Variants in striatin gene are associated with salt-sensitive blood pressure in mice and humans

Hypertension

Volumn 65, Issue 1, 2015, Pages 211-217

  Garza, Amanda E ^a   Rariy, Chevon M ^a   Sun, Bei ^a   Williams, Jonathan S ^a   Lasky Su, Jessica ^b   Baudrand, Rene ^a,c   Yao, Tham ^a   Moize, Burhanuddin ^a   Hafiz, Wan M ^a   Romero, Jose R ^a   Adler, Gail K ^a   Ferri, Claudio ^d   Hopkins, Paul N ^e   Pojoga, Luminita H ^a   Williams, Gordon H ^a  

^a Division of Endocrinology Diabetes and Hypertension   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE   (Chile)

^d UNIVERSITY OF L'AQUILA   (Italy)

^e UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

Blood Pressure; Mouse; Polymorphism; Single Nucleotide; Striatin Protein

Indexed keywords

ALDOSTERONE; ANGIOTENSIN II; EPITHELIAL SODIUM CHANNEL; MINERALOCORTICOID RECEPTOR; PROTEIN; PROTEIN KINASE B; SERUM AND GLUCOCORTICOID REGULATED KINASE 1; SMALL INTERFERING RNA; SODIUM CHLORIDE; STRIATIN; UNCLASSIFIED DRUG; CALMODULIN BINDING PROTEIN; MEMBRANE PROTEIN; MESSENGER RNA; NERVE PROTEIN; SODIUM INTAKE; STRN PROTEIN, HUMAN; STRN PROTEIN, MOUSE;

ALLELE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BLOOD PRESSURE; CONTROLLED STUDY; EMBRYO; EMBRYONIC STEM CELL; ENDOTHELIUM CELL; GENE FREQUENCY; GENE TARGETING; GENETIC VARIABILITY; GENOTYPE; GLOMERULOSA CELL; HAPLOTYPE; HAPLOTYPE MAP; HEART; HEART WEIGHT; HETEROZYGOTE; HOMOZYGOTE; HUMAN; HYPERTENSION; IMMUNOBLOTTING; KIDNEY MASS; KIDNEY PARENCHYMA; MOUSE; NONHUMAN; PLASMA RENIN ACTIVITY; PROTEIN EXPRESSION; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; SINGLE NUCLEOTIDE POLYMORPHISM; SODIUM INTAKE; SODIUM RESTRICTION; WESTERN BLOTTING; ANIMAL; BIOSYNTHESIS; DISEASE MODEL; GENE EXPRESSION REGULATION; GENETICS; KNOCKOUT MOUSE; METABOLISM; PATHOPHYSIOLOGY; PHENOTYPE; POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

ANIMALS; BLOOD PRESSURE; BLOTTING, WESTERN; CALMODULIN-BINDING PROTEINS; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION; GENOTYPE; HUMANS; HYPERTENSION; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; NERVE TISSUE PROTEINS; PHENOTYPE; POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIGNAL TRANSDUCTION; SODIUM, DIETARY;

EID: 84919455998     PISSN: 0194911X     EISSN: 15244563     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.114.04233     Document Type: Article

References (23)

1. Hurwitz S, Fisher ND, Ferri C, Hopkins PN, Williams GH, Hollenberg NK. Controlled analysis of blood pressure sensitivity to sodium intake: interactions with hypertension type. J Hypertens. 2003;21:951-959.
2. Williams GH, Hollenberg NK. Non-modulating hypertension. A subset of sodium-sensitive hypertension. Hypertension. 1991;17(1 suppl):I81-I85.
3. Nabika T, Nara Y, Ikeda K, Endo J, Yamori Y. Genetic heterogeneity of the spontaneously hypertensive rat. Hypertension. 1991;18:12-16.
4. Viengchareun S, Le Menuet D, Martinerie L, Munier M, Pascual-Le Tallec L, Lombs M. The mineralocorticoid receptor: insights into its molecular and (patho)physiological biology. Nucl Recept Signal. 2007;5:e012.
5. Losel RM, Falkenstein E, Feuring M, Schultz A, Tillmann HC, Rossol- Haseroth K, Wehling M. Nongenomic steroid action: controversies, questions, and answers. Physiol Rev. 2003;83:965-1016.
6. Funder JW. Non-genomic actions of aldosterone: role in hypertension. Curr Opin Nephrol Hypertens. 2001;10:227-230.
7. Bernelot Moens SJ, Schnitzler GR, Nickerson M, Guo H, Ueda K, Lu Q, Aronovitz MJ, Nickerson H, Baur WE, Hansen U, Iyer LK, Karas RH. Rapid estrogen receptor signaling is essential for the protective effects of estrogen against vascular injury. Circulation. 2012;126:1993-2004.
8. Grossmann C, Gekle M. New aspects of rapid aldosterone signaling. Mol Cell Endocrinol. 2009;308:53-62.
9. Ueda K, Lu Q, Baur W, Aronovitz MJ, Karas RH. Rapid estrogen receptor signaling mediates estrogen-induced inhibition of vascular smooth muscle cell proliferation. Arterioscler Thromb Vasc Biol. 2013;33:1837-1843.
10. Lu Q, Pallas DC, Surks HK, Baur WE, Mendelsohn ME, Karas RH. Striatin assembles a membrane signaling complex necessary for rapid, nongenomic activation of endothelial NO synthase by estrogen receptor alpha. Proc Natl Acad Sci U S A. 2004;101:17126-17131.
11. Moqrich A, Mattei MG, Bartoli M, Rakitina T, Baillat G, Monneron A, Castets F. Cloning of human striatin cDNA (STRN), gene mapping to 2p22- p21, and preferential expression in brain. Genomics. 1998;51:136-139.
12. Castets F, Rakitina T, Gaillard S, Moqrich A, Mattei MG, Monneron A. Zinedin, SG2NA, and striatin are calmodulin-binding, WD repeat proteins principally expressed in the brain. J Biol Chem. 2000;275:19970-19977.
13. Pojoga LH, Coutinho P, Rivera A, Yao TM, Maldonado ER, Youte R, Adler GK, Williams J, Turchin A, Williams GH, Romero JR. Activation of the mineralocorticoid receptor increases striatin levels. Am J Hypertens. 2012;25:243-249.
14. Coutinho P, Vega C, Pojoga LH, Rivera A, Prado GN, Yao TM, Adler G, Torres-Grajales M, Maldonado ER, Ramos-Rivera A, Williams JS, Williams G, Romero JR. Aldosterones rapid, nongenomic effects are mediated by striatin: a modulator of aldosterones effect on estrogen action. Endocrinology. 2014;155:2233-2243.
15. Pojoga LH, Williams JS, Yao TM, Kumar A, Raffetto JD, do Nascimento GR, Reslan OM, Adler GK, Williams GH, Shi Y, Khalil RA. Histone demethylase LSD1 deficiency during high-salt diet is associated with enhanced vascular contraction, altered NO-cGMP relaxation pathway, and hypertension. Am J Physiol Heart Circ Physiol. 2011;301:H1862-H1871.
16. Chuengsamarn S, Garza AE, Krug AW, Romero JR, Adler GK, Williams GH, Pojoga LH. Direct renin inhibition modulates insulin resistance in caveolin-1-deficient mice. Metabolism. 2013;62:275-281.
17. Braley LM, Menachery AI, Yao T, Mortensen RM, Williams GH. Effect of progesterone on aldosterone secretion in rats. Endocrinology. 1996;137:4773-4778.
18. Hopkins PN, Lifton RP, Hollenberg NK, Jeunemaitre X, Hallouin MC, Skuppin J, Williams CS, Dluhy RG, Lalouel JM, Williams RR, Williams GH. Blunted renal vascular response to angiotensin II is associated with a common variant of the angiotensinogen gene and obesity. J Hypertens. 1996;14:199-207.
19. Hopkins PN, Hunt SC, Jeunemaitre X, Smith B, Solorio D, Fisher ND, Hollenberg NK, Williams GH. Angiotensinogen genotype affects renal and adrenal responses to angiotensin II in essential hypertension. Circulation. 2002;105:1921-1927.
20. Barrett JC, Fry B, Maller J, Daly MJ. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics. 2005;21:263-265.
21. Pojoga LH, Yao TM, Opsasnick LA, Garza AE, Reslan OM, Adler GK, Williams GH, Khalil RA. Dissociation of hyperglycemia from altered vascular contraction and relaxation mechanisms in caveolin-1 null mice. J Pharmacol Exp Ther. 2014;348:260-270.
22. Good DW. Nongenomic actions of aldosterone on the renal tubule. Hypertension. 2007;49:728-739.
23. Underwood PC, Sun B, Williams JS, Pojoga LH, Raby B, Lasky-Su J, Hunt S, Hopkins PN, Jeunemaitre X, Adler GK, Williams GH. The association of the angiotensinogen gene with insulin sensitivity in humans: a tagging single nucleotide polymorphism and haplotype approach. Metabolism. 2011;60:1150-1157.