One-week high-fat diet leads to reduced toll-like receptor 2 expression and function in young healthy men

Nutrition Research

Volumn 34, Issue 12, 2014, Pages 1045-1051

  Wan, Zhongxiao ^a   Durrer, Cody ^a   Mah, Dorrian ^a   Simtchouk, Svetlana ^a   Little, Jonathan P ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Fatty acids; Humans; Inflammation; Lipids; Monocytes; Obesity

Indexed keywords

CD14 ANTIGEN; INTERLEUKIN 1BETA; INTERLEUKIN 6; N PALMITOYL [2,3 BIS(PALMITOYLOXY)PROPYL]CYSTEINYLSERYLLYSYLLYSYLLYSYLLYSINE; PROTEIN P47; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR AGONIST; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; FAT INTAKE; FATTY ACID; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NEUTROPHIL CYTOSOLIC FACTOR 1; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE;

ADULT; ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNITY; INFECTION RISK; LIPID DIET; MALE; NORMAL HUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RECEPTOR DOWN REGULATION; WESTERN BLOTTING; ADOLESCENT; ADVERSE EFFECTS; BLOOD; CLINICAL TRIAL; COMPLICATION; DRUG EFFECTS; FAT INTAKE; IMMUNOLOGY; INFECTION; INFLAMMATION; METABOLISM; MONOCYTE; MONONUCLEAR CELL; OBESITY; REFERENCE VALUE; YOUNG ADULT;

RODENTIA;

ADOLESCENT; ADULT; DIET, HIGH-FAT; DIETARY FATS; FATTY ACIDS, NONESTERIFIED; HUMANS; IMMUNITY; INFECTION; INFLAMMATION; INTERLEUKIN-1BETA; INTERLEUKIN-6; LEUKOCYTES, MONONUCLEAR; MALE; MONOCYTES; NADPH OXIDASE; NF-KAPPA B; OBESITY; REFERENCE VALUES; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR-ALPHA; YOUNG ADULT;

EID: 84919433901     PISSN: 02715317     EISSN: 18790739     Source Type: Journal    
DOI: 10.1016/j.nutres.2014.08.012     Document Type: Article

References (25)

1. Bochicchio G.V., Joshi M., Bochicchio K., Nehman S., Tracy J.K., Scalea T.M. Impact of obesity in the critically ill trauma patient: a prospective study. J Am Coll Surg 2006, 203:533-538.
2. Kuduvalli M., Grayson A.D., Oo A.Y., Fabri B.M., Rashid A. Risk of morbidity and in-hospital mortality in obese patients undergoing coronary artery bypass surgery. Eur J Cardiothorac Surg 2002, 22:787-793.
3. Wang J.H., Doyle M., Manning B.J., Di Wu Q., Blankson S., Redmond H.P. Induction of bacterial lipoprotein tolerance is associated with suppression of toll-like receptor 2 expression. J Biol Chem 2002, 277:36068-36075.
4. Yin J., Peng Y., Wu J., Wang Y., Yao L. Toll-like receptor 2/4 links to free fatty acid-induced inflammation and beta-cell dysfunction. J Leukoc Biol 2014, 95:47-52.
5. Dasu M.R., Jialal I. Free fatty acids in the presence of high glucose amplify monocyte inflammation via toll-like receptors. Am J Physiol Endocrinol Metab 2011, 300:E145-E154.
6. Muzio M., Bosisio D., Polentarutti N., D'Amico G., Stoppacciaro A., Mancinelli R., et al. Differential expression and regulation of toll-like receptors (TLR) in human leukocytes: selective expression of TLR3 in dendritic cells. J Immunol 2000, 164:5998-6004.
7. Nguyen M.T., Favelyukis S., Nguyen A.K., Reichart D., Scott P.A., Jenn A., et al. A subpopulation of macrophages infiltrates hypertrophic adipose tissue and is activated by free fatty acids via Toll-like receptors 2 and 4 and JNK-dependent pathways. J Biol Chem 2007, 282:35279-35292.
8. Bouwens M., Grootte Bromhaar M., Jansen J., Muller M., Afman L.A. Postprandial dietary lipid-specific effects on human peripheral blood mononuclear cell gene expression profiles. Am J Clin Nutr 2010, 91:208-217.
9. Aljada A., Mohanty P., Ghanim H., Abdo T., Tripathy D., Chaudhuri A., et al. Increase in intranuclear nuclear factor kappaB and decrease in inhibitor kappaB in mononuclear cells after a mixed meal: evidence for a proinflammatory effect. Am J Clin Nutr 2004, 79:682-690.
10. Blanco-Colio L.M., Valderrama M., Alvarez-Sala L.A., Bustos C., Ortego M., Hernandez-Presa M.A., et al. Red wine intake prevents nuclear factor-kappaB activation in peripheral blood mononuclear cells of healthy volunteers during postprandial lipemia. Circulation 2000, 102:1020-1026.
11. Snodgrass R.G., Huang S., Choi I.W., Rutledge J.C., Hwang D.H. Inflammasome-mediated secretion of IL-1beta in human monocytes through TLR2 activation; modulation by dietary fatty acids. J Immunol 2013, 191:4337-4347.
12. Amar S., Zhou Q., Shaik-Dasthagirisaheb Y., Leeman S. Diet-induced obesity in mice causes changes in immune responses and bone loss manifested by bacterial challenge. Proc Natl Acad Sci U S A 2007, 104:20466-20471.
13. Zhou Q., Leeman S.E., Amar S. Signaling mechanisms involved in altered function of macrophages from diet-induced obese mice affect immune responses. Proc Natl Acad Sci U S A 2009, 106:10740-10745.
14. Damsgaard C.T., Lauritzen L., Calder P.C., Kjaer T.M., Frokiaer H. Whole-blood culture is a valid low-cost method to measure monocytic cytokines-a comparison of cytokine production in cultures of human whole-blood, mononuclear cells and monocytes. J Immunol Methods 2009, 340:95-101.
15. Elsasser-Beile U., von Kleist S., Gallati H. Evaluation of a test system for measuring cytokine production in human whole blood cell cultures. J Immunol Methods 1991, 139:191-195.
16. Raatz S.K., Bibus D., Thomas W., Kris-Etherton P. Total fat intake modifies plasma fatty acid composition in humans. J Nutr 2001, 131:231-234.
17. Mehta A., Oeser A.M., Carlson M.G. Rapid quantitation of free fatty acids in human plasma by high-performance liquid chromatography. J Chromatogr B Biomed Sci Appl 1998, 719:9-23.
18. Shi H., Kokoeva M.V., Inouye K., Tzameli I., Yin H., Flier J.S. TLR4 links innate immunity and fatty acid-induced insulin resistance. J Clin Invest 2006, 116:3015-3025.
19. Ajuwon K.M., Spurlock M.E. Palmitate activates the NF-kappaB transcription factor and induces IL-6 and TNFalpha expression in 3T3-L1 adipocytes. J Nutr 2005, 135:1841-1846.
20. Wan Z., Ritchie I., Beaudoin M.S., Castellani L., Chan C.B., Wright D.C. IL-6 indirectly modulates the induction of glyceroneogenic enzymes in adipose tissue during exercise. PLoS One 2012, 7:e41719.
21. Jin M.S., Kim S.E., Heo J.Y., Lee M.E., Kim H.M., Paik S.G., et al. Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide. Cell 2007, 130:1071-1082.
22. Lavigne M.C., Malech H.L., Holland S.M., Leto T.L. Genetic requirement of p47phox for superoxide production by murine microglia. FASEB J 2001, 15:285-287.
23. Yang C.S., Shin D.M., Lee H.M., Son J.W., Lee S.J., Akira S., et al. ASK1-p38 MAPK-p47phox activation is essential for inflammatory responses during tuberculosis via TLR2-ROS signalling. Cell Microbiol 2008, 10:741-754.
24. Mendelson M., Michallet A.S., Monneret D., Perrin C., Esteve F., Lombard P.R., et al. Impact of exercise training without caloric restriction on inflammation, insulin resistance and visceral fat mass in obese adolescents. Pediatr Obes 2014, 10.1111/ijpo.255.
25. Ryan A.S., Ge S., Blumenthal J.B., Serra M.C., Prior S.J., Goldberg A.P. Aerobic exercise and weight loss reduce vascular markers of inflammation and improve insulin sensitivity in obese women. J Am Geriatr Soc 2014, 62:607-614.