Tetramethylpyrazine, a natural alkaloid, attenuates pro-inflammatory mediators induced by amyloid β and interferon-γ in rat brain microglia

European Journal of Pharmacology

Volumn 740, Issue , 2014, Pages 504-511

  Kim, Mia ^a   Kim, Sung Ok ^b   Lee, Moonsung ^c   Lee, Joon H ^d   Jung, Woo Sang ^a   Moon, Sang Kwan ^a   Kim, Young Suk ^a   Cho, Ki Ho ^a   Ko, Chang Nam ^a   Lee, Eunjoo H ^c  

^a Kyung Hee University College of Medicine   (South Korea)

^b Daegu Haany University   (South Korea)

^c Kyung Hee University   (South Korea)

^d Konyang University College of Medicine   (South Korea)

Author keywords

Amyloid peptide; Brain inflammation; Microglia; Nitric oxide; Organotypic hippocampal slice culture; TNF

Indexed keywords

AMYLOID BETA PROTEIN; GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; MONOCYTE CHEMOTACTIC PROTEIN 1; NITRIC OXIDE; REACTIVE OXYGEN METABOLITE; TETRAMETHYLPYRAZINE; TUMOR NECROSIS FACTOR ALPHA; AMYLOID BETA-PROTEIN (1-42); AMYLOID BETA-PROTEIN (25-35); ANTIINFLAMMATORY AGENT; CCL2 PROTEIN, RAT; PEPTIDE FRAGMENT; PYRAZINE DERIVATIVE;

ALZHEIMER DISEASE; AMYLOID PLAQUE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CELL CULTURE; CONTROLLED STUDY; DISEASE COURSE; DRUG EFFICACY; HIPPOCAMPUS; INFLAMMATION; LIGUSTICUM CHUANXIONG; MICROGLIA; MOUSE; NERVOUS SYSTEM INFLAMMATION; NEUROPATHOLOGY; NEUROPROTECTION; NONHUMAN; PROTEIN PHOSPHORYLATION; RAT; ANIMAL; BRAIN; CELL LINE; CYTOLOGY; DRUG EFFECTS; MALE; METABOLISM; NERVE CELL; PATHOLOGY; SPRAGUE DAWLEY RAT;

AMYLOID BETA-PEPTIDES; ANIMALS; ANTI-INFLAMMATORY AGENTS; BRAIN; CELL LINE; CELLS, CULTURED; CHEMOKINE CCL2; HIPPOCAMPUS; INTERFERON-GAMMA; INTERLEUKIN-1BETA; MALE; MICE; MICROGLIA; NEURONS; NF-KAPPA B; NITRIC OXIDE; PEPTIDE FRAGMENTS; PYRAZINES; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84919416767     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2014.06.037     Document Type: Article

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