Nek2 is a novel regulator of B cell development and immunological response

BioMed Research International

Volumn 2014, Issue , 2014, Pages

  Gu, Zhimin ^a   Zhou, Wen ^a   Huang, Junwei ^a,b   Yang, Ye ^a   Wendlandt, Erik ^a   Xu, Hongwei ^a   He, Xiao ^c   Tricot, Guido ^a   Zhan, Fenghuang ^a  

^a UNIVERSITY OF IOWA   (United States)

^b SOUTHERN MEDICAL UNIVERSITY   (China)

^c UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NEK2 PROTEIN; PROTEIN SERINE THREONINE KINASE; UNCLASSIFIED DRUG; NEK2 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; B LYMPHOCYTE; BONE MARROW; CARCINOGENESIS; CONTROLLED STUDY; GENE OVEREXPRESSION; GERMINAL CENTER; IMMUNE RESPONSE; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRE B LYMPHOCYTE; PROTEIN EXPRESSION; TRANSGENIC MOUSE; ANIMAL; B CELL LYMPHOMA; BIOSYNTHESIS; CELL LINEAGE; CELL PROLIFERATION; GENETICS; HUMAN; IMMUNOLOGY; MULTIPLE MYELOMA; PATHOLOGY; T LYMPHOCYTE; TUMOR CELL LINE;

MUS MUSCULUS;

ANIMALS; B-LYMPHOCYTES; CELL LINE, TUMOR; CELL LINEAGE; CELL PROLIFERATION; HUMANS; LYMPHOMA, B-CELL; MICE; MICE, TRANSGENIC; MULTIPLE MYELOMA; PROTEIN-SERINE-THREONINE KINASES; T-LYMPHOCYTES;

EID: 84919363386     PISSN: 23146133     EISSN: 23146141     Source Type: Journal    
DOI: 10.1155/2014/621082     Document Type: Article

References (29)

1. Schultz S. J., Fry A. M., Sutterlin C., Ried T., Nigg E. A., Cell cycle-dependent expression of Nek2, a novel human protein kinase related to the NIMA mitotic regulator of Aspergillus nidulans. Cell Growth and Differentiation 1994 5 6 625 635 2-s2.0-0028058885
2. Uto K., Sagata N., Nek2B, a novel maternal form of Nek2 kinase, is essential for the assembly or maintenance of centrosomes in early Xenopus embryos. EMBO Journal 2000 19 8 1816 1826 10.1093/emboj/19.8.1816 2-s2.0-0034678923
3. Fry A. M., The Nek2 protein kinase: a novel regulator of centrosome structure. Oncogene 2002 21 40 6184 6194 10.1038/sj.onc.1205711 2-s2.0-0037048312
4. Fry A. M., Schultz S. J., Bartek J., Nigg E. A., Substrate specificity and cell cycle regulation of the Nek2 protein kinase, a potential human homolog of the mitotic regulator NIMA of Aspergillus nidulans. Journal of Biological Chemistry 1995 270 21 12899 12905 10.1074/jbc.270.21.12899 2-s2.0-0029011885
5. Yong H. K., Jun Y. C., Jeong Y., Wolgemuth D. J., Rhee K., Nek2 localizes to multiple sites in mitotic cells, suggesting its involvement in multiple cellular functions during the cell cycle. Biochemical and Biophysical Research Communications 2002 290 2 730 736 10.1006/bbrc.2001.6212 2-s2.0-0036290778
6. Wu W., Baxter J. E., Wattam S. L., Hayward D. G., Fardilha M., Knebel A., Ford E. M., Da Cruz E Silva E. F., Fry A. M., Alternative splicing controls nuclear translocation of the cell cycle-regulated Nek2 kinase. The Journal of Biological Chemistry 2007 282 36 26431 26440 10.1074/jbc.M704969200 2-s2.0-34548857062
7. Mardin B. R., Lange C., Baxter J. E., Hardy T., Scholz S. R., Fry A. M., Schiebel E., Components of the Hippo pathway cooperate with Nek2 kinase to regulate centrosome disjunction. Nature Cell Biology 2010 12 12 1166 1176 10.1038/ncb2120 2-s2.0-78649870675
8. Naro C., Barbagallo F., Chieffi P., Bourgeois C. F., Paronetto M. P., Sette C., The centrosomal kinase NEK2 is a novel splicing factor kinase involved in cell survival. Nucleic Acids Research 2014 42 5 3218 3227 10.1093/nar/gkt1307 2-s2.0-84898930824
9. Zhou W., Yang Y., Xia J., Wang H., Salama M. E., Xiong W., Xu H., Shetty S., Chen T., Zeng Z., Shi L., Zangari M., Miles R., Bearss D., Tricot G., Zhan F., NEK2 induces drug resistance mainly through activation of efflux drug pumps and is associated with poor prognosis in myeloma and other cancers. Cancer Cell 2013 23 1 48 62 10.1016/j.ccr.2012.12.001 2-s2.0-84872373803
10. Cappello P., Blaser H., Gorrini C., Lin D. C. C., Elia A. J., Wakeham A., Haider S., Boutros P. C., Mason J. M., Miller N. A., Youngson B., Done S. J., Mak T. W., Role of Nek2 on centrosome duplication and aneuploidy in breast cancer cells. Oncogene 2014 33 18 2375 2384 10.1038/onc.2013.183 2-s2.0-84899917293
11. Harrison Pitner M. K., Saavedra H. I., Cdk4 and nek2 signal binucleation and centrosome amplification in a her2+ breast cancer model. PLoS ONE 2013 8 6 e65971 10.1371/journal.pone.0065971 2-s2.0-84878918789
12. Lee J., Gollahon L., Nek2-targeted ASO or siRNA pretreatment enhances anticancer drug sensitivity in triple-negative breast cancer cells. International Journal of Oncology 2013 42 3 839 847 10.3892/ijo.2013.1788 2-s2.0-84873678933
13. Zhong X., Guan X., Dong Q., Yang S., Liu W., Zhang L., Examining Nek2 as a better proliferation marker in non-small cell lung cancer prognosis. Tumor Biology 2014 35 7 7155 7162 10.1007/s13277-014-1935-8
14. Suzuki K., Kokuryo T., Senga T., Yokoyama Y., Nagino M., Hamaguchi M., Novel combination treatment for colorectal cancer using Nek2 siRNA and cisplatin. Cancer Science 2010 101 5 1163 1169 10.1111/j.1349-7006.2010.01504.x 2-s2.0-77953210455
15. Liu X., Gao Y., Lu Y., Zhang J., Li L., Yin F., Upregulation of NEK2 is associated with drug resistance in ovarian cancer. Oncology Reports 2014 31 2 745 754 10.3892/or.2013.2910 2-s2.0-84892421063
16. Zeng X., Shaikh F. Y., Harrison M. K., Adon A. M., Trimboli A. J., Carroll K. A., Sharma N., Timmers C., Chodosh L. A., Leone G., Saavedra H. I., The Ras oncogene signals centrosome amplification in mammary epithelial cells through cyclin D1/Cdk4 and Nek2. Oncogene 2010 29 36 5103 5112 10.1038/onc.2010.253 2-s2.0-77956627154
17. Mbom B. C., Siemers K. A., Ostrowski M. A., Nelson W. J., Barth A. I. M., Nek2 phosphorylates and stabilizes β -catenin at mitotic centrosomes downstream of Plk1. Molecular Biology of the Cell 2014 25 7 977 991 10.1091/mbc.E13-06-0349 2-s2.0-84898756756
18. Wei R., Ngo B., Wu G., Lee W.-H., Phosphorylation of the Ndc80 complex protein, HEC1, by Nek2 kinase modulates chromosome alignment and signaling of the spindle assembly checkpoint. Molecular Biology of the Cell 2011 22 19 3584 3594 10.1091/mbc.E11-01-0012 2-s2.0-80053371243
19. Wu G., Qiu X.-L., Zhou L., Zhu J., Chamberlin R., Lau J., Chen P.-L., Lee W.-H., Small molecule targeting the Hec1/Nek2 mitotic pathway suppresses tumor cell growth in culture and in animal. Cancer Research 2008 68 20 8393 8399 10.1158/0008-5472.CAN-08-1915 2-s2.0-54249132168
20. Nagasawa T., Microenvironmental niches in the bone marrow required for B-cell development. Nature Reviews Immunology 2006 6 2 107 116 10.1038/nri1780 2-s2.0-33644845081
21. Yang Y., Shi J., Tolomelli G., Xu H., Xia J., Wang H., Zhou W., Zhou Y., Das S., Gu Z., Levasseur D., Zhan F., Tricot G., RAR α 2 expression confers myeloma stem cell features. Blood 2013 122 8 1437 1447 10.1182/blood-2013-02-482919 2-s2.0-84886819205
22. Mallampati S., Sun B., Lu Y., Ma H., Gong Y., Wang D., Lee J. S., Lin K., Sun X., Integrated genetic approaches identify the molecular mechanisms of Sox4 in early B-cell development: intricate roles for RAG1/2 and CK1epsilon. Blood 2014 123 26 4064 4076
23. Hardy R. R., Hayakawa K., B cell development pathways. Annual Review of Immunology 2001 19 595 621 10.1146/annurev.immunol.19.1.595 2-s2.0-0035056376
24. Maeda T., Hobbs R. H., Morghoub T., Guernah I., Zelent A., Cordon-Cardo C., Teruya-Feldstein J., Pandolfi P. P., Role of the proto-oncogene Pokemon in cellular transformation and ARF repression. Nature 2005 433 7023 278 285 10.1038/nature03203 2-s2.0-12744269233
25. Baron B. W., Anastasi J., Montag A., Huo D., Baron R. M., Karrison T., Thirman M. J., Subudhi S. K., Chin R. K., Felsher D. W., Fu Y.-X., McKeithan T. W., Baron J. M., The human BCL6 transgene promotes the development of lymphomas in the mouse. Proceedings of the National Academy of Sciences of the United States of America 2004 101 39 14198 14203 10.1073/pnas.0406138101 2-s2.0-4644302712
26. Wang S., Li W., Lv S., Wang Y., Liu Z., Zhang J., Liu T., Niu Y., Abnormal expression of Nek2 and β -catenin in breast carcinoma: clinicopathological correlations. Histopathology 2011 59 4 631 642 10.1111/j.1365-2559.2011.03941.x 2-s2.0-80054962373
27. De Vos S., Hofmann W.-K., Grogan T. M., Krug U., Schrage M., Miller T. P., Braun J. G., Wachsman W., Koeffler H. P., Said J. W., Gene expression profile of serial samples of transformed B-cell lymphomas. Laboratory Investigation 2003 83 2 271 285 10.1097/01.LAB.0000053913.85892.E9 2-s2.0-0037324949
28. Pogue S. L., Kurosaki T., Bolen J., Herbst R., B cell antigen receptor-induced activation of Akt promotes B cell survival and is dependent on Syk kinase. Journal of Immunology 2000 165 3 1300 1306 10.4049/jimmunol.165.3.1300 2-s2.0-0034254421
29. Parker D. C., T cell-dependent B cell activation. Annual Review of Immunology 1993 11 331 360 10.1146/annurev.iy.11.040193.001555 2-s2.0-0027450354