메뉴 건너뛰기




Volumn 55, Issue 12, 2014, Pages 2785-2792

NOTCH1, SF3B1, BIRC3 and TP53 mutations in patients with chronic lymphocytic leukemia undergoing first-line treatment: Correlation with biological parameters and response to treatment

Author keywords

Chronic lymphocytic leukemia; First line treatment; Novel gene mutations

Indexed keywords

ALEMTUZUMAB; BIRC3 PROTEIN; CHLORAMBUCIL; CYCLOPHOSPHAMIDE; FLUDARABINE; NOTCH1 RECEPTOR; PROTEIN; PROTEIN KINASE ZAP 70; PROTEIN P53; RITUXIMAB; SF3B1 PROTEIN; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; BIRC3 PROTEIN, HUMAN; INHIBITOR OF APOPTOSIS PROTEIN; PHOSPHOPROTEIN; SF3B1 PROTEIN, HUMAN; SMALL NUCLEAR RIBONUCLEOPROTEIN; UBIQUITIN PROTEIN LIGASE;

EID: 84919452026     PISSN: 10428194     EISSN: 10292403     Source Type: Journal    
DOI: 10.3109/10428194.2014.898760     Document Type: Article
Times cited : (42)

References (37)
  • 1
    • 72949093335 scopus 로고    scopus 로고
    • From pathogenesistotreatment of chronic lymphocytic leukaemia
    • Zenz T, Mertens D, Küppers R, et al. From pathogenesistotreatment of chronic lymphocytic leukaemia. Nat Rev Cancer 2010; 10: 37-50.
    • (2010) Nat Rev Cancer , vol.10 , pp. 37-50
    • Zenz, T.1    Mertens, D.2    Küppers, R.3
  • 2
    • 0033567907 scopus 로고    scopus 로고
    • Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia
    • Hamblin TJ, Davis Z, Gardiner A, et al. Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia. Blood 1999;94:1848-1854.
    • (1999) Blood , vol.94 , pp. 1848-1854
    • Hamblin, T.J.1    Davis, Z.2    Gardiner, A.3
  • 3
    • 0033567968 scopus 로고    scopus 로고
    • Ig v gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia
    • Damle RN, Wasil T, Fais F, et al. Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia. Blood 1999;94:1840-1847.
    • (1999) Blood , vol.94 , pp. 1840-1847
    • Damle, R.N.1    Wasil, T.2    Fais, F.3
  • 4
    • 0036464608 scopus 로고    scopus 로고
    • CD38 expression and immunoglobulin variable region mutations are independent prognostic variables in chronic lymphocytic leukemia, but CD38 expression may vary during the course of the disease
    • Hamblin TJ, Orchard JA, Ibbotson RE, et al. CD38 expression and immunoglobulin variable region mutations are independent prognostic variables in chronic lymphocytic leukemia, but CD38 expression may vary during the course of the disease. Blood 2002;99:1023-1029.
    • (2002) Blood , vol.99 , pp. 1023-1029
    • Hamblin, T.J.1    Orchard, J.A.2    Ibbotson, R.E.3
  • 5
    • 24944501362 scopus 로고    scopus 로고
    • The prognostic value of CD38 expression in chronic lymphocytic leukaemia patients studied prospectively at diagnosis: A single institute experience
    • Gentile M, Mauro FR, Calabrese E, et al. The prognostic value of CD38 expression in chronic lymphocytic leukaemia patients studied prospectively at diagnosis: a single institute experience. Br J Haematol 2005;130:549-557.
    • (2005) Br J Haematol , vol.130 , pp. 549-557
    • Gentile, M.1    Mauro, F.R.2    Calabrese, E.3
  • 6
    • 0037406968 scopus 로고    scopus 로고
    • ZAP-70 expression as a surrogate for immunoglobulin-variable-region mutations in chronic lymphocytic leukemia
    • Crespo M, Bosch F, Villamor N, et al. ZAP-70 expression as a surrogate for immunoglobulin-variable-region mutations in chronic lymphocytic leukemia. N Engl J Med 2003;348:1764-1775.
    • (2003) N Engl J Med , vol.348 , pp. 1764-1775
    • Crespo, M.1    Bosch, F.2    Villamor, N.3
  • 7
    • 4143105617 scopus 로고    scopus 로고
    • ZAP-70 compared with immunoglobulin heavy-chain gene mutation status as a predictor of disease progression in chronic lymphocytic leukemia
    • Rassenti LZ, Huynh L, Toy TL, et al. ZAP-70 compared with immunoglobulin heavy-chain gene mutation status as a predictor of disease progression in chronic lymphocytic leukemia. N Engl J Med 2004;351:893-901.
    • (2004) N Engl J Med , vol.351 , pp. 893-901
    • Rassenti, L.Z.1    Huynh, L.2    Toy, T.L.3
  • 8
    • 0034727833 scopus 로고    scopus 로고
    • Genomic aberrations and survival in chronic lymphocytic leukemia
    • Döhner H, Stilgenbauer S, Benner A, et al. Genomic aberrations and survival in chronic lymphocytic leukemia. N Engl J Med 2000; 343: 1910-1916.
    • (2000) N Engl J Med , vol.343 , pp. 1910-1916
    • Döhner, H.1    Stilgenbauer, S.2    Benner, A.3
  • 9
    • 77957664665 scopus 로고    scopus 로고
    • Addition of rituximab to fludarabine and cyclophosphamide in patients with chronic lymphocytic leukaemia: A randomised, open-label, phase 3 trial
    • Hallek M, Fischer K, Fingerle-Rowson G, et al. Addition of rituximab to fludarabine and cyclophosphamide in patients with chronic lymphocytic leukaemia: a randomised, open-label, phase 3 trial. Lancet 2010;376:1164-1174.
    • (2010) Lancet , vol.376 , pp. 1164-1174
    • Hallek, M.1    Fischer, K.2    Fingerle-Rowson, G.3
  • 10
    • 69849107362 scopus 로고    scopus 로고
    • Subcutaneous alemtuzumab in fludarabine-refractory chronic lymphocytic leukemia:clinical results and prognostic marker analyses from the CLL2H study of the German Chronic Lymphocytic Leukemia Study Group
    • Stilgenbauer S, Zenz T, Winkler D, et al. Subcutaneous alemtuzumab in fludarabine-refractory chronic lymphocytic leukemia:clinical results and prognostic marker analyses from the CLL2H study of the German Chronic Lymphocytic Leukemia Study Group. J Clin Oncol 2009;27:3994-4001.
    • (2009) J Clin Oncol , vol.27 , pp. 3994-4001
    • Stilgenbauer, S.1    Zenz, T.2    Winkler, D.3
  • 11
    • 79960036578 scopus 로고    scopus 로고
    • Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia
    • Puente XS, Pinyol M, Quesada V, et al. Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia. Nature 2011;475:101-105.
    • (2011) Nature , vol.475 , pp. 101-105
    • Puente, X.S.1    Pinyol, M.2    Quesada, V.3
  • 12
    • 77958567414 scopus 로고    scopus 로고
    • NOTCH1 PEST domain mutation is an adverse prognostic factor in B-CLL
    • Sportoletti P, Baldoni S, Cavalli L, et al. NOTCH1 PEST domain mutation is an adverse prognostic factor in B-CLL. Br J Haematol 2010;151:404-406.
    • (2010) Br J Haematol , vol.151 , pp. 404-406
    • Sportoletti, P.1    Baldoni, S.2    Cavalli, L.3
  • 13
    • 79960353160 scopus 로고    scopus 로고
    • Analysis of the chronic lymphocytic leukemia coding genome:role of NOTCH1 mutational activation
    • Fabbri G, Rasi S, Rossi D, et al. Analysis of the chronic lymphocytic leukemia coding genome:role of NOTCH1 mutational activation. J Exp Med 2011;208:1389-1401.
    • (2011) J Exp Med , vol.208 , pp. 1389-1401
    • Fabbri, G.1    Rasi, S.2    Rossi, D.3
  • 14
    • 84855854025 scopus 로고    scopus 로고
    • Mutations of NOTCH1 are an independent predictor of survival in chronic lymphocytic leukemia
    • Rossi D, Rasi S, Fabbri G, et al. Mutations of NOTCH1 are an independent predictor of survival in chronic lymphocytic leukemia. Blood 2012;119:521-529.
    • (2012) Blood , vol.119 , pp. 521-529
    • Rossi, D.1    Rasi, S.2    Fabbri, G.3
  • 15
    • 84855860383 scopus 로고    scopus 로고
    • NOTCH1 mutations in CLL associated with trisomy 12
    • Balatti V, Bottoni A, Palamarchuk A, et al. NOTCH1 mutations in CLL associated with trisomy 12. Blood 2012;119:329-531.
    • (2012) Blood , vol.119 , pp. 329-531
    • Balatti, V.1    Bottoni, A.2    Palamarchuk, A.3
  • 16
    • 84857739865 scopus 로고    scopus 로고
    • NOTCH1 mutations in +12 chronic lymphocytic leukemia (CLL) confer an unfavorable prognosis, induce a distinctive transcriptional Profiling and ref ne the intermediate prognosis of + 12 CLL
    • Del Giudice I, Rossi D, Chiaretti S, et al. NOTCH1 mutations in +12 chronic lymphocytic leukemia (CLL) confer an unfavorable prognosis, induce a distinctive transcriptional Profiling and ref ne the intermediate prognosis of + 12 CLL. Haematologica 2012;97:437-441.
    • (2012) Haematologica , vol.97 , pp. 437-441
    • Del Giudice, I.1    Rossi, D.2    Chiaretti, S.3
  • 17
    • 84255160977 scopus 로고    scopus 로고
    • Mutations of the SF3B1 splicing factor in chronic lymphocytic leukemia:Association with progression and fludarabine-refractoriness
    • Rossi D, Bruscaggin A, Spina V, et al. Mutations of the SF3B1 splicing factor in chronic lymphocytic leukemia:Association with progression and fludarabine-refractoriness. Blood 2012; 118: 6904-6908.
    • (2012) Blood , vol.118 , pp. 6904-6908
    • Rossi, D.1    Bruscaggin, A.2    Spina, V.3
  • 18
    • 84855370035 scopus 로고    scopus 로고
    • SF3B1 and other novel cancer genes in chronic lymphocytic leukemia
    • Wang L, Lawrence MS, Wan Y, et al. SF3B1 and other novel cancer genes in chronic lymphocytic leukemia. N Engl J Med 2011;365:2497-506.
    • (2011) N Engl J Med , vol.365 , pp. 2497-2506
    • Wang, L.1    Lawrence, M.S.2    Wan, Y.3
  • 19
    • 84555171449 scopus 로고    scopus 로고
    • Exome sequencing identifies recurrent mutations of the splicing factor SF3B1 gene in chronic lymphocytic leukemia. Exome sequencing identifies recurrent mutations of the splicing factor SF3B1 gene in chronic lymphocytic leukemia
    • Quesada V, Conde L, Villamor N, et al. Exome sequencing identifies recurrent mutations of the splicing factor SF3B1 gene in chronic lymphocytic leukemia. Exome sequencing identifies recurrent mutations of the splicing factor SF3B1 gene in chronic lymphocytic leukemia. Nat Genet 2011; 44: 47-52.
    • (2011) Nat Genet , vol.44 , pp. 47-52
    • Quesada, V.1    Conde, L.2    Villamor, N.3
  • 20
    • 84858859064 scopus 로고    scopus 로고
    • Disruption of BIRC3 associates with fludarabine chemorefractoriness in TP53 wild-type chronic lymphocytic leukemia
    • Rossi D, Fangazio M, Rasi S, et al. Disruption of BIRC3 associates with fludarabine chemorefractoriness in TP53 wild-type chronic lymphocytic leukemia. Blood 2012; 119: 2854-2862.
    • (2012) Blood , vol.119 , pp. 2854-2862
    • Rossi, D.1    Fangazio, M.2    Rasi, S.3
  • 21
    • 84877015707 scopus 로고    scopus 로고
    • Clinical implications of the molecular genetics of chronic lymphocytic leukemia
    • Foà R, Del Giudice I, Guarini A, et al. Clinical implications of the molecular genetics of chronic lymphocytic leukemia. Haematologica 2013; 98: 675-685.
    • (2013) Haematologica , vol.98 , pp. 675-685
    • Foà R, D.1
  • 22
    • 84874428346 scopus 로고    scopus 로고
    • Integrated mutational and cytogenetic analysis identifies new prognostic subgroups in chronic lymphocytic leukemia
    • Rossi D, Rasi S, Spina V, et al. Integrated mutational and cytogenetic analysis identifies new prognostic subgroups in chronic lymphocytic leukemia. Blood 2013; 121: 1403-1412.
    • (2013) Blood , vol.121 , pp. 1403-1412
    • Rossi, D.1    Rasi, S.2    Spina, V.3
  • 23
    • 84872469222 scopus 로고    scopus 로고
    • The clinical significance of NOTCH1 and SF3B1 mutations in the UK LRF CLL4 trial
    • Oscier DG, Rose-Zerilli MJ, Winkelmann N, et al. The clinical significance of NOTCH1 and SF3B1 mutations in the UK LRF CLL4 trial. Blood 2013;121:468-475.
    • (2013) Blood , vol.121 , pp. 468-475
    • Oscier, D.G.1    Rose-Zerilli, M.J.2    Winkelmann, N.3
  • 24
    • 84887204270 scopus 로고    scopus 로고
    • NOTCH1, SF3B1 and TP53 mutations in fludarabine-refractory CLL patients treated with alemtuzumab: Results from the CLL2H trial of the GCLLSG
    • Schnaiter A, Paschka P, Rossi M, et al. NOTCH1, SF3B1 and TP53 mutations in fludarabine-refractory CLL patients treated with alemtuzumab: results from the CLL2H trial of the GCLLSG. Blood 2013;122:1266-70.
    • (2013) Blood , vol.122 , pp. 1266-1270
    • Schnaiter, A.1    Paschka, P.2    Rossi, M.3
  • 25
    • 84892510314 scopus 로고    scopus 로고
    • Fludarabine plus alemtuzumab (FA) front-line treatment in young patients with chronic lymphocytic leukemia (CLL) and an adverse biologic profle
    • Nov 19. [Epub ahead of print]
    • Mauro FR, Molica S, Laurenti L, et al. Fludarabine plus alemtuzumab (FA) front-line treatment in young patients with chronic lymphocytic leukemia (CLL) and an adverse biologic profle. Leuk Res 2013 Nov 19. [Epub ahead of print]
    • (2013) Leuk Res
    • Mauro, F.R.1    Molica, S.2    Laurenti, L.3
  • 26
    • 84898486579 scopus 로고    scopus 로고
    • Chlorambucil plus rituximab with or without maintenance rituximab as first-line treatment for elderly chronic lymphocytic leukemia patients
    • Jan 11. [Epub ahead of print]
    • Foà R, Del Giudice I, Cuneo A, et al. Chlorambucil plus rituximab with or without maintenance rituximab as first-line treatment for elderly chronic lymphocytic leukemia patients. Am J Hematol 2014 Jan 11. [Epub ahead of print]
    • (2014) Am J Hematol
    • Foà, R.1    Del Giudice, I.2    Cuneo, A.3
  • 27
    • 79953907199 scopus 로고    scopus 로고
    • White blood cell count at diagnosis and immunoglobulin variable region gene mutations are independent predictors of treatment-free survival in young patients with stage A chronic lymphocytic leukemia
    • Del Giudice I, Mauro FR, De Propris MS, et al. White blood cell count at diagnosis and immunoglobulin variable region gene mutations are independent predictors of treatment-free survival in young patients with stage A chronic lymphocytic leukemia. Haematologica 2011;96:626-630.
    • (2011) Haematologica , vol.96 , pp. 626-630
    • Del Giudice, I.1    Mauro, F.R.2    De Propris, M.S.3
  • 28
    • 33845513520 scopus 로고    scopus 로고
    • ERIC recommendations on IGHV gene mutational status analysis in chronic lymphocytic leukemia
    • Ghia P, Stamatopoulos K, Belessi C, et al.; European Research Initiative on CLL. ERIC recommendations on IGHV gene mutational status analysis in chronic lymphocytic leukemia. Leukemia 2007; 21: 1-3.
    • (2007) Leukemia , vol.21 , pp. 1-3
    • Ghia, P.1    Stamatopoulos, K.2    Belessi, C.3
  • 29
    • 84863778287 scopus 로고    scopus 로고
    • ERIC recommendations on TP53 mutation analysis in chronic lymphocytic leukemia
    • Pospisilova S, Gonzalez D, Malcikova J, et al. ERIC recommendations on TP53 mutation analysis in chronic lymphocytic leukemia. Leukemia 2012; 26: 1458-1461.
    • (2012) Leukemia , vol.26 , pp. 1458-1461
    • Pospisilova, S.1    Gonzalez, D.2    Malcikova, J.3
  • 30
    • 0029981025 scopus 로고    scopus 로고
    • National Cancer Institute-sponsored Working Group lymphocytic leukemia: Revised guidelines for diagnosis and treatment
    • Cheson BD, Bennett JM, Grever M, et al. National Cancer Institute-sponsored Working Group lymphocytic leukemia: revised guidelines for diagnosis and treatment. Blood 1996;87:4990-4997.
    • (1996) Blood , vol.87 , pp. 4990-4997
    • Cheson, B.D.1    Bennett, J.M.2    Grever, M.3
  • 31
    • 45149100665 scopus 로고    scopus 로고
    • Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: A report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute-Working Group 1996 guidelines
    • Hallek M, Cheson BD, Catovsky D, et al. Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: a report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute-Working Group 1996 guidelines. Blood 2008;111:5446-5456.
    • (2008) Blood , vol.111 , pp. 5446-5456
    • Hallek, M.1    Cheson, B.D.2    Catovsky, D.3
  • 32
    • 79957949229 scopus 로고    scopus 로고
    • Mutational status of the TP53 gene as a predictor of response and survival in patients with chronic lymphocytic leukemia: Results from the LRF CLL4 trial
    • Gonzalez D, Martinez P, Wade R, et al. Mutational status of the TP53 gene as a predictor of response and survival in patients with chronic lymphocytic leukemia: results from the LRF CLL4 trial. J Clin Oncol 2011;29:2223-2229.
    • (2011) J Clin Oncol , vol.29 , pp. 2223-2229
    • Gonzalez, D.1    Martinez, P.2    Wade, R.3
  • 33
    • 79551504914 scopus 로고    scopus 로고
    • TP53 mutation and survival in chronic lymphocytic leukemia
    • Zenz T, Eichhorst B, Busch R, et al. TP53 mutation and survival in chronic lymphocytic leukemia. J Clin Oncol 2010;28:4473-4479.
    • (2010) J Clin Oncol , vol.28 , pp. 4473-4479
    • Zenz, T.1    Eichhorst, B.2    Busch, R.3
  • 34
    • 61549089361 scopus 로고    scopus 로고
    • The prognostic value of TP53 mutations in chronic lymphocytic leukemia is independent of Del17p13: Implications for overall survival and chemorefractoriness
    • Rossi D, Cerri M, Deambrogi C, et al. The prognostic value of TP53 mutations in chronic lymphocytic leukemia is independent of Del17p13: implications for overall survival and chemorefractoriness. Clin Cancer Res 2009;15:995-1004.
    • (2009) Clin Cancer Res , vol.15 , pp. 995-1004
    • Rossi, D.1    Cerri, M.2    Deambrogi, C.3
  • 35
    • 84874116316 scopus 로고    scopus 로고
    • Gene mutations and treatment outcome in chronic lymphocytic leukemia: Results from the CLL8 trial
    • Stilgenbauer S, Busch R, Schnaiter A, et al. Gene mutations and treatment outcome in chronic lymphocytic leukemia: results from the CLL8 trial. Blood 2012;120(Suppl. 1): Abstract 433.
    • (2012) Blood , vol.120 , pp. 433
    • Stilgenbauer, S.1    Busch, R.2    Schnaiter, A.3
  • 36
    • 84855231198 scopus 로고    scopus 로고
    • ATM gene alterations in chronic lymphocytic leukemia patients induce a distinct gene expression profile and predict disease progression
    • Guarini A, Marinelli M, Tavolaro S, et al. ATM gene alterations in chronic lymphocytic leukemia patients induce a distinct gene expression profile and predict disease progression. Haematologica 2012;97:47-55.
    • (2012) Haematologica , vol.97 , pp. 47-55
    • Guarini, A.1    Marinelli, M.2    Tavolaro, S.3
  • 37
    • 84879173666 scopus 로고    scopus 로고
    • TP53, SF3B1, and NOTCH1 mutations and outcome of allotransplantation for chronic lymphocytic leukemia: Six-year follow-up of the GCLLSG CLL3X trial
    • Dreger P, Schnaiter A, Zenz T, et al. TP53, SF3B1, and NOTCH1 mutations and outcome of allotransplantation for chronic lymphocytic leukemia: six-year follow-up of the GCLLSG CLL3X trial. Blood 2013;121:3284-3288.
    • (2013) Blood , vol.121 , pp. 3284-3288
    • Dreger, P.1    Schnaiter, A.2    Zenz, T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.