Multiagent imaging of inflammation and infection with radionuclides

Clinical and Translational Imaging

Volumn 1, Issue 6, 2013, Pages 385-396

  Palestro, Christopher J ^a,b,d   Glaudemans, Andor W J M ^c   Dierckx, Rudi A J O ^c  

^a DONALD AND BARBARA ZUCKER SCHOOL OF MEDICINE AT HOFSTRA NORTHWELL   (United States)

^b Northwell Health   (United States)

^c UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^d LONG ISLAND JEWISH MEDICAL CENTER   (United States)

Author keywords

Antimicrobial peptides; Biotin; Gallium citrate; Labeled leukocytes; PET

Indexed keywords

ADALIMUMAB; BESILESOMAB; CONTRAST MEDIUM; COPPER 64; FANOLESOMAB TC 99M; FLUORODEOXYGLUCOSE F 18; GALLIUM 67; GALLIUM 68; GALLIUM CITRATE GA 67; HEXAMETHYLPROPYLENE AMINE OXIME TECHNETIUM TC 99M; INDIUM 111 BIOTIN; INDIUM 111 LEUKOCYTE; INDIUM 111 OXYQUINOLONE; INFLIXIMAB; INTERLEUKIN 2; IODINE 124 FIALURIDINE; RADIOISOTOPE; SULESOMAB; SULESOMAB TC 99M; TECHNETIUM 99M EXAMETAZIME; TECHNETIUM 99M HUMAN BETA DEFENSIN 3; TECHNETIUM 99M INTERLEUKIN 8; TECHNETIUM 99M UBIQUICIDIN; UNCLASSIFIED DRUG;

BLOOD FLOW; CLINICAL TRIAL (TOPIC); COMPUTER ASSISTED TOMOGRAPHY; HUMAN; INFECTION; INFLAMMATION; INTERSTITIAL NEPHRITIS; LEUKOCYTE; META ANALYSIS (TOPIC); MOLECULAR IMAGING; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PYREXIA IDIOPATHICA; REVIEW; SENSITIVITY AND SPECIFICITY; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY;

EID: 84919416842     PISSN: 22815872     EISSN: 22817565     Source Type: Journal    
DOI: 10.1007/s40336-013-0041-z     Document Type: Review

References (72)

1. Palestro CJ (2012) Scintigraphic diagnosis of inflammation and infection. In: Brant WE, Helms CA (eds) Fundamentals of diagnostic radiology, 4th edn. Lippincott, Williams & Wilkins, Philadelphia, pp 1339-1352.
2. Palestro CJ, Love C, Bhargava KK (2009) Labeled leukocyte imaging: current status and future directions. Q J Nucl Med Mol Imaging 53: 105-123.
3. Kumar V (2005) Radiolabeled white blood cells and direct targeting of micro-organisms for infection imaging. Q J Nucl Med Mol Imaging 49: 325-338.
4. Palestro CJ, Swyer AJ, Kim CK, Muzinic M, Goldsmith SJ (1991) Role of In-111 labeled leukocyte scintigraphy in the diagnosis of intracerebral lesions. Clin Nucl Med 16: 305-308.
5. Schmidt KG, Rasmussen JW, Frederiksen PB, Kock-Jensen C, Pedersen NT (1990) Indium-111-granulocyte scintigraphy in brain abscess diagnosis: limitations and pitfalls. J Nucl Med 31: 1121-1127.
6. 99mTc-HMPAO labeled leukocyte SPECT in intracranial lesions. Surg Neurol 44: 338-345.
7. Love C, Opoku-Agyemang P, Tomas MB, Pugliese PV, Bhargava KK, Palestro CJ (2002) Pulmonary activity on labeled leukocyte images: physiologic, pathologic, and imaging correlations. Radiographics 22: 1385-1393.
8. 99mTc-HMPAO-labeled leukocyte SPECT/CT in the characterization and management of patients with infectious endocarditis. J Nucl Med 53: 1235-1243.
9. Cerqueira MD, Jacobson AF (1989) Indium-111 leukocyte scintigraphic detection of myocardial abscess formation in patients with endocarditis. J Nucl Med 30: 703-706.
10. Palestro CJ, Love C, Tronco GG, Tomas MB (2000) Role of radionuclide imaging in the diagnosis of postoperative infection. Radiographics 20: 1649-1660.
11. Palestro CJ (2014) Infection and inflammation. In: Treves ST (ed) Pediatric nuclear medicine and molecular imaging, 4th edn. Springer, New York (in press).
12. Palestro CJ, Love C (2009) Nuclear medicine and diabetic foot infections. Semin Nucl Med 39: 52-65.
13. 99mTc-HMPAO-labelled leukocyte imaging. J Nucl Med 50: 1042-1046.
14. Heiba SI, Kolker D, Mocherla B, Kapoor K, Jiang M, Son H, Rangaswamy B, Kostakoglu L, Savitch I, DaCosta M, Machac J (2010) The optimized evaluation of diabetic foot infection by dual isotope SPECT/CT imaging protocol. J Foot Ankle Surg 49: 529-536.
15. 99mTc-WBC SPECT/CT hybrid imaging. Diabetes Care 35: 1826-1831.
16. 18F-FDG PET/CT replace WBC imaging in the diabetic foot? J Nucl Med 52: 1012-1019.
17. Gemmel F, Dumarey N, Palestro CJ (2006) Radionuclide imaging of spinal infections. Eur J Nucl Med Mol Imaging 33: 1226-1237.
18. Palestro CJ, Love C, Tronco GG, Tomas MB, Rini JN (2006) Combined labeled leukocyte and technetium-99m sulfur colloid marrow imaging for diagnosing musculoskeletal infection: principles, technique, interpretation, indications and limitations. Radiographics 26: 859-870.
19. 99mTc-HMPAO labelled leukocytes in musculoskeletal infections. Eur J Nucl Med Mol Imaging 40: 1760-1769.
20. 99mTc-fanolesomab palatin technologies. IDrugs 6: 1079-1085.
21. 99mTc-labelled white blood cells. Eur J Nucl Med Mol Imaging 38: 899-910.
22. Horger M, Eschmann SM, Pfannenberg C, Storek D, Dammann F, Vonthein R, Claussen CD, Bares R (2003) The value of SPET/CT in chronic osteomyelitis. Eur J Nucl Med Mol Imaging 30: 1665-1673.
23. 99mTc-antigranulocyte SPECT/CT: initial clinical results. Eur J Nucl Med Mol Imaging 37: 1751-1759.
24. Meller J, Ivancevic V, Conrad M, Gratz S, Munz DL, Becker W (1998) Clinical value of immunoscintigraphy in patients with fever of unknown origin. J Nucl Med 39: 1248-1253.
25. 99mTc-anti-granulocyte BW 250/183 an answer? Nucl Med Rev Cent East Eur 7: 165-169.
26. 99mTc anti-granulocyte antibodies. Eur J Radiol 35: 183-192.
27. Real R, Linhares P, Fernandes H, Rosas MJ, Gago MF, Pereira J, Vaz R (2011) Role of Tc-Sulesomab immunoscintigraphy in the management of infection following deep brain stimulation surgery. Neurol Res Int 2011: 817951.
28. 99mTc-labeled interleukin-8. J Nucl Med 42: 117-123.
29. 99mTc-labelled interleukin 8 for the scintigraphic detection of infection and inflammation: first clinical evaluation. J Nucl Med 48: 337-343.
30. 99mTc-interleukin-8 for imaging acute osteomyelitis. J Nucl Med 42: 1257-1264.
31. Signore A, Glaudemans AW (2011) The molecular imaging approach to image infections and inflammation by nuclear medicine techniques. Ann Nucl Med 25: 681-700.
32. 99mTc-ciprofloxacin (Infecton). J Clin Pathol 55: 817-823.
33. 99mTc-HMPAO leukocyte scintigraphy. J Nucl Med 42: 567-574.
34. 99mTc ciprofloxacin imaging for the diagnosis of infection in the postoperative spine. Nucl Med Commun 25: 277-283.
35. 99mTc-ciprofloxacin scintigraphy to discriminate between septic and sterile osteoarticular diseases. J Nucl Med 44: 920-926.
36. 99mTc-ciprofloxacin. J Nucl Med 45: 2088-2094.
37. 111In-biotin scintigraphy in patients with suspected vertebral osteomyelitis. Eur J Nucl Med Mol Imaging 31: 1505-1511.
38. Lazzeri E, Erba P, Perri M, Doria R, Tascini C, Mariani G (2010) Clinical impact of SPECT/CT with In-111 biotin on the management of patients with suspected spine infection. Clin Nucl Med 35: 12-17.
39. 99mTc-antimicrobial peptides: promising candidates for infection imaging. Q J Nucl Med 47: 238-245.
40. Lupetti A, Welling MM, Mazzi U, Nibbering PH, Pauwels EK (2002) Technetium-99m labeled fluconazole and antimicrobial peptides for imaging of Candida albicans and Aspergillus fumigatus infections. Eur J Nucl Med Mol Imaging 29: 674-679.
41. 99mTc-UBI 29-41 scintigraphy for specific detection of experimental Staphylococcus aureus prosthetic joint infections. Eur J Nucl Med Mol Imaging 34: 1302-1309.
42. 99mTc-UBI 29-41 in humans. Nucl Med Biol 31: 373-379.
43. 99mTc-ciprofloxacin scintigraphy in a rabbit model of Staphylococcus aureus prosthetic joint infection. J Nucl Med 43: 239-245.
44. 99mTc-ubiquicidin 29-41 as human infection-imaging agent: clinical trial. J Nucl Med 46: 567-573.
45. 99mTc-labeled ubiquicidin 29-41 antimicrobial peptide for the scintigraphic detection of mediastinitis after cardiac surgery. Arch Med Res 39: 768-774.
46. 99mTc-Ubiquicidin (UBI) scintigraphy in detection of an infectious process. Clin Nucl Med 38: 413-416.
47. 99mtechnetium-labelled-recombinant human beta-defensin-3 in an animal model of infection: a feasibility pilot study. J Nucl Med 50: 823-826.
48. 18F-FDG use in inflammation and infection. J Nucl Med 54: 647-658.
49. 18F-fluorodeoxyglucose imaging in infection and inflammation. Semin Nucl Med 42: 261-266.
50. Forstrom LA, Dunn WL, Mullan BP, Hung JC, Lowe VJ, Thorson LM (2002) Biodistribution and dosimetry of [F-18] fluorodeoxyglucose labelled leukocytes in normal human subjects. Nucl Med Commun 23: 721-725.
51. 18F-FDG-labeled leukocyte PET/CT: initial experience in 21 patients. J Nucl Med 47: 625-632.
52. 111In-oxine-labeled leukocytes for detection of infection. Radiology 238: 978-987.
53. Palestro CJ, Love C, Miller TT (2007) Diagnostic imaging tests and microbial infections. Cell Microbiol 9: 2323-2333.
54. Yilmaz S, Ocak M, Asa S, Aliyev A, Ozhan M, Halac M, Sager S, Kabasakal L, Sonmezoglu K (2012) The different distribution patterns of FDG and FDG-labelled WBC in inflammatory and infectious lesions. Eur J Nucl Med Mol Imaging 39: 1660-1661.
55. Yilmaz S, Asa S, Ozhan M, Halac M (2013) Graft infection imaging with FDG and FDG-labeled leukocytes. Intern Med 52: 1009-1010.
56. 18F-FDG. Nucl Med Biol 36: 545-549.
57. 64Cu PET imaging agents for personalised medicine and drug development using the hexa-aza cage, SarAr. Org Biomol Chem 4: 3350-3357.
58. 64Cu-labeled natriuretic peptide and PET. J Nucl Med 51: 85-91.
59. 7 integrin antibody. Methods Mol Biol 757: 487-496.
60. 64Cu-labelled chitosan-coated magnetic nanoparticles. Mol Imaging Biol 14: 593-598.
61. 68Ga-labeled peptides in PET imaging of infection. Nucl Med Commun 29: 663-665.
62. 68Ga citrate for routine clinical PET. Nucl Med Commun 30: 542-545.
63. 68Ga-citrate PET/CT for evaluating patients with infections of the bone: preliminary results. J Nucl Med 51: 1932-1936.
64. 68Ga-apo-transferrin as a PET imaging agent for detecting Staphylococcus aureus infection. Nucl Med Biol 38: 393-398.
65. 68Ga-siderophores for PET imaging of invasive pulmonary aspergillosis: proof of principle. J Nucl Med 51: 639-645.
66. 68Ga-siderophores as potential radiopharmaceuticals for Aspergillus fumigatus infection imaging. Eur J Nucl Med Mol Imaging 39: 1175-1183.
67. Boerman OC, Laverman P, Oyen WJ (2012) FIAU: from reporter gene imaging to imaging of bacterial proliferation. Am J Nucl Med Mol Imaging 2: 271-272.
68. Bettegowda C, Foss CA, Cheong I, Wang Y, Diaz L, Agrawal N, Fox J, Dick J, Dang LH, Zhou S, Kinzler KW, Vogelstein B, Pomper MG (2005) Imaging bacterial infections with radiolabelled 1-(2′-deoxy-2′fluoro-β-d-arabinofurasonyl)-5-iodouracil. Proc Natl Acad Sci USA 102: 1145-1150.
69. Pullambhatla M, Tessier J, Beck G, Jedynak B, Wurthner JU, Pomper MG (2012) [125I]FIAU imaging in a preclinical model of lung infection: quantification of bacterial load. Am J Nucl Med Mol Imaging 2: 260-270.
70. 124I]FIAU-PET/CT. PLoS One 2: e1007.
71. Conti F, Priori R, Chimenti MS, Coari G, Annovazzi A, Valesini G, Signore A (2005) Successful treatment with intraarticular infliximab for resistant knee monoarthritis in a patient with spondyloarthropathy-a role for scintigraphy with Tc-99 m-infliximab. Arthritis Rheum 52: 1224-1226.
72. Malviya G, Conti F, Chianelli M, Scopinaro F, Dierckx RA, Signore A (2010) Molecular imaging of rheumatoid arthritis by radiolabelled monoclonal antibodies: new imaging strategies to guide molecular therapies. Eur J Nucl Med Mol Imaging 37: 386-398.