Operational research needs toward malaria elimination in China

Advances in Parasitology

Volumn 86, Issue , 2014, Pages 109-133

  Chen, Shen Bo ^a,b   Ju, Chuan ^a,b   Chen, Jun Hu ^a,b   Zheng, Bin ^a,b   Huang, Fang ^a,b   Xiao, Ning ^a,b   Zhou, Xia ^a,b   Ernest, Tambo ^c,d   Zhou, Xiao Nong ^a  

^a CHINESE CENTER FOR DISEASE CONTROL AND PREVENTION   (China)

^b BEIJING HOSPITAL   (China)

^c Center for Sustainable Malaria Control Faculty of Natural and Environmental Science   (China)

^d UNIVERSITY OF PRETORIA   (South Africa)

Author keywords

Diagnosis; Drug resistance; Elimination strategy; Malaria elimination; Operational research; Surveillance tools; Vector biology

Indexed keywords

ARTEMISININ; INSECTICIDE; MALARIA VACCINE;

ARTICLE; CHINA; CLINICAL TRIAL; DIAGNOSTIC TEST; DISEASE CONTROL; EPIDEMIC; GLUCOSE 6 PHOSPHATE DEHYDROGENASE DEFICIENCY; HUMAN; IMMUNOLOGY; MALARIA; PARASITEMIA; PLASMODIUM; RESEARCH PRIORITY; SCREENING; SYSTEM ANALYSIS; SYSTEMATIC REVIEW; ZOOLOGY; ANIMAL; DISEASE CARRIER; DISEASE ERADICATION; EPIDEMIOLOGY; PHYSIOLOGY; VACCINATION;

ANIMALS; CHINA; DISEASE ERADICATION; DISEASE VECTORS; EPIDEMIOLOGIC RESEARCH DESIGN; HUMANS; INSECTICIDES; MALARIA; PLASMODIUM; VACCINATION;

EID: 84919484429     PISSN: 0065308X     EISSN: None     Source Type: Book Series    
DOI: 10.1016/B978-0-12-800869-0.00005-6     Document Type: Chapter

References (121)

1. Technical assistance for the study of the health and educational needs of ethnic minorities in the Greater Mekong Sub Region 1998, ADB, Asian Development Bank, Manila.
2. Agnandji S.T., Lell B., Fernandes J.F., Abossolo B.P., Methogo B.G., Kabwende A.L., et al. A phase 3 trial of RTS,S/AS01 malaria vaccine in African infants. N. Engl. J. Med. 2012, 367:2284-2295.
3. Agnandji S.T., Lell B., Soulanoudjingar S.S., Fernandes J.F., Abossolo B.P., Conzelmann C., et al. First results of phase 3 trial of RTS,S/AS01 malaria vaccine in African children. N. Engl. J. Med. 2011, 365:1863-1875.
4. Alonso P.L., Brown G., Arevalo-Herrera M., Binka F., Chitnis C., Collins F., et al. A research agenda to underpin malaria eradication. PLoS Med. 2011, 8:e1000406.
5. Amaratunga C., Sreng S., Suon S., Phelps E.S., Stepniewska K., Lim P., et al. Artemisinin-resistant Plasmodium falciparum in Pursat province, western Cambodia: a parasite clearance rate study. Lancet Infect. Dis. 2012, 12:851-858.
6. Andersen F., Douglas N.M., Bustos D., Galappaththy G., Qi G., Hsiang M.S., et al. Trends in malaria research in 11 Asian Pacific countries: an analysis of peer-reviewed publications over two decades. Malar. J. 2011, 10:131.
7. Ariey F., Witkowski B., Amaratunga C., Beghain J., Langlois A.C., Khim N., et al. A molecular marker of artemisinin-resistant Plasmodium falciparum malaria. Nature 2014, 505:50-55.
8. Baird J.K., Surjadjaja C. Consideration of ethics in primaquine therapy against malaria transmission. Trends. Parasitol 2011, 12:11-16.
9. Bell D.R., Wilson D.W., Martin L.B. False-positive results of a Plasmodium falciparum histidine-rich protein 2-detecting malaria rapid diagnostic test due to high sensitivity in a community with fluctuating low parasite density. Am. J. Trop. Med. Hyg. 2005, 73:199-203.
10. Bi Y., Hu W., Liu H., Xiao Y., Guo Y., Chen S., et al. Can slide positivity rates predict malaria transmission?. Malar. J. 2012, 11:117.
11. Bojang K.A., Obaro S., Morison L.A., Greenwood B.M. A prospective evaluation of a clinical algorithm for the diagnosis of malaria in Gambian children. Trop. Med. Int. Health 2000, 5:231-236.
12. Bousema T., Drakeley C. Epidemiology and infectivity of Plasmodium falciparum and Plasmodium vivax gametocytes in relation to malaria control and elimination. Clin. Microbiol. Rev. 2011, 12:377-410.
13. Bozdech Z., Llinas M., Pulliam B.L., Wong E.D., Zhu J., DeRisi J.L. The transcriptome of the intraerythrocytic developmental cycle of Plasmodium falciparum. PLoS Biol. 2003, 1:E5.
14. Bozdech Z., Mok S., Hu G., Imwong M., Jaidee A., Russell B., et al. The transcriptome of Plasmodium vivax reveals divergence and diversity of transcriptional regulation in malaria parasites. Proc. Natl. Acad. Sci. U.S.A. 2008, 105:16290-16295.
15. Campbell C.C. Malaria control-addressing challenges to ambitious goals. N. Engl. J. Med. 2009, 361:522-523.
16. Cappellini M.D., Fiorelli G. Glucose-6-phosphate dehydrogenase deficiency. Lancet 2008, 371:64-74.
17. Carlton J.M., Adams J.H., Silva J.C., Bidwell S.L., Lorenzi H., Caler E., et al. Comparative genomics of the neglected human malaria parasite Plasmodium vivax. Nature 2008, 455:757-763.
18. Chen J.H., Jung J.W., Wang Y., Ha K.S., Lu F., Lim C.S., et al. Immunoproteomics profiling of blood stage Plasmodium vivax infection by high-throughput screening assays. J. Proteome Res. 2010, 9:6479-6489.
19. Chen J.H., Lu F., Lim C.S., Kim J.Y., Ahn H.J., Suh I.B., et al. Detection of Plasmodium vivax infection in the Republic of Korea by loop-mediated isothermal amplification (LAMP). Acta Trop. 2010, 113:61-65.
20. Chen J.H., Wang H., Chen J.X., Bergquist R., Tanner M., Utzinger J., Zhou X.N. Frontiers of parasitology research in the People's Republic of China: infection, diagnosis, protection and surveillance. Parasit. Vectors 2012, 5:221.
21. Chen J.H., Wang Y., Ha K.S., Lu F., Suh I.B., Lim C.S., et al. Measurement of naturally acquired humoral immune responses against the C-terminal region of the Plasmodium vivax MSP1 protein using protein arrays. Parasitol. Res. 2011, 109:1259-1266.
22. Cho D., Kim K.H., Park S.C., Kim Y.K., Lee K.N., Lim C.S. Evaluation of rapid immunocapture assays for diagnosis of Plasmodium vivax in Korea. Parasitol. Res. 2001, 87:445-448.
23. Collins W.E., Jeffery G.M. A retrospective examination of the patterns of recrudescence in patients infected with Plasmodium falciparum. Am. J. Trop. Med. Hyg. 1999, 61:44-48.
24. Crompton P.D., Kayala M.A., Traore B., Kayentao K., Ongoiba A., Weiss G.E., et al. A prospective analysis of the Ab response to Plasmodium falciparum before and after a malaria season by protein microarray. Proc. Natl. Acad. Sci. U.S.A. 2010, 107:6958-6963.
25. Daily J.P. Malaria vaccine trials-beyond efficacy end points. N. Engl. J. Med. 2012, 367:2349-2351.
26. Dondorp A.M., Nosten F., Yi P., Das D., Phyo A.P., Tarning J., et al. Artemisinin resistance in Plasmodium falciparum malaria. N. Engl. J. Med. 2009, 361:455-467.
27. Dondorp A.M., Yeung S., White L., Nguon C., Day N.P., Socheat D., von Seidlein L. Artemisinin resistance: current status and scenarios for containment. Nat. Rev. Microbiol. 2010, 8:272-280.
28. Enayati A., Hemingway J. Malaria management: past, present, and future. Annu. Rev. Entomol. 2010, 55:569-591.
29. Fan Y.T., Wang Y., Ju C., Zhang T., Xu B., Hu W., Chen J.H. Systematic analysis of natural antibody responses to P. falciparum merozoite antigens by protein arrays. J. Proteomics 2013, 78:148-158.
30. Feng H., Zheng L., Zhu X., Wang G., Pan Y., Li Y., et al. Genetic diversity of transmission-blocking vaccine candidates Pvs25 and Pvs28 in Plasmodium vivax isolates from Yunnan Province, China. Parasit. Vectors 2011, 4:224.
31. Feng X., Carlton J.M., Joy D.A., Mu J., Furuya T., Suh B.B., et al. Single-nucleotide polymorphisms and genome diversity in Plasmodium vivax. Proc. Natl. Acad. Sci. U.S.A. 2003, 100:8502-8507.
32. Figtree M., Pasay C.J., Slade R., Cheng Q., Cloonan N., Walker J., Saul A. Plasmodium vivax synonymous substitution frequencies, evolution and population structure deduced from diversity in AMA 1 and MSP 1 genes. Mol. Biochem. Parasitol. 2000, 108:53-66.
33. Fund G. East Asia and Pacific Regional Overview: Successes, Challenges and Achivements to Date 2007, The Global Fund to Fight AIDS, Tuberculosis and Malaria, Geneva.
34. Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W., et al. Genome sequence of the human malaria parasite Plasmodium falciparum. Nature 2002, 419:498-511.
35. Good M.F. Immunology. Pasteur approach to a malaria vaccine may take the lead. Science 2013, 341:1352-1353.
36. Grech K., Martinelli A., Pathirana S., Walliker D., Hunt P., Carter R. Numerous, robust genetic markers for Plasmodium chabaudi by the method of amplified fragment length polymorphism. Mol. Biochem. Parasitol. 2002, 123:95-104.
37. Guo X., Zhang D., Wang J., Zhang C., Pan W. Analysis of the population structure of Plasmodium vivax isolates from different areas in China using microsatellites. Int. J. Med. Parasit. Dis. 2012, 39:197-201. (in Chinese).
38. Han E.T. Loop-mediated isothermal amplification test for the molecular diagnosis of malaria. Expert Rev. Mol. Diagn. 2013, 13:205-218.
39. Han E.T., Watanabe R., Sattabongkot J., Khuntirat B., Sirichaisinthop J., Iriko H., et al. Detection of four Plasmodium species by genus- and species-specific loop-mediated isothermal amplification for clinical diagnosis. J. Clin. Microbiol. 2007, 45:2521-2528.
40. Hopkins H., Gonzalez I.J., Polley S.D., Angutoko P., Ategeka J., Asiimwe C., et al. Highly sensitive detection of malaria parasitemia in a malaria-endemic setting: performance of a new loop-mediated isothermal amplification kit in a remote clinic in Uganda. J. Infect. Dis. 2013, 208:645-652.
41. Howes R.E., Battle K.E., Satyagraha A.W., Baird J.K., Hay S.I. G6PD deficiency: global distribution, genetic variants and primaquine therapy. Adv. Parasitol. 2013, 81:133-201.
42. Howes R.E., Dewi M., Piel F.B., Monteiro W.M., Battle K.E., Messina J.P., et al. Spatial distribution of G6PD deficiency variants across malaria-endemic regions. Malar. J. 2013, 12:418.
43. Howes R.E., Piel F.B., Patil A.P., Nyanqiri O.A., Gething P.W., Dewi M., et al. G6PD deficiency prevalence and estimates of affected populations in malaria endemic countries. a geostatistical model-based map 2012, PLoS Med. 9, e1001339.
44. Hu G., Cabrera A., Kono M., Mok S., Chaal B.K., Haase S., et al. Transcriptional profiling of growth perturbations of the human malaria parasite Plasmodium falciparum. Nat. Biotechnol. 2010, 28:91-98.
45. Hu J., Chen Z., Gu J., Wan M., Shen Q., Kieny M.P., et al. Safety and immunogenicity of a malaria vaccine, Plasmodium falciparum AMA-1/MSP-1 chimeric protein formulated in montanide ISA 720 in healthy adults. PLoS One 2008, 3:e1952.
46. Iwagami M., Fukumoto M., Hwang S.Y., Kim S.H., Kho W.G., Kano S. Population structure and transmission dynamics of Plasmodium vivax in the Republic of Korea based on microsatellite DNA analysis. PLoS Negl. Trop. Dis. 2012, 6:e1592.
47. Iwagami M., Hwang S.Y., Kim S.H., Park S.J., Lee G.Y., Matsumoto-Takahashi E.L., et al. Microsatellite DNA analysis revealed a drastic genetic change of Plasmodium vivax population in the Republic of Korea during 2002 and 2003. PLoS Negl. Trop. Dis. 2013, 7:e2522.
48. Jeffares D.C., Pain A., Berry A., Cox A.V., Stalker J., Ingle C.E., et al. Genome variation and evolution of the malaria parasite Plasmodium falciparum. Nat. Genet. 2007, 39:120-125.
49. Jiang G., Song J., Chen P., Wang S. Study on the genotypes of MSP1 and MSP2 genes of Plasmodium falciparum isolates from Hainan Province. South China J. Prev. Med. 2003, 29:9-11. (in Chinese).
50. Karunaweera N.D., Ferreira M.U., Munasinghe A., Barnwell J.W., Collins W.E., King C.L., et al. Extensive microsatellite diversity in the human malaria parasite Plasmodium vivax. Gene 2008, 410:105-112.
51. Khairnar K., Martin D., Lau R., Ralevski F., Pillai D.R. Multiplex real-time quantitative PCR, microscopy and rapid diagnostic immuno-chromatographic tests for the detection of Plasmodium spp: performance, limit of detection analysis and quality assurance. Malar. J. 2009, 8:284.
52. Kidson C., Indaratna K. Ecology, economics and political will: the vicissitudes of malaria strategies in Asia. Parassitologia 1998, 40:39-46.
53. Kilian A.H., Metzger W.G., Mutschelknauss E.J., Kabagambe G., Langi P., Korte R., von Sonnenburg F. Reliability of malaria microscopy in epidemiological studies: results of quality control. Trop. Med. Int. Health 2000, 5:3-8.
54. Kim S., AHN H.J., Kim T.S., NAM H.W. ELISA detection of vivax malaria with recombinant multiple stage-sepcific antigens and its application to survey of residents in endemic areas. Korea J. Parasitol. 2003, 41:203-207.
55. Koepfli C., Ross A., Kiniboro B., Smith T.A., Zimmerman P.A., Siba P., et al. Multiplicity and diversity of Plasmodium vivax infections in a highly endemic region in Papua New Guinea. PLoS Negl. Trop. Dis. 2011, 5:e1424.
56. Lee K.N., Suh I.B., Chang E.A., Kim S.D., Cho N.S., Park P.W., et al. Prevalence of antibodies to the circumsporozite protein of Plasmodium vivax in five different regions of Korea. Trop. Med. Int. Health 2003, 8:1062-1067.
57. Leke R.F., Djokam R.R., Mbu R., Leke R.J., Fogako J., Megnekou R., et al. Detection of the Plasmodium falciparum antigen histidine-rich protein 2 in blood of pregnant women: implications for diagnosing placental malaria. J. Clin. Microbiol. 1999, 37:2992-2996.
58. Li J., Zhang Y., Sullivan M., Hong L., Huang L., Lu F., et al. Typing Plasmodium yoelii microsatellites using a simple and affordable fluorescent labeling method. Mol. Biochem. Parasitol. 2007, 155:94-102.
59. Li J., Zhou B. Biological actions of artemisinin: insights from medicinal chemistry studies. Molecules 2010, 15:1378-1397.
60. Li Y., Zhu Y.M., Jiang H.J., Pan J.P., Wu G.S., Wu J.M., et al. Synthesis and antimalarial activity of artemisinin derivatives containing an amino group. J. Med. Chem. 2000, 43:1635-1640.
61. Liu Y., Cui K., Lu W., Luo W., Wang J., Huang J., Guo C. Synthesis and antimalarial activity of novel dihydro-artemisinin derivatives. Molecules 2011, 16:4527-4538.
62. Lu F., Gao Q., Zhou H., Cao J., Wang W., Lim C.S., et al. Molecular test for vivax malaria with loop-mediated isothermal amplification method in central China. Parasitol. Res. 2012, 110:2439-2444.
63. A research agenda for malaria eradication: diagnoses and diagnostics. PLoS Med. 2011, 8:e1000396. malERA Consultative Group on Diagnoses and Diagnostics.
64. A research agenda for malaria eradication: health systems and operational research. PLoS Med. 2011, 8:e1000397. malERA Consultative Group on Health Systems and Operational Research.
65. A research agenda for malaria eradication: modeling. PLoS Med. 2011, 8:e1000403. malERA Consultative Group on Modeling.
66. A research agenda for malaria eradication: vector control. PLoS Med. 2011, 8:e1000401. malERA Consultative Group on Vector Control.
67. Maresso K., Broeckel U. Genotyping platforms for mass-throughput genotyping with SNPs, including human genome-wide scans. Adv. Genet. 2008, 60:107-139.
68. Martinelli A., Hunt P., Cheesman S.J., Carter R. Amplified fragment length polymorphism measures proportions of malaria parasites carrying specific alleles in complex genetic mixtures. Mol. Biochem. Parasitol. 2004, 136:117-122.
69. Miller L.H., Su X. Artemisinin: discovery from the Chinese herbal garden. Cell 2011, 146:855-858.
70. Miotto O., Almagro-Garcia J., Manske M., Macinnis B., Campino S., Rockett K.A., et al. Multiple populations of artemisinin-resistant Plasmodium falciparum in Cambodia. Nat. Genet. 2013, 45:648-655.
71. Moody A. Rapid diagnostic tests for malaria parasites. Clin. Microbiol. Rev. 2002, 15:66-78.
72. Moore S.J., Min X., Hill N., Jones C., Zaixing Z., Cameron M.M. Border malaria in China: knowledge and use of personal protection by minority populations and implications for malaria control: a questionnaire-based survey. BMC Public Health 2008, 8:344.
73. Mu J., Awadalla P., Duan J., McGee K.M., Keebler J., Seydel K., et al. Genome-wide variation and identification of vaccine targets in the Plasmodium falciparum genome. Nat. Genet. 2007, 39:126-130.
74. Murray C.J., Rosenfeld L.C., Lim S.S., Andrews K.G., Foreman K.J., Haring D., et al. Global malaria mortality between 1980 and 2010: a systematic analysis. Lancet 2012, 379:413-431.
75. Neafsey D.E., Galinsky K., Jiang R.H., Young L., Sykes S.M., Saif S., et al. The malaria parasite Plasmodium vivax exhibits greater genetic diversity than Plasmodium falciparum. Nat. Genet. 2012, 44:1046-1050.
76. Noedl H., Se Y., Schaecher K., Smith B.L., Socheat D., Fukuda M.M. Evidence of artemisinin-resistant malaria in western Cambodia. N. Engl. J. Med. 2008, 359:2619-2620.
77. Olliaro P., Wells T.N. The global portfolio of new antimalarial medicines under development. Clin. Pharmacol. Ther. 2009, 85:584-595.
78. Olotu A., Fegan G., Wambua J., Nyangweso G., Awuondo K.O., Leach A., et al. Four-year efficacy of RTS,S/AS01E and its interaction with malaria exposure. N. Engl. J. Med. 2013, 368:1111-1120.
79. Pan D., Hu J., Ma Q., Pan W., Li M. Diversity and prevalence of the C-terminal region of Plasmodium falciparum merozoite surface protein 1 in China. Acta Trop. 2010, 116:200-205.
80. Pan J.Y., Zhou S.S., Zheng X., Huang F., Wang D.Q., Shen Y.Z., et al. Vector capacity of Anopheles sinensis in malaria outbreak areas of central China. Parasit. Vectors 2012, 5:136.
81. Pan W., Huang D., Zhang Q., Qu L., Zhang D., Zhang X., et al. Fusion of two malaria vaccine candidate antigens enhances product yield, immunogenicity, and antibody-mediated inhibition of parasite growth invitro. J. Immunol. 2004, 172:6167-6174.
82. Park S.K., Lee K.W., Hong S.H., Kim D.S., Lee J.H., Jeon B.H., et al. Development and evaluation of an immunochromatographic kit for the detection of antibody to Plasmodium vivax infection in South Korea. Yonsei Med. J. 2003, 44:747-750.
83. Phyo A.P., Nkhoma S., Stepniewska K., Ashley E.A., Nair S., McGready R., et al. Emergence of artemisinin-resistant malaria on the western border of Thailand: a longitudinal study. Lancet 2012, 379:1960-1966.
84. Qian F., Pan W. Construction of a tetR-integrated Salmonella enterica serovar Typhi CVD908 strain that tightly controls expression of the major merozoite surface protein of Plasmodium falciparum for applications in human Vaccine production. Infect. Immun. 2002, 70:2029-2038.
85. Roestenberg M., McCall M., Hopman J., Wiersma J., Luty A.J., van Gemert G.J., et al. Protection against a malaria challenge by sporozoite inoculation. N. Engl. J. Med. 2009, 361:468-477.
86. Roper C., Elhassan I.M., Hviid L., Giha H., Richardson W., Babiker H., et al. Detection of very low level Plasmodium falciparum infections using the nested polymerase chain reaction and a reassessment of the epidemiology of unstable malaria in Sudan. Am. J. Trop. Med. Hyg. 1996, 54:325-331.
87. Schwartz L., Brown G.V., Genton B., Moorthy V.S. A review of malaria vaccine clinical projects based on the WHO rainbow table. Malar. J. 2012, 11:11.
88. Seder R.A., Chang L.J., Enama M.E., Zephir K.L., Sarwar U.N., Gordon I.J., et al. Protection against malaria by intravenous immunization with a nonreplicating sporozoite vaccine. Science 2013, 341:1359-1365.
89. Sheng H.F., Zhou S.S., Gu Z.C., Zheng X. Malaria situation in the People's Republic of China in 2002. Chin. J. Parasitol. Parasit. Dis. 2003, 21:193-196. (in Chinese).
90. Su X., Wellems T.E. Toward a high-resolution Plasmodium falciparum linkage map: polymorphic markers from hundreds of simple sequence repeats. Genomics 1996, 33:430-444.
91. Su X.Z., Ferdig M.T., Huang Y., Huynh C.Q., Liu A., You J., et al. A genetic map and recombination parameters of the human malaria parasite Plasmodium falciparum. Science 1999, 286:1351-1353.
92. Su X.Z., Hayton K., Wellems T.E. Genetic linkage and associattion analyses for trait mapping in Plasmodium falciparum. Nat. Rev. Genet. 2007, 8:497-506.
93. Su X.Z., Wellems T.E. Plasmodium falciparum: a rapid DNA fingerprinting method using microsatellite sequences within var clusters. Exp. Parasitol. 1997, 86:235-236.
94. Suh I.B., Lee K.H., Kim Y.R., Woo S.K., Kang H.Y., Won Y.D., et al. Comparison of immunological responses to the various types circumsporozoite proteins of Plasmodium vivax in malaria patients of Korea. Microbiol. Immunol. 2004, 48:119-123.
95. Takala S.L., Coulibaly D., Thera M.A., Dicko A., Smith D.L., Guindo A.B., et al. Dynamics of polymorphism in a malaria vaccine antigen at a vaccine-testing site in Mali. PLoS Med. 2007, 4:e93.
96. Tao Z.Y., Zhou H.Y., Xia H., Xu S., Zhu H.W., Culleton R.L., et al. Adaptation of a visualized loop-mediated isothermal amplification technique for field detection of Plasmodium vivax infection. Parasit. Vectors 2011, 4:115.
97. Volkman S.K., Sabeti P.C., DeCaprio D., Neafsey D.E., Schaffner S.F., Milner D.A., et al. A genome-wide map of diversity in Plasmodium falciparum. Nat. Genet. 2007, 39:113-119.
98. Wang J., Huang L., Li J., Fan Q., Long Y., Li Y., Zhou B. Artemisinin directly targets malarial mitochondria through its specific mitochondrial activation. PLoS One 2010, 5:e9582.
99. Wang Z.Y., Jiang L., Cai L., Wang W.J., Zhang Y.G., Hong G.B., et al. Analysis and establishment of loop-mediated isothermal amplication for the diagnosis of Plasmodium vivax. J. Trop. Med 2012, 12:157-161. (in Chinese).
100. Wells T.N., Burrows J.N., Baird J.K. Targeting the hypnozoite reservoir of Plasmodium vivax: the hidden obstacle to malaria elimination. Trends. Parasitol 2010, 26:145-151.
101. White N.J. A vaccine for malaria. N. Engl. J. Med. 2011, 365:1926-1927.
102. New Perspectives: Malaria Diagnosis 1999, WHO, WHO, Geneva, Switzerland.
103. Guidelines for the Treatment of Malaria 2006, WHO, WHO, Geneva, Switzerland.
104. Winzeler E.A. Malaria research in the post-genomic era. Nature 2008, 455:751-756.
105. Xia S., Allotey P., Reidpath D.D., Yang P., Sheng H.F., Zhou X.N. Combating infectious diseases of poverty: a year on. Infect. Dis. Poverty 2013, 2:27.
106. Xu J., Liu H. Border malaria in yunnan, China. Southeast Asian J. Trop. Med. Public Health 1997, 28:456-459.
107. Xu J., Salas M. Moving the Periphery to the Centre: Indigenous People, Culture and Knowledge in Changing Yunnan 2003, Rockefeller Foundation, Bangkok.
108. Xue X., Ding F., Zhang Q., Pan X., Qu L., Pan W. Stability and potency of the Plasmodium falciparum MSP1-19/AMA-1(III) chimeric vaccine candidate with Montanide ISA720 adjuvant. Vaccine 2010, 28:3152-3158.
109. Yang G.J., Gao Q., Zhou S.S., Malone J.B., McCarroll J.C., Tanner M., et al. Mapping and predicting malaria transmission in the People's Republic of China, using integrated biology-driven and statistical models. Geospat. Health 2010, 5:11-22.
110. Yang G.J., Tanner M., Utzinger J., Malone J.B., Bergquist R., Chan E.Y., et al. Malaria surveillance-response strategies in different transmission zones of the People's Republic of China: preparing for climate change. Malar. J. 2012, 11:426.
111. Yang Y., Zhang G., Liu H., Zhang Z., Gao B. Study on MSP-2 gene polymorphism of different geographical strains of Plasmodium falciparum in Yunnan. Chin. Trop. Med. 2004, 4:901-906. (in Chinese).
112. Yang Y.M., Li X.P., Zhang C.L., Li B.F., Liu H., Li L. Creation of cloned strains of chloroquine-resistant Plasmodium falciparum from Yunnan, China with resistance to dihdroartemisinin. J. Path. Biol. 2013, 8:714-717. (in Chinese).
113. Yi H.H., Xu B., Fang C., Song Y.W., Wu P.L., Wang Y.F., et al. Study on the detection of Plasmodium falciparum by fluorescent quantitative loop-mediated isothermal amplication. Chin. Trop. Med 2010, 10:1178-1180. (in Chinese).
114. Zhang C., Zhou H., Wang J., Liu H. Invitro sensitivity of Plasmodium falciparum isolates from China-Myanmar border region to chloroquine piperaquine and pyronaridine. Chin. J. Parasitol. Parasit. Dis. 2012, 30:41-44. (in Chinese).
115. Zhang D., Pan W. Evaluation of three Pichia pastoris-expressed Plasmodium falciparum merozoite proteins as a combination vaccine against infection with blood-stage parasites. Infect. Immun. 2005, 73:6530-6536.
116. Zheng Q., Vanderslott S., Jiang B., Xu L.L., Liu C.S., Huo L.L., et al. Research gaps for three main tropical diseases in the People's Republic of China. Infect. Dis. Poverty 2013, 2:15.
117. Zhou S.S., Tang L.H., Sheng H.F., Wang Y. Malaria situation in the People's Republic of China in 2004. Chin. J. Parasitol. Parasit. Dis. 2006, 24:1-3. (in Chinese).
118. Zhou X., Li S.G., Chen S.B., Wang J.Z., Xu B., Zhou H.J., et al. Co-infections with Babesia microti and Plasmodium parasites along the China-Myanmar border. Infect. Dis. Poverty 2013, 2:24.
119. Zhou X.N., Bergquist R., Tanner M. Elimination of tropical disease through surveillance and response. Infect. Dis. Poverty 2013, 2:1.
120. Zhu H.W., Cao J., Zhou H.Y., Li J.L., Zhu G.D., Gu Y.P., et al. Detection of Plasmodium vivax sporozoites-carrying mosquitoes using loop-mediated isothermal amplication (LAMP). Chin. J. Schisto. Control 2010, 22:158-163. (in Chinese).
121. Zhu X.P., Zhang X.M., Zhou L., Yang Y.P., Gao X. Sequence analysis and genotypes of glutamate rich protein of Plasmodium falciparum isolates from different malaria endemic areas in China. Biomed. Environ. Sci. 2002, 15:1-7.