Rosacea, the face of innate immunity

British Journal of Dermatology

Volumn 171, Issue 6, 2014, Pages 1282-1284

  Dorschner, R A ^a   Williams, M R ^a   Gallo, R L ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; AZELAIC ACID; CAFFEINE; CATHELICIDIN; INTRINSIC FACTOR; KALLIKREIN 5; MATRIX METALLOPROTEINASE; NEUROPEPTIDE; PATTERN RECOGNITION RECEPTOR; TETRACYCLINE; TOLL LIKE RECEPTOR 2; ANTIMICROBIAL CATIONIC PEPTIDE;

ANTIBIOTIC THERAPY; BACILLUS; BACILLUS OLERONIUS; DEMODEX FOLLICULORUM; EMOTIONAL STRESS; EXERCISE; HEAT; HUMAN; IMMUNOPATHOGENESIS; INNATE IMMUNITY; KERATINOCYTE; MAST CELL; NONHUMAN; PATHOPHYSIOLOGY; PROPIONIBACTERIUM ACNES; REVIEW; ROSACEA; SUN; IMMUNOLOGY; PHYSIOLOGY; SKIN DISEASE;

ANTIMICROBIAL CATIONIC PEPTIDES; FACIAL DERMATOSES; HUMANS; IMMUNITY, INNATE; NEUROPEPTIDES; ROSACEA;

EID: 84919429575     PISSN: 00070963     EISSN: 13652133     Source Type: Journal    
DOI: 10.1111/bjd.13446     Document Type: Review

References (21)

1. de Bersaques J,. Historical notes on rosacea. Eur J Dermatol 1995; 5: 16-22.
2. Tan J, Berg M,. Rosacea: current state of epidemiology. J Am Acad Dermatol 2013; 69 (Suppl. 1): S27-35.
3. Wilkin J, Dahl M, Detmar M, et al,. Standard classification of rosacea: report of the National Rosacea Society Expert Committee on the Classification and Staging of Rosacea. J Am Acad Dermatol 2002; 46: 584-7.
4. Yamasaki K, Schauber J, Coda A, et al,. Kallikrein-mediated proteolysis regulates the antimicrobial effects of cathelicidins in skin. FASEB J 2006; 20: 2068-80.
5. Braff MH, Hawkins MA, Di Nardo A, et al,. Structure-function relationships among human cathelicidin peptides: dissociation of antimicrobial properties from host immunostimulatory activities. J Immunol 2005; 174: 4271-8.
6. Koczulla R, von Degenfeld G, Kupatt C, et al,. An angiogenic role for the human peptide antibiotic LL-37/hCAP-18. J Clin Invest 2003; 111: 1665-72.
7. Murakami M, Lopez-Garcis B, Braff M, et al,. Postsecretory processing generates multiple cathelicidins for enhanced topical antimicrobial defense. J Immunol 2004; 172: 3070-7.
8. Yamasaki K, Di Nardo A, Bardan A, et al,. Increased serine protease activity and cathelicidin promotes skin inflammation in rosacea. Nat Med 2007; 13: 975-80.
9. Kanada KN, Nakatsuji T, Gallo RL,. Doxycycline indirectly inhibits proteolytic activation of tryptic kallikrein-related peptidases and activation of cathelicidin. J Invest Dermatol 2012; 132: 1435-42.
10. Rundhaug JE,. Matrix metalloproteinases and angiogenesis. J Cell Mol Med 2005; 9: 267-85.
11. Jang YH, Sim JH, Kang HY, et al,. Immunohistochemical expression of matrix metalloproteinases in the granulomatous rosacea compared with the non-granulomatous rosacea. J Eur Acad Dermatol Venereol 2011; 25: 544-8.
12. Kahari VM, Saarialho-Kere U,. Matrix metalloproteinases in skin. Exp Dermatol 1997; 6: 199-213.
13. Coda AB, Hata T, Miller J, et al,. Cathelicidin, kallikrein 5, and serine protease activity is inhibited during treatment of rosacea with azelaic acid 15% gel. J Am Acad Dermatol 2013; 69: 570-7.
14. Yamasaki K, Kanada K, Macleod DT, et al,. TLR2 expression is increased in rosacea and stimulates enhanced serine protease production by keratinocytes. J Invest Dermatol 2011; 131: 688-97.
15. Schauber J, Dorschner RA, Coda AB, et al,. Injury enhances TLR2 function and antimicrobial peptide expression through a vitamin D-dependent mechanism. J Clin Invest 2007; 117: 803-11.
16. Koller B, Müller-Wiefel AS, Rupec R, et al,. Chitin modulates innate immune responses of keratinocytes. PLoS ONE 2011; 6: e16594.
17. Lacey N, Delaney S, Kavanagh K, Powell FC,. Mite-related bacterial antigens stimulate inflammatory cells in rosacea. Br J Dermatol 2007; 157: 474-81.
18. Galli SJ, Grimbaldeston M, Tsai M,. Immunomodulatory mast cells: negative, as well as positive, regulators of immunity. Nat Rev Immunol 2008; 8: 478-86.
19. Muto Y, Wang Z, Vanderberghe M, et al,. Mast cells are key mediators of cathelicidin-initiated skin inflammation in rosacea. J Invest Dermatol 2014; 134: 2728-36.
20. Roosterman D, Goerge T, Schneider SW, et al,. Neuronal control of skin function: the skin as a neuroimmunoendocrine organ. Physiol Rev 2006; 86: 1309-79.
21. Schwab VD, Sulk M, Seeliger S, et al,. Neurovascular and neuroimmune aspects in the pathophysiology of rosacea. J Investig Dermatol Symp Proc 2011; 15: 53-62.