Excess cholesterol induces mouse egg activation and may cause female infertility

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 46, 2014, Pages E4972-E4980

  Yesilaltay, Ayce ^a   Dokshin, Gregoriy A ^a,b   Busso, Dolores ^c   Wang, Li ^a   Galiani, Dalia ^d   Chavarria, Tony ^a   Vasile, Eliza ^a   Quilaqueo, Linda ^c   Orellana, Juan Andrés ^c   Walzer, Dalia ^a   Shalgi, Ruth ^e   Dekel, Nava ^d   Albertini, David F ^f   Rigotti, Attilio ^c   Page, David C ^a,b   Krieger, Monty ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^c PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE   (Chile)

^d WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^e TEL AVIV UNIVERSITY   (Israel)

^f UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

Author keywords

Cholesterol; Egg; Fertility; HDL; Meiosis

Indexed keywords

CALCIUM; CHOLESTEROL; HIGH DENSITY LIPOPROTEIN RECEPTOR SCAVENGER RECEPTOR CLASS B TYPE 1; MATURATION PROMOTING FACTOR; METHYL BETA CYCLODEXTRIN; MITOGEN ACTIVATED PROTEIN KINASE; SCAVENGER RECEPTOR; UNCLASSIFIED DRUG; BETA CYCLODEXTRIN DERIVATIVE; EGTAZIC ACID; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; METHYL-BETA-CYCLODEXTRIN; SCARB1 PROTEIN, MOUSE; SCAVENGER RECEPTOR B; STRONTIUM; STRONTIUM CHLORIDE;

ANAPHASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CALCIUM CELL LEVEL; CELL CYCLE CHECKPOINT; CELL CYCLE PROGRESSION; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; FEMALE INFERTILITY; GERMINAL VESICLE; IN VITRO STUDY; IN VIVO STUDY; LIPID STORAGE; MEIOSIS; METAPHASE; MOUSE; NONHUMAN; OOCYTE DEVELOPMENT; OOCYTE MATURATION; PATHOGENESIS; POLAR BODY; TELOPHASE; ANIMAL; C57BL MOUSE; CELL SURVIVAL; CYTOLOGY; DEFICIENCY; DRUG EFFECTS; INFERTILITY, FEMALE; KNOCKOUT MOUSE; METABOLISM; OOCYTE; PHYSIOLOGY; SIGNAL TRANSDUCTION;

MUS;

ANIMALS; BETA-CYCLODEXTRINS; CELL SURVIVAL; CHOLESTEROL; CHOLESTEROL, HDL; EGTAZIC ACID; FEMALE; INFERTILITY, FEMALE; MAP KINASE SIGNALING SYSTEM; MEIOSIS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; OOCYTES; POLAR BODIES; SCAVENGER RECEPTORS, CLASS B; STRONTIUM;

EID: 84919479347     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1418954111     Document Type: Article

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