메뉴 건너뛰기




Volumn 98, Issue 5, 2013, Pages 675-685

Clinical implications of the molecular genetics of chronic lymphocytic leukemia

Author keywords

[No Author keywords available]

Indexed keywords

ALEMTUZUMAB; ATM PROTEIN; CHLORAMBUCIL; CYCLOPHOSPHAMIDE; FLUDARABINE; METHYLPREDNISOLONE; NOTCH1 RECEPTOR; PROTEIN P53; RITUXIMAB;

EID: 84877015707     PISSN: 03906078     EISSN: 15928721     Source Type: Journal    
DOI: 10.3324/haematol.2012.069369     Document Type: Article
Times cited : (69)

References (120)
  • 2
    • 45149100665 scopus 로고    scopus 로고
    • Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: A report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute-Working Group 1996 guidelines
    • Hallek M, Cheson BD, Catovsky D, Caligaris-Cappio F, Dighiero G, Döhner H, et al. Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: a report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute-Working Group 1996 guidelines. Blood. 2008;111(12): 5446-56.
    • (2008) Blood , vol.111 , Issue.12 , pp. 5446-5456
    • Hallek, M.1    Cheson, B.D.2    Catovsky, D.3    Caligaris-Cappio, F.4    Dighiero, G.5    Döhner, H.6
  • 4
    • 40749132494 scopus 로고    scopus 로고
    • Chronic lymphocytic leukaemia
    • Dighiero G, Hamblin TJ. Chronic lymphocytic leukaemia. Lancet. 2008;371(9617): 1017-29.
    • (2008) Lancet , vol.371 , Issue.9617 , pp. 1017-1029
    • Dighiero, G.1    Hamblin, T.J.2
  • 6
    • 0019427092 scopus 로고
    • A new prognostic classification of chronic lymphocytic leukemia derived from a multivariate survival analysis
    • Binet JL, Auquier A, Dighiero G, Chastang C, Piguet H, Goasguen J, et al. A new prognostic classification of chronic lymphocytic leukemia derived from a multivariate survival analysis. Cancer. 1981;48(1):198-206.
    • (1981) Cancer , vol.48 , Issue.1 , pp. 198-206
    • Binet, J.L.1    Auquier, A.2    Dighiero, G.3    Chastang, C.4    Piguet, H.5    Goasguen, J.6
  • 7
    • 0024255987 scopus 로고
    • Natural history of chronic lymphocytic leukemia: On the progression and progression and prognosis of early clinical stages
    • Montserrat E, Viñolas N, Reverter JC, Rozman C. Natural history of chronic lymphocytic leukemia: on the progression and progression and prognosis of early clinical stages. Nouv Rev Fr Hematol. 1988;30(5-6): 359-61.
    • (1988) Nouv Rev Fr Hematol , vol.30 , Issue.5-6 , pp. 359-361
    • Montserrat, E.1    Viñolas, N.2    Reverter, J.C.3    Rozman, C.4
  • 8
    • 0025132331 scopus 로고
    • Natural history of stage A chronic lymphocytic leukaemia untreated patients
    • French Cooperative Group on Chronic Lymphocytic Leukaemia
    • French Cooperative Group on Chronic Lymphocytic Leukaemia. Natural history of stage A chronic lymphocytic leukaemia untreated patients. Br J Haematol. 1990;76 (1):45-57.
    • (1990) Br J Haematol , vol.76 , Issue.1 , pp. 45-57
  • 9
    • 0344729013 scopus 로고    scopus 로고
    • Chlorambucil in indolent chronic lymphocytic leukemia. French Cooperative Group on Chronic Lymphocytic Leukemia
    • Dighiero G, Maloum K, Desablens B, Cazin B, Navarro M, Leblay R, et al. Chlorambucil in indolent chronic lymphocytic leukemia. French Cooperative Group on Chronic Lymphocytic Leukemia. N Engl J Med. 1998;338(21):1506-14.
    • (1998) N Engl J Med , vol.338 , Issue.21 , pp. 1506-1514
    • Dighiero, G.1    Maloum, K.2    Desablens, B.3    Cazin, B.4    Navarro, M.5    Leblay, R.6
  • 10
    • 79953907199 scopus 로고    scopus 로고
    • White blood cell count at diagnosis and immunoglobulin variable region gene mutations are independent predictors of treatment-free survival in young patients with stage A chronic lymphocytic leukemia
    • Del Giudice I, Mauro FR, De Propris MS, Santangelo S, Marinelli M, Peragine N, et al. White blood cell count at diagnosis and immunoglobulin variable region gene mutations are independent predictors of treatment-free survival in young patients with stage A chronic lymphocytic leukemia. Haematologica. 2011;96(4):626-30.
    • (2011) Haematologica , vol.96 , Issue.4 , pp. 626-630
    • Del Giudice, I.1    Mauro, F.R.2    de Propris, M.S.3    Santangelo, S.4    Marinelli, M.5    Peragine, N.6
  • 11
    • 80755127112 scopus 로고    scopus 로고
    • Multivariable model for time to first treatment in patients with chronic lymphocytic leukemia
    • Wierda WG, O'Brien S, Wang X, Faderl S, Ferrajoli A, Do KA, et al. Multivariable model for time to first treatment in patients with chronic lymphocytic leukemia. J Clin Oncol. 2011;29(31):4088-95.
    • (2011) J Clin Oncol , vol.29 , Issue.31 , pp. 4088-4095
    • Wierda, W.G.1    O'Brien, S.2    Wang, X.3    Faderl, S.4    Ferrajoli, A.5    Do, K.A.6
  • 12
    • 70349260657 scopus 로고    scopus 로고
    • Improving survival in patients with chronic lymphocytic leukemia (1980-2008): The Hospital Clinic of Barcelona experience
    • Abrisqueta P, Pereira A, Rozman C, Aymerich M, Giné E, Moreno C, et al. Improving survival in patients with chronic lymphocytic leukemia (1980-2008): the Hospital Clinic of Barcelona experience. Blood. 2009;114(10):2044-50.
    • (2009) Blood , vol.114 , Issue.10 , pp. 2044-2050
    • Abrisqueta, P.1    Pereira, A.2    Rozman, C.3    Aymerich, M.4    Giné, E.5    Moreno, C.6
  • 13
    • 59449108884 scopus 로고    scopus 로고
    • Validation of a new prognostic index for patients with chronic lymphocytic leukemia
    • Shanafelt TD, Jenkins G, Call TG, Zent CS, Slager S, Bowen DA, et al. Validation of a new prognostic index for patients with chronic lymphocytic leukemia. Cancer. 2009;115(2):363-72.
    • (2009) Cancer , vol.115 , Issue.2 , pp. 363-372
    • Shanafelt, T.D.1    Jenkins, G.2    Call, T.G.3    Zent, C.S.4    Slager, S.5    Bowen, D.A.6
  • 14
    • 78349244388 scopus 로고    scopus 로고
    • Age at diagnosis and the utility of prognostic testing in patients with chronic lymphocytic leukemia
    • Shanafelt TD, Rabe KG, Kay NE, Zent CS, Jelinek DF, Reinalda MS, et al. Age at diagnosis and the utility of prognostic testing in patients with chronic lymphocytic leukemia. Cancer. 2010;116(20):4777-87.
    • (2010) Cancer , vol.116 , Issue.20 , pp. 4777-4787
    • Shanafelt, T.D.1    Rabe, K.G.2    Kay, N.E.3    Zent, C.S.4    Jelinek, D.F.5    Reinalda, M.S.6
  • 15
    • 79959214932 scopus 로고    scopus 로고
    • Multicentre validation of a prognostic index for overall survival in chronic lymphocytic leukaemia
    • Bulian P, Tarnani M, Rossi D, Forconi F, Del Poeta G, Bertoni F, et al. Multicentre validation of a prognostic index for overall survival in chronic lymphocytic leukaemia. Hematol Oncol. 2011;29(2):91-9.
    • (2011) Hematol Oncol , vol.29 , Issue.2 , pp. 91-99
    • Bulian, P.1    Tarnani, M.2    Rossi, D.3    Forconi, F.4    Del Poeta, G.5    Bertoni, F.6
  • 16
    • 0025112785 scopus 로고
    • Prognostic subgroups in B-cell chronic lymphocytic leukemia defined by specific chromosomal abnormalities
    • Juliusson G, Oscier DG, Fitchett M, Ross FM, Stockdill G, Mackie MJ, et al. Prognostic subgroups in B-cell chronic lymphocytic leukemia defined by specific chromosomal abnormalities. N Engl J Med. 1990;323(11): 720-4.
    • (1990) N Engl J Med , vol.323 , Issue.11 , pp. 720-724
    • Juliusson, G.1    Oscier, D.G.2    Fitchett, M.3    Ross, F.M.4    Stockdill, G.5    Mackie, M.J.6
  • 18
    • 54049141334 scopus 로고    scopus 로고
    • Monoallelic TP53 inactivation is associated with poor prognosis in chronic lymphocytic leukemia: Results from a detailed genetic characterization with long-term follow-up
    • Zenz T, Kröber A, Scherer K, Häbe S, Bühler A, Benner A, et al. Monoallelic TP53 inactivation is associated with poor prognosis in chronic lymphocytic leukemia: results from a detailed genetic characterization with long-term follow-up. Blood. 2008;112(8): 3322-9.
    • (2008) Blood , vol.112 , Issue.8 , pp. 3322-3329
    • Zenz, T.1    Kröber, A.2    Scherer, K.3    Häbe, S.4    Bühler, A.5    Benner, A.6
  • 19
    • 61549089361 scopus 로고    scopus 로고
    • The prognostic value of TP53 mutations in chronic lymphocytic leukemia is independent of Del17p13: Implications for overall survival and chemorefractoriness
    • Rossi D, Cerri M, Deambrogi C, Sozzi E, Cresta S, Rasi S, et al. The prognostic value of TP53 mutations in chronic lymphocytic leukemia is independent of Del17p13: implications for overall survival and chemorefractoriness. Clin Cancer Res. 2009;15(3):995-1004.
    • (2009) Clin Cancer Res , vol.15 , Issue.3 , pp. 995-1004
    • Rossi, D.1    Cerri, M.2    Deambrogi, C.3    Sozzi, E.4    Cresta, S.5    Rasi, S.6
  • 20
    • 73949135028 scopus 로고    scopus 로고
    • Monoallelic and biallelic inactivation of TP53 gene in chronic lymphocytic leukemia: Selection, impact on survival, and response to DNA damage
    • Malcikova J, Smardova J, Rocnova L, Tichy B, Kuglik P, Vranova V, et al. Monoallelic and biallelic inactivation of TP53 gene in chronic lymphocytic leukemia: selection, impact on survival, and response to DNA damage. Blood. 2009;114(26):5307-14.
    • (2009) Blood , vol.114 , Issue.26 , pp. 5307-5314
    • Malcikova, J.1    Smardova, J.2    Rocnova, L.3    Tichy, B.4    Kuglik, P.5    Vranova, V.6
  • 21
    • 58249117812 scopus 로고    scopus 로고
    • The detection of TP53 mutations in chronic lymphocytic leukemia independently predicts rapid disease progression and is highly correlated with a complex aberrant karyotype
    • Dicker F, Herholz H, Schnittger S, Nakao A, Patten N, Wu L, et al. The detection of TP53 mutations in chronic lymphocytic leukemia independently predicts rapid disease progression and is highly correlated with a complex aberrant karyotype. Leukemia. 2009; 23(1):117-24.
    • (2009) Leukemia , vol.23 , Issue.1 , pp. 117-124
    • Dicker, F.1    Herholz, H.2    Schnittger, S.3    Nakao, A.4    Patten, N.5    Wu, L.6
  • 22
    • 0033566329 scopus 로고    scopus 로고
    • Somatic ATM mutations indicate a pathogenic role of ATM in Bcell chronic lymphocytic leukemia
    • Schaffner C, Stilgenbauer S, Rappold GA, Döhner H, Lichter P. Somatic ATM mutations indicate a pathogenic role of ATM in Bcell chronic lymphocytic leukemia. Blood. 1999;94(2):748-53.
    • (1999) Blood , vol.94 , Issue.2 , pp. 748-753
    • Schaffner, C.1    Stilgenbauer, S.2    Rappold, G.A.3    Döhner, H.4    Lichter, P.5
  • 23
    • 0033513587 scopus 로고    scopus 로고
    • Inactivation of ataxia telangiectasia mutated gene in B-cell chronic lymphocytic leukaemia
    • Stankovic T, Weber P, Stewart G, Bedenham T, Murray J, Byrd PJ, et al. Inactivation of ataxia telangiectasia mutated gene in B-cell chronic lymphocytic leukaemia. Lancet. 1999;353(9146):26-9.
    • (1999) Lancet , vol.353 , Issue.9146 , pp. 26-29
    • Stankovic, T.1    Weber, P.2    Stewart, G.3    Bedenham, T.4    Murray, J.5    Byrd, P.J.6
  • 24
    • 27644450586 scopus 로고    scopus 로고
    • Mutations in the ATM gene lead to impaired overall and treatment-free survival that is independent of IGVH mutation status in patients with BCLL
    • Austen B, Powell JE, Alvi A, Edwards I, Hooper L, Starczynski J, et al. Mutations in the ATM gene lead to impaired overall and treatment-free survival that is independent of IGVH mutation status in patients with BCLL. Blood. 2005;106(9):3175-82.
    • (2005) Blood , vol.106 , Issue.9 , pp. 3175-3182
    • Austen, B.1    Powell, J.E.2    Alvi, A.3    Edwards, I.4    Hooper, L.5    Starczynski, J.6
  • 25
    • 84855231198 scopus 로고    scopus 로고
    • ATM gene alterations in chronic lymphocytic leukemia patients induce a distinct gene expression profile and predict disease progression
    • Guarini A, Marinelli M, Tavolaro S, Bellacchio E, Magliozzi M, Chiaretti S, et al. ATM gene alterations in chronic lymphocytic leukemia patients induce a distinct gene expression profile and predict disease progression. Haematologica. 2012;97(1):47-55.
    • (2012) Haematologica , vol.97 , Issue.1 , pp. 47-55
    • Guarini, A.1    Marinelli, M.2    Tavolaro, S.3    Bellacchio, E.4    Magliozzi, M.5    Chiaretti, S.6
  • 26
    • 79960353160 scopus 로고    scopus 로고
    • Analysis of the chronic lymphocytic leukemia coding genome: Role of NOTCH1 mutational activation
    • Fabbri G, Rasi S, Rossi D, Trifonov V, Khiabanian H, Ma J, et al. Analysis of the chronic lymphocytic leukemia coding genome: role of NOTCH1 mutational activation. J Exp Med. 2011;208(7):1389-401.
    • (2011) J Exp Med , vol.208 , Issue.7 , pp. 1389-1401
    • Fabbri, G.1    Rasi, S.2    Rossi, D.3    Trifonov, V.4    Khiabanian, H.5    Ma, J.6
  • 27
    • 79960036578 scopus 로고    scopus 로고
    • Wholegenome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia
    • Puente XS, Pinyol M, Quesada V, Conde L, Ordóñez GR, Villamor N, et al. Wholegenome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia. Nature. 2011;475(7354):101-5.
    • (2011) Nature , vol.475 , Issue.7354 , pp. 101-105
    • Puente, X.S.1    Pinyol, M.2    Quesada, V.3    Conde, L.4    Ordóñez, G.R.5    Villamor, N.6
  • 28
    • 84555171449 scopus 로고    scopus 로고
    • Exome sequencing identifies recurrent mutations of the splicing factor SF3B1 gene in chronic lymphocytic leukemia
    • Quesada V, Conde L, Villamor N, Ordóñez GR, Jares P, Bassaganyas L, et al. Exome sequencing identifies recurrent mutations of the splicing factor SF3B1 gene in chronic lymphocytic leukemia. Nat Genet. 2011;44 (1):47-52.
    • (2011) Nat Genet , vol.44 , Issue.1 , pp. 47-52
    • Quesada, V.1    Conde, L.2    Villamor, N.3    Ordóñez, G.R.4    Jares, P.5    Bassaganyas, L.6
  • 29
    • 84255160977 scopus 로고    scopus 로고
    • Mutations of the SF3B1 splicing factor in chronic lymphocytic leukemia: Association with progression and fludarabine-refractoriness
    • Rossi D, Bruscaggin A, Spina V, Rasi S, Khiabanian H, Messina M, et al. Mutations of the SF3B1 splicing factor in chronic lymphocytic leukemia: association with progression and fludarabine-refractoriness. Blood. 2011;118(26):6904-8.
    • (2011) Blood , vol.118 , Issue.26 , pp. 6904-6908
    • Rossi, D.1    Bruscaggin, A.2    Spina, V.3    Rasi, S.4    Khiabanian, H.5    Messina, M.6
  • 30
  • 32
    • 84855854025 scopus 로고    scopus 로고
    • Mutations of NOTCH1 are an independent predictor of survival in chronic lymphocytic leukemia
    • Rossi D, Rasi S, Fabbri G, Spina V, Fangazio M, Forconi F, et al. Mutations of NOTCH1 are an independent predictor of survival in chronic lymphocytic leukemia. Blood. 2012;119(2):521-9.
    • (2012) Blood , vol.119 , Issue.2 , pp. 521-529
    • Rossi, D.1    Rasi, S.2    Fabbri, G.3    Spina, V.4    Fangazio, M.5    Forconi, F.6
  • 33
    • 84858859064 scopus 로고    scopus 로고
    • Disruption of BIRC3 associates with fludarabine chemorefractoriness in TP53 wild-type chronic lymphocytic leukemia
    • Rossi D, Fangazio M, Rasi S, Vaisitti T, Monti S, Cresta S, et al. Disruption of BIRC3 associates with fludarabine chemorefractoriness in TP53 wild-type chronic lymphocytic leukemia. Blood. 2012;119(12):2854-62.
    • (2012) Blood , vol.119 , Issue.12 , pp. 2854-2862
    • Rossi, D.1    Fangazio, M.2    Rasi, S.3    Vaisitti, T.4    Monti, S.5    Cresta, S.6
  • 35
    • 78650307334 scopus 로고    scopus 로고
    • TP53 mutation profile in chronic lymphocytic leukemia: Evidence for a disease specific profile from a comprehensive analysis of 268 mutations
    • Zenz T, Vollmer D, Trbusek M, Smardova J, Benner A, Soussi T, et al. TP53 mutation profile in chronic lymphocytic leukemia: evidence for a disease specific profile from a comprehensive analysis of 268 mutations. Leukemia. 2010;24(12):2072-9.
    • (2010) Leukemia , vol.24 , Issue.12 , pp. 2072-2079
    • Zenz, T.1    Vollmer, D.2    Trbusek, M.3    Smardova, J.4    Benner, A.5    Soussi, T.6
  • 36
    • 84874532132 scopus 로고    scopus 로고
    • Identification of molecular and functional patterns of p53 alterations in chronic lymphocytic leukemia patients in different phases of the disease
    • Marinelli M, Peragine N, Di Maio V, Chiaretti S, De Propris MS, Raponi S, et al. Identification of molecular and functional patterns of p53 alterations in chronic lymphocytic leukemia patients in different phases of the disease. Haematologica. 2013;98 (3):371-5.
    • (2013) Haematologica , vol.98 , Issue.3 , pp. 371-375
    • Marinelli, M.1    Peragine, N.2    Di Maio, V.3    Chiaretti, S.4    de Propris, M.S.5    Raponi, S.6
  • 37
    • 84865433349 scopus 로고    scopus 로고
    • DNA damage checkpoints in stem cells, ageing and cancer
    • Sperka T, Wang J, Rudolph KL. DNA damage checkpoints in stem cells, ageing and cancer. Nat Rev Mol Cell Biol. 2012;13(9): 579-90.
    • (2012) Nat Rev Mol Cell Biol , vol.13 , Issue.9 , pp. 579-590
    • Sperka, T.1    Wang, J.2    Rudolph, K.L.3
  • 38
    • 84867231324 scopus 로고    scopus 로고
    • Incidence and clinical implications of ATM aberrations in chronic lymphocytic leukemia
    • Ouillette P, Li J, Shaknovich R, Li Y, Melnick A, Shedden K, et al. Incidence and clinical implications of ATM aberrations in chronic lymphocytic leukemia. Genes Chromosomes Cancer. 2012;51(12):1125-32.
    • (2012) Genes Chromosomes Cancer , vol.51 , Issue.12 , pp. 1125-1132
    • Ouillette, P.1    Li, J.2    Shaknovich, R.3    Li, Y.4    Melnick, A.5    Shedden, K.6
  • 39
    • 84871798242 scopus 로고    scopus 로고
    • Biallelic ATM Inactivation Significantly Reduces Survival in Patients Treated on the United Kingdom Leukemia Research Fund Chronic Lymphocytic Leukemia 4 Trial
    • Skowronska A, Parker A, Ahmed G, Oldreive C, Davis Z, Richards S, et al. Biallelic ATM Inactivation Significantly Reduces Survival in Patients Treated on the United Kingdom Leukemia Research Fund Chronic Lymphocytic Leukemia 4 Trial. J Clin Oncol. 2012;30(36):4524-32.
    • (2012) J Clin Oncol , vol.30 , Issue.36 , pp. 4524-4532
    • Skowronska, A.1    Parker, A.2    Ahmed, G.3    Oldreive, C.4    Davis, Z.5    Richards, S.6
  • 40
    • 80555129351 scopus 로고    scopus 로고
    • Oncogenic and tumor suppressor functions of Notch in cancer: It's NOTCH what you think
    • Lobry C, Oh P, Aifantis I. Oncogenic and tumor suppressor functions of Notch in cancer: it's NOTCH what you think. J Exp Med. 2011;208(10):1931-5.
    • (2011) J Exp Med , vol.208 , Issue.10 , pp. 1931-1935
    • Lobry, C.1    Oh, P.2    Aifantis, I.3
  • 41
    • 77952316273 scopus 로고    scopus 로고
    • Functions of notch signaling in the immune system: Consensus and controversies
    • Yuan JS, Kousis PC, Suliman S, Visan I, Guidos CJ. Functions of notch signaling in the immune system: consensus and controversies. Annu Rev Immunol. 2010;28:343-65.
    • (2010) Annu Rev Immunol , vol.28 , pp. 343-365
    • Yuan, J.S.1    Kousis, P.C.2    Suliman, S.3    Visan, I.4    Guidos, C.J.5
  • 42
    • 59649083306 scopus 로고    scopus 로고
    • Constitutively activated Notch signaling is involved in survival and apoptosis resistance of B-CLL cells
    • Rosati E, Sabatini R, Rampino G, Tabilio A, Di Ianni M, Fettucciari K, et al. Constitutively activated Notch signaling is involved in survival and apoptosis resistance of B-CLL cells. Blood. 2009;113(4):856-65.
    • (2009) Blood , vol.113 , Issue.4 , pp. 856-865
    • Rosati, E.1    Sabatini, R.2    Rampino, G.3    Tabilio, A.4    Di Ianni, M.5    Fettucciari, K.6
  • 44
    • 79951516547 scopus 로고    scopus 로고
    • Molecular pathogenesis and targeted therapies for NOTCH1-induced T-cell acute lymphoblastic leukemia
    • Paganin M, Ferrando A. Molecular pathogenesis and targeted therapies for NOTCH1-induced T-cell acute lymphoblastic leukemia. Blood Rev. 2011;25(2):83-90.
    • (2011) Blood Rev , vol.25 , Issue.2 , pp. 83-90
    • Paganin, M.1    Ferrando, A.2
  • 45
    • 84857739865 scopus 로고    scopus 로고
    • NOTCH1 mutations in +12 chronic lymphocytic leukemia (CLL) confer an unfavorable prognosis, induce a distinctive transcriptional profiling and refine the intermediate prognosis of +12 CLL
    • Del Giudice I, Rossi D, Chiaretti S, Marinelli M, Tavolaro S, Gabrielli S, et al. NOTCH1 mutations in +12 chronic lymphocytic leukemia (CLL) confer an unfavorable prognosis, induce a distinctive transcriptional profiling and refine the intermediate prognosis of +12 CLL. Haematologica. 2012;97(3): 437-41.
    • (2012) Haematologica , vol.97 , Issue.3 , pp. 437-441
    • Del Giudice, I.1    Rossi, D.2    Chiaretti, S.3    Marinelli, M.4    Tavolaro, S.5    Gabrielli, S.6
  • 47
    • 84863580564 scopus 로고    scopus 로고
    • Different distribution of NOTCH1 mutations in chronic lymphocytic leukemia with isolated trisomy 12 or associated with other chromosomal alterations
    • López C, Delgado J, Costa D, Conde L, Ghita G, Villamor N, et al. Different distribution of NOTCH1 mutations in chronic lymphocytic leukemia with isolated trisomy 12 or associated with other chromosomal alterations. Genes Chromosomes Cancer. 2012; 51(9):881-9.
    • (2012) Genes Chromosomes Cancer , vol.51 , Issue.9 , pp. 881-889
    • López, C.1    Delgado, J.2    Costa, D.3    Conde, L.4    Ghita, G.5    Villamor, N.6
  • 49
    • 78049416081 scopus 로고    scopus 로고
    • Alternative pre-mRNA splicing regulation in cancer: Pathways and programs unhinged
    • David CJ, Manley JL. Alternative pre-mRNA splicing regulation in cancer: pathways and programs unhinged. Genes Dev. 2010;24 (21):2343-64.
    • (2010) Genes Dev , vol.24 , Issue.21 , pp. 2343-2364
    • David, C.J.1    Manley, J.L.2
  • 50
    • 60349104299 scopus 로고    scopus 로고
    • The spliceosome: Design principles of a dynamic RNP machine
    • Wahl MC, Will CL, Lührmann R. The spliceosome: design principles of a dynamic RNP machine. Cell. 2009;136(4):701-8.
    • (2009) Cell , vol.136 , Issue.4 , pp. 701-708
    • Wahl, M.C.1    Will, C.L.2    Lührmann, R.3
  • 51
    • 0029664530 scopus 로고    scopus 로고
    • The SAP, a new family of proteins, associate and function positively with the SIT4 phosphatase
    • Luke MM, Della Seta F, Di Como CJ, Sugimoto H, Kobayashi R, Arndt KT. The SAP, a new family of proteins, associate and function positively with the SIT4 phosphatase. Mol Cell Biol 1996;16(6):2744-55.
    • (1996) Mol Cell Biol , vol.16 , Issue.6 , pp. 2744-2755
    • Luke, M.M.1    della Seta, F.2    Di Como, C.J.3    Sugimoto, H.4    Kobayashi, R.5    Arndt, K.T.6
  • 52
    • 0032523934 scopus 로고    scopus 로고
    • Phosphorylation of spliceosomal protein SAP 155 coupled with splicing catalysis
    • Wang C, Chua K, Seghezzi W, Lees E, Gozani O, Reed R. Phosphorylation of spliceosomal protein SAP 155 coupled with splicing catalysis. Genes Dev. 1998;12(10): 1409-14.
    • (1998) Genes Dev , vol.12 , Issue.10 , pp. 1409-1414
    • Wang, C.1    Chua, K.2    Seghezzi, W.3    Lees, E.4    Gozani, O.5    Reed, R.6
  • 53
    • 0032880119 scopus 로고    scopus 로고
    • Characterization of a protein complex containing spliceosomal proteins SAPs 49, 130, 145, and 155
    • Das BK, Xia L, Palandjian L, Gozani O, Chyung Y, Reed R. Characterization of a protein complex containing spliceosomal proteins SAPs 49, 130, 145, and 155. Mol Cell Biol. 1999;19(10):6796-802.
    • (1999) Mol Cell Biol , vol.19 , Issue.10 , pp. 6796-6802
    • Das, B.K.1    Xia, L.2    Palandjian, L.3    Gozani, O.4    Chyung, Y.5    Reed, R.6
  • 54
    • 67650724069 scopus 로고    scopus 로고
    • Regulation and function of NF-kappaB transcription factors in the immune system
    • Vallabhapurapu S, Karin M. Regulation and function of NF-kappaB transcription factors in the immune system. Annu Rev Immunol. 2009;27:693-733.
    • (2009) Annu Rev Immunol , vol.27 , pp. 693-733
    • Vallabhapurapu, S.1    Karin, M.2
  • 55
    • 0037149542 scopus 로고    scopus 로고
    • TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2
    • Li X, Yang Y, Ashwell JD. TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2. Nature. 2002;416(6878):345-7.
    • (2002) Nature , vol.416 , Issue.6878 , pp. 345-347
    • Li, X.1    Yang, Y.2    Ashwell, J.D.3
  • 56
    • 56349164239 scopus 로고    scopus 로고
    • Noncanonical NF-kappaB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK
    • Zarnegar BJ, Wang Y, Mahoney DJ, Dempsey PW, Cheung HH, He J, et al. Noncanonical NF-kappaB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK. Nat Immunol. 2008;9(12):1371-8.
    • (2008) Nat Immunol , vol.9 , Issue.12 , pp. 1371-1378
    • Zarnegar, B.J.1    Wang, Y.2    Mahoney, D.J.3    Dempsey, P.W.4    Cheung, H.H.5    He, J.6
  • 57
    • 78149369048 scopus 로고    scopus 로고
    • Non-canonical NF- B activation and abnormal B cell accumulation in mice expressing ubiquitin protein ligase-inactive c-IAP2
    • Conze DB, Zhao Y, Ashwell JD. Non-canonical NF- B activation and abnormal B cell accumulation in mice expressing ubiquitin protein ligase-inactive c-IAP2. PLoS Biol. 2010;8(10):e1000518.
    • (2010) PLoS Biol , vol.8 , Issue.10
    • Conze, D.B.1    Zhao, Y.2    Ashwell, J.D.3
  • 58
    • 84869462358 scopus 로고    scopus 로고
    • CIAP2 represses IKK/-mediated activation of MDM2 to prevent p53 degradation
    • Lau R, Niu MY, Pratt MA. cIAP2 represses IKK/-mediated activation of MDM2 to prevent p53 degradation. Cell Cycle. 2012;11 (21):4009-19.
    • (2012) Cell Cycle , vol.11 , Issue.21 , pp. 4009-4019
    • Lau, R.1    Niu, M.Y.2    Pratt, M.A.3
  • 59
    • 9144220762 scopus 로고    scopus 로고
    • Involvement of BAFF and APRIL in the resistance to apoptosis of B-CLL through an autocrine pathway
    • Kern C, Cornuel JF, Billard C, Tang R, Rouillard D, Stenou V, et al. Involvement of BAFF and APRIL in the resistance to apoptosis of B-CLL through an autocrine pathway. Blood. 2004;103(2):679-88.
    • (2004) Blood , vol.103 , Issue.2 , pp. 679-688
    • Kern, C.1    Cornuel, J.F.2    Billard, C.3    Tang, R.4    Rouillard, D.5    Stenou, V.6
  • 60
    • 33846258010 scopus 로고    scopus 로고
    • BAFF and APRIL support chronic lymphocytic leukemia Bcell survival through activation of the canonical NF-kappaB pathway
    • Endo T, Nishio M, Enzler T, Cottam HB, Fukuda T, James DF, et al. BAFF and APRIL support chronic lymphocytic leukemia Bcell survival through activation of the canonical NF-kappaB pathway. Blood. 2007;109 (2):703-10.
    • (2007) Blood , vol.109 , Issue.2 , pp. 703-710
    • Endo, T.1    Nishio, M.2    Enzler, T.3    Cottam, H.B.4    Fukuda, T.5    James, D.F.6
  • 61
    • 47149090375 scopus 로고    scopus 로고
    • The NFkappaB subunit Rel A is associated with in vitro survival and clinical disease progression in chronic lymphocytic leukemia and represents a promising therapeutic target
    • Hewamana S, Alghazal S, Lin TT, Clement M, Jenkins C, Guzman ML, et al. The NFkappaB subunit Rel A is associated with in vitro survival and clinical disease progression in chronic lymphocytic leukemia and represents a promising therapeutic target. Blood. 2008;111(9):4681-9.
    • (2008) Blood , vol.111 , Issue.9 , pp. 4681-4689
    • Hewamana, S.1    Alghazal, S.2    Lin, T.T.3    Clement, M.4    Jenkins, C.5    Guzman, M.L.6
  • 62
    • 77957366071 scopus 로고    scopus 로고
    • Interaction with vascular endothelium enhances survival in primary chronic lymphocytic leukemia cells via NF-kappaB activation and de novo gene transcription
    • Buggins AG, Pepper C, Patten PE, Hewamana S, Gohil S, Moorhead J, et al. Interaction with vascular endothelium enhances survival in primary chronic lymphocytic leukemia cells via NF-kappaB activation and de novo gene transcription. Cancer Res. 2010;70(19):7523-33.
    • (2010) Cancer Res , vol.70 , Issue.19 , pp. 7523-7533
    • Buggins, A.G.1    Pepper, C.2    Patten, P.E.3    Hewamana, S.4    Gohil, S.5    Moorhead, J.6
  • 63
    • 78751549662 scopus 로고    scopus 로고
    • The lymph node microenvironment promotes B-cell receptor signaling, NF-kappaB activation, and tumor proliferation in chronic lymphocytic leukemia
    • Herishanu Y, Pérez-Galán P, Liu D, Biancotto A, Pittaluga S, Vire B, et al. The lymph node microenvironment promotes B-cell receptor signaling, NF-kappaB activation, and tumor proliferation in chronic lymphocytic leukemia. Blood. 2011;117(2):563-74.
    • (2011) Blood , vol.117 , Issue.2 , pp. 563-574
    • Herishanu, Y.1    Pérez-Galán, P.2    Liu, D.3    Biancotto, A.4    Pittaluga, S.5    Vire, B.6
  • 66
    • 67651053001 scopus 로고    scopus 로고
    • Increased frequency (12%) of circulating chronic lymphocytic leukemia-like B-cell clones in healthy subjects using a highly sensitive multicolor flow cytometry approach
    • Nieto WG, Almeida J, Romero A, Teodosio C, Lopez A, Henriques AF, et al. Increased frequency (12%) of circulating chronic lymphocytic leukemia-like B-cell clones in healthy subjects using a highly sensitive multicolor flow cytometry approach. Blood. 2009;114(1):33-7.
    • (2009) Blood , vol.114 , Issue.1 , pp. 33-37
    • Nieto, W.G.1    Almeida, J.2    Romero, A.3    Teodosio, C.4    Lopez, A.5    Henriques, A.F.6
  • 67
    • 66949168111 scopus 로고    scopus 로고
    • The prognosis of clinical monoclonal B cell lymphocytosis differs from prognosis of Rai 0 chronic lymphocytic leukaemia and is recapitulated by biological risk factors
    • Rossi D, Sozzi E, Puma A, De Paoli L, Rasi S, Spina V, et al. The prognosis of clinical monoclonal B cell lymphocytosis differs from prognosis of Rai 0 chronic lymphocytic leukaemia and is recapitulated by biological risk factors. Br J Haematol. 2009;146(1):64-75.
    • (2009) Br J Haematol , vol.146 , Issue.1 , pp. 64-75
    • Rossi, D.1    Sozzi, E.2    Puma, A.3    de Paoli, L.4    Rasi, S.5    Spina, V.6
  • 68
    • 80054691036 scopus 로고    scopus 로고
    • General population low-count CLL-like MBL persists over time without clinical progression, although carrying the same cytogenetic abnormalities of CLL
    • Fazi C, Scarfo L, Pecciarini L, Cottini F, Dagklis A, Janus A, et al. General population low-count CLL-like MBL persists over time without clinical progression, although carrying the same cytogenetic abnormalities of CLL. Blood. 2011;118(25):6618-25.
    • (2011) Blood , vol.118 , Issue.25 , pp. 6618-6625
    • Fazi, C.1    Scarfo, L.2    Pecciarini, L.3    Cottini, F.4    Dagklis, A.5    Janus, A.6
  • 69
    • 84858297642 scopus 로고    scopus 로고
    • Monoclonal B-cell lymphocytosis is closely related to chronic lymphocytic leukaemia and may be better classified as early-stage CLL
    • Kern W, Bacher U, Haferlach C, Dicker F, Alpermann T, Schnittger S, et al. Monoclonal B-cell lymphocytosis is closely related to chronic lymphocytic leukaemia and may be better classified as early-stage CLL. Br J Haematol. 2012;157(1):86-96.
    • (2012) Br J Haematol , vol.157 , Issue.1 , pp. 86-96
    • Kern, W.1    Bacher, U.2    Haferlach, C.3    Dicker, F.4    Alpermann, T.5    Schnittger, S.6
  • 70
    • 79953117852 scopus 로고    scopus 로고
    • The genetics of Richter syndrome reveals disease heterogeneity and predicts survival after transformation
    • Rossi D, Spina V, Deambrogi C, Rasi S, Laurenti L, Stamatopoulos K, et al. The genetics of Richter syndrome reveals disease heterogeneity and predicts survival after transformation. Blood. 2011;117(12):3391-401.
    • (2011) Blood , vol.117 , Issue.12 , pp. 3391-3401
    • Rossi, D.1    Spina, V.2    Deambrogi, C.3    Rasi, S.4    Laurenti, L.5    Stamatopoulos, K.6
  • 71
    • 84855243926 scopus 로고    scopus 로고
    • Analysis of NOTCH1 mutations in monoclonal B-cell lymphocytosis
    • Rasi S, Monti S, Spina V, Foà R, Gaidano G, Rossi D. Analysis of NOTCH1 mutations in monoclonal B-cell lymphocytosis. Haematologica. 2012;97(1):153-4.
    • (2012) Haematologica , vol.97 , Issue.1 , pp. 153-154
    • Rasi, S.1    Monti, S.2    Spina, V.3    Foà, R.4    Gaidano, G.5    Rossi, D.6
  • 73
    • 77949422979 scopus 로고    scopus 로고
    • Monoclonal B-cell lymphocytosis (MBL): Biology, natural history and clinical management
    • Shanafelt TD, Ghia P, Lanasa MC, Landgren O, Rawstron AC. Monoclonal B-cell lymphocytosis (MBL): biology, natural history and clinical management. Leukemia. 2010; 24(3):512-20.
    • (2010) Leukemia , vol.24 , Issue.3 , pp. 512-520
    • Shanafelt, T.D.1    Ghia, P.2    Lanasa, M.C.3    Landgren, O.4    Rawstron, A.C.5
  • 74
    • 31544434508 scopus 로고    scopus 로고
    • Fludarabine plus cyclophosphamide versus fludarabine alone in first-line therapy of younger patients with chronic lymphocytic leukemia
    • Eichhorst BF, Busch R, Hopfinger G, Pasold R, Hensel M, Steinbrecher C, et al. Fludarabine plus cyclophosphamide versus fludarabine alone in first-line therapy of younger patients with chronic lymphocytic leukemia. Blood. 2006;107(3):885-91.
    • (2006) Blood , vol.107 , Issue.3 , pp. 885-891
    • Eichhorst, B.F.1    Busch, R.2    Hopfinger, G.3    Pasold, R.4    Hensel, M.5    Steinbrecher, C.6
  • 75
    • 69849107362 scopus 로고    scopus 로고
    • Subcutaneous alemtuzumab in fludarabine-refractory chronic lymphocytic leukemia: Clinical results and prognostic marker analyses from the CLL2H study of the German Chronic Lymphocytic Leukemia Study Group
    • Stilgenbauer S, Zenz T, Winkler D, Bühler A, Schlenk RF, Groner S, et al. Subcutaneous alemtuzumab in fludarabine-refractory chronic lymphocytic leukemia: clinical results and prognostic marker analyses from the CLL2H study of the German Chronic Lymphocytic Leukemia Study Group. J Clin Oncol. 2009;27(24):3994-4001.
    • (2009) J Clin Oncol , vol.27 , Issue.24 , pp. 3994-4001
    • Stilgenbauer, S.1    Zenz, T.2    Winkler, D.3    Bühler, A.4    Schlenk, R.F.5    Groner, S.6
  • 76
    • 34447530283 scopus 로고    scopus 로고
    • Assessment of fludarabine plus cyclophosphamide for patients with chronic lymphocytic leukaemia (the LRF CLL4 Trial): A randomised controlled trial
    • Catovsky D, Richards S, Matutes E, Oscier D, Dyer MJ, Bezares RF, et al. Assessment of fludarabine plus cyclophosphamide for patients with chronic lymphocytic leukaemia (the LRF CLL4 Trial): a randomised controlled trial. Lancet. 2007;370 (9583):230-9.
    • (2007) Lancet , vol.370 , Issue.9583 , pp. 230-239
    • Catovsky, D.1    Richards, S.2    Matutes, E.3    Oscier, D.4    Dyer, M.J.5    Bezares, R.F.6
  • 77
    • 77957664665 scopus 로고    scopus 로고
    • Addition of rituximab to fludarabine and cyclophosphamide in patients with chronic lymphocytic leukaemia: A randomised, open-label, phase 3 trial
    • Hallek M, Fischer K, Fingerle-Rowson G, Fink AM, Busch R, Mayer J, et al. Addition of rituximab to fludarabine and cyclophosphamide in patients with chronic lymphocytic leukaemia: a randomised, open-label, phase 3 trial. Lancet. 2010;376(9747):1164-74.
    • (2010) Lancet , vol.376 , Issue.9747 , pp. 1164-1174
    • Hallek, M.1    Fischer, K.2    Fingerle-Rowson, G.3    Fink, A.M.4    Busch, R.5    Mayer, J.6
  • 78
    • 70350511471 scopus 로고    scopus 로고
    • Detailed analysis of p53 pathway defects in fludarabine-refractory chronic lymphocytic leukemia (CLL): Dissecting the contribution of 17p deletion, TP53 mutation, p53-p21 dysfunction, and miR34a in a prospective clinical trial
    • Zenz T, Häbe S, Denzel T, Mohr J, Winkler D, Bühler A, et al. Detailed analysis of p53 pathway defects in fludarabine-refractory chronic lymphocytic leukemia (CLL): dissecting the contribution of 17p deletion, TP53 mutation, p53-p21 dysfunction, and miR34a in a prospective clinical trial. Blood. 2009;114(13):2589-97.
    • (2009) Blood , vol.114 , Issue.13 , pp. 2589-2597
    • Zenz, T.1    Häbe, S.2    Denzel, T.3    Mohr, J.4    Winkler, D.5    Bühler, A.6
  • 80
    • 79957949229 scopus 로고    scopus 로고
    • Mutational status of the TP53 gene as a predictor of response and survival in patients with chronic lymphocytic leukemia: Results from the LRF CLL4 trial
    • Gonzalez D, Martinez P, Wade R, Hockley S, Oscier D, Matutes E, et al. Mutational status of the TP53 gene as a predictor of response and survival in patients with chronic lymphocytic leukemia: results from the LRF CLL4 trial. J Clin Oncol. 2011; 29(16):2223-9.
    • (2011) J Clin Oncol , vol.29 , Issue.16 , pp. 2223-2229
    • Gonzalez, D.1    Martinez, P.2    Wade, R.3    Hockley, S.4    Oscier, D.5    Matutes, E.6
  • 81
    • 85172051894 scopus 로고    scopus 로고
    • MGA, A Suppressor of MYC, is Recurrently Inactivated in High Risk Chronic Lymphocytic Leukemia
    • 2012 Nov 12 [Epub ahead of print
    • De Paoli L, Cerri M, Monti S, Rasi S, Spina V, Bruscaggin A, et al. MGA, A Suppressor of MYC, is Recurrently Inactivated in High Risk Chronic Lymphocytic Leukemia. Leuk Lymphoma. 2012 Nov 12 [Epub ahead of print].
    • Leuk Lymphoma
    • de Paoli, L.1    Cerri, M.2    Monti, S.3    Rasi, S.4    Spina, V.5    Bruscaggin, A.6
  • 82
    • 33750577939 scopus 로고    scopus 로고
    • Prospective evaluation of clonal evolution during long-term follow-up of patients with untreated early-stage chronic lymphocytic leukemia
    • Shanafelt TD, Witzig TE, Fink SR, Jenkins RB, Paternoster SF, Smoley SA, et al. Prospective evaluation of clonal evolution during long-term follow-up of patients with untreated early-stage chronic lymphocytic leukemia. J Clin Oncol. 2006;24(28):4634-41.
    • (2006) J Clin Oncol , vol.24 , Issue.28 , pp. 4634-4641
    • Shanafelt, T.D.1    Witzig, T.E.2    Fink, S.R.3    Jenkins, R.B.4    Paternoster, S.F.5    Smoley, S.A.6
  • 83
    • 36349025291 scopus 로고    scopus 로고
    • Clonal evolution in chronic lymphocytic leukemia: Acquisition of high-risk genomic aberrations associated with unmutated VH, resistance to therapy, and short survival
    • Stilgenbauer S, Sander S, Bullinger L, Benner A, Leupolt E, Winkler D, et al. Clonal evolution in chronic lymphocytic leukemia: acquisition of high-risk genomic aberrations associated with unmutated VH, resistance to therapy, and short survival. Haematologica. 2007;92(9):1242-5.
    • (2007) Haematologica , vol.92 , Issue.9 , pp. 1242-1245
    • Stilgenbauer, S.1    Sander, S.2    Bullinger, L.3    Benner, A.4    Leupolt, E.5    Winkler, D.6
  • 84
    • 52649091186 scopus 로고    scopus 로고
    • Genomic complexity identifies patients with aggressive chronic lymphocytic leukemia
    • Kujawski L, Ouillette P, Erba H, Saddler C, Jakubowiak A, Kaminski M, et al. Genomic complexity identifies patients with aggressive chronic lymphocytic leukemia. Blood. 2008;112(5):1993-2003.
    • (2008) Blood , vol.112 , Issue.5 , pp. 1993-2003
    • Kujawski, L.1    Ouillette, P.2    Erba, H.3    Saddler, C.4    Jakubowiak, A.5    Kaminski, M.6
  • 85
    • 74249084263 scopus 로고    scopus 로고
    • Large but not small copy-number alterations correlate to high-risk genomic aberrations and survival in chronic lymphocytic leukemia: A high-resolution genomic screening of newly diagnosed patients
    • Gunnarsson R, Isaksson A, Mansouri M, Göransson H, Jansson M, Cahill N, et al. Large but not small copy-number alterations correlate to high-risk genomic aberrations and survival in chronic lymphocytic leukemia: a high-resolution genomic screening of newly diagnosed patients. Leukemia. 2010;24(1):211-5.
    • (2010) Leukemia , vol.24 , Issue.1 , pp. 211-215
    • Gunnarsson, R.1    Isaksson, A.2    Mansouri, M.3    Göransson, H.4    Jansson, M.5    Cahill, N.6
  • 86
    • 76049087341 scopus 로고    scopus 로고
    • Aggressive chronic lymphocytic leukemia with elevated genomic complexity is associated with multiple gene defects in the response to DNA double-strand breaks
    • Ouillette P, Fossum S, Parkin B, Ding L, Bockenstedt P, Al-Zoubi A, et al. Aggressive chronic lymphocytic leukemia with elevated genomic complexity is associated with multiple gene defects in the response to DNA double-strand breaks. Clin Cancer Res. 2010;16(3):835-47.
    • (2010) Clin Cancer Res , vol.16 , Issue.3 , pp. 835-847
    • Ouillette, P.1    Fossum, S.2    Parkin, B.3    Ding, L.4    Bockenstedt, P.5    Al-Zoubi, A.6
  • 87
    • 79961059215 scopus 로고    scopus 로고
    • Array-based genomic screening at diagnosis and during follow-up in chronic lymphocytic leukemia
    • Gunnarsson R, Mansouri L, Isaksson A, Göransson H, Cahill N, Jansson M, et al. Array-based genomic screening at diagnosis and during follow-up in chronic lymphocytic leukemia. Haematologica. 2011;96(8): 1161-9.
    • (2011) Haematologica , vol.96 , Issue.8 , pp. 1161-1169
    • Gunnarsson, R.1    Mansouri, L.2    Isaksson, A.3    Göransson, H.4    Cahill, N.5    Jansson, M.6
  • 88
    • 80052936981 scopus 로고    scopus 로고
    • Acquired genomic copy number aberrations and survival in chronic lymphocytic leukemia
    • Ouillette P, Collins R, Shakhan S, Li J, Peres E, Kujawski L, et al. Acquired genomic copy number aberrations and survival in chronic lymphocytic leukemia. Blood. 2011;118(11): 3051-61.
    • (2011) Blood , vol.118 , Issue.11 , pp. 3051-3061
    • Ouillette, P.1    Collins, R.2    Shakhan, S.3    Li, J.4    Peres, E.5    Kujawski, L.6
  • 89
    • 84863785266 scopus 로고    scopus 로고
    • Quantification of subclonal distributions of recurrent genomic aberrations in paired pretreatment and relapse samples from patients with B-cell chronic lymphocytic leukemia
    • Knight SJ, Yau C, Clifford R, Timbs AT, Sadighi Akha E, Dréau HM, et al. Quantification of subclonal distributions of recurrent genomic aberrations in paired pretreatment and relapse samples from patients with B-cell chronic lymphocytic leukemia. Leukemia. 2012;26(7):1564-75.
    • (2012) Leukemia , vol.26 , Issue.7 , pp. 1564-1575
    • Knight, S.J.1    Yau, C.2    Clifford, R.3    Timbs, A.T.4    Sadighi, A.E.5    Dréau, H.M.6
  • 90
    • 84860705573 scopus 로고    scopus 로고
    • Characteristics of chronic lymphocytic leukemia with somatically acquired mutations in NOTCH1 exon 34
    • Shedden K, Li Y, Ouillette P, Malek SN. Characteristics of chronic lymphocytic leukemia with somatically acquired mutations in NOTCH1 exon 34. Leukemia 2012; 26(5):1108-10.
    • (2012) Leukemia , vol.26 , Issue.5 , pp. 1108-1110
    • Shedden, K.1    Li, Y.2    Ouillette, P.3    Malek, S.N.4
  • 91
    • 84869753284 scopus 로고    scopus 로고
    • Monitoring chronic lymphocytic leukemia progression by whole genome sequencing reveals heterogeneous clonal evolution patterns
    • Schuh A, Becq J, Humphray S, Alexa A, Burns A, Clifford R, et al. Monitoring chronic lymphocytic leukemia progression by whole genome sequencing reveals heterogeneous clonal evolution patterns. Blood. 2012;120(20):4191-6.
    • (2012) Blood , vol.120 , Issue.20 , pp. 4191-4196
    • Schuh, A.1    Becq, J.2    Humphray, S.3    Alexa, A.4    Burns, A.5    Clifford, R.6
  • 92
    • 84863778287 scopus 로고    scopus 로고
    • ERIC recommendations on TP53 mutation analysis in chronic lymphocytic leukemia
    • Pospisilova S, Gonzalez D, Malcikova J, Trbusek M, Rossi D, Kater AP, et al. ERIC recommendations on TP53 mutation analysis in chronic lymphocytic leukemia. Leukemia. 2012;26(7):1458-61.
    • (2012) Leukemia , vol.26 , Issue.7 , pp. 1458-1461
    • Pospisilova, S.1    Gonzalez, D.2    Malcikova, J.3    Trbusek, M.4    Rossi, D.5    Kater, A.P.6
  • 93
    • 84874428346 scopus 로고    scopus 로고
    • Integrated mutational and cytogenetic analysis identifies new prognostic subgroups in chronic lymphocytic leukemia
    • Rossi D, Rasi S, Spina V, Bruscaggin A, Monti S, Ciardullo C, et al. Integrated mutational and cytogenetic analysis identifies new prognostic subgroups in chronic lymphocytic leukemia. Blood. 2013;121(8):1403-12.
    • (2013) Blood , vol.121 , Issue.8 , pp. 1403-1412
    • Rossi, D.1    Rasi, S.2    Spina, V.3    Bruscaggin, A.4    Monti, S.5    Ciardullo, C.6
  • 94
    • 70349231440 scopus 로고    scopus 로고
    • De novo deletion 17p13.1 chronic lymphocytic leukemia shows significant clinical heterogeneity: The M. D. Anderson and Mayo Clinic experience
    • Tam CS, Shanafelt TD, Wierda WG, Abruzzo LV, Van Dyke DL, O'Brien S, et al. De novo deletion 17p13.1 chronic lymphocytic leukemia shows significant clinical heterogeneity: the M. D. Anderson and Mayo Clinic experience. Blood. 2009;114(5):957-64.
    • (2009) Blood , vol.114 , Issue.5 , pp. 957-964
    • Tam, C.S.1    Shanafelt, T.D.2    Wierda, W.G.3    Abruzzo, L.V.4    van Dyke, D.L.5    O'Brien, S.6
  • 95
    • 79951869041 scopus 로고    scopus 로고
    • TP53 Mutations and Outcome After Fludarabine and Cyclophosphamide (FC) or FC Plus Rituximab (FCR) in the CLL8 Trial of the GCLLSG
    • Abstract 1267
    • Zenz T, Patrick H, Busch R, Helfrich H, Winkler D, Bühler A, et al. TP53 Mutations and Outcome After Fludarabine and Cyclophosphamide (FC) or FC Plus Rituximab (FCR) in the CLL8 Trial of the GCLLSG. Blood. 2009;114(22):Abstract 1267.
    • (2009) Blood , vol.114 , Issue.22
    • Zenz, T.1    Patrick, H.2    Busch, R.3    Helfrich, H.4    Winkler, D.5    Bühler, A.6
  • 96
    • 79960116871 scopus 로고    scopus 로고
    • Missense mutations located in structural p53 DNA-binding motifs are associated with extremely poor survival in chronic lymphocytic leukemia
    • Trbusek M, Smardova J, Malcikova J, Sebejova L, Dobes P, Svitakova M, et al. Missense mutations located in structural p53 DNA-binding motifs are associated with extremely poor survival in chronic lymphocytic leukemia. J Clin Oncol. 2011;29(19): 2703-8.
    • (2011) J Clin Oncol , vol.29 , Issue.19 , pp. 2703-2708
    • Trbusek, M.1    Smardova, J.2    Malcikova, J.3    Sebejova, L.4    Dobes, P.5    Svitakova, M.6
  • 97
    • 36849045647 scopus 로고    scopus 로고
    • Mutation status of the residual ATM allele is an important determinant of the cellular response to chemotherapy and survival in patients with chronic lymphocytic leukemia containing an 11q deletion
    • Austen B, Skowronska A, Baker C, Powell JE, Gardiner A, Oscier D, et al. Mutation status of the residual ATM allele is an important determinant of the cellular response to chemotherapy and survival in patients with chronic lymphocytic leukemia containing an 11q deletion. J Clin Oncol. 2007;25(34): 5448-57.
    • (2007) J Clin Oncol , vol.25 , Issue.34 , pp. 5448-5457
    • Austen, B.1    Skowronska, A.2    Baker, C.3    Powell, J.E.4    Gardiner, A.5    Oscier, D.6
  • 99
    • 84873567287 scopus 로고    scopus 로고
    • NOTCH1 and SF3B1 mutations can be added to the hierarchical prognostic classification in chronic lymphocytic leukemia
    • Mansouri L, Cahill N, Gunnarsson R, Smedby KE, Tjönnfjord E, Hjalgrim H, et al. NOTCH1 and SF3B1 mutations can be added to the hierarchical prognostic classification in chronic lymphocytic leukemia. Leukemia. 2013;27(2):512-4.
    • (2013) Leukemia , vol.27 , Issue.2 , pp. 512-514
    • Mansouri, L.1    Cahill, N.2    Gunnarsson, R.3    Smedby, K.E.4    Tjönnfjord, E.5    Hjalgrim, H.6
  • 100
    • 84863833162 scopus 로고    scopus 로고
    • Different impact of NOTCH1 and SF3B1 mutations on the risk of chronic lymphocytic leukemia transformation to Richter syndrome
    • Rossi D, Rasi S, Spina V, Fangazio M, Monti S, Greco M, et al. Different impact of NOTCH1 and SF3B1 mutations on the risk of chronic lymphocytic leukemia transformation to Richter syndrome. Br J Haematol. 2012;158(3):426-9.
    • (2012) Br J Haematol , vol.158 , Issue.3 , pp. 426-429
    • Rossi, D.1    Rasi, S.2    Spina, V.3    Fangazio, M.4    Monti, S.5    Greco, M.6
  • 102
    • 84877083141 scopus 로고    scopus 로고
    • NOTCH1, SF3B1 and TP53 mutations in fludarabinerefractory CLL patients treated with alemtuzumab: Results from the CLL2H trial of the CCLLSG
    • Abstract 710
    • Schnaiter A, Rossi M, Paschka P, Cazzola M, Döhner K, Edelmann J, et al. NOTCH1, SF3B1 and TP53 mutations in fludarabinerefractory CLL patients treated with alemtuzumab: results from the CLL2H trial of the CCLLSG. Blood. 2012;120(21):Abstract 710.
    • (2012) Blood , vol.120 , Issue.21
    • Schnaiter, A.1    Rossi, M.2    Paschka, P.3    Cazzola, M.4    Döhner, K.5    Edelmann, J.6
  • 103
    • 11144357657 scopus 로고    scopus 로고
    • Alemtuzumab is an effective therapy for chronic lymphocytic leukemia with p53 mutations and deletions
    • Lozanski G, Heerema NA, Flinn IW, Smith L, Harbison J, Webb J, et al. Alemtuzumab is an effective therapy for chronic lymphocytic leukemia with p53 mutations and deletions. Blood. 2004;103(9):3278-81.
    • (2004) Blood , vol.103 , Issue.9 , pp. 3278-3281
    • Lozanski, G.1    Heerema, N.A.2    Flinn, I.W.3    Smith, L.4    Harbison, J.5    Webb, J.6
  • 104
    • 27144437196 scopus 로고    scopus 로고
    • The efficacy of alemtuzumab for refractory chronic lymphocytic leukemia in relation to cytogenetic abnormalities of p53
    • Osuji NC, Del Giudice I, Matutes E, Wotherspoon AC, Dearden C, Catovsky D. The efficacy of alemtuzumab for refractory chronic lymphocytic leukemia in relation to cytogenetic abnormalities of p53. Haematologica. 2005;90(10):1435-6.
    • (2005) Haematologica , vol.90 , Issue.10 , pp. 1435-1436
    • Osuji, N.C.1    Del Giudice, I.2    Matutes, E.3    Wotherspoon, A.C.4    Dearden, C.5    Catovsky, D.6
  • 105
    • 37649004407 scopus 로고    scopus 로고
    • Alemtuzumab compared with chlorambucil as first-line therapy for chronic lymphocytic leukemia
    • Hillmen P, Skotnicki AB, Robak T, Jaksic B, Dmoszynska A, Wu J, et al. Alemtuzumab compared with chlorambucil as first-line therapy for chronic lymphocytic leukemia. J Clin Oncol. 2007;25(35):5616-23.
    • (2007) J Clin Oncol , vol.25 , Issue.35 , pp. 5616-5623
    • Hillmen, P.1    Skotnicki, A.B.2    Robak, T.3    Jaksic, B.4    Dmoszynska, A.5    Wu, J.6
  • 106
    • 82555169679 scopus 로고    scopus 로고
    • Fludarabine plus alemtuzumab versus fludarabine alone in patients with previously treated chronic lymphocytic leukaemia: A randomised phase 3 trial
    • Elter T, Gercheva-Kyuchukova L, Pylylpenko H, Robak T, Jaksic B, Rekhtman G, et al. Fludarabine plus alemtuzumab versus fludarabine alone in patients with previously treated chronic lymphocytic leukaemia: a randomised phase 3 trial. Lancet Oncol. 2011;12(13):1204-13.
    • (2011) Lancet Oncol , vol.12 , Issue.13 , pp. 1204-1213
    • Elter, T.1    Gercheva-Kyuchukova, L.2    Pylylpenko, H.3    Robak, T.4    Jaksic, B.5    Rekhtman, G.6
  • 107
    • 80054107144 scopus 로고    scopus 로고
    • An openlabel, pilot study of fludarabine, cyclophosphamide, and alemtuzumab in relapsed/refractory patients with B-cell chronic lymphocytic leukemia
    • Montillo M, Tedeschi A, Petrizzi VB, Ricci F, Crugnola M, Spriano M, et al. An openlabel, pilot study of fludarabine, cyclophosphamide, and alemtuzumab in relapsed/refractory patients with B-cell chronic lymphocytic leukemia. Blood. 2011;118(15):4079-85.
    • (2011) Blood , vol.118 , Issue.15 , pp. 4079-4085
    • Montillo, M.1    Tedeschi, A.2    Petrizzi, V.B.3    Ricci, F.4    Crugnola, M.5    Spriano, M.6
  • 108
    • 80052180048 scopus 로고    scopus 로고
    • Frontline chemoimmunotherapy with fludarabine, cyclophosphamide, alemtuzumab, and rituximab for high-risk chronic lymphocytic leukemia
    • Parikh SA, Keating MJ, O'Brien S, Wang X, Ferrajoli A, Faderl S, et al. Frontline chemoimmunotherapy with fludarabine, cyclophosphamide, alemtuzumab, and rituximab for high-risk chronic lymphocytic leukemia. Blood. 2011;118(8):2062-8.
    • (2011) Blood , vol.118 , Issue.8 , pp. 2062-2068
    • Parikh, S.A.1    Keating, M.J.2    O'Brien, S.3    Wang, X.4    Ferrajoli, A.5    Faderl, S.6
  • 109
    • 84856272135 scopus 로고    scopus 로고
    • An Italian retrospective study on the routine clinical use of low-dose alemtuzumab in relapsed/refractory chronic lymphocytic leukaemia patients
    • Cortelezzi A, Gritti G, Laurenti L, Cuneo A, Ciolli S, Di Renzo N, et al. An Italian retrospective study on the routine clinical use of low-dose alemtuzumab in relapsed/refractory chronic lymphocytic leukaemia patients. Br J Haematol. 2012;156(4):481-9.
    • (2012) Br J Haematol , vol.156 , Issue.4 , pp. 481-489
    • Cortelezzi, A.1    Gritti, G.2    Laurenti, L.3    Cuneo, A.4    Ciolli, S.5    Di Renzo, N.6
  • 110
    • 84861795688 scopus 로고    scopus 로고
    • Excess mortality after treatment with fludarabine and cyclophosphamide in combination with alemtuzumab in previously untreated patients with chronic lymphocytic leukemia in a randomized phase 3 trial
    • Lepretre S, Aurran T, Mahé B, Cazin B, Tournilhac O, Maisonneuve H, et al. Excess mortality after treatment with fludarabine and cyclophosphamide in combination with alemtuzumab in previously untreated patients with chronic lymphocytic leukemia in a randomized phase 3 trial. Blood. 2012;119(22):5104-10.
    • (2012) Blood , vol.119 , Issue.22 , pp. 5104-5110
    • Lepretre, S.1    Aurran, T.2    Mahé, B.3    Cazin, B.4    Tournilhac, O.5    Maisonneuve, H.6
  • 111
    • 84863769805 scopus 로고    scopus 로고
    • Alemtuzumab in combination with methylprednisolone is a highly effective induction regimen for patients with chronic lymphocytic leukemia and deletion of TP53: Final results of the national cancer research institute CLL206 trial
    • Pettitt AR, Jackson R, Carruthers S, Dodd J, Dodd S, Oates M, et al. Alemtuzumab in combination with methylprednisolone is a highly effective induction regimen for patients with chronic lymphocytic leukemia and deletion of TP53: final results of the national cancer research institute CLL206 trial. J Clin Oncol. 2012;30(14):1647-55.
    • (2012) J Clin Oncol , vol.30 , Issue.14 , pp. 1647-1655
    • Pettitt, A.R.1    Jackson, R.2    Carruthers, S.3    Dodd, J.4    Dodd, S.5    Oates, M.6
  • 112
    • 84871249105 scopus 로고    scopus 로고
    • Fludarabine and cyclophosphamide in combination with alemtuzumab (FCCam) in patients with primary high-risk, relapsed or refractory chronic lymphocytic leukemia
    • Elter T, James R, Busch R, Winkler D, Ritgen M, Böttcher S, et al. Fludarabine and cyclophosphamide in combination with alemtuzumab (FCCam) in patients with primary high-risk, relapsed or refractory chronic lymphocytic leukemia. Leukemia. 2012; 26(12):2549-52.
    • (2012) Leukemia , vol.26 , Issue.12 , pp. 2549-2552
    • Elter, T.1    James, R.2    Busch, R.3    Winkler, D.4    Ritgen, M.5    Böttcher, S.6
  • 113
    • 20644447584 scopus 로고    scopus 로고
    • Allogeneic stem-cell transplantation may overcome the adverse prognosis of unmutated VH gene in patients with chronic lymphocytic leukemia
    • Moreno C, Villamor N, Colomer D, Esteve J, Martino R, Nomdedéu J, et al. Allogeneic stem-cell transplantation may overcome the adverse prognosis of unmutated VH gene in patients with chronic lymphocytic leukemia. J Clin Oncol. 2005;23(15):3433-8.
    • (2005) J Clin Oncol , vol.23 , Issue.15 , pp. 3433-3438
    • Moreno, C.1    Villamor, N.2    Colomer, D.3    Esteve, J.4    Martino, R.5    Nomdedéu, J.6
  • 114
    • 55549097826 scopus 로고    scopus 로고
    • Allogeneic hematopoietic stem-cell transplantation for chronic lymphocytic leukemia with 17p deletion: A retrospective European Group for Blood and Marrow Transplantation analysis
    • Schetelig J, van Biezen A, Brand R, Caballero D, Martino R, Itala M, et al. Allogeneic hematopoietic stem-cell transplantation for chronic lymphocytic leukemia with 17p deletion: a retrospective European Group for Blood and Marrow Transplantation analysis. J Clin Oncol. 2008;26(31):5094-100.
    • (2008) J Clin Oncol , vol.26 , Issue.31 , pp. 5094-5100
    • Schetelig, J.1    van Biezen, A.2    Brand, R.3    Caballero, D.4    Martino, R.5    Itala, M.6
  • 115
    • 54449093967 scopus 로고    scopus 로고
    • Five-year follow-up of patients with advanced chronic lymphocytic leukemia treated with allogeneic hematopoietic cell transplantation after nonmyeloablative conditioning
    • Sorror ML, Storer BE, Sandmaier BM, Maris M, Shizuru J, Maziarz R, et al. Five-year follow-up of patients with advanced chronic lymphocytic leukemia treated with allogeneic hematopoietic cell transplantation after nonmyeloablative conditioning. J Clin Oncol. 2008;26(30):4912-20.
    • (2008) J Clin Oncol , vol.26 , Issue.30 , pp. 4912-4940
    • Sorror, M.L.1    Storer, B.E.2    Sandmaier, B.M.3    Maris, M.4    Shizuru, J.5    Maziarz, R.6
  • 116
    • 77957743452 scopus 로고    scopus 로고
    • Allogeneic stem cell transplantation provides durable disease control in poor-risk chronic lymphocytic leukemia: Long-term clinical and MRD results of the German CLL Study Group CLL3X trial
    • Dreger P, Döhner H, Ritgen M, Böttcher S, Busch R, Dietrich S, et al. Allogeneic stem cell transplantation provides durable disease control in poor-risk chronic lymphocytic leukemia: long-term clinical and MRD results of the German CLL Study Group CLL3X trial. Blood. 2010;116(14):2438-47.
    • (2010) Blood , vol.116 , Issue.14 , pp. 2438-2447
    • Dreger, P.1    Döhner, H.2    Ritgen, M.3    Böttcher, S.4    Busch, R.5    Dietrich, S.6
  • 117
    • 33845543049 scopus 로고    scopus 로고
    • Indications for allogeneic stem cell transplantation in chronic lymphocytic leukemia: The EBMT transplant consensus
    • Dreger P, Corradini P, Kimby E, Michallet M, Milligan D, Schetelig J, et al. Indications for allogeneic stem cell transplantation in chronic lymphocytic leukemia: the EBMT transplant consensus. Leukemia. 2007;21(1):12-7.
    • (2007) Leukemia , vol.21 , Issue.1 , pp. 12-17
    • Dreger, P.1    Corradini, P.2    Kimby, E.3    Michallet, M.4    Milligan, D.5    Schetelig, J.6
  • 118
    • 77950502126 scopus 로고    scopus 로고
    • Ofatumumab as single-agent CD20 immunotherapy in fludarabine-refractory chronic lymphocytic leukemia
    • Wierda WG, Kipps TJ, Mayer J, Stilgenbauer S, Williams CD, Hellmann A, et al. Ofatumumab as single-agent CD20 immunotherapy in fludarabine-refractory chronic lymphocytic leukemia. J Clin Oncol. 2010;28(10):1749-55.
    • (2010) J Clin Oncol , vol.28 , Issue.10 , pp. 1749-1755
    • Wierda, W.G.1    Kipps, T.J.2    Mayer, J.3    Stilgenbauer, S.4    Williams, C.D.5    Hellmann, A.6
  • 119
    • 84877080091 scopus 로고    scopus 로고
    • Emerging role of kinase targeted strategies in chronic lymphocytic leukemia
    • 2012
    • Wiestner A. Emerging role of kinase targeted strategies in chronic lymphocytic leukemia. Hematology Am Soc Hematol Educ Program. 2012;2012:88-96.
    • (2012) Hematology Am Soc Hematol Educ Program , pp. 88-96
    • Wiestner, A.1
  • 120
    • 84871806385 scopus 로고    scopus 로고
    • Bruton tyrosine kinase inhibitor ibrutinib (PCI-32765) has significant activity in patients with relapsed/refractory B-cell malignancies
    • Advani RH, Buggy JJ, Sharman JP, Smith SM, Boyd TE, Grant B, et al. Bruton tyrosine kinase inhibitor ibrutinib (PCI-32765) has significant activity in patients with relapsed/refractory B-cell malignancies. J Clin Oncol. 2013;31(1):88-94.
    • (2013) J Clin Oncol , vol.31 , Issue.1 , pp. 88-94
    • Advani, R.H.1    Buggy, J.J.2    Sharman, J.P.3    Smith, S.M.4    Boyd, T.E.5    Grant, B.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.