Dendritic cells from control but not atopic donors respond to contact and respiratory sensitizer treatment in vitro with differential cytokine production and altered stimulatory capacity

Clinical and Experimental Allergy

Volumn 38, Issue 7, 2008, Pages 1148-1159

  Holden, N J ^a   Bedford, P A ^a   McCarthy, N E ^a   Marks, N A ^b   Ind, P W ^b   Jowsey, I R ^c   Basketter, D A ^c   Knight, S C ^a  

^a ST MARK S HOSPITAL   (United Kingdom)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

^c UNILEVER RESEARCH   (United Kingdom)

Author keywords

Atopy; Contact hypersensitivity; DNCB; TMA

Indexed keywords

1 CHLORO 2,4 DINITROBENZENE; GAMMA INTERFERON; HAPTEN; INTERLEUKIN 12; INTERLEUKIN 13; TRIMELLITIC ANHYDRIDE; IRRITANT AGENT; PHTHALIC ANHYDRIDE;

ADULT; ARTICLE; ATOPY; CELL VIABILITY; CONTACT ALLERGY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; FEMALE; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IN VITRO STUDY; LYMPHOCYTE PROLIFERATION; MALE; PHENOTYPE; PRIORITY JOURNAL; RESPIRATORY TRACT ALLERGY; SENSITIZATION; T LYMPHOCYTE; AGED; BIOSYNTHESIS; CELL PROLIFERATION; DRUG EFFECT; IMMEDIATE TYPE HYPERSENSITIVITY; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; METABOLISM; MIDDLE AGED;

ADULT; AGED; CELL PROLIFERATION; DENDRITIC CELLS; DINITROCHLOROBENZENE; FEMALE; HAPTENS; HUMANS; HYPERSENSITIVITY, IMMEDIATE; INTERFERON TYPE II; INTERLEUKIN-12; INTERLEUKIN-13; IRRITANTS; LYMPHOCYTE ACTIVATION; MALE; MIDDLE AGED; PHTHALIC ANHYDRIDES; T-LYMPHOCYTES;

EID: 54449097136     PISSN: 09547894     EISSN: 13652222     Source Type: Journal    
DOI: 10.1111/j.1365-2222.2008.02997.x     Document Type: Article

References (45)

1. Macatonia SE, Knight SC, Edwards AJ, Griffiths S, Fryer P. Localization of antigen on lymph node dendritic cells after exposure to the contact sensitizer fluorescein isothiocyanate. Functional and morphological studies. J Exp Med 1987; 166: 1654-67.
2. Reutter K, Jager D, Degwert J, Hoppe U. In vitro model for contact sensitization: II. Induction of IL-1[beta] mRNA in human blood-derived dendritic cells by contact sensitizers. Toxicol In Vitro 1997; 11:619-26.
3. Aiba S, Terunuma A, Manome H, Tagami H. Dendritic cells differently respond to haptens and irritants by their production of cytokines and expression of co-stimulatory molecules. Eur J Immunol 1997; 27:3031-8.
4. Coutant KD, de Fraissinette AB, Cordier A, Ulrich P. Modulation of the activity of human monocyte-derived dendritic cells by chemical haptens, a metal allergen, and a staphylococcal super- antigen. Toxicol Sci 1999; 52:189-98.
5. Rougier N, Redziniak G, Mougin D, Schmitt D, Vincent C. In vitro evaluation of the sensitization potential of weak contact allergens using langerhans-like dendritic cells and autologous T cells. Toxicology 2000; 145:73-82.
6. 2 and 2,4-dinitrochlorobenzene. J Invest Dermatol 2003; 120:390-9.
7. Mizuashi M, Ohtani T, Nakagawa S, Aiba S. Redox imbalance induced by contact sensitizers triggers the maturation of den dritic cells. J Invest Dermatol 2005; 124:579-86.
8. Cumberbatch M, Gould SJ, Peters SW, Basketter DA, Dearman RJ, Kimber I. Influence of topical exposure to chemical allergens on murine Langerhans cells.: comparison of2,4-dinitrochlorobenzene with trimellitic anhydride. J Clin Lab Immunol 1992; 37:65-81.
9. Warbrick EV, Dearman RJ, Kimber I. Induced changes in total serum IgE concentration in the Brown Norway rat: potential for identification of chemical respiratory allergens. J Appl Toxicol 2002; 22:1-11.
10. Tee RD, Cullinan P, Welch J, Burge PS, Newman-Taylor AJ.
11. Specific IgE to isocyanates: a useful diagnostic role in occupational asthma. J Allergy ClinImmunol 1998; 101:709-15.
12. Dearman RJ, Moussavi A, Kemeny DM, Kimber I. Contribution of CD4+and CD8+T lymphocyte subsets to the cytokine secretion patterns induced in mice during sensitization to contact and respiratory chemical allergens. Immunology 1996; 89:502-10.
13. Warbrick EV, Dearman RJ, Basketter DA, Gerberick GF, Ryan CA, Kimber I. Analysis of cytokine mRNA expression following repeated exposure of mice to chemical contact and respiratory allergens. J Appl Toxicol 1998; 18:205-13.
14. Vandebriel RJ, De Jong WH, Spiekstra SW et al. Assessment of preferential T-helper 1 or T-helper 2 induction by low molecular weight compounds using the local lymph node assay in conjunction with RT-PCR and ELISA for interferon-gamma and interleukin-4. Toxicol Appl Pharmacol 2000; 162:77-85.
15. Ryan CA, Dearman RJ, Kimber I, Gerberick F. Inducible inter- leukin 4(IL-4) production and mRNA expression following exposure of mice to chemical allergens. Toxicol Lett 1998; 94: 1-11.
16. Pichowski JS, Cumberbatch M, Dearman RJ, Basketter DA, Kimber I. Allergen-induced changes in interleukin 1 beta(IL-1 beta) mRNA expression by human blood-derived dendritic cells: inter-individual differences and relevance for sensitization testing. J Appl Toxicol 2001; 21:115-21.
17. Parronchi P, Macchia D, Piccinni MP et al. Allergen- and bacterial antigen-specific T-cell clones established from atopic donors show a different profile of cytokine production. Proc Natl Acad Sci USA 1991; 88:4538-42.
18. Reider N, Reider D, Ebner S et al. Dendritic cells contribute to the development of atopy by an insufficiency in IL-12 production. J Allergy ClinImmunol 2002; 109:89-95.
19. Kaminishi K, Soma Y, Kawa Y, Mizoguchi M. Flow cytometric analysis of IL-4, IL-13 and IFN-gamma expression in peripheral blood mononuclear cells and detection of circulating IL-13 in patients with atopic dermatitis provide evidence for the involvement of type 2 cytokines in the disease. J Dermatol Sci 2002; 29:19-25.
20. Cronin E, McFadden JP. Patients with atopic eczema do become sensitized to contact allergens. Contact Dermat 1993; 28:225-8.
21. Rees J, Friedmann PS, Matthews JN. Contact sensitivity to dinitrochlorobenzene is impaired in atopic subjects. Controversy revisited. Arch Dermatol 1990; 126:1173-5.
22. Buchvald D, Lundeberg L. Impaired responses ofperipheral blood mononuclear cells to nickel in patients with nickel-allergic contact dermatitis and concomitant atopic dermatitis. Br J Dermatol 2004; 150:484-92.
23. Knight SC, Farrant J, Bryant A et al. Non-adherent, low-density cells from human peripheral blood contain dendritic cells and monocytes, both with veiled morphology. Immunology 1986; 57:595-603.
24. McLellan AD, Starling GC, Hart DN. Isolation of human blood dendritic cells by discontinuous Nycodenz gradient centrifuga- tion. JImmunol Methods 1995; 184:81-9.
25. Bagwell B. A journey through flow cytometric immunofluorescence analyses - finding accurate and robustalgorithms that estimate positive fraction distributions. Clin Immunol Newslett 1996; 16:33-7.
26. Panoskaltsis N, Reid CDL, Knight SC. Quantification and cyto- kine production of circulating lymphoid and myeloid cells in acute myelogenous leukaemia. Leukemia 2003; 17:716-30.
27. Hart AL, Al Hassi HO, Rigby RJ et al. Characteristics of intestinal dendritic cells in inflammatory bowel diseases. Gastroenterology 2005; 129:50-65.
28. Knight SC, Bedford PA, Stagg AJ. Mixed leukocyte reactions in measuring immunity. In: Lotz MT, Thomson AW, eds. London: Elsevier, 2005; 350-60.
29. Dearman RJ, Moussavi A, Kemeny DM, Kimber I. Contribution of CD4+and CD8+T lymphocyte subsets to the cytokine secretion patterns induced in mice during sensitization to contact and respiratory chemical allergens. Immunology 1996; 89:502-10.
30. Pickard C, Smith AM, Cooper H et al. Investigation of mechanisms underlying the T-cell response to the hapten 2,4-dinitro- chlorobenzene. J Invest Dermatol 2007; 127:630-7.
31. Straube F, Grenet O, Bruegger P, Ulrich P. Contact allergens and irritants show discrete differences in the activation of human monocyte-derived dendritic cells: consequences for in vitro detection of contact allergens. Arch Toxicol 2005; 79:37-46.
32. Traidl C, Jugert F, Krieg T, Merk H, Nunzelmann N. Inhibition of allergic contact dermatitis to DNCB but not to Oxazolone in interleukin-4-deficient mice. J Invest Dermatol 1999; 112: 476-82.
33. Cumberbatch M, Dearman J, Kimber I. Contribution of cutaneous interleukin-10 to the polarisation of immune responses to chemical contact and respiratory allergens. Br JDermatol 2005; 152 :840-1.
34. Akbari O, DeKruyff RH, Umetsu DT. Pulmonary dendritic cells producing IL-10 mediate tolerance induced by respiratory exposure to antigen. Nat Immunol 2001; 2:725-31.
35. Toebak MJ, Moed H, von Blomberg MB et al. Intrinsic characteristics of contact and respiratory allergens influence production of polarizing cytokines by dendritic cells. Contact Dermat 2006; 55:238-45.
36. Reider N, Reider D, Ebner S et al. Dendritic cells contribute to the development of atopy by an insufficiency in IL-12 production. J Allergy ClinImmunol 2002; 109:89-95.
37. Bellinghausen I, Brand U, Knop J, Saloga J. Comparison of allergen-stimulated dendritic cells from atopic and nonatopic donors dissecting their effect on autologous naive and memory T helper cells of such donors. J Allergy Clin Immunol 2000; 105:988-96.
38. Leonard C, Tormey V, Burke C, Poulter LW. Allergen-induced cytokine production in atopic disease and its relationship to disease severity. Am JRespir CellMol Biol 1997; 17:368-75.
39. Bellinghausen I, Brand P, Bottcher I, Klostermann B, Knop J, Saloga J. Production of interleukin-13 by human dendritic cells after stimulation with protein allergens is a key factor for induction of T helper 2 cytokines and is associated with activation of signal transducer and activator of transcription-6. Immunology 2003; 108:167-76.
40. Padilla J, Daley E, Chow A et al. IL-13 regulates the immune response to inhaled antigens. J Immunol 2005; 174:8097-105.
41. de Waal MR, Abrams JS, Zurawski SM et al. Differential regulation of IL-13 and IL-4 production by human CD+and CD4+Th0, Th1 and Th2T cell clones and EBV-transformed B cells. IntImmunol 1995; 7:1405-16.
42. Yu CR, Kirken RA, Malabarba MG, Young HA, Ortaldo JR. Differential regulation of the Janus kinase-STAT pathway and biologic function of IL-13 in primary human NK and T cells: a comparative study with IL-4. J Immunol 1998; 161: 218-27.
43. Muro S, Wiewrodt R, Thomas A et al. A novel endocytic pathway induced by clustering endothelial ICAM-1 or PECAM-1. JCellSci 2003; 116:1599-609.
44. Paine R, Morris SB, Jin H, Baleeiro CEO, Wilcoxen SE. ICAM-1 facilitates alveolar macrophage phagocytic activity through effects on migration over the AEC surface. Am J Physiol-Lung Cell MolPhysiol 2002; 283:L180-7. 44 Hopkins JE, Naisbitt DJ, Kitteringham NR, Dearman RJ, Kimber I, Park BK. Selective haptenation of cellular or extracellular protein by chemical allergens: association with cytokine polarization. Chem Res Toxicol 2005; 18:375-81.
45. Pickard C, Smith AM, Cooper H et al. Investigation of mechanisms underlying the T-cell response to the hapten 2,4-dinitrochlorobenzene. J Invest Dermatol 2007; 127:630-7.