Hypoxia-induced deoxycytidine kinase contributes to epithelial proliferation in pulmonary fibrosis

American Journal of Respiratory and Critical Care Medicine

Volumn 190, Issue 12, 2014, Pages 1402-1412

  Weng, Tingting ^a   Poth, Jens M ^b   Karmouty Quintana, Harry ^a   Garcia Morales, Luis J ^a,c   Melicoff, Ernestina ^d   Luo, Fayong ^a   Chen, Ning Yuan ^a   Evans, Christopher M ^b   Bunge, Raquel R ^c   Bruckner, Brian A ^c,e   Loebe, Matthias ^c,e   Volcik, Kelly A ^a   Eltzschig, Holger K ^b   Blackburn, Michael R ^a  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^c HOUSTON METHODIST RESEARCH INSTITUTE   (United States)

^d BAYLOR COLLEGE OF MEDICINE   (United States)

^e HOUSTON METHODIST HOSPITAL   (United States)

Author keywords

Airway remodeling; Hyperplastic epithelial cells; Hypoxia inducible factor 1

Indexed keywords

BLEOMYCIN; CASPASE 3; CASPASE 7; CHEMOKINE RECEPTOR CCR2; COLLAGEN TYPE 1; COLLAGENASE 3; DEOXYADENOSINE TRIPHOSPHATE; DEOXYCYTIDINE KINASE; DEOXYRIBONUCLEOTIDE; DOXYCYCLINE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MATRILYSIN; MONOCYTE CHEMOTACTIC PROTEIN 1; RNA 18S;

ANIMAL EXPERIMENT; ARTERIAL OXYGEN SATURATION; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DISEASE COURSE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; HYPOXIA; IMMUNOHISTOCHEMISTRY; KNOCKOUT MOUSE; LUNG ALVEOLUS EPITHELIUM; LUNG FIBROSIS; MOUSE; NONHUMAN; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; WESTERN BLOTTING; ANIMAL; ANOXIA; C57BL MOUSE; CELL LINE; COMPLICATION; ENZYMOLOGY; IDIOPATHIC PULMONARY FIBROSIS; LUNG ALVEOLUS; MALE; PATHOPHYSIOLOGY; PHYSIOLOGY; RESPIRATORY TRACT MUCOSA;

ANIMALS; ANOXIA; CELL LINE; CELL PROLIFERATION; DEOXYCYTIDINE KINASE; HUMANS; IDIOPATHIC PULMONARY FIBROSIS; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PULMONARY ALVEOLI; REAL-TIME POLYMERASE CHAIN REACTION; RESPIRATORY MUCOSA;

EID: 84919341532     PISSN: 1073449X     EISSN: 15354970     Source Type: Journal    
DOI: 10.1164/rccm.201404-0744OC     Document Type: Article

References (42)

1. Gay SE, Kazerooni EA, Toews GB, Lynch JP III, Gross BH, Cascade PN, Spizarny DL, Flint A, Schork MA, Whyte RI, et al. Idiopathic pulmonary fibrosis: Predicting response to therapy and survival. Am J Respir Crit Care Med 1998;157: 1063-1072.
2. Hoo ZH, Whyte MK. Idiopathic pulmonary fibrosis. Thorax 2012;67: 742-746.
3. Tzouvelekis A, Harokopos V, Paparountas T, Oikonomou N, Chatziioannou A, Vilaras G, Tsiambas E, Karameris A, Bouros D, Aidinis V. Comparative expression profiling in pulmonary fibrosis suggests a role of hypoxia-inducible factor-1alpha in disease pathogenesis. Am J Respir Crit Care Med 2007;176: 1108-1119.
4. Strieter RM, Mehrad B. New mechanisms of pulmonary fibrosis. Chest 2009;136: 1364-1370.
5. Weng T, Karmouty-Quintana H, Garcia-Morales LJ, Molina JG, Pedroza M, Bunge RR, Bruckner BA, Loebe M, Seethamraju H, Blackburn MR. Hypoxia-induced deoxycytidine kinase expression contributes to apoptosis in chronic lung disease [abstract]. FASEB J 2013;27: 2013-2026.
6. de Souza PM, Lindsay MA. Apoptosis as a therapeutic target for the treatment of lung disease. Curr Opin Pharmacol 2005;5: 232-237.
7. Fadeel B, Orrenius S, Zhivotovsky B. Apoptosis in human disease: A new skin for the old ceremony? Biochem Biophys Res Commun 1999;266: 699-717.
8. Drakopanagiotakis F, Xifteri A, Polychronopoulos V, Bouros D. Apoptosis in lung injury and fibrosis. Eur Respir J 2008;32: 1631-1638.
9. Selman M, Pardo A. Role of epithelial cells in idiopathic pulmonary fibrosis: From innocent targets to serial killers. Proc Am Thorac Soc 2006;3: 364-372.
10. Yu G, Kovkarova-Naumovski E, Jara P, Parwani A, Kass D, Ruiz V, Lopez-Otín C, Rosas IO, Gibson KF, Cabrera S, et al. Matrix metalloproteinase-19 is a key regulator of lung fibrosis in mice and humans. Am J Respir Crit Care Med 2012;186: 752-762.
11. Dancer RC, Wood AM, Thickett DR. Metalloproteinases in idiopathic pulmonary fibrosis. Eur Respir J 2011;38: 1461-1467.
12. Crosby LM, Waters CM. Epithelial repair mechanisms in the lung. Am J Physiol Lung Cell Mol Physiol 2010;298: L715-L731.
13. Araya J, Cambier S, Markovics JA, Wolters P, Jablons D, Hill A, Finkbeiner W, Jones K, Broaddus VC, Sheppard D, et al. Squamous metaplasia amplifies pathologic epithelial-mesenchymal interactions in COPD patients. J Clin Invest 2007;117: 3551-3562.
14. Staub M, Spasokukotskaja T, Benczur M, Antoni F. DNA synthesis and nucleoside metabolism in human tonsillar lymphocyte subpopulations. Acta Otolaryngol Suppl 1988;454: 118-124.
15. Weng T, Karmouty-Quintana H, Pedroza M, Molina JG, Blackburn MR. Hypoxia mediated up regulation of deoxycytidine kinase contributes to deoxyadenosine mediated apoptosis during pulmonary fibrosis. Presented at Keystone Symposia: Fibrosis. April 2, 2012, Big Sky, MT.
16. Karmouty-Quintana H, Zhong H, Acero L, Weng T, Melicoff E, West JD, Hemnes A, Grenz A, Eltzschig HK, Blackwell TS, et al. The A2B adenosine receptor modulates pulmonary hypertension associated with interstitial lung disease. FASEB J 2012;26: 2546-2557.
17. Tichelaar JW, Lu W, Whitsett JA. Conditional expression of fibroblast growth factor-7 in the developing and mature lung. J Biol Chem 2000;275: 11858-11864.
18. Perl AK, Wert SE, Nagy A, Lobe CG, Whitsett JA. Early restriction of peripheral and proximal cell lineages during formation of the lung. Proc Natl Acad Sci USA 2002;99: 10482-10487.
19. Eckle T, Brodsky K, Bonney M, Packard T, Han J, Borchers CH, Mariani TJ, Kominsky DJ, Mittelbronn M, Eltzschig HK. HIF1A reduces acute lung injury by optimizing carbohydrate metabolism in the alveolar epithelium. PLoS Biol 2013;11: E1001665.
20. Zhou Y, Murthy JN, Zeng D, Belardinelli L, Blackburn MR. Alterations in adenosine metabolism and signaling in patients with chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis. PLoS One 2010;5: E9224.
21. Wakamiya M, Blackburn MR, Jurecic R, McArthur MJ, Geske RS, Cartwright J Jr, Mitani K, Vaishnav S, Belmont JW, Kellems RE, et al. Disruption of the adenosine deaminase gene causes hepatocellular impairment and perinatal lethality in mice. Proc Natl Acad Sci USA 1995;92: 3673-3677.
22. Epstein AC, Gleadle JM, McNeill LA, Hewitson KS, O'Rourke J, Mole DR, Mukherji M, Metzen E, Wilson MI, Dhanda A, et al. C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation. Cell 2001;107: 43-54.
23. Haeberle HA, Dürrstein C, Rosenberger P, Hosakote YM, Kuhlicke J, Kempf VA, Garofalo RP, Eltzschig HK. Oxygen-independent stabilization of hypoxia inducible factor (HIF)-1 during RSV infection. PLoS One 2008;3: E3352.
24. Ashcroft T, Simpson JM, Timbrell V. Simple method of estimating severity of pulmonary fibrosis on a numerical scale. J Clin Pathol 1988;41: 467-470.
25. Hubner RH, Gitter W, El Mokhtari NE, Mathiak M, Both M, Bolte H, Freitag-Wolf S, Bewig B. Standardized quantification of pulmonary fibrosis in histological samples. BioTechniques 2008;44: 507-511, 514-517.
26. Moore BB, Hogaboam CM. Murine models of pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol 2008;294: L152-L160.
27. Ezzie ME, Piper MG, Montague C, Newland CA, Opalek JM, Baran C, Ali N, Brigstock D, Lawler J, Marsh CB. Thrombospondin-1-deficient mice are not protected from bleomycin-induced pulmonary fibrosis. Am J Respir Cell Mol Biol 2011;44: 556-561.
28. Zhou Y, Schneider DJ, Morschl E, Song L, Pedroza M, Karmouty-Quintana H, Le T, Sun CX, Blackburn MR. Distinct roles for the A2B adenosine receptor in acute and chronic stages of bleomycininduced lung injury. J Immunol 2011;186: 1097-1106.
29. Tuder RM, Yun JH, Bhunia A, Fijalkowska I. Hypoxia and chronic lung disease. J Mol Med (Berl) 2007;85: 1317-1324.
30. Arnér ES, Eriksson S. Mammalian deoxyribonucleoside kinases. Pharmacol Ther 1995;67: 155-186.
31. Keszler G, Spasokoukotskaja T, Csapo Z, Virga S, Staub M, Sasvari-Szekely M. Selective increase of dATP pools upon activation of deoxycytidine kinase in lymphocytes: Implications in apoptosis. Nucleosides Nucleotides Nucleic Acids 2004;23: 1335-1342.
32. Pitsiou G, Papakosta D, Bouros D. Pulmonary hypertension in idiopathic pulmonary fibrosis: A review. Respiration 2011;82: 294-304.
33. Raghu G, Collard HR, Egan JJ, Martinez FJ, Behr J, Brown KK, Colby TV, Cordier JF, Flaherty KR, Lasky JA, et al.; ATS/ERS/JRS/ALAT Committee on Idiopathic Pulmonary Fibrosis. An official ATS/ERS/JRS/ALAT statement: Idiopathic pulmonary fibrosis: Evidence-based guidelines for diagnosis and management. Am J Respir Crit Care Med 2011;183: 788-824.
34. Iwazaki A, Imai K, Nakanishi K, Yoshioka M. Intravenously administered 29-deoxycytidine suppresses mouse myeloma tumor growth. Biol Pharm Bull 2012;35: 251-255.
35. Vancheri C. Common pathways in idiopathic pulmonary fibrosis and cancer. Eur Respir Rev 2013;22: 265-272.
36. Nishimura Y, Hida W, Taguchi O, Sakurai M, Ichinose M, Inoue H, Takishima T. Respiratory muscle strength and gas exchange in neuromuscular diseases: Comparison with chronic pulmonary emphysema and idiopathic pulmonary fibrosis. Tohoku J Exp Med 1989;159: 57-68.
37. Weitzenblum E, Ehrhart M, Rasaholinjanahary J, Hirth C. Pulmonary hemodynamics in idiopathic pulmonary fibrosis and other interstitial pulmonary diseases. Respiration 1983;44: 118-127.
38. Degryse AL, Tanjore H, Xu XC, Polosukhin VV, Jones BR, McMahon FB, Gleaves LA, Blackwell TS, Lawson WE. Repetitive intratracheal bleomycin models several features of idiopathic pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol 2010;299: L442-L452.
39. Pullamsetti SS, Savai R, Dumitrascu R, Dahal BK, Wilhelm J, Konigshoff M, Zakrzewicz D, Ghofrani HA, Weissmann N, Eickelberg O, et al. The role of dimethylarginine dimethylaminohydrolase in idiopathic pulmonary fibrosis. Sci Transl Med 2011;3: 87ra53.
40. Inoshima I, Kuwano K, Hamada N, Yoshimi M, Maeyama T, Hagimoto N, Nakanishi Y, Hara N. Induction of CDK inhibitor p21 gene as a new therapeutic strategy against pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol 2004;286: L727-L733.
41. Krizhanovsky V, Yon M, Dickins RA, Hearn S, Simon J, Miething C, Yee H, Zender L, Lowe SW. Senescence of activated stellate cells limits liver fibrosis. Cell 2008;134: 657-667.
42. Kim KH, Chen CC, Monzon RI, Lau LF. Matricellular protein CCN1 promotes regression of liver fibrosis through induction of cellular senescence in hepatic myofibroblasts. Mol Cell Biol 2013;33: 2078-2090.