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Volumn 119, Issue 3, 2014, Pages 503-512

Medical therapy of gliomas

Author keywords

Chemotherapy; Clinical trial; Glioblastoma; Gliomas; Molecular profile; Multidisciplinary; Targeted treatment

Indexed keywords

AFATINIB; AFLIBERCEPT; ANGIOGENESIS INHIBITOR; B RAF KINASE; BEVACIZUMAB; BORTEZOMIB; CARBOPLATIN; CARMUSTINE; CEDIRANIB; CILENGITIDE; DACOMITINIB; ENZASTAURIN; ERLOTINIB; EVEROLIMUS; GEFITINIB; IRINOTECAN; ISOCITRATE DEHYDROGENASE 1; LOMUSTINE; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; PLACEBO; PROCARBAZINE; PROTEIN P53; TEMOZOLOMIDE; TEMSIROLIMUS; TIPIFARNIB; VINCRISTINE;

EID: 84919426467     PISSN: 0167594X     EISSN: 15737373     Source Type: Journal    
DOI: 10.1007/s11060-014-1495-1     Document Type: Review
Times cited : (15)

References (102)
  • 1
    • 34250182404 scopus 로고    scopus 로고
    • Chemotherapy delivery issues in central nervous system malignancy: a reality check
    • PID: 17538176, COI: 1:CAS:528:DC%2BD2sXnsVShu7o%3D
    • Muldoon LL, Soussain C, Jahnke K et al (2007) Chemotherapy delivery issues in central nervous system malignancy: a reality check. J Clin Oncol 25:2295–2305
    • (2007) J Clin Oncol , vol.25 , pp. 2295-2305
    • Muldoon, L.L.1    Soussain, C.2    Jahnke, K.3
  • 2
    • 34447343798 scopus 로고    scopus 로고
    • Lessons learned in the development of targeted therapy for malignant gliomas
    • PID: 17620423, COI: 1:CAS:528:DC%2BD2sXnsVyqu7k%3D
    • Omuro AM, Faivre S, Raymond E (2007) Lessons learned in the development of targeted therapy for malignant gliomas. Mol Cancer Ther 6:1909–1919
    • (2007) Mol Cancer Ther , vol.6 , pp. 1909-1919
    • Omuro, A.M.1    Faivre, S.2    Raymond, E.3
  • 3
    • 54049107406 scopus 로고    scopus 로고
    • Neurooncology clinical trial design for targeted therapies: lessons learned from the North American brain tumor consortium
    • PID: 18559968
    • Chang SM, Lamborn KR, Kuhn JG et al (2008) Neurooncology clinical trial design for targeted therapies: lessons learned from the North American brain tumor consortium. Neuro-Oncology 10:631–642
    • (2008) Neuro-Oncology , vol.10 , pp. 631-642
    • Chang, S.M.1    Lamborn, K.R.2    Kuhn, J.G.3
  • 4
    • 67649084009 scopus 로고    scopus 로고
    • Targeted therapy for malignant glioma patients: lessons learned and the road ahead
    • PID: 19560740, COI: 1:CAS:528:DC%2BD1MXhsFent7bI
    • Huang TT, Sarkaria SM, Cloughesy TF, Mischel PS (2009) Targeted therapy for malignant glioma patients: lessons learned and the road ahead. Neurotherapeutics 6:500–512
    • (2009) Neurotherapeutics , vol.6 , pp. 500-512
    • Huang, T.T.1    Sarkaria, S.M.2    Cloughesy, T.F.3    Mischel, P.S.4
  • 5
    • 0037745729 scopus 로고    scopus 로고
    • Prospective clinical trials of intracranial low-grade glioma in adults and children
    • PID: 12816721
    • Shaw EG, Wisoff JH (2003) Prospective clinical trials of intracranial low-grade glioma in adults and children. Neuro-Oncology 5:153–160
    • (2003) Neuro-Oncology , vol.5 , pp. 153-160
    • Shaw, E.G.1    Wisoff, J.H.2
  • 6
    • 84865785710 scopus 로고    scopus 로고
    • Randomized trial of radiation therapy plus procarbazine, lomustine, and vincristine chemotherapy for supratentorial adult low-grade glioma: initial results of RTOG 9802
    • PID: 22851558, COI: 1:CAS:528:DC%2BC38XhsVKlsLjF
    • Shaw EG, Wang M, Coons SW et al (2012) Randomized trial of radiation therapy plus procarbazine, lomustine, and vincristine chemotherapy for supratentorial adult low-grade glioma: initial results of RTOG 9802. J Clin Oncol 30:3065–3070
    • (2012) J Clin Oncol , vol.30 , pp. 3065-3070
    • Shaw, E.G.1    Wang, M.2    Coons, S.W.3
  • 7
    • 84919426428 scopus 로고    scopus 로고
    • Phase III study of radiation therapy (RT) with or without procarbazine, CCNU, and vincristine (PCV) in low grade gliomas: RTOG 9802 with Alliance, ECOG, and SWOG
    • Buckner JC, Pugh SL, Shaw EG (2014) Phase III study of radiation therapy (RT) with or without procarbazine, CCNU, and vincristine (PCV) in low grade gliomas: RTOG 9802 with Alliance, ECOG, and SWOG. ASCO meeting abstracts 32:2001
    • (2014) ASCO meeting abstracts , vol.32 , pp. 2001
    • Buckner, J.C.1    Pugh, S.L.2    Shaw, E.G.3
  • 8
    • 0037089635 scopus 로고    scopus 로고
    • Prognostic factors for survival in adult patients with cerebral low-grade glioma
    • PID: 11956268
    • Pignatti F, van den Bent M, Curran D et al (2002) Prognostic factors for survival in adult patients with cerebral low-grade glioma. J Clin Oncol 20:2076–2084
    • (2002) J Clin Oncol , vol.20 , pp. 2076-2084
    • Pignatti, F.1    van den Bent, M.2    Curran, D.3
  • 9
    • 84916627726 scopus 로고    scopus 로고
    • A phase II study of a temozolomide-based chemoradiotherapy regimen for high-risk low-grade gliomas: preliminary results of RTOG 0424
    • Fisher BJ, Lui J, Macdonald DR et al (2013) A phase II study of a temozolomide-based chemoradiotherapy regimen for high-risk low-grade gliomas: preliminary results of RTOG 0424. ASCO meeting abstracts 31:2008
    • (2013) ASCO meeting abstracts , vol.31 , pp. 2008
    • Fisher, B.J.1    Lui, J.2    Macdonald, D.R.3
  • 10
    • 4143143288 scopus 로고    scopus 로고
    • Temozolomide as initial treatment for adults with low-grade oligodendrogliomas or oligoastrocytomas and correlation with chromosome 1p deletions
    • PID: 15284265, COI: 1:CAS:528:DC%2BD2cXpsVGrs7o%3D
    • Hoang-Xuan K, Capelle L, Kujas M et al (2004) Temozolomide as initial treatment for adults with low-grade oligodendrogliomas or oligoastrocytomas and correlation with chromosome 1p deletions. J Clin Oncol 22:3133–3138
    • (2004) J Clin Oncol , vol.22 , pp. 3133-3138
    • Hoang-Xuan, K.1    Capelle, L.2    Kujas, M.3
  • 11
    • 0037441784 scopus 로고    scopus 로고
    • Phase II trial of temozolomide in patients with progressive low-grade glioma
    • PID: 12586801, COI: 1:CAS:528:DC%2BD2cXpsVGrur8%3D
    • Quinn JA, Reardon DA, Friedman AH et al (2003) Phase II trial of temozolomide in patients with progressive low-grade glioma. J Clin Oncol 21:646–651
    • (2003) J Clin Oncol , vol.21 , pp. 646-651
    • Quinn, J.A.1    Reardon, D.A.2    Friedman, A.H.3
  • 12
    • 0038352148 scopus 로고    scopus 로고
    • Phase II study of first-line chemotherapy with temozolomide in recurrent oligodendroglial tumors: the European Organization for Research and Treatment of Cancer Brain Tumor Group Study 26971
    • PID: 12829671
    • van den Bent MJ, Taphoorn MJ, Brandes AA et al (2003) Phase II study of first-line chemotherapy with temozolomide in recurrent oligodendroglial tumors: the European Organization for Research and Treatment of Cancer Brain Tumor Group Study 26971. J Clin Oncol 21:2525–2528
    • (2003) J Clin Oncol , vol.21 , pp. 2525-2528
    • van den Bent, M.J.1    Taphoorn, M.J.2    Brandes, A.A.3
  • 13
    • 9144274013 scopus 로고    scopus 로고
    • Temozolomide chemotherapy for progressive low-grade glioma: clinical benefits and radiological response
    • PID: 14630675, COI: 1:STN:280:DC%2BD3srltVWgsw%3D%3D
    • Pace A, Vidiri A, Galie E et al (2003) Temozolomide chemotherapy for progressive low-grade glioma: clinical benefits and radiological response. Ann Oncol 14:1722–1726
    • (2003) Ann Oncol , vol.14 , pp. 1722-1726
    • Pace, A.1    Vidiri, A.2    Galie, E.3
  • 14
    • 0031756784 scopus 로고    scopus 로고
    • PCV chemotherapy for recurrent oligodendrogliomas and oligoastrocytomas
    • PID: 9802850, COI: 1:STN:280:DyaK1M%2Fhslymsg%3D%3D
    • Soffietti R, Ruda R, Bradac GB, Schiffer D (1998) PCV chemotherapy for recurrent oligodendrogliomas and oligoastrocytomas. Neurosurgery 43:1066–1073
    • (1998) Neurosurgery , vol.43 , pp. 1066-1073
    • Soffietti, R.1    Ruda, R.2    Bradac, G.B.3    Schiffer, D.4
  • 15
    • 13444265882 scopus 로고    scopus 로고
    • Successful treatment of low-grade oligodendroglial tumors with a chemotherapy regimen of procarbazine, lomustine, and vincristine
    • PID: 15637687
    • Stege EM, Kros JM, de Bruin HG et al (2005) Successful treatment of low-grade oligodendroglial tumors with a chemotherapy regimen of procarbazine, lomustine, and vincristine. Cancer 103:802–809
    • (2005) Cancer , vol.103 , pp. 802-809
    • Stege, E.M.1    Kros, J.M.2    de Bruin, H.G.3
  • 16
    • 33947604513 scopus 로고    scopus 로고
    • Treatment of newly diagnosed symptomatic pure low-grade oligodendrogliomas with PCV chemotherapy
    • PID: 17388986, COI: 1:STN:280:DC%2BD2s7osl2hsQ%3D%3D
    • Lebrun C, Fontaine D, Bourg V et al (2007) Treatment of newly diagnosed symptomatic pure low-grade oligodendrogliomas with PCV chemotherapy. Eur J Neurol 14:391–398
    • (2007) Eur J Neurol , vol.14 , pp. 391-398
    • Lebrun, C.1    Fontaine, D.2    Bourg, V.3
  • 17
    • 0037440219 scopus 로고    scopus 로고
    • Phase II trial of procarbazine, lomustine, and vincristine as initial therapy for patients with low-grade oligodendroglioma or oligoastrocytoma: efficacy and associations with chromosomal abnormalities
    • PID: 12525516, COI: 1:CAS:528:DC%2BD2cXpsVWqs7w%3D
    • Buckner JC, Gesme D Jr, O’Fallon JR et al (2003) Phase II trial of procarbazine, lomustine, and vincristine as initial therapy for patients with low-grade oligodendroglioma or oligoastrocytoma: efficacy and associations with chromosomal abnormalities. J Clin Oncol 21:251–255
    • (2003) J Clin Oncol , vol.21 , pp. 251-255
    • Buckner, J.C.1    Gesme, D.2    O’Fallon, J.R.3
  • 18
    • 0038157019 scopus 로고    scopus 로고
    • Second-line chemotherapy with temozolomide in recurrent oligodendroglioma after PCV (procarbazine, lomustine and vincristine) chemotherapy: EORTC Brain Tumor Group phase II study 26972
    • PID: 12649108
    • van den Bent MJ, Chinot O, Boogerd W et al (2003) Second-line chemotherapy with temozolomide in recurrent oligodendroglioma after PCV (procarbazine, lomustine and vincristine) chemotherapy: EORTC Brain Tumor Group phase II study 26972. Ann Oncol 14:599–602
    • (2003) Ann Oncol , vol.14 , pp. 599-602
    • van den Bent, M.J.1    Chinot, O.2    Boogerd, W.3
  • 19
    • 9144220435 scopus 로고    scopus 로고
    • Phase II study of primary temozolomide chemotherapy in patients with WHO grade II gliomas
    • PID: 14630674, COI: 1:STN:280:DC%2BD3srltVWgsg%3D%3D
    • Brada M, Viviers L, Abson C et al (2003) Phase II study of primary temozolomide chemotherapy in patients with WHO grade II gliomas. Ann Oncol 14:1715–1721
    • (2003) Ann Oncol , vol.14 , pp. 1715-1721
    • Brada, M.1    Viviers, L.2    Abson, C.3
  • 20
    • 1642275594 scopus 로고    scopus 로고
    • Monitoring temozolomide treatment of low-grade glioma with proton magnetic resonance spectroscopy
    • PID: 14970853, COI: 1:CAS:528:DC%2BD2cXht12itbc%3D
    • Murphy PS, Viviers L, Abson C et al (2004) Monitoring temozolomide treatment of low-grade glioma with proton magnetic resonance spectroscopy. Br J Cancer 90:781–786
    • (2004) Br J Cancer , vol.90 , pp. 781-786
    • Murphy, P.S.1    Viviers, L.2    Abson, C.3
  • 21
    • 34247179006 scopus 로고    scopus 로고
    • Toxicity and efficacy of protracted low dose temozolomide for the treatment of low grade gliomas
    • PID: 17082887, COI: 1:CAS:528:DC%2BD2sXlvF2ju7c%3D
    • Pouratian N, Gasco J, Sherman JH, Shaffrey ME, Schiff D (2007) Toxicity and efficacy of protracted low dose temozolomide for the treatment of low grade gliomas. J Neurooncol 82:281–288
    • (2007) J Neurooncol , vol.82 , pp. 281-288
    • Pouratian, N.1    Gasco, J.2    Sherman, J.H.3    Shaffrey, M.E.4    Schiff, D.5
  • 22
    • 33750563258 scopus 로고    scopus 로고
    • A t(1;19)(q10;p10) mediates the combined deletions of 1p/19q and predicts a better prognosis of patients with oligodendroglioma
    • PID: 17047046, COI: 1:CAS:528:DC%2BD28XhtVyiur3I
    • Jenkins RB, Blair H, Ballman KV et al (2006) A t(1;19)(q10;p10) mediates the combined deletions of 1p/19q and predicts a better prognosis of patients with oligodendroglioma. Cancer Res 66:9852–9861
    • (2006) Cancer Res , vol.66 , pp. 9852-9861
    • Jenkins, R.B.1    Blair, H.2    Ballman, K.V.3
  • 23
    • 84910149887 scopus 로고    scopus 로고
    • Temozolomide chemotherapy versus radiotherapy in molecularly characterized (1p loss) low-grade glioma: a randomized phase III intergroup study by the EORTC/NCIC-CTG/TROG/MRC-CTU (EORTC 22033-26033)
    • Baumert BG, Mason WP, Ryan G et al (2013) Temozolomide chemotherapy versus radiotherapy in molecularly characterized (1p loss) low-grade glioma: a randomized phase III intergroup study by the EORTC/NCIC-CTG/TROG/MRC-CTU (EORTC 22033-26033). ASCO meeting abstracts 31:2007
    • (2013) ASCO meeting abstracts , vol.31 , pp. 2007
    • Baumert, B.G.1    Mason, W.P.2    Ryan, G.3
  • 24
    • 84899451831 scopus 로고    scopus 로고
    • The molecular and cell biology of pediatric low-grade gliomas
    • PID: 23624918, COI: 1:CAS:528:DC%2BC3sXms1WgsL0%3D
    • Chen YH, Gutmann DH (2014) The molecular and cell biology of pediatric low-grade gliomas. Oncogene 33:2019–2026
    • (2014) Oncogene , vol.33 , pp. 2019-2026
    • Chen, Y.H.1    Gutmann, D.H.2
  • 25
    • 34547432233 scopus 로고    scopus 로고
    • Methylation of the PTEN promoter defines low-grade gliomas and secondary glioblastoma
    • PID: 17504928, COI: 1:CAS:528:DC%2BD2sXpt1agsLo%3D
    • Wiencke JK, Zheng S, Jelluma N et al (2007) Methylation of the PTEN promoter defines low-grade gliomas and secondary glioblastoma. Neuro-Oncology 9:271–279
    • (2007) Neuro-Oncology , vol.9 , pp. 271-279
    • Wiencke, J.K.1    Zheng, S.2    Jelluma, N.3
  • 26
    • 77949265515 scopus 로고    scopus 로고
    • Activation of PI3K/mTOR pathway occurs in most adult low-grade gliomas and predicts patient survival
    • PID: 19705067, COI: 1:CAS:528:DC%2BC3cXhtleiu7s%3D
    • McBride SM, Perez DA, Polley MY et al (2010) Activation of PI3K/mTOR pathway occurs in most adult low-grade gliomas and predicts patient survival. J Neurooncol 97:33–40
    • (2010) J Neurooncol , vol.97 , pp. 33-40
    • McBride, S.M.1    Perez, D.A.2    Polley, M.Y.3
  • 27
    • 84892373020 scopus 로고    scopus 로고
    • Mutational analysis reveals the origin and therapy-driven evolution of recurrent glioma
    • PID: 24336570, COI: 1:CAS:528:DC%2BC2cXktVyktQ%3D%3D
    • Johnson BE, Mazor T, Hong C et al (2014) Mutational analysis reveals the origin and therapy-driven evolution of recurrent glioma. Science 343:189–193
    • (2014) Science , vol.343 , pp. 189-193
    • Johnson, B.E.1    Mazor, T.2    Hong, C.3
  • 28
    • 0023930146 scopus 로고
    • Successful chemotherapy for recurrent malignant oligodendroglioma
    • PID: 3382171, COI: 1:STN:280:DyaL1c3ltV2ntA%3D%3D
    • Cairncross JG, Macdonald DR (1988) Successful chemotherapy for recurrent malignant oligodendroglioma. Ann Neurol 23:360–364
    • (1988) Ann Neurol , vol.23 , pp. 360-364
    • Cairncross, J.G.1    Macdonald, D.R.2
  • 29
    • 0027972896 scopus 로고
    • Chemotherapy for anaplastic oligodendroglioma. National Cancer Institute of Canada Clinical Trials Group
    • PID: 7931469, COI: 1:STN:280:DyaK2M%2Fhs1ylsQ%3D%3D
    • Cairncross G, Macdonald D, Ludwin S et al (1994) Chemotherapy for anaplastic oligodendroglioma. National Cancer Institute of Canada Clinical Trials Group. J Clin Oncol 12:2013–2021
    • (1994) J Clin Oncol , vol.12 , pp. 2013-2021
    • Cairncross, G.1    Macdonald, D.2    Ludwin, S.3
  • 30
    • 33745575716 scopus 로고    scopus 로고
    • Phase III trial of chemotherapy plus radiotherapy compared with radiotherapy alone for pure and mixed anaplastic oligodendroglioma: intergroup radiation therapy oncology group trial 9402
    • PID: 16782910, COI: 1:CAS:528:DC%2BD28XntV2hurg%3D
    • Cairncross G, Berkey B, Shaw E et al (2006) Phase III trial of chemotherapy plus radiotherapy compared with radiotherapy alone for pure and mixed anaplastic oligodendroglioma: intergroup radiation therapy oncology group trial 9402. J Clin Oncol 24:2707–2714
    • (2006) J Clin Oncol , vol.24 , pp. 2707-2714
    • Cairncross, G.1    Berkey, B.2    Shaw, E.3
  • 31
    • 84873338121 scopus 로고    scopus 로고
    • Phase III trial of chemoradiotherapy for anaplastic oligodendroglioma: long-term results of RTOG 9402
    • PID: 23071247, COI: 1:CAS:528:DC%2BC3sXis1Cgtbk%3D
    • Cairncross G, Wang M, Shaw E et al (2013) Phase III trial of chemoradiotherapy for anaplastic oligodendroglioma: long-term results of RTOG 9402. J Clin Oncol 31:337–343
    • (2013) J Clin Oncol , vol.31 , pp. 337-343
    • Cairncross, G.1    Wang, M.2    Shaw, E.3
  • 32
    • 33745532038 scopus 로고    scopus 로고
    • Adjuvant procarbazine, lomustine, and vincristine improves progression-free survival but not overall survival in newly diagnosed anaplastic oligodendrogliomas and oligoastrocytomas: a randomized European Organisation for Research and Treatment of Cancer phase III trial
    • PID: 16782911
    • van den Bent MJ, Carpentier AF, Brandes AA et al (2006) Adjuvant procarbazine, lomustine, and vincristine improves progression-free survival but not overall survival in newly diagnosed anaplastic oligodendrogliomas and oligoastrocytomas: a randomized European Organisation for Research and Treatment of Cancer phase III trial. J Clin Oncol 24:2715–2722
    • (2006) J Clin Oncol , vol.24 , pp. 2715-2722
    • van den Bent, M.J.1    Carpentier, A.F.2    Brandes, A.A.3
  • 33
    • 73349121355 scopus 로고    scopus 로고
    • MGMT promoter methylation is prognostic but not predictive for outcome to adjuvant PCV chemotherapy in anaplastic oligodendroglial tumors: a report from EORTC Brain Tumor Group Study 26951
    • PID: 19901104
    • van den Bent MJ, Dubbink HJ, Sanson M et al (2009) MGMT promoter methylation is prognostic but not predictive for outcome to adjuvant PCV chemotherapy in anaplastic oligodendroglial tumors: a report from EORTC Brain Tumor Group Study 26951. J Clin Oncol 27:5881–5886
    • (2009) J Clin Oncol , vol.27 , pp. 5881-5886
    • van den Bent, M.J.1    Dubbink, H.J.2    Sanson, M.3
  • 34
    • 73249136924 scopus 로고    scopus 로고
    • Molecular analysis of anaplastic oligodendroglial tumors in a prospective randomized study: a report from EORTC study 26951
    • PID: 19224764
    • Kouwenhoven MC, Gorlia T, Kros JM et al (2009) Molecular analysis of anaplastic oligodendroglial tumors in a prospective randomized study: a report from EORTC study 26951. Neuro-Oncology 11:737–746
    • (2009) Neuro-Oncology , vol.11 , pp. 737-746
    • Kouwenhoven, M.C.1    Gorlia, T.2    Kros, J.M.3
  • 35
    • 84873345824 scopus 로고    scopus 로고
    • Adjuvant procarbazine, lomustine, and vincristine chemotherapy in newly diagnosed anaplastic oligodendroglioma: long-term follow-up of EORTC brain tumor group study 26951
    • PID: 23071237
    • van den Bent MJ, Brandes AA, Taphoorn MJ et al (2013) Adjuvant procarbazine, lomustine, and vincristine chemotherapy in newly diagnosed anaplastic oligodendroglioma: long-term follow-up of EORTC brain tumor group study 26951. J Clin Oncol 31:344–350
    • (2013) J Clin Oncol , vol.31 , pp. 344-350
    • van den Bent, M.J.1    Brandes, A.A.2    Taphoorn, M.J.3
  • 36
    • 65949101643 scopus 로고    scopus 로고
    • Phase II trial of preirradiation and concurrent temozolomide in patients with newly diagnosed anaplastic oligodendrogliomas and mixed anaplastic oligoastrocytomas: RTOG BR0131
    • PID: 18779504, COI: 1:CAS:528:DC%2BD1MXkvFentrc%3D
    • Vogelbaum MA, Berkey B, Peereboom D et al (2009) Phase II trial of preirradiation and concurrent temozolomide in patients with newly diagnosed anaplastic oligodendrogliomas and mixed anaplastic oligoastrocytomas: RTOG BR0131. Neuro-Oncology 11:167–175
    • (2009) Neuro-Oncology , vol.11 , pp. 167-175
    • Vogelbaum, M.A.1    Berkey, B.2    Peereboom, D.3
  • 37
    • 0035340512 scopus 로고    scopus 로고
    • Safety and efficacy of temozolomide in patients with recurrent anaplastic oligodendrogliomas after standard radiotherapy and chemotherapy
    • PID: 11331324, COI: 1:CAS:528:DC%2BD3MXjvVelur0%3D
    • Chinot OL, Honore S, Dufour H et al (2001) Safety and efficacy of temozolomide in patients with recurrent anaplastic oligodendrogliomas after standard radiotherapy and chemotherapy. J Clin Oncol 19:2449–2455
    • (2001) J Clin Oncol , vol.19 , pp. 2449-2455
    • Chinot, O.L.1    Honore, S.2    Dufour, H.3
  • 38
    • 0032729803 scopus 로고    scopus 로고
    • Procarbazine, lomustine, and vincristine (PCV) chemotherapy for anaplastic astrocytoma: a retrospective review of radiation therapy oncology group protocols comparing survival with carmustine or PCV adjuvant chemotherapy
    • PID: 10550132, COI: 1:CAS:528:DyaK1MXnvVGlt74%3D
    • Prados MD, Scott C, Curran WJ Jr, Nelson DF, Leibel S, Kramer S (1999) Procarbazine, lomustine, and vincristine (PCV) chemotherapy for anaplastic astrocytoma: a retrospective review of radiation therapy oncology group protocols comparing survival with carmustine or PCV adjuvant chemotherapy. J Clin Oncol 17:3389–3395
    • (1999) J Clin Oncol , vol.17 , pp. 3389-3395
    • Prados, M.D.1    Scott, C.2    Curran, W.J.3    Nelson, D.F.4    Leibel, S.5    Kramer, S.6
  • 39
    • 0037161024 scopus 로고    scopus 로고
    • Chemotherapy in adult high-grade glioma: a systematic review and meta-analysis of individual patient data from 12 randomised trials
    • PID: 11937180, COI: 1:CAS:528:DC%2BD38XisV2htro%3D
    • Stewart LA (2002) Chemotherapy in adult high-grade glioma: a systematic review and meta-analysis of individual patient data from 12 randomised trials. Lancet 359:1011–1018
    • (2002) Lancet , vol.359 , pp. 1011-1018
    • Stewart, L.A.1
  • 40
    • 0035863293 scopus 로고    scopus 로고
    • (2001) Randomized trial of procarbazine, lomustine, and vincristine in the adjuvant treatment of high-grade astrocytoma: a Medical Research Council trial. J Clin Oncol 19:509–518
    • (2001) Randomized trial of procarbazine, lomustine, and vincristine in the adjuvant treatment of high-grade astrocytoma: a Medical Research Council trial. J Clin Oncol 19:509–518
  • 41
    • 73349134695 scopus 로고    scopus 로고
    • NOA-04 randomized phase III trial of sequential radiochemotherapy of anaplastic glioma with procarbazine, lomustine, and vincristine or temozolomide
    • PID: 19901110, COI: 1:CAS:528:DC%2BC3cXhtVWis7g%3D
    • Wick W, Hartmann C, Engel C et al (2009) NOA-04 randomized phase III trial of sequential radiochemotherapy of anaplastic glioma with procarbazine, lomustine, and vincristine or temozolomide. J Clin Oncol 27:5874–5880
    • (2009) J Clin Oncol , vol.27 , pp. 5874-5880
    • Wick, W.1    Hartmann, C.2    Engel, C.3
  • 42
    • 20044372154 scopus 로고    scopus 로고
    • MGMT gene silencing and benefit from temozolomide in glioblastoma
    • PID: 15758010, COI: 1:CAS:528:DC%2BD2MXit1Wktro%3D
    • Hegi ME, Diserens AC, Gorlia T et al (2005) MGMT gene silencing and benefit from temozolomide in glioblastoma. N Engl J Med 352:997–1003
    • (2005) N Engl J Med , vol.352 , pp. 997-1003
    • Hegi, M.E.1    Diserens, A.C.2    Gorlia, T.3
  • 44
    • 60849115270 scopus 로고    scopus 로고
    • IDH1 and IDH2 mutations in gliomas
    • PID: 19228619, COI: 1:CAS:528:DC%2BD1MXitFWru7o%3D
    • Yan H, Parsons DW, Jin G et al (2009) IDH1 and IDH2 mutations in gliomas. N Engl J Med 360:765–773
    • (2009) N Engl J Med , vol.360 , pp. 765-773
    • Yan, H.1    Parsons, D.W.2    Jin, G.3
  • 45
    • 0032855728 scopus 로고    scopus 로고
    • Multicenter phase II trial of temozolomide in patients with anaplastic astrocytoma or anaplastic oligoastrocytoma at first relapse. Temodal Brain Tumor Group
    • PID: 10561351, COI: 1:CAS:528:DyaK1MXmtlWru7s%3D
    • Yung WK, Prados MD, Yaya-Tur R et al (1999) Multicenter phase II trial of temozolomide in patients with anaplastic astrocytoma or anaplastic oligoastrocytoma at first relapse. Temodal Brain Tumor Group. J Clin Oncol 17:2762–2771
    • (1999) J Clin Oncol , vol.17 , pp. 2762-2771
    • Yung, W.K.1    Prados, M.D.2    Yaya-Tur, R.3
  • 46
    • 70350461699 scopus 로고    scopus 로고
    • Bevacizumab alone and in combination with irinotecan in recurrent glioblastoma
    • PID: 19720927, COI: 1:CAS:528:DC%2BD1MXhtlGgtbbM
    • Friedman HS, Prados MD, Wen PY et al (2009) Bevacizumab alone and in combination with irinotecan in recurrent glioblastoma. J Clin Oncol 27:4733–4740
    • (2009) J Clin Oncol , vol.27 , pp. 4733-4740
    • Friedman, H.S.1    Prados, M.D.2    Wen, P.Y.3
  • 47
    • 58149470640 scopus 로고    scopus 로고
    • Salvage chemotherapy with bevacizumab for recurrent alkylator-refractory anaplastic astrocytoma
    • PID: 18953491, COI: 1:CAS:528:DC%2BD1MXjvFelsg%3D%3D
    • Chamberlain MC, Johnston S (2009) Salvage chemotherapy with bevacizumab for recurrent alkylator-refractory anaplastic astrocytoma. J Neurooncol 91:359–367
    • (2009) J Neurooncol , vol.91 , pp. 359-367
    • Chamberlain, M.C.1    Johnston, S.2
  • 48
    • 20044366163 scopus 로고    scopus 로고
    • Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma
    • PID: 15758009, COI: 1:CAS:528:DC%2BD2MXit1Wksbk%3D
    • Stupp R, Mason WP, van den Bent MJ et al (2005) Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med 352:987–996
    • (2005) N Engl J Med , vol.352 , pp. 987-996
    • Stupp, R.1    Mason, W.P.2    van den Bent, M.J.3
  • 49
    • 68949085460 scopus 로고    scopus 로고
    • Randomized phase II trial of chemoradiotherapy followed by either dose-dense or metronomic temozolomide for newly diagnosed glioblastoma
    • PID: 19506159, COI: 1:CAS:528:DC%2BD1MXhtFaitrrJ
    • Clarke JL, Iwamoto FM, Sul J et al (2009) Randomized phase II trial of chemoradiotherapy followed by either dose-dense or metronomic temozolomide for newly diagnosed glioblastoma. J Clin Oncol 27:3861–3867
    • (2009) J Clin Oncol , vol.27 , pp. 3861-3867
    • Clarke, J.L.1    Iwamoto, F.M.2    Sul, J.3
  • 50
    • 77951648272 scopus 로고    scopus 로고
    • Phase II trial of continuous dose-intense temozolomide in recurrent malignant glioma: RESCUE study
    • PID: 20308655, COI: 1:CAS:528:DC%2BC3cXmtlSksrk%3D
    • Perry JR, Belanger K, Mason WP et al (2010) Phase II trial of continuous dose-intense temozolomide in recurrent malignant glioma: RESCUE study. J Clin Oncol 28:2051–2057
    • (2010) J Clin Oncol , vol.28 , pp. 2051-2057
    • Perry, J.R.1    Belanger, K.2    Mason, W.P.3
  • 51
    • 84891785971 scopus 로고    scopus 로고
    • Dose-dense temozolomide for newly diagnosed glioblastoma: a randomized phase III clinical trial
    • PID: 24101040, COI: 1:CAS:528:DC%2BC3sXhvFSksrbF
    • Gilbert MR, Wang M, Aldape KD et al (2013) Dose-dense temozolomide for newly diagnosed glioblastoma: a randomized phase III clinical trial. J Clin Oncol 31:4085–4091
    • (2013) J Clin Oncol , vol.31 , pp. 4085-4091
    • Gilbert, M.R.1    Wang, M.2    Aldape, K.D.3
  • 52
    • 69549145898 scopus 로고    scopus 로고
    • The potential role and application of PARP inhibitors in cancer treatment
    • PID: 19208614, COI: 1:CAS:528:DC%2BD1MXivFSiu7w%3D
    • Chalmers AJ (2009) The potential role and application of PARP inhibitors in cancer treatment. Br Med Bull 89:23–40
    • (2009) Br Med Bull , vol.89 , pp. 23-40
    • Chalmers, A.J.1
  • 53
    • 54049112348 scopus 로고    scopus 로고
    • Replication-dependent radiosensitization of human glioma cells by inhibition of poly(ADP-ribose) polymerase: mechanisms and therapeutic potential
    • PID: 18954712, COI: 1:CAS:528:DC%2BD1cXht12gur7O
    • Dungey FA, Loser DA, Chalmers AJ (2008) Replication-dependent radiosensitization of human glioma cells by inhibition of poly(ADP-ribose) polymerase: mechanisms and therapeutic potential. Int J Radiat Oncol Biol Phys 72:1188–1197
    • (2008) Int J Radiat Oncol Biol Phys , vol.72 , pp. 1188-1197
    • Dungey, F.A.1    Loser, D.A.2    Chalmers, A.J.3
  • 54
    • 71049139405 scopus 로고    scopus 로고
    • Poly(ADP-ribose) polymerase inhibitors in cancer treatment: a clinical perspective
    • PID: 19926276, COI: 1:CAS:528:DC%2BD1MXhsFGrsbjN
    • Sandhu SK, Yap TA, de Bono JS (2010) Poly(ADP-ribose) polymerase inhibitors in cancer treatment: a clinical perspective. Eur J Cancer 46:9–20
    • (2010) Eur J Cancer , vol.46 , pp. 9-20
    • Sandhu, S.K.1    Yap, T.A.2    de Bono, J.S.3
  • 55
    • 84865558322 scopus 로고    scopus 로고
    • Temozolomide versus standard 6-week radiotherapy versus hypofractionated radiotherapy in patients older than 60 years with glioblastoma: the Nordic randomised, phase III trial
    • PID: 22877848
    • Malmstrom A, Gronberg BH, Marosi C et al (2012) Temozolomide versus standard 6-week radiotherapy versus hypofractionated radiotherapy in patients older than 60 years with glioblastoma: the Nordic randomised, phase III trial. Lancet Oncol 13:916–926
    • (2012) Lancet Oncol , vol.13 , pp. 916-926
    • Malmstrom, A.1    Gronberg, B.H.2    Marosi, C.3
  • 56
    • 84863091424 scopus 로고    scopus 로고
    • Temozolomide chemotherapy alone versus radiotherapy alone for malignant astrocytoma in the elderly: the NOA-08 randomised, phase III trial
    • PID: 22578793, COI: 1:CAS:528:DC%2BC38XhtVShtrjK
    • Wick W, Platten M, Meisner C et al (2012) Temozolomide chemotherapy alone versus radiotherapy alone for malignant astrocytoma in the elderly: the NOA-08 randomised, phase III trial. Lancet Oncol 13:707–715
    • (2012) Lancet Oncol , vol.13 , pp. 707-715
    • Wick, W.1    Platten, M.2    Meisner, C.3
  • 57
    • 84896886566 scopus 로고    scopus 로고
    • Treatment options and outcomes for glioblastoma in the elderly patient
    • PID: 24591820
    • Arvold ND, Reardon DA (2014) Treatment options and outcomes for glioblastoma in the elderly patient. Clin Interv Aging 9:357–367
    • (2014) Clin Interv Aging , vol.9 , pp. 357-367
    • Arvold, N.D.1    Reardon, D.A.2
  • 58
    • 33947191055 scopus 로고    scopus 로고
    • Phase II trial of bevacizumab and irinotecan in recurrent malignant glioma
    • PID: 17317837, COI: 1:CAS:528:DC%2BD2sXhvF2htr8%3D
    • Vredenburgh JJ, Desjardins A, Herndon JE 2nd et al (2007) Phase II trial of bevacizumab and irinotecan in recurrent malignant glioma. Clin Cancer Res 13:1253–1259
    • (2007) Clin Cancer Res , vol.13 , pp. 1253-1259
    • Vredenburgh, J.J.1    Desjardins, A.2    Herndon, J.E.3
  • 59
    • 59949083263 scopus 로고    scopus 로고
    • Phase II trial of single-agent bevacizumab followed by bevacizumab plus irinotecan at tumor progression in recurrent glioblastoma
    • PID: 19114704, COI: 1:CAS:528:DC%2BD1MXjsVCjs7o%3D
    • Kreisl TN, Kim L, Moore K et al (2009) Phase II trial of single-agent bevacizumab followed by bevacizumab plus irinotecan at tumor progression in recurrent glioblastoma. J Clin Oncol 27:740–745
    • (2009) J Clin Oncol , vol.27 , pp. 740-745
    • Kreisl, T.N.1    Kim, L.2    Moore, K.3
  • 60
    • 84892409919 scopus 로고    scopus 로고
    • A randomized phase II study of carboplatin and bevacizumab in recurrent glioblastoma multiforme (CABARET)
    • Field KM, Simes J, Wheeler H et al (2013) A randomized phase II study of carboplatin and bevacizumab in recurrent glioblastoma multiforme (CABARET). ASCO meeting abstracts 31:2017
    • (2013) ASCO meeting abstracts , vol.31 , pp. 2017
    • Field, K.M.1    Simes, J.2    Wheeler, H.3
  • 61
    • 84885421539 scopus 로고    scopus 로고
    • A randomized phase II study of bevacizumab versus bevacizumab plus lomustine versus lomustine single agent in recurrent glioblastoma: The Dutch BELOB study
    • Taal W, Oosterkamp HM, Walenkamp AME et al (2013) A randomized phase II study of bevacizumab versus bevacizumab plus lomustine versus lomustine single agent in recurrent glioblastoma: The Dutch BELOB study. ASCO meeting abstracts2013 31:2001
    • (2013) ASCO meeting abstracts2013 , vol.31 , pp. 2001
    • Taal, W.1    Oosterkamp, H.M.2    Walenkamp, A.M.E.3
  • 62
    • 45249097586 scopus 로고    scopus 로고
    • Phase II pilot study of bevacizumab in combination with temozolomide and regional radiation therapy for up-front treatment of patients with newly diagnosed glioblastoma multiforme: interim analysis of safety and tolerability
    • PID: 18355978, COI: 1:CAS:528:DC%2BD1cXoslWqsLo%3D
    • Lai A, Filka E, McGibbon B et al (2008) Phase II pilot study of bevacizumab in combination with temozolomide and regional radiation therapy for up-front treatment of patients with newly diagnosed glioblastoma multiforme: interim analysis of safety and tolerability. Int J Radiat Oncol Biol Phys 71:1372–1380
    • (2008) Int J Radiat Oncol Biol Phys , vol.71 , pp. 1372-1380
    • Lai, A.1    Filka, E.2    McGibbon, B.3
  • 63
    • 84894114159 scopus 로고    scopus 로고
    • A randomized trial of bevacizumab for newly diagnosed glioblastoma
    • PID: 24552317, COI: 1:CAS:528:DC%2BC2cXjt1alu7o%3D
    • Gilbert MR, Dignam JJ, Armstrong TS et al (2014) A randomized trial of bevacizumab for newly diagnosed glioblastoma. N Engl J Med 370:699–708
    • (2014) N Engl J Med , vol.370 , pp. 699-708
    • Gilbert, M.R.1    Dignam, J.J.2    Armstrong, T.S.3
  • 64
    • 84894194756 scopus 로고    scopus 로고
    • Bevacizumab plus radiotherapy-temozolomide for newly diagnosed glioblastoma
    • PID: 24552318, COI: 1:CAS:528:DC%2BC2cXjt1alu7s%3D
    • Chinot OL, Wick W, Mason W et al (2014) Bevacizumab plus radiotherapy-temozolomide for newly diagnosed glioblastoma. N Engl J Med 370:709–722
    • (2014) N Engl J Med , vol.370 , pp. 709-722
    • Chinot, O.L.1    Wick, W.2    Mason, W.3
  • 65
    • 84892392643 scopus 로고    scopus 로고
    • Bevacizumab, irinotecan, and radiotherapy versus standard temozolomide and radiotherapy in newly diagnosed, MGMT-nonmethylated glioblastoma patients: first results from the randomized multicenter GLARIUS trial
    • Herrlinger U, Schaefer N, Steinbach JP et al (2013) Bevacizumab, irinotecan, and radiotherapy versus standard temozolomide and radiotherapy in newly diagnosed, MGMT-nonmethylated glioblastoma patients: first results from the randomized multicenter GLARIUS trial. ASCO meeting abstracts 31:LBA2000
    • (2013) ASCO meeting abstracts 31:LBA2000
    • Herrlinger, U.1    Schaefer, N.2    Steinbach, J.P.3
  • 66
    • 33846149645 scopus 로고    scopus 로고
    • AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients
    • PID: 17222792, COI: 1:CAS:528:DC%2BD2sXhtFClsLc%3D
    • Batchelor TT, Sorensen AG, di Tomaso E et al (2007) AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients. Cancer Cell 11:83–95
    • (2007) Cancer Cell , vol.11 , pp. 83-95
    • Batchelor, T.T.1    Sorensen, A.G.2    di Tomaso, E.3
  • 67
    • 84887116872 scopus 로고    scopus 로고
    • Phase III randomized trial comparing the efficacy of cediranib as monotherapy, and in combination with lomustine, versus lomustine alone in patients with recurrent glioblastoma
    • PID: 23940216, COI: 1:CAS:528:DC%2BC3sXhs1ahur7O
    • Batchelor TT, Mulholland P, Neyns B et al (2013) Phase III randomized trial comparing the efficacy of cediranib as monotherapy, and in combination with lomustine, versus lomustine alone in patients with recurrent glioblastoma. J Clin Oncol 31:3212–3218
    • (2013) J Clin Oncol , vol.31 , pp. 3212-3218
    • Batchelor, T.T.1    Mulholland, P.2    Neyns, B.3
  • 68
    • 79960111080 scopus 로고    scopus 로고
    • Phase II study of aflibercept in recurrent malignant glioma: a North American Brain Tumor Consortium study
    • PID: 21606416
    • de Groot JF, Lamborn KR, Chang SM et al (2011) Phase II study of aflibercept in recurrent malignant glioma: a North American Brain Tumor Consortium study. J Clin Oncol 29:2689–2695
    • (2011) J Clin Oncol , vol.29 , pp. 2689-2695
    • de Groot, J.F.1    Lamborn, K.R.2    Chang, S.M.3
  • 69
    • 57149108506 scopus 로고    scopus 로고
    • Randomized phase II study of cilengitide, an integrin-targeting arginine-glycine-aspartic acid peptide, in recurrent glioblastoma multiforme
    • PID: 18981465, COI: 1:CAS:528:DC%2BD1MXmsVSrsw%3D%3D
    • Reardon DA, Fink KL, Mikkelsen T et al (2008) Randomized phase II study of cilengitide, an integrin-targeting arginine-glycine-aspartic acid peptide, in recurrent glioblastoma multiforme. J Clin Oncol 26:5610–5617
    • (2008) J Clin Oncol , vol.26 , pp. 5610-5617
    • Reardon, D.A.1    Fink, K.L.2    Mikkelsen, T.3
  • 70
    • 77954924659 scopus 로고    scopus 로고
    • Phase I/IIa study of cilengitide and temozolomide with concomitant radiotherapy followed by cilengitide and temozolomide maintenance therapy in patients with newly diagnosed glioblastoma
    • PID: 20439646, COI: 1:CAS:528:DC%2BC3cXoslyktLs%3D
    • Stupp R, Hegi ME, Neyns B et al (2010) Phase I/IIa study of cilengitide and temozolomide with concomitant radiotherapy followed by cilengitide and temozolomide maintenance therapy in patients with newly diagnosed glioblastoma. J Clin Oncol 28:2712–2718
    • (2010) J Clin Oncol , vol.28 , pp. 2712-2718
    • Stupp, R.1    Hegi, M.E.2    Neyns, B.3
  • 71
    • 84892379628 scopus 로고    scopus 로고
    • Cilengitide combined with standard treatment for patients with newly diagnosed glioblastoma and methylated O6-methylguanine-DNA methyltransferase (MGMT) gene promoter: key results of the multicenter, randomized, open-label, controlled, phase III CENTRIC study
    • Stupp R, Hegi ME, Gorlia T et al (2013) Cilengitide combined with standard treatment for patients with newly diagnosed glioblastoma and methylated O6-methylguanine-DNA methyltransferase (MGMT) gene promoter: key results of the multicenter, randomized, open-label, controlled, phase III CENTRIC study. ASCO meeting abstracts 31:LBA2009
    • (2013) ASCO meeting abstracts 31:LBA2009
    • Stupp, R.1    Hegi, M.E.2    Gorlia, T.3
  • 72
    • 77949891455 scopus 로고    scopus 로고
    • Phase III study of enzastaurin compared with lomustine in the treatment of recurrent intracranial glioblastoma
    • PID: 20124186, COI: 1:CAS:528:DC%2BC3cXktF2ltb4%3D
    • Wick W, Puduvalli VK, Chamberlain MC et al (2010) Phase III study of enzastaurin compared with lomustine in the treatment of recurrent intracranial glioblastoma. J Clin Oncol 28:1168–1174
    • (2010) J Clin Oncol , vol.28 , pp. 1168-1174
    • Wick, W.1    Puduvalli, V.K.2    Chamberlain, M.C.3
  • 73
    • 77956700164 scopus 로고    scopus 로고
    • Phase II study of XL184 (BMS 907351), an inhibitor of MET, VEGFR2, and RET, in patients (pts) with progressive glioblastoma (GB)
    • Wen PY, Prados M, Schiff D et al (2010) Phase II study of XL184 (BMS 907351), an inhibitor of MET, VEGFR2, and RET, in patients (pts) with progressive glioblastoma (GB). ASCO meeting abstracts 28:2006
    • (2010) ASCO meeting abstracts , vol.28 , pp. 2006
    • Wen, P.Y.1    Prados, M.2    Schiff, D.3
  • 74
    • 84885009230 scopus 로고    scopus 로고
    • Enzastaurin before and concomitant with radiation therapy, followed by enzastaurin maintenance therapy, in patients with newly diagnosed glioblastoma without MGMT promoter hypermethylation
    • PID: 23911595, COI: 1:CAS:528:DC%2BC3sXhsFegsL3N
    • Wick W, Steinbach JP, Platten M et al (2013) Enzastaurin before and concomitant with radiation therapy, followed by enzastaurin maintenance therapy, in patients with newly diagnosed glioblastoma without MGMT promoter hypermethylation. Neuro-Oncology 15:1405–1412
    • (2013) Neuro-Oncology , vol.15 , pp. 1405-1412
    • Wick, W.1    Steinbach, J.P.2    Platten, M.3
  • 75
    • 9144261587 scopus 로고    scopus 로고
    • Phase I trial of irinotecan (CPT-11) in patients with recurrent malignant glioma: a North American Brain Tumor Consortium study
    • PID: 14769140, COI: 1:CAS:528:DC%2BD2cXht1aqsr8%3D
    • Prados MD, Yung WK, Jaeckle KA et al (2004) Phase I trial of irinotecan (CPT-11) in patients with recurrent malignant glioma: a North American Brain Tumor Consortium study. Neuro-Oncology 6:44–54
    • (2004) Neuro-Oncology , vol.6 , pp. 44-54
    • Prados, M.D.1    Yung, W.K.2    Jaeckle, K.A.3
  • 76
    • 33745183568 scopus 로고    scopus 로고
    • Phase I trial of erlotinib with radiation therapy in patients with glioblastoma multiforme: results of North Central Cancer Treatment Group protocol N0177
    • PID: 16626884, COI: 1:CAS:528:DC%2BD28Xmt1Gkurk%3D
    • Krishnan S, Brown PD, Ballman KV et al (2006) Phase I trial of erlotinib with radiation therapy in patients with glioblastoma multiforme: results of North Central Cancer Treatment Group protocol N0177. Int J Radiat Oncol Biol Phys 65:1192–1199
    • (2006) Int J Radiat Oncol Biol Phys , vol.65 , pp. 1192-1199
    • Krishnan, S.1    Brown, P.D.2    Ballman, K.V.3
  • 77
    • 1842500007 scopus 로고    scopus 로고
    • Phase II trial of gefitinib in recurrent glioblastoma
    • PID: 14638850, COI: 1:CAS:528:DC%2BD2cXpsVKhsr8%3D
    • Rich JN, Reardon DA, Peery T et al (2004) Phase II trial of gefitinib in recurrent glioblastoma. J Clin Oncol 22:133–142
    • (2004) J Clin Oncol , vol.22 , pp. 133-142
    • Rich, J.N.1    Reardon, D.A.2    Peery, T.3
  • 78
    • 62449150719 scopus 로고    scopus 로고
    • Randomized phase II trial of erlotinib versus temozolomide or carmustine in recurrent glioblastoma: EORTC brain tumor group study 26034
    • PID: 19204207
    • van den Bent MJ, Brandes AA, Rampling R et al (2009) Randomized phase II trial of erlotinib versus temozolomide or carmustine in recurrent glioblastoma: EORTC brain tumor group study 26034. J Clin Oncol 27:1268–1274
    • (2009) J Clin Oncol , vol.27 , pp. 1268-1274
    • van den Bent, M.J.1    Brandes, A.A.2    Rampling, R.3
  • 79
    • 27744606737 scopus 로고    scopus 로고
    • Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors
    • PID: 16282176, COI: 1:CAS:528:DC%2BD2MXht1SrtrrE
    • Mellinghoff IK, Wang MY, Vivanco I et al (2005) Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors. N Engl J Med 353:2012–2024
    • (2005) N Engl J Med , vol.353 , pp. 2012-2024
    • Mellinghoff, I.K.1    Wang, M.Y.2    Vivanco, I.3
  • 80
    • 59149086517 scopus 로고    scopus 로고
    • Phase II study of erlotinib plus temozolomide during and after radiation therapy in patients with newly diagnosed glioblastoma multiforme or gliosarcoma
    • PID: 19075262, COI: 1:CAS:528:DC%2BD1MXivFyjurk%3D
    • Prados MD, Chang SM, Butowski N et al (2009) Phase II study of erlotinib plus temozolomide during and after radiation therapy in patients with newly diagnosed glioblastoma multiforme or gliosarcoma. J Clin Oncol 27:579–584
    • (2009) J Clin Oncol , vol.27 , pp. 579-584
    • Prados, M.D.1    Chang, S.M.2    Butowski, N.3
  • 81
    • 57149118473 scopus 로고    scopus 로고
    • Phase I/II trial of erlotinib and temozolomide with radiation therapy in the treatment of newly diagnosed glioblastoma multiforme: North Central Cancer Treatment Group Study N0177
    • PID: 18955445, COI: 1:CAS:528:DC%2BD1MXmsVSrsg%3D%3D
    • Brown PD, Krishnan S, Sarkaria JN et al (2008) Phase I/II trial of erlotinib and temozolomide with radiation therapy in the treatment of newly diagnosed glioblastoma multiforme: North Central Cancer Treatment Group Study N0177. J Clin Oncol 26:5603–5609
    • (2008) J Clin Oncol , vol.26 , pp. 5603-5609
    • Brown, P.D.1    Krishnan, S.2    Sarkaria, J.N.3
  • 82
    • 84875239034 scopus 로고    scopus 로고
    • RTOG 0211: a phase I/II study of radiation therapy with concurrent gefitinib for newly diagnosed glioblastoma patients
    • PID: 23182702, COI: 1:CAS:528:DC%2BC38XhslCnt7jJ
    • Chakravarti A, Wang M, Robins HI et al (2013) RTOG 0211: a phase I/II study of radiation therapy with concurrent gefitinib for newly diagnosed glioblastoma patients. Int J Radiat Oncol Biol Phys 85:1206–1211
    • (2013) Int J Radiat Oncol Biol Phys , vol.85 , pp. 1206-1211
    • Chakravarti, A.1    Wang, M.2    Robins, H.I.3
  • 83
    • 80053583913 scopus 로고    scopus 로고
    • A phase II study of daily afatinib (BIBW 2992) with or without temozolomide (21/28 days) in the treatment of patients with recurrent glioblastoma
    • Eisenstat DD, Nabors LB, Mason WP et al (2011) A phase II study of daily afatinib (BIBW 2992) with or without temozolomide (21/28 days) in the treatment of patients with recurrent glioblastoma. ASCO meeting abstracts 29:2010
    • (2011) ASCO meeting abstracts , vol.29 , pp. 2010
    • Eisenstat, D.D.1    Nabors, L.B.2    Mason, W.P.3
  • 84
    • 21044431575 scopus 로고    scopus 로고
    • Phase II study of CCI-779 in patients with recurrent glioblastoma multiforme
    • PID: 16012795, COI: 1:CAS:528:DC%2BD2MXmtVymtLY%3D
    • Chang SM, Wen P, Cloughesy T et al (2005) Phase II study of CCI-779 in patients with recurrent glioblastoma multiforme. Invest New Drugs 23:357–361
    • (2005) Invest New Drugs , vol.23 , pp. 357-361
    • Chang, S.M.1    Wen, P.2    Cloughesy, T.3
  • 85
    • 33747058029 scopus 로고    scopus 로고
    • Phase II trial of tipifarnib in patients with recurrent malignant glioma either receiving or not receiving enzyme-inducing antiepileptic drugs: a North American Brain Tumor Consortium Study
    • PID: 16877733, COI: 1:CAS:528:DC%2BD28XovVSjsbo%3D
    • Cloughesy TF, Wen PY, Robins HI et al (2006) Phase II trial of tipifarnib in patients with recurrent malignant glioma either receiving or not receiving enzyme-inducing antiepileptic drugs: a North American Brain Tumor Consortium Study. J Clin Oncol 24:3651–3656
    • (2006) J Clin Oncol , vol.24 , pp. 3651-3656
    • Cloughesy, T.F.1    Wen, P.Y.2    Robins, H.I.3
  • 86
    • 33746807790 scopus 로고    scopus 로고
    • Pilot study of the combination of EGFR and mTOR inhibitors in recurrent malignant gliomas
    • PID: 16832099, COI: 1:CAS:528:DC%2BD28XlvFylu7c%3D
    • Doherty L, Gigas DC, Kesari S et al (2006) Pilot study of the combination of EGFR and mTOR inhibitors in recurrent malignant gliomas. Neurology 67:156–158
    • (2006) Neurology , vol.67 , pp. 156-158
    • Doherty, L.1    Gigas, D.C.2    Kesari, S.3
  • 87
    • 23944453425 scopus 로고    scopus 로고
    • Phase II trial of temsirolimus (CCI-779) in recurrent glioblastoma multiforme: a North Central Cancer Treatment Group Study
    • PID: 15998902, COI: 1:CAS:528:DC%2BD2MXpslOrtLw%3D
    • Galanis E, Buckner JC, Maurer MJ et al (2005) Phase II trial of temsirolimus (CCI-779) in recurrent glioblastoma multiforme: a North Central Cancer Treatment Group Study. J Clin Oncol 23:5294–5304
    • (2005) J Clin Oncol , vol.23 , pp. 5294-5304
    • Galanis, E.1    Buckner, J.C.2    Maurer, M.J.3
  • 88
    • 75049084471 scopus 로고    scopus 로고
    • Phase II trial of erlotinib plus sirolimus in adults with recurrent glioblastoma
    • PID: 19562254, COI: 1:CAS:528:DC%2BC3cXpsVSjtA%3D%3D
    • Reardon DA, Desjardins A, Vredenburgh JJ et al (2010) Phase II trial of erlotinib plus sirolimus in adults with recurrent glioblastoma. J Neurooncol 96:219–230
    • (2010) J Neurooncol , vol.96 , pp. 219-230
    • Reardon, D.A.1    Desjardins, A.2    Vredenburgh, J.J.3
  • 89
    • 65349141942 scopus 로고    scopus 로고
    • Phase II trial of vorinostat in recurrent glioblastoma multiforme: a north central cancer treatment group study
    • PID: 19307505, COI: 1:CAS:528:DC%2BD1MXls1Cgtb4%3D
    • Galanis E, Jaeckle KA, Maurer MJ et al (2009) Phase II trial of vorinostat in recurrent glioblastoma multiforme: a north central cancer treatment group study. J Clin Oncol 27:2052–2058
    • (2009) J Clin Oncol , vol.27 , pp. 2052-2058
    • Galanis, E.1    Jaeckle, K.A.2    Maurer, M.J.3
  • 90
    • 67349138194 scopus 로고    scopus 로고
    • Phase I trial using proteasome inhibitor bortezomib and concurrent temozolomide and radiotherapy for central nervous system malignancies
    • PID: 19084346, COI: 1:CAS:528:DC%2BD1MXls1yntrs%3D
    • Kubicek GJ, Werner-Wasik M, Machtay M et al (2009) Phase I trial using proteasome inhibitor bortezomib and concurrent temozolomide and radiotherapy for central nervous system malignancies. Int J Radiat Oncol Biol Phys 74:433–439
    • (2009) Int J Radiat Oncol Biol Phys , vol.74 , pp. 433-439
    • Kubicek, G.J.1    Werner-Wasik, M.2    Machtay, M.3
  • 91
    • 52949127312 scopus 로고    scopus 로고
    • An integrated genomic analysis of human glioblastoma multiforme
    • PID: 18772396, COI: 1:CAS:528:DC%2BD1cXhtFCrtLrE
    • Parsons DW, Jones S, Zhang X et al (2008) An integrated genomic analysis of human glioblastoma multiforme. Science 321:1807–1812
    • (2008) Science , vol.321 , pp. 1807-1812
    • Parsons, D.W.1    Jones, S.2    Zhang, X.3
  • 92
    • 33644820339 scopus 로고    scopus 로고
    • Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis
    • PID: 16530701, COI: 1:CAS:528:DC%2BD28XivFWjtL4%3D
    • Phillips HS, Kharbanda S, Chen R et al (2006) Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis. Cancer Cell 9:157–173
    • (2006) Cancer Cell , vol.9 , pp. 157-173
    • Phillips, H.S.1    Kharbanda, S.2    Chen, R.3
  • 93
    • 73649123907 scopus 로고    scopus 로고
    • Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1
    • PID: 20129251, COI: 1:CAS:528:DC%2BC3cXkvFKgsL4%3D
    • Verhaak RG, Hoadley KA, Purdom E et al (2010) Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1. Cancer Cell 17:98–110
    • (2010) Cancer Cell , vol.17 , pp. 98-110
    • Verhaak, R.G.1    Hoadley, K.A.2    Purdom, E.3
  • 94
    • 84859847164 scopus 로고    scopus 로고
    • Emerging insights into the molecular and cellular basis of glioblastoma
    • PID: 22508724, COI: 1:CAS:528:DC%2BC38XmsFyqsLk%3D
    • Dunn GP, Rinne ML, Wykosky J et al (2012) Emerging insights into the molecular and cellular basis of glioblastoma. Genes Dev 26:756–784
    • (2012) Genes Dev , vol.26 , pp. 756-784
    • Dunn, G.P.1    Rinne, M.L.2    Wykosky, J.3
  • 95
    • 33645732219 scopus 로고    scopus 로고
    • Molecular pathology of malignant gliomas
    • PID: 18039109, COI: 1:CAS:528:DC%2BD28XktVOitbw%3D
    • Louis DN (2006) Molecular pathology of malignant gliomas. Annu Rev Pathol 1:97–117
    • (2006) Annu Rev Pathol , vol.1 , pp. 97-117
    • Louis, D.N.1
  • 96
    • 73649088347 scopus 로고    scopus 로고
    • Mutant metabolic enzymes are at the origin of gliomas
    • PID: 19996293, COI: 1:CAS:528:DC%2BD1MXhsFGrtbrE
    • Yan H, Bigner DD, Velculescu V, Parsons DW (2009) Mutant metabolic enzymes are at the origin of gliomas. Cancer Res 69:9157–9159
    • (2009) Cancer Res , vol.69 , pp. 9157-9159
    • Yan, H.1    Bigner, D.D.2    Velculescu, V.3    Parsons, D.W.4
  • 97
    • 84862776826 scopus 로고    scopus 로고
    • 2-Hydroxyglutarate detection by magnetic resonance spectroscopy in IDH-mutated patients with gliomas
    • PID: 22281806, COI: 1:CAS:528:DC%2BC38XhtlOktrw%3D
    • Choi C, Ganji SK, DeBerardinis RJ et al (2012) 2-Hydroxyglutarate detection by magnetic resonance spectroscopy in IDH-mutated patients with gliomas. Nat Med 18:624–629
    • (2012) Nat Med , vol.18 , pp. 624-629
    • Choi, C.1    Ganji, S.K.2    DeBerardinis, R.J.3
  • 98
    • 70249097408 scopus 로고    scopus 로고
    • Isocitrate dehydrogenase 1 codon 132 mutation is an important prognostic biomarker in gliomas
    • PID: 19636000, COI: 1:CAS:528:DC%2BD1MXhtF2jtLrP
    • Sanson M, Marie Y, Paris S et al (2009) Isocitrate dehydrogenase 1 codon 132 mutation is an important prognostic biomarker in gliomas. J Clin Oncol 27:4150–4154
    • (2009) J Clin Oncol , vol.27 , pp. 4150-4154
    • Sanson, M.1    Marie, Y.2    Paris, S.3
  • 99
    • 84875735943 scopus 로고    scopus 로고
    • IDH/MGMT-driven molecular classification of low-grade glioma is a strong predictor for long-term survival
    • PID: 23408861, COI: 1:CAS:528:DC%2BC3sXltVOms7o%3D
    • Leu S, von Felten S, Frank S et al (2013) IDH/MGMT-driven molecular classification of low-grade glioma is a strong predictor for long-term survival. Neuro-Oncology 15:469–479
    • (2013) Neuro-Oncology , vol.15 , pp. 469-479
    • Leu, S.1    von Felten, S.2    Frank, S.3
  • 100
    • 79960700556 scopus 로고    scopus 로고
    • Altered telomeres in tumors with ATRX and DAXX mutations
    • PID: 21719641, COI: 1:CAS:528:DC%2BC3MXovF2mtb8%3D
    • Heaphy CM, de Wilde RF, Jiao Y et al (2011) Altered telomeres in tumors with ATRX and DAXX mutations. Science 333:425
    • (2011) Science , vol.333 , pp. 425
    • Heaphy, C.M.1    de Wilde, R.F.2    Jiao, Y.3
  • 101
    • 80052608062 scopus 로고    scopus 로고
    • Mutations in CIC and FUBP1 contribute to human oligodendroglioma
    • PID: 21817013, COI: 1:CAS:528:DC%2BC3MXhtFWqurnF
    • Bettegowda C, Agrawal N, Jiao Y et al (2011) Mutations in CIC and FUBP1 contribute to human oligodendroglioma. Science 333:1453–1455
    • (2011) Science , vol.333 , pp. 1453-1455
    • Bettegowda, C.1    Agrawal, N.2    Jiao, Y.3
  • 102
    • 84869994008 scopus 로고    scopus 로고
    • Molecular predictors of outcome in low-grade glioma
    • PID: 23160425
    • Weiler M, Wick W (2012) Molecular predictors of outcome in low-grade glioma. Curr Opin Neurol 25:767–773
    • (2012) Curr Opin Neurol , vol.25 , pp. 767-773
    • Weiler, M.1    Wick, W.2


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