Intromitochondrial IκB/NF-κB signaling pathway is involved in amyloid β peptide-induced mitochondrial dysfunction

Journal of Bioenergetics and Biomembranes

Volumn 46, Issue 5, 2014, Pages 371-376

  Shi, Chun ^a   Zhu, XiaoMing ^b   Wang, Jisheng ^a   Long, Dahong ^a  

^a GUANGZHOU MEDICAL UNIVERSITY   (China)

^b MACAU UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Macao)

Author keywords

Amyloid protein; I B; Mitochondria; NF B

Indexed keywords

3 (4 METHYLPHENYLSULFONYL) 2 PROPENENITRILE; AMYLOID BETA PROTEIN[1-42]; CYTOCHROME C OXIDASE; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; AMYLOID BETA PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIPPOCAMPUS; MITOCHONDRION; MOUSE; MTT ASSAY; NERVE CELL; NEUROTOXICITY; NONHUMAN; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; ALZHEIMER DISEASE; ANIMAL; APOPTOSIS; CELL LINE; METABOLISM; PATHOLOGY; PHOSPHORYLATION; PHYSIOLOGY;

MURINAE;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; APOPTOSIS; CELL LINE; ELECTRON TRANSPORT COMPLEX IV; HIPPOCAMPUS; I-KAPPA B PROTEINS; MICE; MITOCHONDRIA; NEURONS; NF-KAPPA B; PHOSPHORYLATION; SIGNAL TRANSDUCTION;

EID: 84919402950     PISSN: 0145479X     EISSN: 15736881     Source Type: Journal    
DOI: 10.1007/s10863-014-9567-7     Document Type: Article

References (18)

1. Abramov AY, Canevari L, Duchen MR (2004) Beta-amyloid peptides induce mitochondrial dysfunction and oxidative stress in astrocytes and death of neurons through activation of NADPH oxidase. J Neurosci 24(2):565–575
2. Boissiere F, Hunot S, Faucheux B, Duyckaerts C, Hauw JJ, Agid Y, Hirsch EC (1997) Nuclear translocation of NF-jB in cholinergic neurons of patients with Alzheimer’s disease. Neuroreport 8(13):2849–2852
3. Canevari L, Clark JB, Bates TE (1999) β-Amyloid fragment 25–35 selectively decreases complex IV activity in isolated mitochondria. FEBS Lett 457(1):131–134
4. Cha MY, Han SH, Son SM, Hong HS, Choi YJ, Byun J, Mook-Jung I (2012) Mitochondria-specific accumulation of amyloid β induces mitochondrial dysfunction leading to apoptotic cell death. PLoS One 7(4):e34929
5. Chen JX, Yan SD (2007) Amyloid-beta-induced mitochondrial dysfunction. J Alzheimers Dis 12(2):177–184
6. Cogswell PC, Kashatus DF, Keifer JA, Guttridge DC, Reuther JY, Bristow C, Roy S, Nicholson DW, Baldwin AS Jr (2003) NF-kappa B and I kappa B alpha are found in the mitochondria. Evidence for regulation of mitochondrial gene expression by NF-kappa B. J Biol Chem 278(5):2963–2968
7. Duan W, Rangnekar VM, Mattson MP (1999) Prostate apoptosis response-4 production in synaptic compartments following apoptoticand excitotoxic insults: evidence for a pivotal role in mitochondrial dysfunction and neuronal degeneration. J Neurochem 72(6):2312–2322
8. Ferrer I, Marti E, Lopez E, Tortosa A (1998) NF-kB immunoreactivity is observed in association with beta A4 diffuse plaques in patients with Alzheimer’s disease. Neuropathol Appl Neurobiol 24(4):271–277
9. Hansson Petersen CA, Alikhani N, Behbahani H, Wiehager B, Pavlov PF, Alafuzoff I, Leinonen V, Ito A, Winblad B, Glaser E, Ankarcrona M (2008) The amyloid betapeptide is imported into mitochondria via the TOM import machinery and localized tomitochondrial cristae. Proc Natl Acad Sci U S A 105(35):13145–13150
10. Hirai K, Aliev G, Nunomura A, Fujioka H, Russell RM, Atwood CS, Johnson AB, Kress Y, Vinters HV, Tabaton M, Shimohama S, Cash AD, Siedlak SL, Harris PL, Jones PK, Petersen PB, Perry G, Smith MA (2001) Mitochondrial abnormalities in Alzheimer’s disease. J Neurosci 21(9):3017–3023
11. Kaltschmidt B, Uherek M, Volk B, Baeuerle PA, Kaltschmidt C (1997) Transcription factor NF-kappaB is activated in primary neurons by amyloid beta peptides and in neurons surrounding early plaques from patients with Alzheimer’s disease. Proc Natl Acad Sci U S A 94(6):2642–2647
12. Lai AY, McLaurin J (2010) Mechanisms of amyloid-beta peptide uptake by neurons: the role of lipid rafts and lipid raft-associated proteins. Int J Alzheimers Dis 2011:548380
13. Mattson MP, Camandola S (2001) NF-kappaB in neuronal plasticity and neurodegenerative disorders. J Clin Invest 107(3):247–254
14. Moreira PI, Santos MS, Moreno A, Rego AC, Oliveira C (2002) Effect of amyloid beta-peptide on permeability transition pore: a comparative study. J Neurosci Res 69(2):257–267
15. Oeckinghaus A, Ghosh S (2009) The NF-kappaB family of transcription factors and its regulation. Cold Spring Harb Perspect Biol 1(4):a000034
16. Parks JK, Smith TS, Trimmer PA, Bennett JP, Parker WD (2001) Neurotoxic Abeta peptides increase oxidative stress invivo through NMDA receptor and nitric-oxide-synthase mechanisms, and inhibit complex IV activity and induce a mitochondrial permeability transition invitro. J Neurochem 76(4):1050–1056
17. Spuch C, Ortolano S,Navarro C (2012) LRP-1 and LRP-2 receptors function in the membrane neuron. Trafficking mechanisms and proteolytic processing in Alzheimer's disease. Front Physiol 3:269
18. Terai K, Matsuo A, McGeer PL (1996) Enhancement of immunoreactivity for NF-kappaB in the hippocampal formation and cerebral cortex of Alzheimer’s disease. Brain Res 735(1):159–168