High rates of congenital cytomegalovirus infection linked with maternal HIV infection among neonatal admissions at a large referral center in sub-saharan Africa

Clinical Infectious Diseases

Volumn 58, Issue 5, 2014, Pages 728-735

  Mwaanza, Nyaxewo ^a,b   Chilukutu, Lophina ^a,c   Tembo, John ^a,c   Kabwe, Mwila ^a   Musonda, Kunda ^d   Kapasa, Monica ^b   Chabala, Chishala ^a,b   Sinyangwe, Sylvester ^a,b   Mwaba, Peter ^a,e   Zumla, Alimuddin ^a   Bates, Matthew ^a,c  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b Department of Paediatrics and Child Health ^*  (United Kingdom)

^c UNIVERSITY TEACHING HOSPITAL   (Zambia)

^d LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^e MINISTRY OF HEALTH   (Zambia)

Author keywords

Africa; CMV; congenital; HIV; neonate

Indexed keywords

IMMUNOGLOBULIN M; VIRUS ANTIBODY; VIRUS DNA;

AFRICA SOUTH OF THE SAHARA; BLOOD; COMPLICATION; CROSS-SECTIONAL STUDY; CYTOMEGALOVIRUS INFECTIONS; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HOSPITALIZATION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MALE; NEWBORN; PREGNANCY; PREGNANCY COMPLICATIONS, INFECTIOUS; PREVALENCE; REAL TIME POLYMERASE CHAIN REACTION; RISK FACTOR; SALIVA; SERUM; STATISTICS AND NUMERICAL DATA; TERTIARY CARE CENTER; URINE; VIROLOGY;

AFRICA SOUTH OF THE SAHARA; ANTIBODIES, VIRAL; CROSS-SECTIONAL STUDIES; CYTOMEGALOVIRUS INFECTIONS; DNA, VIRAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HIV INFECTIONS; HOSPITALIZATION; HUMANS; IMMUNOGLOBULIN M; INFANT, NEWBORN; MALE; PREGNANCY; PREGNANCY COMPLICATIONS, INFECTIOUS; PREVALENCE; REAL-TIME POLYMERASE CHAIN REACTION; RISK FACTORS; SALIVA; SERUM; TERTIARY CARE CENTERS; URINE;

EID: 84894257405     PISSN: 10584838     EISSN: 15376591     Source Type: Journal    
DOI: 10.1093/cid/cit766     Document Type: Article

References (30)

1. Mocarski ES Jr, Shenk T, Pass RF. Cytomegaloviruses. In: Knipe DM, Howley PM. Fields virology. 5th ed. Vol 2. Philidelphia: Lippincot,Williams andWilkins, 2007:2701-72.
2. Grosse SD, Ross DS, Dollard SC. Congenital cytomegalovirus (CMV) infection as a cause of permanent bilateral hearing loss: a quantitative assessment. J Clin Virol 2008; 41:57-62.
3. Bate SL, Dollard SC, Cannon MJ. Cytomegalovirus seroprevalence in the United States: the national health and nutrition examination surveys, 1988-2004. Clin Infect Dis 2010; 50:1439-47.
4. Tookey PA, Ades AE, Peckham CS. Cytomegalovirus prevalence in pregnant women: the influence of parity. Arch Dis Child 1992; 67(7 Spec No):779-83.
5. Schoub BD, Johnson S, McAnerney JM, et al. Is antenatal screening for rubella and cytomegalovirus justified? S Afr Med J 1993; 83:108-10.
6. Rodier MH, Berthonneau J, Bourgoin A, et al. Seroprevalences of Toxoplasma, malaria, rubella, cytomegalovirus, HIV and treponemal infections among pregnant women in Cotonou, Republic of Benin. Acta Trop 1995; 59:271-7.
7. Fowler KB, Stagno S, Pass RF, Britt WJ, Boll TJ, Alford CA. The outcome of congenital cytomegalovirus infection in relation to maternal antibody status. N Engl J Med 1992; 326:663-7.
8. Stroffolini T, Ngatchu T, Chiaramonte M, et al. Prevalence of cytomegalovirus seropositivity in an urban childhood population in Cameroon. New Microbiol 1993; 16:83-5.
9. Bello C, Whittle H. Cytomegalovirus infection in Gambian mothers and their babies. J Clin Pathol 1991; 44:366-9.
10. Schopfer K, Lauber E, Krech U. Congenital cytomegalovirus infection in newborn infants of mothers infected before pregnancy. Arch Dis Child 1978; 53:536-9.
11. van der Sande MA, Kaye S, Miles DJ, et al. Risk factors for and clinical outcome of congenital cytomegalovirus infection in a peri-urbanWest-African birth cohort. PLoS One 2007; 2:e492.
12. Manicklal S, Emery VC, Lazzarotto T, Boppana SB, Gupta RK. The "silent" global burden of congenital cytomegalovirus. Clin Microbiol Rev 2013; 26:86-102.
13. Mussi-Pinhata MM, Yamamoto AY, Moura Brito RM, et al. Birth prevalence and natural history of congenital cytomegalovirus infection in a highly seroimmune population. Clin Infect Dis 2009; 49:522-8.
14. Yamamoto AY, Mussi-Pinhata MM, Isaac Mde L, et al. Congenital cytomegalovirus infection as a cause of sensorineural hearing loss in a highly immune population. Pediatr Infect Dis J 2011; 30:1043-6.
15. Kovacs A, Schluchter M, Easley K, et al. Cytomegalovirus infection and HIV-1 disease progression in infants born to HIV-1-infected women. Pediatric Pulmonary and Cardiovascular Complications of Vertically Transmitted HIV Infection Study Group. N Engl JMed 1999; 341:77-84.
16. Doyle M, Atkins JT, Rivera-Matos IR. Congenital cytomegalovirus infection in infants infected with human immunodeficiency virus type 1. Pediatr Infect Dis J 1996; 15:1102-6.
17. Frederick T, Homans J, Spencer L, et al. The effect of prenatal highly active antiretroviral therapy on the transmission of congenital and perinatal/early postnatal cytomegalovirus among HIV-infected and HIVexposed infants. Clin Infect Dis 2012; 55:877-84.
18. Gompels UA, Larke N, Sanz-Ramos M, et al. Human cytomegalovirus infant infection adversely affects growth and development in maternally HIV-exposed and unexposed infants in Zambia. Clin Infect Dis 2012; 54:434-42.
19. Khansarinejad B, Soleimanjahi H, Mirab Samiee S, Hamidieh AA, Paryan M, Sanahmadi Y. Quantitation of human cytomegalovirus DNA in plasma using an affordable in-house qPCR assay. J Virol Methods 2012; 183:170-5.
20. Cannon MJ, Hyde TB, Schmid DS. Review of cytomegalovirus shedding in bodily fluids and relevance to congenital cytomegalovirus infection. Rev Med Virol 2011; 21:240-55.
21. Albanna EA, El-Latif RS, Sharaf HA, Gohar MK, Ibrahim BM. Diagnosis of congenital cytomegalovirus infection in high risk neonates. Mediterr J Hematol Infect Dis 2013; 5:e2013049.
22. Tomasik T, Opozda A, Pietrzyk JJ. Cytomegalovirus infection-diagnostic and therapeutic difficulties in neonatal intensive care unit [in Polish]. Przegl Lek 2010; 67:18-24.
23. Clarke LM, Duerr A, Feldman J, Sierra MF, Daidone BJ, Landesman SH. Factors associated with cytomegalovirus infection among human immunodeficiency virus type 1-seronegative and-seropositive women from an urban minority community. J Infect Dis 1996; 173:77-82.
24. Schoenfisch AL, Dollard SC, Amin M, et al. Cytomegalovirus (CMV) shedding is highly correlated with markers of immunosuppression in CMV-seropositive women. J Med Microbiol 2011; 60(Pt 6):768-74.
25. Lurain NS, Robert ES, Xu J, et al. HIV type 1 and cytomegalovirus coinfection in the female genital tract. J Infect Dis 2004; 190:619-23.
26. Chandwani S, Kaul A, Bebenroth D, et al. Cytomegalovirus infection in human immunodeficiency virus type 1-infected children. Pediatr Infect Dis J 1996; 15:310-4.
27. Mostad SB, Kreiss JK, Ryncarz AJ, et al. Cervical shedding of cytomegalovirus in human immunodeficiency virus type 1-infected women. J Med Virol 1999; 59:469-73.
28. Makasa M, Kasonka L, Chisenga M, et al. Early growth of infants of HIV-infected and uninfected Zambian women. Trop Med Int Health 2007; 12:594-602.
29. Arpadi S, Fawzy A, Aldrovandi GM, et al. Growth faltering due to breastfeeding cessation in uninfected children born to HIV-infected mothers in Zambia. Am J Clin Nutr 2009; 90:344-53.
30. Khamduang W, Jourdain G, Sirirungsi W, et al. The interrelated transmission of HIV-1 and cytomegalovirus during gestation and delivery in the offspring of HIV-infected mothers. J Acquir Immune Defic Syndr 2011; 58:188-92.