Identification of a mitotic Rac-GEF, Trio, that counteracts MgcRacGAP function during cytokinesis

Molecular Biology of the Cell

Volumn 25, Issue 25, 2014, Pages 4063-4071

  Cannet, Aude ^a   Schmidt, Susanne ^a   Delaval, Bénédicte ^a   Debant, Anne ^a  

^a UNIV MONTPELLIER   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN RELATED PROTEIN 2; ACTIN RELATED PROTEIN 3; F ACTIN; GUANINE NUCLEOTIDE EXCHANGE FACTOR; PROTEIN MGCRACGAP; RAC1 PROTEIN; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; ACTIN; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; MGCRACGAP; PROTEIN SERINE THREONINE KINASE; TRIO PROTEIN, HUMAN;

ACTIN FILAMENT; ARTICLE; CELL DIVISION; CONTROLLED STUDY; CYTOKINESIS; HELA CELL LINE; HUMAN; HUMAN CELL; PROTEIN ANALYSIS; PROTEIN DEPLETION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; METABOLISM; PHYSIOLOGY; TIME LAPSE IMAGING;

ACTINS; CYTOKINESIS; GTPASE-ACTIVATING PROTEINS; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HELA CELLS; HUMANS; PROTEIN-SERINE-THREONINE KINASES; TIME-LAPSE IMAGING;

EID: 84919479078     PISSN: 10591524     EISSN: 19394586     Source Type: Journal    
DOI: 10.1091/mbc.E14-06-1153     Document Type: Article

References (32)

1. Bastos RN, Penate X, Bates M, Hammond D, Barr FA (2012). CYK4 inhibits Rac1-dependent PAK1 and ARHGEF7 effector pathways during cytokinesis. J Cell Biol 198, 865-880.
2. Bateman J, Shu H, Van Vactor D (2000). The guanine nucleotide exchange factor trio mediates axonal development in the Drosophila embryo. Neuron 26, 93-106.
3. Bellanger JM, Lazaro JB, Diriong S, Fernandez A, Lamb N, Debant A (1998). The two guanine nucleotide exchange factor domains of Trio link the Rac1 and the RhoA pathways in vivo. Oncogene 16, 147-152.
4. Bement WM, Benink HA, von Dassow G (2005). A microtubule-dependent zone of active RhoA during cleavage plane specification. J Cell Biol 170, 91-101.
5. Blangy A, Vignal E, Schmidt S, Debant A, Gauthier-Rouvière C, Fort P (2000). TrioGEF1 controls Rac- and Cdc42-dependent cell structures through the direct activation of rhoG. J Cell Sci 113, 729-739.
6. Bouquier N, Vignal E, Charrasse S, Weill M, Schmidt S, Léonetti J-P, Blangy A, Fort P (2009). A cell active chemical GEF inhibitor selectively targets the Trio/RhoG/Rac1 signaling pathway. Chem Biol 16, 657-666.
7. Briançon-Marjollet A, Ghogha A, Nawabi H, Triki I, Auziol C, Fromont S, Piché C, Enslen H, Chebli K, Cloutier JF, et al. (2008). Trio mediates netrin-1-induced Rac1 activation in axon outgrowth and guidance. Mol Cell Biol 28, 2314-2323.
8. Canman JC, Lewellyn L, Laband K, Smerdon SJ, Desai A, Bowerman B, Oegema K (2008). Inhibition of Rac by the GAP activity of centralspindlin is essential for cytokinesis. Science 322, 1543-1546.
9. D'Avino PP, Glover DM (2009). Cytokinesis: mind the GAP. Nat Cell Biol 11, 112-114.
10. DeGeer J, Boudeau J, Schmidt S, Bedford F, Lamarche-Vane N, Debant A (2013). Tyrosine phosphorylation of the Rho guanine nucleotide exchange factor Trio regulates netrin-1/DCC-mediated cortical axon outgrowth. Mol Cell Biol 33, 739-751.
11. Estrach S, Schmidt S, Diriong S, Penna A, Blangy A, Fort P, Debant A (2002). The human Rho-GEF trio and its target GTPase RhoG are involved in the NGF pathway, leading to neurite outgrowth. Curr Biol 12, 307-312.
12. Hirose K, Kawashima T, Iwamoto I, Nosaka T, Kitamura T (2001). MgcRacGAP is involved in cytokinesis through associating with mitotic spindle and midbody. J Biol Chem 276, 5821-5828.
13. Jaffe AB, Hall A (2005). RHO GTPASES: biochemistry and biology. Annu Rev Cell Dev Biol 21, 247-269.
14. Jantsch-Plunger V, Gönczy P, Romano A, Schnabel H, Hamill D, Schnabel R, Hyman AA, Glotzer M (2000). CYK-4: A Rho family gtpase activating protein. (GAP) required for central spindle formation and cytokinesis. J Cell Biol 149, 1391-1404.
15. Jordan SN, Canman JC (2012). Rho GTPases in animal cell cytokinesis: an occupation by the one percent. Cytoskeleton 69, 919-930.
16. Li Y, Guo Z, Chen H, Dong Z, Pan ZK, Ding H, Su S-B, Huang S (2011). HOXC8-dependent cadherin 11 expression facilitates breast cancer cell migration through Trio and Rac. Genes Cancer 2, 880-888.
17. Loria A, Longhini KM, Glotzer M (2012). The RhoGAP domain of CYK-4 has an essential role in RhoA activation. Curr Biol 22, 213-219.
18. Moshfegh Y, Bravo-Cordero JJ, Miskolci V, Condeelis J, Hodgson L (2014). A Trio-Rac1-Pak1 signalling axis drives invadopodia disassembly. Nat Cell Biol 16, 574-586.
19. Newsome TP, Schmidt S, Dietzl G, Keleman K, Åsling B, Debant A, Dickson BJ (2000). Trio combines with Dock to regulate Pak activity during photoreceptor axon pathfinding in Drosophila. Cell 101, 283-294.
20. Piekny A, Werner M, Glotzer M (2005). Cytokinesis: welcome to the Rho zone. Trends Cell Biol 15, 651-658.
21. Pollard TD (2007). Regulation of actin filament assembly by Arp2/3 complex and formins. Annu Rev Biophys Biomol Struct 36, 451-477.
22. Rossman KL, Der CJ, Sondek J (2005). GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors. Nat Rev Mol Cell Biol 6, 167.
23. Schmidt A, Hall A (2002). Guanine nucleotide exchange factors for Rho GTPases: turning on the switch. Genes Dev 16, 1587-1609.
24. Seguin L, Liot C, Mzali R, Harada R, Siret A, Nepveu A, Bertoglio J (2009). CUX1 and E2F1 regulate coordinated expression of the mitotic complex genes Ect2, MgcRacGAP, and MKLP1 in S phase. Mol Cell Biol 29, 570-581.
25. Steffen A, Faix J, Resch GP, Linkner J, Wehland J, Small JV, Rottner K, Stradal TE B (2006). Filopodia formation in the absence of functional WAVE- and Arp2/3-complexes. Mol Biol Cell 17, 2581-2591.
26. Steven R, Kubiseski TJ, Zheng H, Kulkarni S, Mancillas J, Ruiz Morales A, Hogue CW, Pawson T, Culotti J (1998). UNC-73 activates the Rac GTPase and is required for cell and growth cone migrations in C. elegans. Cell 92, 785-795.
27. Touré A, Dorseuil O, Morin L, Timmons P, Jégou B, Reibel L, Gacon G (1998). MgcRacGAP, a new human GTPase-activating protein for Rac and Cdc42 similar to Drosophila rotundRacGAP gene product, is ex?pressed in male germ cells. J Biol Chem 273, 6019-6023.
28. Van Rijssel J, Hoogenboezem M, Wester L, Hordijk PL, Van Buul JD (2012). The N-terminal DH-PH domain of Trio induces cell spreading and migration by regulating lamellipodia dynamics in a Rac1-dependent fashion. PLoS One 7, e29912.
29. Wolfe BA, Takaki T, Petronczki M, Glotzer M (2009). Polo-like kinase 1 directs assembly of the HsCyk-4 RhoGAP/Ect2 RhoGEF complex to initiate cleavage furrow formation. PLoS Biol 7, e1000110.
30. Yoshizaki H, Ohba Y, Kurokawa K, Itoh RE, Nakamura T, Mochizuki N, Nagashima K, Matsuda M (2003). Activity of Rho-family GTPases during cell division as visualized with FRET-based probes. J Cell Biol 162, 223-232.
31. Yoshizaki H, Ohba Y, Parrini M-C, Dulyaninova NG, Bresnick AR, Mochizuki N, Matsuda M (2004). Cell type-specific regulation of RhoA activity during cytokinesis. J Biol Chem 279, 44756-44762.
32. Yüce O, Piekny A, Glotzer M (2005). An ECT2-centralspindlin complex regulates the localization and function of RhoA. J Cell Biol 170, 571-582.