K, Richardson B, Bunts L, et al. (2014) Accelerated Suppression of Primary Epstein-Barr Virus Infection in HIV-Infected Infants Initiating Lopinavir/Ritonavir-Based Versus Nevirapine-Based Combination Antiretroviral Therapy. Clin Infect Dis 58: 1333-7.
40. Chan KH, Tam JS, Peiris JS, Seto WH, Ng MH (2001) Epstein-Barr virus (EBV) infection in infancy. J Clin Virol 21: 57-62.
41. Miller CS, Berger JR, Mootoor Y, Avdiushko SA, Zhu H, et al. (2006) High prevalence of multiple human herpesviruses in saliva from human immunodeficiency virus-infected persons in the era of highly active antiretroviral therapy. Journal of clinical microbiology 44: 2409-2415.
42. Schaftenaar E, Verjans GM, Getu S, McIntyre JA, Struthers HE, et al. (2014) High seroprevalence of human herpesviruses in HIV-infected individuals attending primary healthcare facilities in rural South Africa. PLoS One 9: e99243.
43. Ito Y, Shibata-Watanabe Y, Kawada J, Maruyama K, Yagasaki H, et al. (2009) Cytomegalovirus and Epstein-Barr virus coinfection in three toddlers with prolonged illnesses. J Med Virol 81: 1399-1402.
44. Wang X, Yang K, Wei C, Huang Y, Zhao D (2010) Coinfection with EBV/CMV and other respiratory agents in children with suspected infectious mononucleosis. Virol J 7: 247.
45. Alvarez-Lafuente R, Aguilera B, Suarez-Mier MA, Morentin B, Vallejo G, et al. (2008) Detection of human herpesvirus-6, Epstein-Barr virus and cytomegalovirus in formalin-fixed tissues from sudden infant death: a study with quantitative real-time PCR. Forensic Science International 178: 106-111.
46. Holder B, Miles DJ, Kaye S, Crozier S, Mohammed NI, et al. (2010) Epstein-Barr virus but not cytomegalovirus is associated with reduced vaccine antibody responses in Gambian infants. PLoS One 5: e14013.
47. Nilsson C, Linde A, Montgomery SM, Gustafsson L, Nasman P, et al. (2005) Does early EBV infection protect against IgE sensitization? The Journal of Allergy and Clinical Immunology 116: 438-444.
48. Saghafian-Hedengren S, Sundstrom Y, Sohlberg E, Nilsson C, Linde A, et al. (2009) Herpesvirus seropositivity in childhood associates with decreased monocyte-induced NK cell IFN-gamma production. Journal of Immunology 182: 2511-2517.
49. Goldberg GN, Fulginiti VA, Ray CG, Ferry P, Jones JF, et al. (1981) In utero Epstein-Barr virus (infectious mononucleosis) infection. JAMA 246: 1579-1581.
50. Joncas JH, Wills A, McLaughlin B (1977) Congenital infection with cytomegalovirus and Epstein-Barr virus. Can Med Assoc J 117: 1417-1418.
51. Schuster V, Janssen W, Seidenspinner S, Kreth HW (1993) [Congenital Epstein-Barr virus infection]. Monatsschr Kinderheilkd 141: 401-404.
52. Joncas J, Boucher J, Granger-Julien M, Filion C (1974) Epstein-Barr virus infection in the neonatal period and in childhood. Can Med Assoc J 110: 33-37.
53. McMichael G, MacLennan A, Gibson C, Alvino E, Goldwater P, et al. (2012) Cytomegalovirus and Epstein-Barr virus may be associated with some cases of cerebral palsy. J Matern Fetal Neonatal Med 25: 2078-2081.