Malawi polyomavirus is a prevalent human virus that interacts with known tumor suppressors

Journal of Virology

Volumn 89, Issue 1, 2015, Pages 857-862

  Berrios, Christian ^a,b   Jung, Joonil ^c   Primi, Blake ^d,e   Wang, Michael ^f   Pedamallu, Chandrasekhar ^a,c   Duke, Fujiko ^a,c   Marcelus, Christina ^a   Cheng, Jingwei ^a,g   Garcea, Robert L ^d,e   Meyerson, Matthew ^a,c,h   DeCaprio, James A ^a,b,g  

^a DANA FARBER CANCER INSTITUTE   (United States)

^b HARVARD UNIVERSITY   (United States)

^c BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^d UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF COLORADO   (United States)

^f University of Colorado Denver and Children s Hospital Colorado   (United States)

^g BRIGHAM AND WOMEN S HOSPITAL   (United States)

^h HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P107; PROTEIN P130; PROTEIN P53; PROTEIN PRB; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG; VIRUS LARGE T ANTIGEN; VIRUS PROTEIN; VIRUS SMALL T ANTIGEN; PROTEIN BINDING; VIRUS DNA; VIRUS T ANTIGEN;

ANTIGEN BINDING; ANTIGEN EXPRESSION; ARTICLE; BINDING AFFINITY; CELL GROWTH; COMPLEX FORMATION; CONTROLLED STUDY; MALAWI POLYOMAVIRUS; NONHUMAN; NUCLEOTIDE SEQUENCE; POLYOMA VIRUS; PROTEIN DETERMINATION; PROTEIN PROTEIN INTERACTION; VIRUS ATTACHMENT; VIRUS CELL INTERACTION; ADOLESCENT; ADULT; AGED; CHEMISTRY; CHILD; DNA SEQUENCE; FEMALE; GENETICS; HOST PATHOGEN INTERACTION; HUMAN; INFANT; MALE; METABOLISM; MIDDLE AGED; MOLECULAR GENETICS; PHYSIOLOGY; POLYOMAVIRUS; POLYOMAVIRUS INFECTIONS; PRESCHOOL CHILD; VERY ELDERLY; VIROLOGY; YOUNG ADULT;

POLYOMAVIRUS; SIMIAN VIRUS 40;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANTIGENS, VIRAL, TUMOR; CHILD; CHILD, PRESCHOOL; DNA, VIRAL; FEMALE; HOST-PATHOGEN INTERACTIONS; HUMANS; INFANT; MALE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; POLYOMAVIRUS; POLYOMAVIRUS INFECTIONS; PROTEIN BINDING; SEQUENCE ANALYSIS, DNA; SEROEPIDEMIOLOGIC STUDIES; TUMOR SUPPRESSOR PROTEINS; YOUNG ADULT;

EID: 84919459054     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.02328-14     Document Type: Article

References (41)

1. DeCaprio JA, Garcea RL. 2013. A cornucopia of human polyomaviruses. Nat Rev Microbiol 11:264-276. http://dx.doi.org/10.1038/nrmicro2992.
2. Jiang M, Abend JR, Johnson SF, Imperiale MJ. 2009. The role of polyomaviruses in human disease. Virology 384:266-273. http://dx.doi.org/10.1016/j.virol.2008.09.027.
3. van der Meijden E, Janssens RW, Lauber C, Bouwes Bavinck JN, Gorbalenya AE, Feltkamp MC. 2010. Discovery of a new human polyomavirus associated with trichodysplasia spinulosa in an immunocompromized patient. PLoS Pathog 6:e1001024. http://dx.doi.org/10.1371/journal.ppat.1001024.
4. Feng H, Shuda M, Chang Y, Moore PS. 2008. Clonal integration of a polyomavirus in human Merkel cell carcinoma. Science 319:1096-1100. http://dx.doi.org/10.1126/science.1152586.
5. Rodig SJ, Cheng J, Wardzala J, DoRosario A, Scanlon JJ, Laga AC, Martinez-Fernandez A, Barletta JA, Bellizzi AM, Sadasivam S, Holloway DT, Cooper DJ, Kupper TS, Wang LC, DeCaprio JA. 2012. Improved detection suggests all Merkel cell carcinomas harbor Merkel polyomavirus. J Clin Invest 122:4645-4653. http://dx.doi.org/10.1172/JCI64116.
6. Gaynor AM, Nissen MD, Whiley DM, Mackay IM, Lambert SB, Wu G, Brennan DC, Storch GA, Sloots TP, Wang D. 2007. Identification of a novel polyomavirus from patients with acute respiratory tract infections. PLoS Pathog 3:e64. http://dx.doi.org/10.1371/journal.ppat.0030064.
7. Allander T, Andreasson K, Gupta S, Bjerkner A, Bogdanovic G, Persson MA, Dalianis T, Ramqvist T, Andersson B. 2007. Identification of a third human polyomavirus. J Virol 81:4130-4136. http://dx.doi.org/10.1128/JVI.00028-07.
8. Schowalter RM, Pastrana DV, Pumphrey KA, Moyer AL, Buck CB. 2010. Merkel cell polyomavirus and two previously unknown polyomaviruses are chronically shed from human skin. Cell Host Microbe 7:509-515. http://dx.doi.org/10.1016/j.chom.2010.05.006.
9. Ho J, Jedrych JJ, Feng H, Natalie AA, Grandinetti L, Mirvish E, Crespo MM, Yadav D, Fasanella KE, Proksell S, Kuan S-FF, Pastrana DV, Buck CB, Shuda Y, Moore PS, Chang Y. 17 September 2014, posting date. Human polyomavirus 7-associated pruritic rash and viremia in transplant recipients. J Infect Dis http://dx.doi.org/10.1093/infdis/jiu524.
10. Sauvage V, Foulongne V, Cheval J, Ar Gouilh M, Pariente K, Dereure O, Manuguerra JC, Richardson J, Lecuit M, Burguiere A, Caro V, Eloit M. 2011. Human polyomavirus related to African green monkey lymphotropic polyomavirus. Emerg Infect Dis 17:1364-1370. http://dx.doi.org/10.3201/eid1708.110278.
11. Zur Hausen H, Gissmann L. 1979. Lymphotropic papovaviruses isolated from African green monkey and human cells. Med Microbiol Immunol 167:137-153. http://dx.doi.org/10.1007/BF02121180.
12. Siebrasse EA, Reyes A, Lim ES, Zhao G, Mkakosya RS, Manary MJ, Gordon JI, Wang D. 2012. Identification of MW polyomavirus, a novel polyomavirus in human stool. J Virol 86:10321-10326. http://dx.doi.org/10.1128/JVI.01210-12.
13. Lim ES, Reyes A, Antonio M, Saha D, Ikumapayi UN, Adeyemi M, Stine OC, Skelton R, Brennan DC, Mkakosya RS, Manary MJ, Gordon JI, Wang D. 2013. Discovery of STL polyomavirus, a polyomavirus of ancestral recombinant origin that encodes a unique T antigen by alternative splicing. Virology 436:295-303. http://dx.doi.org/10.1016/j.virol.2012.12.005.
14. Korup S, Rietscher J, Calvignac-Spencer S, Trusch F, Hofmann J, Moens U, Sauer I, Voigt S, Schmuck R, Ehlers B. 2013. Identification of a novel human polyomavirus in organs of the gastrointestinal tract. PLoS One 8:e58021. http://dx.doi.org/10.1371/journal.pone.0058021.
15. Mishra N, Pereira M, Rhodes RH, An P, Pipas JM, Jain K, Kapoor A, Briese T, Faust PL, Lipkin WI. 1 May 2014, posting date. Identification of a novel polyomavirus in a pancreatic transplant recipient with retinal blindness and vasculitic myopathy. J Infect Dis http://dx.doi.org/10.1093/infdis/jiu250.
16. Buck CB, Phan GQ, Raiji MT, Murphy PM, McDermott DH, McBride AA. 2012. Complete genome sequence of a tenth human polyomavirus. J Virol 86:10887. http://dx.doi.org/10.1128/JVI.01690-12.
17. Yu G, Greninger AL, Isa P, Phan TG, Martinez MA, de la Luz Sanchez M, Contreras JF, Santos-Preciado JI, Parsonnet J, Miller S, DeRisi JL, Delwart E, Arias CF, Chiu CY. 2012. Discovery of a novel polyomavirus in acute diarrheal samples from children. PLoS One 7:e49449. http://dx.doi.org/10.1371/journal.pone.0049449.
18. Kawai T, Malech HL. 2009. WHIM syndrome: congenital immune deficiency disease. Curr Opin Hematol 16:20-26. http://dx.doi.org/10.1097/MOH.0b013e32831ac557.
19. Hagopian WA, Lernmark A, Rewers MJ, Simell OG, She JX, Ziegler AG, Krischer JP, Akolkar B. 2006. TEDDY-The Environmental Determinants of Diabetes in the Young: an observational clinical trial. Ann N Y Acad Sci 1079:320-326. http://dx.doi.org/10.1196/annals.1375.049.
20. Dean FB, Hosono S, Fang L, Wu X, Faruqi AF, Bray-Ward P, Sun Z, Zong Q, Du Y, Du J, Driscoll M, Song W, Kingsmore SF, Egholm M, Lasken RS. 2002. Comprehensive human genome amplification using multiple displacement amplification. Proc Natl Acad Sci USA 99:5261-5266. http://dx.doi.org/10.1073/pnas.082089499.
21. Bentley DR, Balasubramanian S, Swerdlow HP, Smith GP, Milton J, Brown CG, Hall KP, Evers DJ, Barnes CL, Bignell HR, Boutell JM, Bryant J, Carter RJ, Keira Cheetham R, Cox AJ, Ellis DJ, Flatbush MR, Gormley NA, Humphray SJ, Irving LJ, Karbelashvili MS, Kirk SM, Li H, Liu X, Maisinger KS, Murray LJ, Obradovic B, Ost T, Parkinson ML, Pratt MR, Rasolonjatovo IM, Reed MT, Rigatti R, Rodighiero C, Ross MT, Sabot A, Sankar SV, Scally A, Schroth GP, Smith ME, Smith VP, Spiridou A, Torrance PE, Tzonev SS, Vermaas EH, Walter K, Wu X, Zhang L, Alam MD, Anastasi C, et al. 2008. Accurate whole human genome sequencing using reversible terminator chemistry. Nature 456: 53-59. http://dx.doi.org/10.1038/nature07517.
22. Kostic AD, Ojesina AI, Pedamallu CS, Jung J, Verhaak RG, Getz G, Meyerson M. 2011. PathSeq: software to identify or discover microbes by deep sequencing of human tissue. Nat Biotechnol 29:393-396. http://dx.doi.org/10.1038/nbt.1868.
23. Grabherr MG, Haas BJ, Yassour M, Levin JZ, Thompson DA, Amit I, Adiconis X, Fan L, Raychowdhury R, Zeng Q, Chen Z, Mauceli E, Hacohen N, Gnirke A, Rhind N, di Palma F, Birren BW, Nusbaum C, Lindblad-Toh K, Friedman N, Regev A. 2011. Full-length transcriptome assembly from RNA-Seq data without a reference genome. Nat Biotechnol 29:644-652. http://dx.doi.org/10.1038/nbt.1883.
24. Johne R, Buck CB, Allander T, Atwood WJ, Garcea RL, Imperiale MJ, Major EO, Ramqvist T, Norkin LC. 2011. Taxonomical developments in the family Polyomaviridae. Arch Virol 156:1627-1634. http://dx.doi.org/10.1007/s00705-011-1008-x.
25. Kean JM, Rao S, Wang M, Garcea RL. 2009. Seroepidemiology of human polyomaviruses. PLoS Pathog 5:e1000363. http://dx.doi.org/10.1371/journal.ppat.1000363.
26. Nicol JT, Leblond V, Arnold F, Guerra G, Mazzoni E, Tognon M, Coursaget P, Touzé A. 30 October 2013. Seroprevalence of human Malawi polyomavirus. J Clin Microbiol http://dx.doi.org/10.1128/JCM.02730-13.
27. Rozenblatt-Rosen O, Deo RC, Padi M, Adelmant G, Calderwood MA, Rolland T, Grace M, Dricot A, Askenazi M, Tavares M, Pevzner SJ, Abderazzaq F, Byrdsong D, Carvunis AR, Chen AA, Cheng J, Correll M, Duarte M, Fan C, Feltkamp MC, Ficarro SB, Franchi R, Garg BK, Gulbahce N, Hao T, Holthaus AM, James R, Korkhin A, Litovchick L, Mar JC, Pak TR, Rabello S, Rubio R, Shen Y, Singh S, Spangle JM, Tasan M, Wanamaker S, Webber JT, Roecklein-Canfield J, Johannsen E, Barabasi AL, Beroukhim R, Kieff E, Cusick ME, Hill DE, Munger K, Marto JA, Quackenbush J, Roth FP, et al. 2012. Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins. Nature 487:491-495. http://dx.doi.org/10.1038/nature11288.
28. DeCaprio JA. 2009. How the Rb tumor suppressor structure and function was revealed by the study of adenovirus and SV40. Virology 384:274-284. http://dx.doi.org/10.1016/j.virol.2008.12.010.
29. Lane D, Levine A. 2010. p53 research: the past thirty years and the next thirty years. Cold Spring Harb Perspect Biol 2:a000893. http://dx.doi.org/10.1101/cshperspect.a000893.
30. Pallas DC, Shahrik LK, Martin BL, Jaspers S, Miller TB, Brautigan DL, Roberts TM. 1990. Polyoma small and middle T antigens and SV40 small t antigen form stable complexes with protein phosphatase 2A. Cell 60: 167-176. http://dx.doi.org/10.1016/0092-8674(90)90726-U.
31. Yang SI, Lickteig RL, Estes R, Rundell K, Walter G, Mumby MC. 1991. Control of protein phosphatase 2A by simian virus 40 small-t antigen. Mol Cell Biol 11:1988-1995.
32. Hahn WC, Dessain SK, Brooks MW, King JE, Elenbaas B, Sabatini DM, DeCaprio JA, Weinberg RA. 2002. Enumeration of the simian virus 40 early region elements necessary for human cell transformation. Mol Cell Biol 22: 2111-2123. http://dx.doi.org/10.1128/MCB.22.7.2111-2123.2002.
33. Sablina AA, Hector M, Colpaert N, Hahn WC. 2010. Identification of PP2A complexes and pathways involved in cell transformation. Cancer Res 70: 10474-10484. http://dx.doi.org/10.1158/0008-5472.CAN-10-2855.
34. Sowa ME, Bennett EJ, Gygi SP, Harper JW. 2009. Defining the human deubiquitinating enzyme interaction landscape. Cell 138:389-403. http://dx.doi.org/10.1016/j.cell.2009.04.042.
35. Shuda M, Kwun HJ, Feng H, Chang Y, Moore PS. 2011. Human Merkel cell polyomavirus small T antigen is an oncoprotein targeting the 4E-BP1 translation regulator. J Clin Invest 121:3623-3634. http://dx.doi.org/10.1172/JCI46323.
36. Krek W, DeCaprio JA. 1995. Cell synchronization. Methods Enzymol 254:114-124.
37. Pipas JM, Levine AJ. 2001. Role of T antigen interactions with p53 in tumorigenesis. Semin Cancer Biol 11:23-30. http://dx.doi.org/10.1006/scbi.2000.0343.
38. Howley PM, Livingston DM. 2009. Small DNA tumor viruses: large contributors to biomedical sciences. Virology 384:256-259. http://dx.doi.org/10.1016/j.virol.2008.12.006.
39. Cheng J, Rozenblatt-Rosen O, Paulson KG, Nghiem P, Decaprio JA. 20 March 2013. Merkel cell polyomavirus large T antigen has growth promoting and inhibitory activities. J Virol http://dx.doi.org/10.1128/JVI.00385-13.
40. Borchert S, Czech-Sioli M, Neumann F, Schmidt C, Wimmer P, Dobner T, Grundhoff A, Fischer N. 2014. High-affinity Rb binding, p53 inhibition, subcellular localization, and transformation by wild-type or tumorderived shortened Merkel cell polyomavirus large T antigens. J Virol 88: 3144-3160. http://dx.doi.org/10.1128/JVI.02916-13.
41. Li J, Wang X, Diaz J, Tsang SH, Buck CB, You J. 2013. Merkel cell polyomavirus large T antigen disrupts host genomic integrity and inhibits cellular proliferation. J Virol 87:9173-9188. http://dx.doi.org/10.1128/JVI.01216-13.