메뉴 건너뛰기




Volumn 13, Issue 1, 2015, Pages 23-31

Azelnidipine and glucose tolerance: Possible indications and treatment selection for hypertensive patients with metabolic disorders

Author keywords

anti atherogenic effect; anti inflammatory effect; anti oxidative effect; azelnidipine; cardiovascular and metabolic disorders; essential hypertension; glucose tolerance; insulin resistance

Indexed keywords

ANGIOTENSIN RECEPTOR ANTAGONIST; AZELNIDIPINE; CALCIUM CHANNEL BLOCKING AGENT; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; AZETIDINE 2 CARBOXYLIC ACID; DIHYDROPYRIDINE DERIVATIVE;

EID: 84919459099     PISSN: 14779072     EISSN: 17448344     Source Type: Journal    
DOI: 10.1586/14779072.2015.986464     Document Type: Review
Times cited : (7)

References (89)
  • 1
    • 84878844094 scopus 로고    scopus 로고
    • Can the effectiveness of hypertension management be improved
    • Ruilope LM. Can the effectiveness of hypertension management be improved Expert Rev Cardiovasc Ther 2013;11: 689-95
    • (2013) Expert Rev Cardiovasc Ther , vol.11 , pp. 689-695
    • Ruilope, L.M.1
  • 2
    • 84864844848 scopus 로고    scopus 로고
    • Diabetes and hypertension: The bad companions
    • Ferrannini E, Cushman WC. Diabetes and hypertension: the bad companions. Lancet 2012;380:601-10
    • (2012) Lancet , vol.380 , pp. 601-610
    • Ferrannini, E.1    Cushman, W.C.2
  • 3
    • 84879383234 scopus 로고    scopus 로고
    • Cardiovascular disease epidemiology in Asia: An overview
    • Ohira T, Iso H. Cardiovascular disease epidemiology in Asia: an overview. Circ J 2013;77:1646-52
    • (2013) Circ J , vol.77 , pp. 1646-1652
    • Ohira, T.1    Iso, H.2
  • 4
    • 33746367481 scopus 로고    scopus 로고
    • Antihypertensive medications and the risk of incident type 2 diabetes
    • Taylor EN, Hu FB, Curhan GC. Antihypertensive medications and the risk of incident type 2 diabetes. Diabetes Care 2006;29:1065-70
    • (2006) Diabetes Care , vol.29 , pp. 1065-1070
    • Taylor, E.N.1    Hu, F.B.2    Curhan, G.C.3
  • 5
    • 0035050460 scopus 로고    scopus 로고
    • Diabetes, hypertension, and cardiovascular disease: An update
    • Sowers JR, Epstein M, Frohlich ED. Diabetes, hypertension, and cardiovascular disease: an update. Hypertension 2001;37: 1053-9
    • (2001) Hypertension , vol.37 , pp. 1053-1059
    • Sowers, J.R.1    Epstein, M.2    Frohlich, E.D.3
  • 6
    • 67449091321 scopus 로고    scopus 로고
    • Prevention of diabetes in hypertensive patients: Results and implications from the VALUE trial
    • Zhou MS, Schulman IH. Prevention of diabetes in hypertensive patients: results and implications from the VALUE trial. Vasc Health Risk Manag 2009;5:361-8
    • (2009) Vasc Health Risk Manag , vol.5 , pp. 361-368
    • Zhou, M.S.1    Schulman, I.H.2
  • 7
    • 0024464119 scopus 로고
    • Antihypertensive effects of CS-905, a novel dihydropyridine Ca++ channel blocker
    • Oizumi K, Nishino H, Koike H, et al. Antihypertensive effects of CS-905, a novel dihydropyridine Ca++ channel blocker. Jpn J Pharmacol 1989;51:57-64
    • (1989) Jpn J Pharmacol , vol.51 , pp. 57-64
    • Oizumi, K.1    Nishino, H.2    Koike, H.3
  • 8
    • 0024388376 scopus 로고
    • Beneficial renal effects of CS-905, a novel dihydropyridine calcium blocker, in SHR
    • Oizumi K, Nishino H, Miyamoto M, et al. Beneficial renal effects of CS-905, a novel dihydropyridine calcium blocker, in SHR. Jpn J Pharmacol 1989;51:501-8
    • (1989) Jpn J Pharmacol , vol.51 , pp. 501-508
    • Oizumi, K.1    Nishino, H.2    Miyamoto, M.3
  • 9
    • 0025282803 scopus 로고
    • Antihypertensive effect of CS-905, a novel dihydropyridine calcium blocker, in conscious hypertensive dogs
    • Oizumi K, Miyamoto M, Koike H. Antihypertensive effect of CS-905, a novel dihydropyridine calcium blocker, in conscious hypertensive dogs. Jpn J Pharmacol 1990;53:264-6
    • (1990) Jpn J Pharmacol , vol.53 , pp. 264-266
    • Oizumi, K.1    Miyamoto, M.2    Koike, H.3
  • 10
    • 84876214016 scopus 로고    scopus 로고
    • Inhibitory effects of azelnidipine tablets on morning hypertension
    • Kario K, Sato Y, Shirayama M, et al. Inhibitory effects of azelnidipine tablets on morning hypertension. Drugs R D 2013;13: 3-73
    • (2013) Drugs R D , vol.13 , pp. 3-73
    • Kario, K.1    Sato, Y.2    Shirayama, M.3
  • 11
    • 0042357086 scopus 로고    scopus 로고
    • Azelnidipine CS 905, Calblock, RS 9054
    • Azelnidipine. CS 905, Calblock, RS 9054. Drugs R D 2003;4:122-5
    • (2003) Drugs R D , vol.4 , pp. 122-125
  • 12
    • 36949040124 scopus 로고    scopus 로고
    • Clinical study with azelnidipine in patients with essential hypertension Antiarteriosclerotic and cardiac hypertrophy-inhibitory effects and influence on autonomic nervous activity
    • Nada T, Nomura M, Koshiba K, et al. Clinical study with azelnidipine in patients with essential hypertension. Antiarteriosclerotic and cardiac hypertrophy-inhibitory effects and influence on autonomic nervous activity. Arzneimittelforschung 2007;57:698-704
    • (2007) Arzneimittelforschung , vol.57 , pp. 698-704
    • Nada, T.1    Nomura, M.2    Koshiba, K.3
  • 13
    • 33751183092 scopus 로고    scopus 로고
    • Calcium channel blocker azelnidipine reduces glucose intolerance in diabetic mice via different mechanism than angiotensin receptor blocker olmesartan
    • Iwai M, Li HS, Chen R, et al. Calcium channel blocker azelnidipine reduces glucose intolerance in diabetic mice via different mechanism than angiotensin receptor blocker olmesartan. J Pharmacol Exp Ther 2006;319:1081-7
    • (2006) J Pharmacol Exp Ther , vol.319 , pp. 1081-1087
    • Iwai, M.1    Li, H.S.2    Chen, R.3
  • 14
    • 42649142646 scopus 로고    scopus 로고
    • Effects of antihypertensive drugs and exercise training on insulin sensitivity in spontaneously hypertensive rats
    • Guo Q, Minami N, Mori N, et al. Effects of antihypertensive drugs and exercise training on insulin sensitivity in spontaneously hypertensive rats. Hypertens Res 2008;31:525-33
    • (2008) Hypertens Res , vol.31 , pp. 525-533
    • Guo, Q.1    Minami, N.2    Mori, N.3
  • 15
    • 78649501982 scopus 로고    scopus 로고
    • Azelnidipine protects myocardium in hyperglycemia-induced cardiac damage
    • Kain V, Kumar S, Puranik AS, Sitasawad SL. Azelnidipine protects myocardium in hyperglycemia-induced cardiac damage. Cardiovasc Diabetol 2010;9:82
    • (2010) Cardiovasc Diabetol , vol.9 , pp. 82
    • Kain, V.1    Kumar, S.2    Puranik, A.S.3    Sitasawad, S.L.4
  • 16
    • 80052559673 scopus 로고    scopus 로고
    • Effects of calcium channel blockers on glucose tolerance, inflammatory state, and circulating progenitor cells in non-diabetic patients with essential hypertension: A comparative study between azelnidipine and amlodipine on glucose tolerance and endothelial function-a crossover trial (AGENT)
    • Fukao K, Shimada K, Hiki M, et al. Effects of calcium channel blockers on glucose tolerance, inflammatory state, and circulating progenitor cells in non-diabetic patients with essential hypertension: a comparative study between azelnidipine and amlodipine on glucose tolerance and endothelial function-a crossover trial (AGENT). Cardiovasc Diabetol 2011;10:79
    • (2011) Cardiovasc Diabetol , vol.10 , pp. 79
    • Fukao, K.1    Shimada, K.2    Hiki, M.3
  • 17
    • 84866650068 scopus 로고    scopus 로고
    • The combination of OLmesartan and a CAlcium channel blocker (azelnidipine) or candesartan and a calcium channel blocker (amlodipine) in type 2 diabetic hypertensive patients: The OLCA study
    • Daikuhara H, Kikuchi F, Ishida T. The combination of OLmesartan and a CAlcium channel blocker (azelnidipine) or candesartan and a calcium channel blocker (amlodipine) in type 2 diabetic hypertensive patients: the OLCA study. Diab Vasc Dis Res 2012;9:280-6
    • (2012) Diab Vasc Dis Res , vol.9 , pp. 280-286
    • Daikuhara, H.1    Kikuchi, F.2    Ishida, T.3
  • 18
    • 2042422314 scopus 로고    scopus 로고
    • Azelnidipine, a newly developed long-acting calcium antagonist, inhibits tumor necrosis factor-alpha-induced interleukin-8 expression in endothelial cells through its anti-oxidative properties
    • Yamagishi S, Inagaki Y, Nakamura K, Imaizumi T. Azelnidipine, a newly developed long-acting calcium antagonist, inhibits tumor necrosis factor-alpha-induced interleukin-8 expression in endothelial cells through its anti-oxidative properties. J Cardiovasc Pharmacol 2004;43:724-30
    • (2004) J Cardiovasc Pharmacol , vol.43 , pp. 724-730
    • Yamagishi, S.1    Inagaki, Y.2    Nakamura, K.3    Imaizumi, T.4
  • 19
    • 66149084424 scopus 로고    scopus 로고
    • Combination use of immune complexes and a Ca2(+) channel blocker azelnidipine enhances interleukin-12 p40 secretion without T helper type 17 cytokine secretion in human monocyte-derived dendritic cells
    • Abe T, Fuse I, Narita M, et al. Combination use of immune complexes and a Ca2(+) channel blocker azelnidipine enhances interleukin-12 p40 secretion without T helper type 17 cytokine secretion in human monocyte-derived dendritic cells. Clin Exp Immunol 2009;156:405-12
    • (2009) Clin Exp Immunol , vol.156 , pp. 405-412
    • Abe, T.1    Fuse, I.2    Narita, M.3
  • 20
    • 79955703193 scopus 로고    scopus 로고
    • Azelnidipine and amlodipine anti-coronary atherosclerosis trial in hypertensive patients undergoing coronary intervention by serial volumetric intravascular ultrasound analysis in Juntendo University (ALPS-J)
    • Kojima T, Miyauchi K, Yokoyama T, et al. Azelnidipine and amlodipine anti-coronary atherosclerosis trial in hypertensive patients undergoing coronary intervention by serial volumetric intravascular ultrasound analysis in Juntendo University (ALPS-J). Circ J 2011;75:1071-9
    • (2011) Circ J , vol.75 , pp. 1071-1079
    • Kojima, T.1    Miyauchi, K.2    Yokoyama, T.3
  • 21
    • 79961009650 scopus 로고    scopus 로고
    • Assessment and treatment of cardiovascular risk in prediabetes: Impaired glucose tolerance and impaired fasting glucose
    • DeFronzo RA, Abdul-Ghani M. Assessment and treatment of cardiovascular risk in prediabetes: impaired glucose tolerance and impaired fasting glucose. Am J Cardiol 2011;108:3B-24B
    • (2011) Am J Cardiol , vol.108 , pp. 3B-24B
    • Defronzo, R.A.1    Abdul-Ghani, M.2
  • 22
  • 23
    • 79955469177 scopus 로고    scopus 로고
    • Cardiovascular outcomes in Framingham participants with diabetes: The importance of blood pressure
    • Chen G, McAlister FA, Walker RL, et al. Cardiovascular outcomes in Framingham participants with diabetes: the importance of blood pressure. Hypertension 2011;57: 891-7
    • (2011) Hypertension , vol.57 , pp. 891-897
    • Chen, G.1    McAlister, F.A.2    Walker, R.L.3
  • 24
    • 33644975021 scopus 로고    scopus 로고
    • Prehypertension, diabetes, and cardiovascular disease risk in a population-based sample: The Strong Heart Study
    • Zhang Y, Lee ET, Devereux RB, et al. Prehypertension, diabetes, and cardiovascular disease risk in a population-based sample: the Strong Heart Study. Hypertension 2006;47:410-14
    • (2006) Hypertension , vol.47 , pp. 410-414
    • Zhang, Y.1    Lee, E.T.2    Devereux, R.B.3
  • 25
    • 36849022128 scopus 로고    scopus 로고
    • Blood pressure and risk of developing type 2 diabetes mellitus: The Women's Health Study
    • Conen D, Ridker PM, Mora S, et al. Blood pressure and risk of developing type 2 diabetes mellitus: the Women's Health Study. Eur Heart J 2007;28:2937-43
    • (2007) Eur Heart J , vol.28 , pp. 2937-2943
    • Conen, D.1    Ridker, P.M.2    Mora, S.3
  • 26
    • 84867391526 scopus 로고    scopus 로고
    • High-normal blood pressure and long-term risk of type 2 diabetes: 35-year prospective population based cohort study of men
    • Stahl CH, Novak M, Lappas G, et al. High-normal blood pressure and long-term risk of type 2 diabetes: 35-year prospective population based cohort study of men. BMC Cardiovasc Disord 2012;12:89
    • (2012) BMC Cardiovasc Disord , vol.12 , pp. 89
    • Stahl, C.H.1    Novak, M.2    Lappas, G.3
  • 27
    • 24644510705 scopus 로고    scopus 로고
    • Long-term effects of ramipril on cardiovascular events and on diabetes: Results of the HOPE study extension
    • HOPE/HOPETOO Study Investigators
    • Bosch J, Lonn E, Pogue J, HOPE/HOPETOO Study Investigators. Long-term effects of ramipril on cardiovascular events and on diabetes: results of the HOPE study extension. Circulation 2005;112:1339-46
    • (2005) Circulation , vol.112 , pp. 1339-1346
    • Bosch, J.1    Lonn, E.2    Pogue, J.3
  • 28
    • 25444469437 scopus 로고    scopus 로고
    • Cardiovascular morbidity and mortality in hypertensive patients with lower versus higher risk: A LIFE substudy
    • Franklin SS, Wachtell K, Papademetriou V, et al. Cardiovascular morbidity and mortality in hypertensive patients with lower versus higher risk: a LIFE substudy. Hypertension 2005;46:492-9
    • (2005) Hypertension , vol.46 , pp. 492-499
    • Franklin, S.S.1    Wachtell, K.2    Papademetriou, V.3
  • 29
    • 21844434198 scopus 로고    scopus 로고
    • Candesartan in Heart Failure-Assessment of Reduction in Mortality and Morbidity Program Investigators Effects of candesartan on the development of a new diagnosis of diabetes mellitus in patients with heart failure
    • Yusuf S, Ostergren JB, Gerstein HC, et al. Candesartan in Heart Failure-Assessment of Reduction in Mortality and Morbidity Program Investigators. Effects of candesartan on the development of a new diagnosis of diabetes mellitus in patients with heart failure. Circulation 2005;112:48-53
    • (2005) Circulation , vol.112 , pp. 48-53
    • Yusuf, S.1    Ostergren, J.B.2    Gerstein, H.C.3
  • 30
    • 0034729993 scopus 로고    scopus 로고
    • Morbidity and mortality in patients randomised to double-blind treatment with a long-acting calcium-channel blocker or diuretic in the International Nifedipine GITS study: Intervention as a Goal in Hypertension Treatment (INSIGHT)
    • Brown MJ, Palmer CR, Castaigne A, et al. Morbidity and mortality in patients randomised to double-blind treatment with a long-acting calcium-channel blocker or diuretic in the International Nifedipine GITS study: intervention as a Goal in Hypertension Treatment (INSIGHT). Lancet 2000;356:366-72
    • (2000) Lancet , vol.356 , pp. 366-372
    • Brown, M.J.1    Palmer, C.R.2    Castaigne, A.3
  • 31
    • 33750999057 scopus 로고    scopus 로고
    • Fasting glucose levels and incident diabetes mellitus in older nondiabetic adults randomized to receive 3 different classes of antihypertensive treatment: A report from the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT)
    • ALLHAT Collaborative Research Group
    • Barzilay JI, Davis BR, Cutler JA, et al. ALLHAT Collaborative Research Group. Fasting glucose levels and incident diabetes mellitus in older nondiabetic adults randomized to receive 3 different classes of antihypertensive treatment: a report from the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT). Arch Intern Med 2006;166: 2191-201
    • (2006) Arch Intern Med , vol.166 , pp. 2191-2201
    • Barzilay, J.I.1    Davis, B.R.2    Cutler, J.A.3
  • 32
    • 33747434821 scopus 로고    scopus 로고
    • The Valsartan Antihypertensive Long-Term Use Evaluation (VALUE) trial: Outcomes in patients receiving monotherapy
    • Julius S, Weber MA, Kjeldsen SE, et al. The Valsartan Antihypertensive Long-Term Use Evaluation (VALUE) trial: outcomes in patients receiving monotherapy. Hypertension 2006;48:385-91
    • (2006) Hypertension , vol.48 , pp. 385-391
    • Julius, S.1    Weber, M.A.2    Kjeldsen, S.E.3
  • 33
    • 2342652390 scopus 로고    scopus 로고
    • Adverse prognostic significance of new diabetes in treated hypertensive subjects
    • Verdecchia P, Reboldi G, Angeli F, et al. Adverse prognostic significance of new diabetes in treated hypertensive subjects. Hypertension 2004;43:963-9
    • (2004) Hypertension , vol.43 , pp. 963-969
    • Verdecchia, P.1    Reboldi, G.2    Angeli, F.3
  • 34
    • 45149101077 scopus 로고    scopus 로고
    • Insulin response to oral glucose load is associated with coronary artery disease in subjects with normal glucose tolerance
    • Miyazaki T, Shimada K, Iwama Y, et al. Insulin response to oral glucose load is associated with coronary artery disease in subjects with normal glucose tolerance. J Atheroscler Thromb 2008;15:6-12
    • (2008) J Atheroscler Thromb , vol.15 , pp. 6-12
    • Miyazaki, T.1    Shimada, K.2    Iwama, Y.3
  • 35
    • 0028918866 scopus 로고
    • Asymptomatic hyperglycaemia is associated with increased intimal plus medial thickness of the carotid artery
    • Yamasaki Y, Kawamori R, Matsushima H, et al. Asymptomatic hyperglycaemia is associated with increased intimal plus medial thickness of the carotid artery. Diabetologia 1995;38:585-91
    • (1995) Diabetologia , vol.38 , pp. 585-591
    • Yamasaki, Y.1    Kawamori, R.2    Matsushima, H.3
  • 36
    • 84871841465 scopus 로고    scopus 로고
    • What should be the antihypertensive drug of choice in diabetic patients and should we avoid drugs that increase glucose levels Pro and Cons
    • Standl E, Erbach M, Schnell O. What should be the antihypertensive drug of choice in diabetic patients and should we avoid drugs that increase glucose levels Pro and Cons. Diabetes Metab Res Rev 2012;28:60-6
    • (2012) Diabetes Metab Res Rev , vol.28 , pp. 60-66
    • Standl, E.1    Erbach, M.2    Schnell, O.3
  • 37
    • 33846294746 scopus 로고    scopus 로고
    • Incident diabetes in clinical trials of antihypertensive drugs: A network meta-analysis
    • Elliott WJ, Meyer PM. Incident diabetes in clinical trials of antihypertensive drugs: a network meta-analysis. Lancet 2007;369: 201-7
    • (2007) Lancet , vol.369 , pp. 201-207
    • Elliott, W.J.1    Meyer, P.M.2
  • 38
    • 0035904369 scopus 로고    scopus 로고
    • Ramipril and the development of diabetes
    • HOPE Study Investigators
    • Yusuf S, Gerstein H, Hoogwerf B, et al. HOPE Study Investigators. Ramipril and the development of diabetes. JAMA 2001;286:1882-5
    • (2001) JAMA , vol.286 , pp. 1882-1885
    • Yusuf, S.1    Gerstein, H.2    Hoogwerf, B.3
  • 39
    • 33747434821 scopus 로고    scopus 로고
    • The Valsartan Antihypertensive Long-Term Use Evaluation (VALUE) trial: Outcomes in patients receiving monotherapy
    • Julius S, Weber MA, Kjeldsen SE, et al. The Valsartan Antihypertensive Long-Term Use Evaluation (VALUE) trial: outcomes in patients receiving monotherapy. Hypertension 2006;48:385-91
    • (2006) Hypertension , vol.48 , pp. 385-391
    • Julius, S.1    Weber, M.A.2    Kjeldsen, S.E.3
  • 40
    • 79957944588 scopus 로고    scopus 로고
    • Prevention of Events with an ACE Inhibitor (PEACE) Investigators. Opposing effects of b blockers and angiotensin-converting enzyme inhibitors on development of new-onset diabetes mellitus in patients with stable coronary artery disease
    • Vardeny O, Uno H, Braunwald E, et al. Prevention of Events with an ACE Inhibitor (PEACE) Investigators. Opposing effects of b blockers and angiotensin-converting enzyme inhibitors on development of new-onset diabetes mellitus in patients with stable coronary artery disease. Am J Cardiol 2011;107:1705-9
    • (2011) Am J Cardiol , vol.107 , pp. 1705-1709
    • Vardeny, O.1    Uno, H.2    Braunwald, E.3
  • 41
    • 77951453096 scopus 로고    scopus 로고
    • Effect of valsartan on the incidence of diabetes and cardiovascular events
    • NAVIGATOR Study Group
    • NAVIGATOR Study Group. McMurray JJ, Holman RR, Haffner SM, et al. Effect of valsartan on the incidence of diabetes and cardiovascular events. N Engl J Med 2010;362:1477-90
    • (2010) N Engl J Med , vol.362 , pp. 1477-1490
    • McMurray, J.J.1    Holman, R.R.2    Haffner, S.M.3
  • 42
    • 84890074773 scopus 로고    scopus 로고
    • Role of diuretics, b blockers, and statins in increasing the risk of diabetes in patients with impaired glucose tolerance: Reanalysis of data from the NAVIGATOR study
    • Shen L, Shah BR, Reyes EM, et al. Role of diuretics, b blockers, and statins in increasing the risk of diabetes in patients with impaired glucose tolerance: reanalysis of data from the NAVIGATOR study. BMJ 2013;347:f6745
    • (2013) BMJ , vol.347 , pp. f6745
    • Shen, L.1    Shah, B.R.2    Reyes, E.M.3
  • 43
    • 84904463854 scopus 로고    scopus 로고
    • A randomised controlled trial for the evaluation of risk for type 2 diabetes in hypertensive patients receiving thiazide diuretics: Diuretics in the Management of Essential hypertension (DIME) study
    • DIME Investigators
    • Ueda S, Morimoto T, Ando ST, et al. DIME Investigators. A randomised controlled trial for the evaluation of risk for type 2 diabetes in hypertensive patients receiving thiazide diuretics: diuretics In the Management of Essential hypertension (DIME) study. BMJ Open 2014;4:e004576
    • (2014) BMJ Open , vol.4 , pp. e004576
    • Ueda, S.1    Morimoto, T.2    Ando, S.T.3
  • 44
    • 42549160401 scopus 로고    scopus 로고
    • New onset diabetes during antihypertensive therapy
    • Alderman MH. New onset diabetes during antihypertensive therapy. Am J Hypertens 2008;21:493-9
    • (2008) Am J Hypertens , vol.21 , pp. 493-499
    • Alderman, M.H.1
  • 46
    • 84895075448 scopus 로고    scopus 로고
    • Impact of TCF7L2 single nucleotide polymorphisms on hydrochlorothiazide-induced diabetes
    • Karnes JH, Gong Y, Pacanowski MA, et al. Impact of TCF7L2 single nucleotide polymorphisms on hydrochlorothiazide-induced diabetes. Pharmacogenet Genom 2013;23:697-705
    • (2013) Pharmacogenet Genom , vol.23 , pp. 697-705
    • Karnes, J.H.1    Gong, Y.2    Pacanowski, M.A.3
  • 47
    • 84884592019 scopus 로고    scopus 로고
    • Association of KCNJ1 variation with change in fasting glucose and new onset diabetes during HCTZ treatment
    • Karnes JH, McDonough CW, Gong Y, et al. Association of KCNJ1 variation with change in fasting glucose and new onset diabetes during HCTZ treatment. Pharmacogenom J 2013;13:430-6
    • (2013) Pharmacogenom J , vol.13 , pp. 430-436
    • Karnes, J.H.1    McDonough, C.W.2    Gong, Y.3
  • 48
    • 76949103329 scopus 로고    scopus 로고
    • Effects of beta-blockers on glucose and lipid metabolism
    • Fonseca VA. Effects of beta-blockers on glucose and lipid metabolism. Curr Med Res Opin 2010;26:615-29
    • (2010) Curr Med Res Opin , vol.26 , pp. 615-629
    • Fonseca, V.A.1
  • 49
    • 84880784392 scopus 로고    scopus 로고
    • Effect of calcium channel blockers on incidence of diabetes: A meta-analysis
    • Noto H, Goto A, Tsujimoto T, Noda M. Effect of calcium channel blockers on incidence of diabetes: a meta-analysis. Diabetes Metab Syndr Obes 2013;6:257-61
    • (2013) Diabetes Metab Syndr Obes , vol.6 , pp. 257-261
    • Noto, H.1    Goto, A.2    Tsujimoto, T.3    Noda, M.4
  • 50
    • 0036033604 scopus 로고    scopus 로고
    • Pharmacological characteristics of azelnidipine a long-acting calcium antagonist having vascular affinity No. 2)-antihypertensive effect and pharmacokinetics in spontaneously hypertensive rats (SHR) [in Japanese]
    • Sada T, Mizuno M, Miyama T, et al. Pharmacological characteristics of azelnidipine, a long-acting calcium antagonist, having vascular affinity (No. 2)-antihypertensive effect and pharmacokinetics in spontaneously hypertensive rats (SHR) [in Japanese]. Jpn Pharmacol Ther 2002;30: 711-20
    • (2002) Jpn Pharmacol Ther , vol.30 , pp. 711-720
    • Sada, T.1    Mizuno, M.2    Miyama, T.3
  • 51
    • 0024464119 scopus 로고
    • Antihypertensive effects of CS-905, a novel dihydropyridine Ca++ channel blocker, in SHR
    • Oizumi K, Nishino H, Koike H, et al. Antihypertensive effects of CS-905, a novel dihydropyridine Ca++ channel blocker, in SHR. Jpn J Pharmacol 1989;51:57-64
    • (1989) Jpn J Pharmacol , vol.51 , pp. 57-64
    • Oizumi, K.1    Nishino, H.2    Koike, H.3
  • 52
    • 84872344430 scopus 로고    scopus 로고
    • The pharmacological differences in antianginal effects of long-lasting calcium channel blockers: Azelnidipine and amlodipine
    • Fujisawa M, Yorikane R, Matsuoka Y, et al. The pharmacological differences in antianginal effects of long-lasting calcium channel blockers: azelnidipine and amlodipine. J Cardiovasc Pharmacol 2013;61:63-9
    • (2013) J Cardiovasc Pharmacol , vol.61 , pp. 63-69
    • Fujisawa, M.1    Yorikane, R.2    Matsuoka, Y.3
  • 53
    • 0021861363 scopus 로고
    • Kinetics of binding of membrane-active drugs to receptor sites Diffusion-limited rates for a membrane bilayer approach of 1,4-dihydropyridine calcium channel antagonists to their active site
    • Rhodes DG, Sarmiento JG, Herbette LG. Kinetics of binding of membrane-active drugs to receptor sites. Diffusion-limited rates for a membrane bilayer approach of 1,4-dihydropyridine calcium channel antagonists to their active site. Mol Pharmacol 1985;27:612-23
    • (1985) Mol Pharmacol , vol.27 , pp. 612-623
    • Rhodes, D.G.1    Sarmiento, J.G.2    Herbette, L.G.3
  • 54
    • 0042398164 scopus 로고    scopus 로고
    • Phase i study of CS-905 a new calcium antagonist-III : A multiple dose study on healthy volunteers. [in Japanese]
    • Nakashima M, Kawabata K, Sasahara K, Phase I study of CS-905, a new calcium antagonist-III : a multiple dose study on healthy volunteers. [in Japanese]. Rinsho Iyaku 2000;16:191-205
    • (2000) Rinsho Iyaku , vol.16 , pp. 191-205
    • Nakashima, M.1    Kawabata, K.2    Sasahara, K.3
  • 56
    • 1642464732 scopus 로고    scopus 로고
    • Azelnidipine and amlodipine: A comparison of their pharmacokinetics and effects on ambulatory blood pressure
    • Kuramoto K, Ichikawa S, Hirai A, et al. Azelnidipine and amlodipine: a comparison of their pharmacokinetics and effects on ambulatory blood pressure. Hypertens Res 2003;26:201-8
    • (2003) Hypertens Res , vol.26 , pp. 201-208
    • Kuramoto, K.1    Ichikawa, S.2    Hirai, A.3
  • 57
    • 0032948114 scopus 로고    scopus 로고
    • A new Ca-antagonist, azelnidipine, reduced blood pressure during exercise without augmentation of sympathetic nervous system in essential hypertension: A randomized, double-blind, placebo-controlled trial
    • Arita M, Hashizume T, Tanigawa K, et al. A new Ca-antagonist, azelnidipine, reduced blood pressure during exercise without augmentation of sympathetic nervous system in essential hypertension: a randomized, double-blind, placebo-controlled trial. J Cardiovasc Pharmacol 1999;33:186-92
    • (1999) J Cardiovasc Pharmacol , vol.33 , pp. 186-192
    • Arita, M.1    Hashizume, T.2    Tanigawa, K.3
  • 58
    • 0344215360 scopus 로고    scopus 로고
    • Efficacy and safety of CS-905 (azelnidipine) monotherapy on essential hypertension in the long-term treatment [in Japanese]
    • Yoshinaga K, Iimura O, Abe K, et al. Efficacy and safety of CS-905 (azelnidipine) monotherapy on essential hypertension in the long-term treatment [in Japanese]. Rinsho Iyaku 1999;15:943-83
    • (1999) Rinsho Iyaku , vol.15 , pp. 943-983
    • Yoshinaga, K.1    Iimura, O.2    Abe, K.3
  • 59
    • 0344215358 scopus 로고    scopus 로고
    • Efficacy and safety of CS-905 (azelnidipine) combination therapy on essential hypertension [in Japanese]
    • Hirai A, Terano T, Saito Y. Efficacy and safety of CS-905 (azelnidipine) combination therapy on essential hypertension [in Japanese]. Rinsho Iyaku 1999;15:505-1545
    • (1999) Rinsho Iyaku , vol.15 , pp. 505-1545
    • Hirai, A.1    Terano, T.2    Saito, Y.3
  • 60
    • 84865496465 scopus 로고    scopus 로고
    • Obesity and metabolic syndrome as related to cardiovascular disease
    • Nikolopoulou A, Kadoglou NP. Obesity and metabolic syndrome as related to cardiovascular disease. Expert Rev Cardiovasc Ther 2010;10:933-9
    • (2010) Expert Rev Cardiovasc Ther , vol.10 , pp. 933-939
    • Nikolopoulou, A.1    Kadoglou, N.P.2
  • 61
    • 1642487733 scopus 로고    scopus 로고
    • Antioxidant effect of a new calcium antagonist, azelnidipine, in cultured human arterial endothelial cells
    • Shinomiya K, Mizushige K, Fukunaga M, et al. Antioxidant effect of a new calcium antagonist, azelnidipine, in cultured human arterial endothelial cells. J Int Med Res 2004;32:170-5
    • (2004) J Int Med Res , vol.32 , pp. 170-175
    • Shinomiya, K.1    Mizushige, K.2    Fukunaga, M.3
  • 62
    • 30144438668 scopus 로고    scopus 로고
    • Azelnidipine, a dihydropyridine-based calcium antagonist, inhibits angiotensin II-induced oxidative stress generation and downregulation of pigment epithelium-derived factor mRNA levels in microvascular endothelial cells
    • Matsui T, Yamagishi S, Nakamura K, et al. Azelnidipine, a dihydropyridine-based calcium antagonist, inhibits angiotensin II-induced oxidative stress generation and downregulation of pigment epithelium-derived factor mRNA levels in microvascular endothelial cells. Drugs Exp Clin Res 2005;31:215-19
    • (2005) Drugs Exp Clin Res , vol.31 , pp. 215-219
    • Matsui, T.1    Yamagishi, S.2    Nakamura, K.3
  • 63
    • 34250886902 scopus 로고    scopus 로고
    • Antioxidative effects of azelnidipine on mesangial cell proliferation induced by highly concentrated insulin
    • Manabe S, Okura T, Fukuoka T, Higaki J. Antioxidative effects of azelnidipine on mesangial cell proliferation induced by highly concentrated insulin. Eur J Pharmacol 2007;567:252-7
    • (2007) Eur J Pharmacol , vol.567 , pp. 252-257
    • Manabe, S.1    Okura, T.2    Fukuoka, T.3    Higaki, J.4
  • 64
    • 0842311007 scopus 로고    scopus 로고
    • Calcium channel blocker azelnidipine enhances vascular protective effects of AT1 receptor blocker olmesartan
    • Jinno T, Iwai M, Li Z, et al. Calcium channel blocker azelnidipine enhances vascular protective effects of AT1 receptor blocker olmesartan. Hypertension 2004;43: 263-9
    • (2004) Hypertension , vol.43 , pp. 263-269
    • Jinno, T.1    Iwai, M.2    Li, Z.3
  • 65
    • 33748540075 scopus 로고    scopus 로고
    • Enhancement of cardiac oxidative stress by tachycardia and its critical role in cardiac hypertrophy and fibrosis
    • Yamamoto E, Lai ZF, Yamashita T, et al. Enhancement of cardiac oxidative stress by tachycardia and its critical role in cardiac hypertrophy and fibrosis. J Hypertens 2006;24:2057-69
    • (2006) J Hypertens , vol.24 , pp. 2057-2069
    • Yamamoto, E.1    Lai, Z.F.2    Yamashita, T.3
  • 66
    • 34250643958 scopus 로고    scopus 로고
    • Azelnidipine reduces urinary protein excretion and urinary liver-type fatty acid binding protein in patients with hypertensive chronic kidney disease
    • Nakamura T, Sugaya T, Kawagoe Y, et al. Azelnidipine reduces urinary protein excretion and urinary liver-type fatty acid binding protein in patients with hypertensive chronic kidney disease. Am J Med Sci 2007;333:321-6
    • (2007) Am J Med Sci , vol.333 , pp. 321-326
    • Nakamura, T.1    Sugaya, T.2    Kawagoe, Y.3
  • 67
    • 40649083850 scopus 로고    scopus 로고
    • Calcium channel blocker, azelnidipine, reduces lipid hydroperoxides in patients with type 2 diabetes independent of blood pressure
    • Ohmura C, Watada H, Shimizu T, et al. Calcium channel blocker, azelnidipine, reduces lipid hydroperoxides in patients with type 2 diabetes independent of blood pressure. Endocr J 2007;54:805-11
    • (2007) Endocr J , vol.54 , pp. 805-811
    • Ohmura, C.1    Watada, H.2    Shimizu, T.3
  • 68
    • 48349097293 scopus 로고    scopus 로고
    • Combination therapy with renin-angiotensin system inhibitors and the calcium channel blocker azelnidipine decreases plasma inflammatory markers and urinary oxidative stress markers in patients with diabetic nephropathy
    • Ogawa S, Mori T, Nako K, Ito S. Combination therapy with renin-angiotensin system inhibitors and the calcium channel blocker azelnidipine decreases plasma inflammatory markers and urinary oxidative stress markers in patients with diabetic nephropathy. Hypertens Res 2008;31: 1147-55
    • (2008) Hypertens Res , vol.31 , pp. 1147-1155
    • Ogawa, S.1    Mori, T.2    Nako, K.3    Ito, S.4
  • 69
    • 79961190086 scopus 로고    scopus 로고
    • Additive antioxidative effects of azelnidipine on angiotensin receptor blocker olmesartan treatment for type 2 diabetic patients with albuminuria
    • Abe M, Maruyama N, Okada K, et al. Additive antioxidative effects of azelnidipine on angiotensin receptor blocker olmesartan treatment for type 2 diabetic patients with albuminuria. Hypertens Res 2011;34:935-41
    • (2011) Hypertens Res , vol.34 , pp. 935-941
    • Abe, M.1    Maruyama, N.2    Okada, K.3
  • 70
    • 84871536778 scopus 로고    scopus 로고
    • Neutrophil to lymphocyte ratio and cardiovascular diseases: A review
    • Bhat T, Teli S, Rijal J, et al. Neutrophil to lymphocyte ratio and cardiovascular diseases: a review. Expert Rev Cardiovasc Ther 2013;11:55-9
    • (2013) Expert Rev Cardiovasc Ther , vol.11 , pp. 55-59
    • Bhat, T.1    Teli, S.2    Rijal, J.3
  • 71
    • 33748304270 scopus 로고    scopus 로고
    • Azelnidipine, a new calcium channel blocker, inhibits endothelial inflammatory response by reducing intracellular levels of reactive oxygen species
    • Naito Y, Shimozawa M, Manabe H, et al. Azelnidipine, a new calcium channel blocker, inhibits endothelial inflammatory response by reducing intracellular levels of reactive oxygen species. Eur J Pharmacol 2006;546:11-18
    • (2006) Eur J Pharmacol , vol.546 , pp. 11-18
    • Naito, Y.1    Shimozawa, M.2    Manabe, H.3
  • 72
    • 33747432630 scopus 로고    scopus 로고
    • A third-generation, long-acting, dihydropyridine calcium antagonist, azelnidipine, attenuates stent-associated neointimal formation in non-human primates
    • Nakano K, Egashira K, Tada H, et al. A third-generation, long-acting, dihydropyridine calcium antagonist, azelnidipine, attenuates stent-associated neointimal formation in non-human primates. J Hypertens 2006;24:1881-9
    • (2006) J Hypertens , vol.24 , pp. 1881-1889
    • Nakano, K.1    Egashira, K.2    Tada, H.3
  • 73
    • 33750439866 scopus 로고    scopus 로고
    • SDF-1-induced adhesion of monocytes to vascular endothelium is modulated by azelnidipine via protein kinase C inhibition
    • Takahashi K, Shimokado K, Yoshida M. SDF-1-induced adhesion of monocytes to vascular endothelium is modulated by azelnidipine via protein kinase C inhibition. Eur J Pharmacol 2006;552:162-9
    • (2006) Eur J Pharmacol , vol.552 , pp. 162-169
    • Takahashi, K.1    Shimokado, K.2    Yoshida, M.3
  • 74
    • 84904489189 scopus 로고    scopus 로고
    • Azelnidipine inhibits cultured rat aortic smooth muscle cell death induced by cyclic mechanical stretch
    • Zhao J, Ozawa K, Kyotani Y, et al. Azelnidipine inhibits cultured rat aortic smooth muscle cell death induced by cyclic mechanical stretch. PLoS One 2014;9: e102813
    • (2014) PLoS One , vol.9 , pp. e102813
    • Zhao, J.1    Ozawa, K.2    Kyotani, Y.3
  • 75
    • 77954513334 scopus 로고    scopus 로고
    • Cytokine reducing effect of azelnidipine in human peripheral blood mononuclear cells
    • Miura R, Nakamura K, Miura D, et al. Cytokine reducing effect of azelnidipine in human peripheral blood mononuclear cells. Biol Pharm Bull 2010;33:1148-51
    • (2010) Biol Pharm Bull , vol.33 , pp. 1148-1151
    • Miura, R.1    Nakamura, K.2    Miura, D.3
  • 76
    • 34249736309 scopus 로고    scopus 로고
    • Effects of calcium channel blocker azelnidipine on experimental abdominal aortic aneurysms
    • Yokokura H, Hiromatsu S, Akashi H, et al. Effects of calcium channel blocker azelnidipine on experimental abdominal aortic aneurysms. Surg Today 2007;37: 468-73
    • (2007) Surg Today , vol.37 , pp. 468-473
    • Yokokura, H.1    Hiromatsu, S.2    Akashi, H.3
  • 77
    • 84888050809 scopus 로고    scopus 로고
    • Azelnidipine suppresses the progression of aortic aneurysm in wild mice model through anti-inflammatory effects
    • Kurobe H, Matsuoka Y, Hirata Y, et al. Azelnidipine suppresses the progression of aortic aneurysm in wild mice model through anti-inflammatory effects. J Thorac Cardiovasc Surg 2013;146:1501-8
    • (2013) J Thorac Cardiovasc Surg , vol.146 , pp. 1501-1508
    • Kurobe, H.1    Matsuoka, Y.2    Hirata, Y.3
  • 78
    • 84905910492 scopus 로고    scopus 로고
    • Synergistic neuroprotective effects of combined treatment with olmesartan plus azelnidipine in stroke-prone spontaneously hypertensive rats
    • Omote Y, Deguchi K, Kono S, et al. Synergistic neuroprotective effects of combined treatment with olmesartan plus azelnidipine in stroke-prone spontaneously hypertensive rats. J Neurosci Res 2014;92: 1330-7
    • (2014) J Neurosci Res , vol.92 , pp. 1330-1337
    • Omote, Y.1    Deguchi, K.2    Kono, S.3
  • 79
    • 84898987994 scopus 로고    scopus 로고
    • Effects of combination therapy with olmesartan and azelnidipine on serum osteoprotegerin in patients with hypertension
    • Uzui H, Morishita T, Nakano A, et al. Effects of combination therapy with olmesartan and azelnidipine on serum osteoprotegerin in patients with hypertension. J Cardiovasc Pharmacol Ther 2014;19:304-9
    • (2014) J Cardiovasc Pharmacol Ther , vol.19 , pp. 304-309
    • Uzui, H.1    Morishita, T.2    Nakano, A.3
  • 80
    • 33644514960 scopus 로고    scopus 로고
    • Effects of a new calcium channel blocker, azelnidipine, on systemic hemodynamics and renal sympathetic nerve activity in spontaneously hypertensive rats
    • Shokoji T, Fujisawa Y, Kiyomoto H, et al. Effects of a new calcium channel blocker, azelnidipine, on systemic hemodynamics and renal sympathetic nerve activity in spontaneously hypertensive rats. Hypertens Res 2005;28:1017-23
    • (2005) Hypertens Res , vol.28 , pp. 1017-1023
    • Shokoji, T.1    Fujisawa, Y.2    Kiyomoto, H.3
  • 81
    • 33845917516 scopus 로고    scopus 로고
    • Long-acting calcium channel blocker, azelnidipine, increases endothelial nitric oxide synthase in the brain and inhibits sympathetic nerve activity
    • Kimura Y, Hirooka Y, Sagara Y, Sunagawa K. Long-acting calcium channel blocker, azelnidipine, increases endothelial nitric oxide synthase in the brain and inhibits sympathetic nerve activity. Clin Exp Hypertens 2007;29:13-21
    • (2007) Clin Exp Hypertens , vol.29 , pp. 13-21
    • Kimura, Y.1    Hirooka, Y.2    Sagara, Y.3    Sunagawa, K.4
  • 82
    • 59449089843 scopus 로고    scopus 로고
    • Azelnidipine decreases sympathetic nerve activity via antioxidant effect in the rostral ventrolateral medulla of stroke-prone spontaneously hypertensive rats
    • Konno S, Hirooka Y, Araki S, et al. Azelnidipine decreases sympathetic nerve activity via antioxidant effect in the rostral ventrolateral medulla of stroke-prone spontaneously hypertensive rats. J Cardiovasc Pharmacol 2008;52:555-60
    • (2008) J Cardiovasc Pharmacol , vol.52 , pp. 555-560
    • Konno, S.1    Hirooka, Y.2    Araki, S.3
  • 83
    • 34249067683 scopus 로고    scopus 로고
    • Azelnidipine attenuates cardiovascular and sympathetic responses to air-jet stress in genetically hypertensive rats
    • Nakamoto M, Ohya Y, Sakima A, et al. Azelnidipine attenuates cardiovascular and sympathetic responses to air-jet stress in genetically hypertensive rats. Hypertens Res 2007;30:359-66
    • (2007) Hypertens Res , vol.30 , pp. 359-366
    • Nakamoto, M.1    Ohya, Y.2    Sakima, A.3
  • 84
    • 84857940074 scopus 로고    scopus 로고
    • Azelnidipine attenuates glomerular damage in Dahl salt-sensitive rats by suppressing sympathetic nerve activity
    • Nagasu H, Satoh M, Fujimoto S, et al. Azelnidipine attenuates glomerular damage in Dahl salt-sensitive rats by suppressing sympathetic nerve activity. Hypertens Res 2012;35:348-55
    • (2012) Hypertens Res , vol.35 , pp. 348-355
    • Nagasu, H.1    Satoh, M.2    Fujimoto, S.3
  • 85
    • 84906092308 scopus 로고    scopus 로고
    • Differential effects of azelnidipine and amlodipine on sympathetic nerve activity in patients with primary hypertension
    • Inomata J, Murai H, Kaneko S, et al. Differential effects of azelnidipine and amlodipine on sympathetic nerve activity in patients with primary hypertension. J Hypertens 2014;32:1898-904
    • (2014) J Hypertens , vol.32 , pp. 1898-1904
    • Inomata, J.1    Murai, H.2    Kaneko, S.3
  • 86
    • 66749181130 scopus 로고    scopus 로고
    • Postprandial hyperglycemia as an etiological factor in vascular failure
    • Node K, Inoue T. Postprandial hyperglycemia as an etiological factor in vascular failure. Cardiovasc Diabetol 2009;8:23
    • (2009) Cardiovasc Diabetol , vol.8 , pp. 23
    • Node, K.1    Inoue, T.2
  • 87
    • 34147126829 scopus 로고    scopus 로고
    • The role of TNF-alpha in chronic inflammatory conditions, intermediary metabolism, and cardiovascular risk
    • Popa C, Netea MG, van Riel PL, et al. The role of TNF-alpha in chronic inflammatory conditions, intermediary metabolism, and cardiovascular risk. J Lipid Res 2007;48: 751-62
    • (2007) J Lipid Res , vol.48 , pp. 751-762
    • Popa, C.1    Netea, M.G.2    Van Riel, P.L.3
  • 88
    • 73849138948 scopus 로고    scopus 로고
    • A randomized, double-blind, four-arm parallel-group study of the efficacy and safety of azelnidipine and olmesartan medoxomil combination therapy compared with each monotherapy in Japanese patients with essential hypertension: The REZALT study
    • Ogihara T, Saruta T, Shimada K, Kuramoto K. A randomized, double-blind, four-arm parallel-group study of the efficacy and safety of azelnidipine and olmesartan medoxomil combination therapy compared with each monotherapy in Japanese patients with essential hypertension: the REZALT study. Hypertens Res 2009;32:1148-54
    • (2009) Hypertens Res , vol.32 , pp. 1148-1154
    • Ogihara, T.1    Saruta, T.2    Shimada, K.3    Kuramoto, K.4
  • 89
    • 84919434256 scopus 로고    scopus 로고
    • Antihypertensive drugs and glucose metabolism
    • Rizos CV, Elisaf MS. Antihypertensive drugs and glucose metabolism. World J Cardiol 2014;6:517-30
    • (2014) World J Cardiol , vol.6 , pp. 517-530
    • Rizos, C.V.1    Elisaf, M.S.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.