Specific activation of dendritic cells enhances clearance of Bacillus anthracis following infection

PLoS ONE

Volumn 9, Issue 11, 2014, Pages 1-9

  Thompson, Iain J T ^a   Mann, Elizabeth R ^b   Stokes, Margaret G ^a   English, Nicholas R ^b   Knight, Stella C ^b   Williamson, Diane ^a  

^a DEFENCE SCIENCE AND TECHNOLOGY LABORATORY   (United Kingdom)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALUMINUM POTASSIUM SULFATE; ANTHRAX VACCINE; B7 ANTIGEN; CD40 ANTIGEN; CD86 ANTIGEN; CPG OLIGODEOXYNUCLEOTIDE; IMMUNOLOGICAL ADJUVANT; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; RECOMBINANT PROTECTIVE ANTIGEN; UNCLASSIFIED DRUG; BACTERIAL ANTIGEN; CYTOKINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTHRAX; ARTICLE; BACILLUS ANTHRACIS; BACTERIAL CLEARANCE; BONE MARROW DERIVED DENDRITIC CELL; CELL ACTIVATION; CELL SURVIVAL; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE PRODUCTION; EX VIVO STUDY; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNITY; IMMUNIZATION; MOUSE; NONHUMAN; PROTEIN EXPRESSION; SPLEEN CELL; UPREGULATION; ADOPTIVE TRANSFER; ANIMAL; BIOSYNTHESIS; CELL DIVISION; CELLULAR IMMUNITY; CYTOLOGY; DENDRITIC CELL; IMMUNOLOGY; METABOLISM; PHYSIOLOGY; SPLEEN; SURVIVAL ANALYSIS; T LYMPHOCYTE; VACCINATION;

BACILLUS ANTHRACIS; BACTERIA (MICROORGANISMS); MURINAE; MUS;

ADOPTIVE TRANSFER; ANIMALS; ANTHRAX; ANTIGENS, BACTERIAL; BACILLUS ANTHRACIS; CELL DIVISION; CYTOKINES; DENDRITIC CELLS; HUMANS; IMMUNITY, CELLULAR; MICE; SPLEEN; SURVIVAL ANALYSIS; T-LYMPHOCYTES; VACCINATION;

EID: 84919484537     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0109720     Document Type: Article

References (20)

1. Banchereau J, Briere F, Caux C, Davoust J, Lebecque S, et al. (2000) Immunobiology of dendritic cells. Annual Review of Immunology 18: 767-+.
2. Mahnke K, Guo M, Lee S, Sepulveda H, Swain SL, et al. (2000) The dendritic cell receptor for endocytosis, DEC-205, can recycle and enhance antigen presentation via major histocompatibility complex class II-positive lysosomal compartments. Journal of Cell Biology 151: 673-683.
3. Banchereau J, Steinman RM (1998) Dendritic cells and the control of immunity. Nature 392: 245-252.
4. Palucka K, Banchereau J (2012) Cancer immunotherapy via dendritic cells. Nature Reviews Cancer 12: 265-277.
5. Do Y, Koh H, Park CG, Dudziak D, Seo P, et al. (2010) Targeting of LcrV virulence protein from Yersinia pestis to dendritic cells protects mice against pneumonic plague. European Journal of Immunology 40: 2791-2796.
6. Okinaka R, Cloud K, Hampton O, Hoffmaster A, Hill K, et al. (1999) Sequence, assembly and analysis of pX01 and pX02. Journal of Applied Microbiology 87: 261-262.
7. Turnbull PCB (1991) Anthrax Vaccines - Past, Present and Future. Vaccine 9: 533-539.
8. Ivins BE, Welkos SL (1988) Recent Advances in the Development of An Improved, Human Anthrax Vaccine. European Journal of Epidemiology 4: 12-19.
9. Reuveny S, White MD, Adar YY, Kafri Y, Altboum Z, et al. (2001) Search for correlates of protective immunity conferred by anthrax vaccine. Infection and Immunity 69: 2888-2893.
10. Welkos S, Little S, Friedlander A, Fritz D, Fellows P (2001) The role of antibodies to Bacillus anthracis and anthrax toxin components in inhibiting the early stages of infection by anthrax spores. Microbiology-Sgm 147: 1677-1685.
11. Ivins BE, Welkos SL, Little SF, Crumrine MH, Nelson GO (1992) Immunization Against Anthrax with Bacillus-Anthracis Protective Antigen Combined with Adjuvants. Infection and Immunity 60: 662-668.
12. Elvin SJ, Healey GD, Westwood A, Knight SC, Eyles JE, et al. (2006) Protection against heterologous Burkholderia pseudomallei strains by dendritic cell immunization. Infection and Immunity 74: 1706-1711.
13. Welkos SL, Friedlander AM (1988) Pathogenesis and Genetic-Control of Resistance to the Sterne Strain of Bacillus-Anthracis. Microbial Pathogenesis 4: 53-69.
14. Welkos SL, Keener TJ, Gibbs PH (1986) Differences in Susceptibility of Inbred Mice to Bacillus-Anthracis. Infection and Immunity 51: 795-800.
15. Inaba K, Inaba M, Romani N, Aya H, Deguchi M, et al. (1992) Generation of Large Numbers of Dendritic Cells from Mouse Bone-Marrow Cultures Supplemented with Granulocyte Macrophage Colony-Stimulating Factor. Journal of Experimental Medicine 176: 1693-1702.
16. Lutz MB, Kukutsch N, Ogilvie ALJ, Rossner S, Koch F, et al. (1999) An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow. Journal of Immunological Methods 223: 77-92.
17. Knight SC, Farrant J, Bryant A, Edwards AJ, Burman S, et al. (1986) Nonadherent, low-density cells from human peripheral-blood contain dendritic cells and monocytes, both with veiled morphology. Immunology 57: 595-603.
18. Holden NJ, Bedford PA, McCarthy NE, Marks NA, Ind PW, et al. (2008) Dendritic cells from control but not atopic donors respond to contact and respiratory sensitizer treatment in vitro with differential cytokine production and altered stimulatory capacity. Clinical and Experimental Allergy 38: 1148-1159.
19. Healey GD, Elvin SJ, Morton M, Williamson ED (2005) Humoral and cell-mediated adaptive immune responses are required for protection against Burkholderia pseudomallei challenge and bacterial clearance postinfection. Infection and Immunity 73: 5945-5951.
20. Flick-Smith HC, Waters EL, Walker NJ, Miller J, Stagg AJ, et al. (2005) Mouse model characterisation for anthrax vaccine development: comparison of one inbred and one outbred mouse strain. Microbial Pathogenesis 38: 33-40.