Clinical Significance of Myeloid-Derived Suppressor Cells in Human Renal Transplantation with Acute T Cell-Mediated Rejection

Inflammation

Volumn 37, Issue 5, 2014, Pages 1799-1805

  Meng, Fanhang ^a   Chen, SiYang ^b   Guo, Xuekun ^a   Chen, Zhiyong ^a   Huang, Xianen ^a   Lai, Yongtong ^a   Lin, Minzhuan ^a  

^a GUANGZHOU MEDICAL UNIVERSITY   (China)

^b THE FIRST AFFILIATED HOSPITAL OF SUN YAT SEN UNIVERSITY   (China)

Author keywords

IL 17; MDSC; renal transplantation; Treg

Indexed keywords

CD11B ANTIGEN; CD33 ANTIGEN; HLA DR ANTIGEN; INTERLEUKIN 17; METHYLPREDNISOLONE; OKT 3; THYMOCYTE ANTIBODY;

ACUTE T CELL MEDIATED REJECTION; ADULT; ARTICLE; BLOOD CELL RATIO; BONE MARROW CELL; CD4+ T LYMPHOCYTE; CELL ISOLATION; CLINICAL ARTICLE; CYTOKINE PRODUCTION; DISEASE SEVERITY; FEMALE; FLUORESCENCE ACTIVATED CELL SORTING; GRAFT RECIPIENT; GRAFT SURVIVAL; HUMAN; HUMAN CELL; IN VITRO STUDY; KIDNEY ALLOGRAFT; KIDNEY ALLOGRAFT REJECTION; KIDNEY TRANSPLANTATION; MALE; PERIPHERAL BLOOD MONONUCLEAR CELL; REGULATORY T LYMPHOCYTE; SUPPRESSOR CELL; SURVIVAL TIME; TISSUE INJURY; ADVERSE EFFECTS; CELL CULTURE; GRAFT REJECTION; IMMUNOLOGY; MONONUCLEAR CELL; PHYSIOLOGY; RETROSPECTIVE STUDY; TIME; TRANSPLANTATION;

ANIMALIA;

CELLS, CULTURED; GRAFT REJECTION; GRAFT SURVIVAL; HUMANS; KIDNEY TRANSPLANTATION; LEUKOCYTES, MONONUCLEAR; MYELOID CELLS; RETROSPECTIVE STUDIES; T-LYMPHOCYTES, REGULATORY; TIME FACTORS;

EID: 84918821461     PISSN: 03603997     EISSN: 15732576     Source Type: Journal    
DOI: 10.1007/s10753-014-9910-5     Document Type: Article

References (25)

1. Dugast, A.S., T. Haudebourg, F. Coulon, M. Heslan, F. Haspot, N. Poirier, D.S.R. Vuillefroy, C. Usal, H. Smit, B. Martinet, et al. 2008. Myeloid-derived suppressor cells accumulate in kidney allograft tolerance and specifically suppress effector T cell expansion. Journal of Immunology 180: 7898–7906.
2. Luan, Y., E. Mosheir, M.C. Menon, D. Wilson, C. Woytovich, J. Ochando, et al. 2013. Monocytic myeloid-derived suppressor cells accumulate in renal transplant patients and mediate CD4(+) Foxp3(+) Treg expansion. American Journal of Transplantation: Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons 13: 3123–3131.
3. Garcia, M.R., L. Ledgerwood, Y. Yang, J. Xu, G. Lal, B. Burrell, G. Ma, D. Hashimoto, Y. Li, P. Boros, et al. 2010. Monocytic suppressive cells mediate cardiovascular transplantation tolerance in mice. Journal of Clinical Investigation 120: 2486–2496.
4. Turnquist, H.R., Z. Zhao, B.R. Rosborough, Q. Liu, A. Castellaneta, K. Isse, Z. Wang, M. Lang, D.B. Stolz, X.X. Zheng, et al. 2011. IL-33 expands suppressive CD11b+Gr-1(int) and regulatory T cells, including ST2L+Foxp3+ cells, and mediates regulatory T cell-dependent promotion of cardiac allograft survival. Journal of Immunology 187: 4598–4610.
5. Hori, S., T. Nomura, and S. Sakaguchi. 2003. Control of regulatory T cell development by the transcription factor Foxp3. Science 299: 1057–1061.
6. Bestard, O., J.M. Cruzado, M. Mestre, A. Caldes, J. Bas, M. Carrera, et al. 2007. Achieving donor-specific hyporesponsiveness is associated with FOXP3+ regulatory T cell recruitment in human renal allograft infiltrates. Journal of Immunology 179: 4901–4909.
7. Afzali, B., G. Lombardi, R.I. Lechler, and G.M. Lord. 2007. The role of T helper 17 (Th17) and regulatory T cells (Treg) in human organ transplantation and autoimmune disease. Clinical and Experimental Immunology 148: 32–46.
8. Eastaff-Leung, N., N. Mabarrack, A. Barbour, A. Cummins, and S. Barry. 2010. Foxp3+ regulatory T cells, Th17 effector cells, and cytokine environment in inflammatory bowel disease. Journal of Clinical Immunology 30: 80–89.
9. Ratajczak, P., A. Janin, R. Peffault de Latour, C. Leboeuf, A. Desveaux, K. Keyvanfar, et al. 2010. Th17/Treg ratio in human graft-versus-host disease. Blood 116: 1165–1171.
10. Cheng, X., X. Yu, Y.J. Ding, Q.Q. Fu, J.J. Xie, T.T. Tang, et al. 2008. The Th17/Treg imbalance in patients with acute coronary syndrome. Clinical Immunology 127: 89–97.
11. Chung, B.H., H.J. Oh, S.G. Piao, H.S. Hwang, I.O. Sun, S.R. Choi, et al. 2012. Clinical significance of the ratio between FOXP3 positive regulatory T cell and interleukin-17 secreting cell in renal allograft biopsies with acute T-cell-mediated rejection. Immunology 136: 344–351.
12. Ma, S., Cheng, Q., Cai, Y., Gong, H., Wu, Y., Yu, X., et al. 2014. IL-17A produced by gammadelta T cells promotes tumor growth in Hepatocellular Carcinoma. Cancer res
13. Guan, Q., S. Moreno, G. Qing, C.R. Weiss, L. Lu, C.N. Bernstein, et al. 2013. The role and potential therapeutic application of myeloid-derived suppressor cells in TNBS-induced colitis. Journal of Leukocyte Biology 94: 803–811.
14. Solez, K., R.B. Colvin, L.C. Racusen, B. Sis, P.F. Halloran, P.E. Birk, et al. 2007. Banff '05 Meeting Report: differential diagnosis of chronic allograft injury and elimination of chronic allograft nephropathy ('CAN'). American Journal of Transplantation: Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons 7: 518–526.
15. Racusen, L.C., R.B. Colvin, K. Solez, M.J. Mihatsch, P.F. Halloran, P.M. Campbell, et al. 2003. Antibody-mediated rejection criteria—an addition to the Banff 97 classification of renal allograft rejection. American Journal of Transplantation: Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons 3: 708–714.
16. Nagaraj, S., M. Collazo, C.A. Corzo, J.I. Youn, M. Ortiz, D. Quiceno, et al. 2009. Regulatory myeloid suppressor cells in health and disease. Cancer Research 69: 7503–7506.
17. Filipazzi, P., R. Valenti, V. Huber, L. Pilla, P. Canese, M. Iero, et al. 2007. Identification of a new subset of myeloid suppressor cells in peripheral blood of melanoma patients with modulation by a granulocyte-macrophage colony-stimulation factor-based antitumor vaccine. Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology 25: 2546–2553.
18. Huang, B., P.Y. Pan, Q. Li, A.I. Sato, D.E. Levy, J. Bromberg, et al. 2006. Gr-1+CD115+ immature myeloid suppressor cells mediate the development of tumor-induced T regulatory cells and T-cell anergy in tumor-bearing host. Cancer Research 66: 1123–1131.
19. Ochs, H.D., M. Oukka, and T.R. Torgerson. 2009. TH17 cells and regulatory T cells in primary immunodeficiency diseases. The Journal of Allergy and Clinical Immunology 123: 977–983. quiz 984–5.
20. Groux, H., A. O'Garra, M. Bigler, M. Rouleau, S. Antonenko, J.E. de Vries, et al. 1997. A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature 389: 737–742.
21. Itoh, M., T. Takahashi, N. Sakaguchi, Y. Kuniyasu, J. Shimizu, F. Otsuka, et al. 1999. Thymus and autoimmunity: production of CD25+CD4+ naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance. Journal of Immunology 162: 5317–5326.
22. Wood, K.J., and S. Sakaguchi. 2003. Regulatory T cells in transplantation tolerance. Nature Reviews Immunology 3: 199–210.
23. Bettelli, E., M. Oukka, and V.K. Kuchroo. 2007. T(H)-17 cells in the circle of immunity and autoimmunity. Nature Immunology 8: 345–350.
24. Ivanov, I.I., B.S. McKenzie, L. Zhou, C.E. Tadokoro, A. Lepelley, J.J. Lafaille, et al. 2006. The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell 126: 1121–1133.
25. Kolls, J.K., and A. Linden. 2004. Interleukin-17 family members and inflammation. Immunity 21: 467–476.