Pharmacological properties of azelnidipine, a long-acting calcium channel blocker with high-affinity for vascular tissues (Part 2): Antihypertensive effects and pharmacokinetics in Spontaneously Hypertensive Rats (SHR)

Japanese Pharmacology and Therapeutics

Volumn 30, Issue 9, 2002, Pages 711-720

  Sada, Toshio ^a   Mizuno, Makoto ^a   Miyama, Chizuru ^a   Ohata, Keiko ^a   Yamamura, Naotoshi ^a   Oizumi, Kiyoshi ^a   Kazui, Miho ^a   Fukuda, Kuniaki ^a   Nishino, Hiroshi ^a   Koike, Hiroyuki ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

AMLODIPINE; ANTIHYPERTENSIVE AGENT; AZELNIDIPINE; CALCIUM CHANNEL; CALCIUM CHANNEL BLOCKING AGENT; TRITIUM;

ANIMAL MODEL; ANIMAL TISSUE; ANTIHYPERTENSIVE THERAPY; ARTICLE; BINDING AFFINITY; BLOOD PRESSURE; CARDIOVASCULAR EFFECT; CONTROLLED STUDY; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; DRUG HALF LIFE; DRUG RECEPTOR BINDING; HEART RATE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROPHOBICITY; HYPERTENSION; NONHUMAN; PARTITION COEFFICIENT; RAT; SPONTANEOUSLY HYPERTENSIVE RAT;

EID: 0036033604     PISSN: 03863603     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. Burges RA, Dodd MG, Gardiner DG. Pharmacologic profiles of amlodipine. Am J Cardiol 1989; 64: 101-181.
2. Stopher DA, Beresford AP, Macrae PV, Humphrey MJ. The metabolism and pharmacokinetics of amlodipine in humans and animals. J Cardiovasc Pharmacol 1988; 12 (Suppl 7): S55-S59.
3. Faulkner JK, McGibney D, Chasseaud LF, Perry JL, Taylor IW. The pharmacokinetics of amlodipine in healthy volunteers after single intravenous and oral doses and after 14 repeated oral doses given once daily. Br J Clin Pharmacol 1986; 22: 21-5.
4. ++-channel blocker. Jpn J Pharmacol 1989; 51: 57-64.
5. Yagil Y, Lustig A. Azelnidipine (CS-905), a novel dihydropyridine calcium channel blocker with gradual onset and prolonged duration of action. Cardiovasc Drug Rev 1995; 13: 137-48.
6. Scher AM. Control of arterial pressure: Measurement of pressure and flow. In: Ruch TC, Patton HD, editors. Physiology and Biophysics. Philadelphia: WB Saunders Company; 1965. p.660-83.
7. Abe Y, Komori T, Miura K, Tanaka T, Imanishi M, Okahara T, et al. Effects of the calcium antagonist nicardipine on renal function and renin release in dogs. J Cardiovasc Pharmacol 1983; 5: 254-9.
8. 2+ antagonist (nifedipine) in hypertensive patients. Jpn Heart J 1976; 17: 479-84.
9. Rhodes DG, Sarmiento JG, Herbette LG. Kinetics of binding of membrane-active drugs to receptor sites: Diffusion-limited rates for a membrane bilayer approach of 1,4-dihydropyridine calcium channel antagonists to their active site. Mol Pharmacol 1985; 27: 612-23.