Restoring mood balance in depression: Ketamine reverses deficit in dopamine-dependent synaptic plasticity

Biological Psychiatry

Volumn 76, Issue 12, 2014, Pages 927-936

  Belujon, Pauline ^a   Grace, Anthony A ^a  

^a UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

Dopamine; ketamine; learned helplessness; nucleus accumbens; synaptic plasticity; ventral tegmental area

Indexed keywords

DOPAMINE; KETAMINE; SEROTONIN UPTAKE INHIBITOR; 8 CHLORO 2,3,4,5 TETRAHYDRO 3 METHYL 5 PHENYL 1H 3 BENZAZEPIN 7 OL HYDROGEN MALEATE; ANTIDEPRESSANT AGENT; BENZAZEPINE DERIVATIVE; DOPAMINE RECEPTOR STIMULATING AGENT;

ADULT; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIDEPRESSANT ACTIVITY; ARTICLE; AVOIDANCE BEHAVIOR; CONTROLLED STUDY; DEPRESSION; DOPAMINERGIC NERVE CELL; ELECTROPHYSIOLOGICAL PROCEDURES; ESCAPE BEHAVIOR; FOOTSHOCK; HELPLESSNESS; HIPPOCAMPUS; IN VIVO STUDY; LEARNED HELPLESSNESS; LIMBIC SYSTEM; LONG TERM POTENTIATION; LOW DRUG DOSE; MAJOR DEPRESSION; MALE; MOOD; NERVE CELL PLASTICITY; NERVE STIMULATION; NONHUMAN; NUCLEUS ACCUMBENS; RAT; THERAPY EFFECT; TREATMENT RESISTANT DEPRESSION; TREATMENT RESPONSE; VENTRAL TEGMENTUM; WISTAR KYOTO RAT; ACTION POTENTIAL; ANIMAL; BRAIN; DISEASE MODEL; DRUG EFFECTS; ELECTROSHOCK; NERVE TRACT; PATHOLOGY; PHYSIOLOGY; REACTION TIME; TIME FACTOR;

ACTION POTENTIALS; ANIMALS; ANTIDEPRESSIVE AGENTS; BENZAZEPINES; BRAIN; DEPRESSION; DISEASE MODELS, ANIMAL; DOPAMINE AGONISTS; DOPAMINERGIC NEURONS; ELECTROSHOCK; HELPLESSNESS, LEARNED; KETAMINE; LONG-TERM POTENTIATION; MALE; NEURAL PATHWAYS; RATS; RATS, INBRED WKY; REACTION TIME; TIME FACTORS;

EID: 84919390439     PISSN: 00063223     EISSN: 18732402     Source Type: Journal    
DOI: 10.1016/j.biopsych.2014.04.014     Document Type: Article

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