Curcumin, a Natural Antioxidant, Acts as a Noncompetitive Inhibitor of Human RNase L in Presence of Its Cofactor 2-5A in Vitro

BioMed Research International

Volumn 2014, Issue , 2014, Pages

  Gupta, Ankush ^a   Rath, Pramod C ^a  

^a JAWAHARLAL NEHRU UNIVERSITY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL FACTOR; COFACTOR 2 5A; CURCUMIN; RIBONUCLEASE L; UNCLASSIFIED DRUG; 2-5A-DEPENDENT RIBONUCLEASE; ANTIOXIDANT; DOUBLE STRANDED RNA; RIBONUCLEASE;

ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG PROTEIN BINDING; DRUG STRUCTURE; ENZYME INHIBITION; IN VITRO STUDY; MOLECULAR DOCKING; MOUSE; NONHUMAN; RNA DEGRADATION; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; CHEMISTRY; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; HUMAN; INNATE IMMUNITY; PROTEIN CONFORMATION; X RAY CRYSTALLOGRAPHY;

MAMMALIA;

ANTIOXIDANTS; CRYSTALLOGRAPHY, X-RAY; CURCUMIN; ENDORIBONUCLEASES; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HUMANS; IMMUNITY, INNATE; MOLECULAR DOCKING SIMULATION; PROTEIN CONFORMATION; RNA, DOUBLE-STRANDED;

EID: 84919454547     PISSN: 23146133     EISSN: 23146141     Source Type: Journal    
DOI: 10.1155/2014/817024     Document Type: Article

References (30)

1. C. Bisbal and R. H. Silverman, "Diverse functions of RNase L and implications in pathology, " Biochimie, vol. 89, no. 6-7, pp. 789-798, 2007.
2. M. Nakanishi, Y. Goto, and Y. Kitade, "2-5A induces a conformational change in the ankyrin-repeat domain of RNase L, " Proteins: A Structure, Function and Genetics, vol. 60, no. 1, pp. 131-138, 2005.
3. R. H. Silverman, "Implications for RNase L in prostate cancer biology, " Biochemistry, vol. 42, no. 7, pp. 1805-1812, 2003.
4. B. E. Madsen, E. M. Ramos, M. Boulard et al., "Germline mutation in RNASEL predicts increased risk of head and neck, uterine cervix and breast cancer, " PLoSONE, vol. 3, no.6, Article ID e2492, 2008.
5. M. Frémont, K.ElBakkouri, F. Vaeyens, C. V. Herst, K. deMeirleir, and P. Englebienne, "2′, 5′-Oligoadenylate size is critical to protect RNase L against proteolytic cleavage in chronic fatigue syndrome, " Experimental and Molecular Pathology, vol. 78, no. 3, pp. 239-246, 2005.
6. M. Pandey, G. D. Bajaj, and P. C. Rath, "Induction of the interferon-inducible RNA-degrading enzyme, RNase L, by stress-inducing agents in the human cervical carcinoma cells, " RNA Biology, vol. 1, no. 1, pp. 21-27, 2004.
7. L. Wang, A. Zhou, S. Vasavada et al., "Elevated Levels of 2′, 5′-linked oligoadenylate-dependent ribonuclease L occur as an early event in colorectal tumorigenesis, " Clinical Cancer Research, vol. 1, no. 11, pp. 1421-1428, 1995.
8. C. Riemer, I. Queck, D. Simon, R. Kurth, and M. Baier, "Identification of upregulated genes in scrapie-infected brain tissue, " Journal of Virology, vol. 74, no. 21, pp. 10245-10248, 2000.
9. F. Le Roy, T. Salehzada, C. Bisbal, J. P. Dougherty, and S. W. Peltz, "A newly discovered function for RNase L in regulating translation termination, Nature Structural & Molecular Biology, vol. 12, no. 6, pp. 505-512, 2005.
10. X.-L. Li, H. J. Ezelle, T.-J. Kang et al., "An essential role for the antiviral endoribonuclease, RNase-L, in antibacterial immunity, " Proceedings of the National Academy of Sciences of the United States of America, vol. 105, no. 52, pp. 20816-20821, 2008.
11. B. B. Aggarwal and B. Sung, "Pharmacological basis for the role of curcumin in chronic diseases: A n age-old spice with modern targets, " Trends in Pharmacological Sciences, vol. 30, no. 2, pp. 85-94, 2009.
12. A.Zhou, B. A. Hassel, and R. H. Silverman, "Expressioncloning of 2-5A-dependent RNAase: A uniquely regulated mediator of interferon action, " Cell, vol. 72, no. 5, pp. 753-765, 1993.
13. A. Gupta and P. C. Rath, "Expression, purification and characterization of the interferon-inducible, antiviral and tumoursuppressor protein, human RNase L, " Journal of Biosciences, vol. 37, no. 1, pp. 103-113, 2012.
14. A. Yoshimura, M. Nakanishi, C. Yatome, and Y. Kitade, "Comparative study on the biological properties of 2′, 5′- oligoadenylate derivatives with purified human RNase L expressed in E. coli, " Journal of Biochemistry, vol. 132, no. 4, pp. 643-648, 2002.
15. C. Auffray and F. Rougeon, "Purification of mouse immunoglobulin heavy-chain messenger RNAs from total myeloma tumor RNA, " European Journal of Biochemistry, vol. 107, no. 2, pp. 303-314, 1980.
16. H. Yuchen, J. Donovan, S. Rath, G. Whitney, A. Chitrakar, and A. Korennykh, "Structure of human RNase L reveals the basis for regulated RNA decay in the IFN response, " Science, vol. 343, pp. 1244-1248, 2014.
17. B. Huang, "Metapocket: A meta approach to improve protein ligand binding site prediction, " OMICS: A Journal of Integrative Biology, vol. 13, no. 4, pp. 325-330, 2009.
18. O. Trott and A. J. Olson, "AutoDock Vina: A improving the speed and accuracy of docking with a new scoring function, efficient optimization and multithreading, " Journal of Computational Chemistry, vol. 31, no. 2, pp. 455-461, 2010.
19. A. Majhi, G. M. Rahman, S. Panchal, and J. Das, "Binding of curcumin and its long chain derivatives to the activator binding domain of novel protein kinase C, " Bioorganic and Medicinal Chemistry, vol. 18, no. 4, pp. 1591-1598, 2010.
20. A. Goel, A. B. Kunnumakkara, and B. B. Aggarwal, "Curcumin as Curecumin: A from kitchen to clinic, " Biochemical Pharmacology, vol. 75, no. 4, pp. 787-809, 2008.
21. H. Haung, E. Zeqiraj, B. Dong et al., "Dimeric structure of pseudokinase RNase L bound to 2-5A reveals a basis for interferon-induced antiviral activity, Molecular Cell, vol. 53, no. 2, pp. 221-234, 2014.
22. H. Gradišar, M. M. Keber, P. Pristovšek, and R. Jerala, "MD-2 as the target of curcumin in the inhibition of response to LPS, " Journal of Leukocyte Biology, vol. 82, no. 4, pp. 968-974, 2007.
23. F. Zsila, Z. Bikádi, and M. Simonyi, "Induced circular dichroism spectra reveal binding of the antiinflammatory curcumin to human α1-acid glycoprotein, " Bioorganic & Medicinal Chemistry, vol. 12, no. 12, pp. 3239-3245, 2004.
24. B. Dong and R. H. Silverman, "A bipartite model of 2-5Adependent RNase L, " Journal of Biological Chemistry, vol. 272, no. 35, pp. 22236-22242, 1997.
25. B.A.Hassel, A. Zhou, C. Sotomayor, A.Maran, and R. H. Silverman, "A dominant negative mutant of 2-5A-dependent RNase suppresses antiproliferative and antiviral effects of interferon, " EMBO Journal, vol. 12, no. 8, pp. 3297-3304, 1993.
26. M. Nakanishi, A. Yoshimura, N. Ishida, Y. Ueno, and Y. Kitade, "Contribution of Tyr712 and Phe716 to the activity of human RNase L, " European Journal of Biochemistry, vol. 271, no. 13, pp. 2737-2744, 2004.
27. C. S.Thakur, B.K. Jha, B.Dong et al., "Small-molecule activators of RNase L with broad-spectrum antiviral activity, " Proceedings of the National Academy of Sciences of the United States of America, vol. 104, no. 23, pp. 9585-9590, 2007.
28. S. Singh and B. B. Aggarwal, "Activation of transcription factor NF-κB is suppressed by curcumin (diferuloylmethane), " The Journal of Biological Chemistry, vol. 270, no. 42, pp. 24995-25000, 1995.
29. G. Gomez, G. Mansouraty, J. Gardea, and M. Narayan, "Acceleration of oxidative protein folding by curcumin through novel non-redox chemistry, " Biochemical and Biophysical Research Communications, vol. 364, no. 3, pp. 561-566, 2007.
30. A. Gupta and P. C. Rath, "Expression of mRNA and proteinprotein interaction of the antiviral endoribonuclease RNase L in mouse spleen, " International Journal of Biological Macromolecules, vol. 69, pp. 307-318, 2014.