A systematic review of the outcomes of osteoporotic fracture patients after hospital discharge: Morbidity, subsequent fractures, and mortality

Therapeutics and Clinical Risk Management

Volumn 10, Issue , 2014, Pages 937-948

  Nazrun, Ahmad Shuid ^a   Tzar, Mohd Nizam ^a   Mokhtar, Sabarul Afian ^b   Mohamed, Isa Naina ^a  

^a Department of Pharmacology ^*  (Malaysia)

^b UNIVERSITI KEBANGSAAN MALAYSIA MEDICAL CENTER   (Malaysia)

Author keywords

Hip fracture; Osteoporosis; Vertebral fracture

Indexed keywords

FEMUR NECK FRACTURE; FRAGILITY FRACTURE; FUNCTIONAL DISEASE; HEALTH CARE COST; HEALTH CARE UTILIZATION; HIP FRACTURE; HOME CARE; HOSPITAL READMISSION; HUMAN; LENGTH OF STAY; MORBIDITY; MORTALITY; QUALITY OF LIFE; RADIUS FRACTURE; REHABILITATION CARE; REVIEW; SPINE FRACTURE; STANDARDIZED MORTALITY RATIO; SURGICAL MORTALITY; SYSTEMATIC REVIEW;

EID: 84918798263     PISSN: 11766336     EISSN: 1178203X     Source Type: Journal    
DOI: 10.2147/TCRM.S72456     Document Type: Review

References (62)

1. Ben Sedrine W, Radican L, Reginster JY. On conducting burden-of-osteoporosis studies: a review of the core concepts and practical issues. A study carried out under the auspices of a WHO Collaborating Center. Rheumatology (Oxford). 2001;40(1):7–14.
2. Adachi JD, Ioannidis G, Pickard L, et al. The association between osteoporotic fractures and health-related quality of life as measured by the Health Utilities Index in the Canadian Multicentre Osteoporosis Study (CaMos). Osteoporos Int. 2003;14(11):895–904.
3. Johnell O, Kanis J. Epidemiology of osteoporotic fractures. Osteoporosis Int. 2005;16(Suppl 2):S3–S7.
4. Papaioannou A, Morin S, Cheung AM, et al; Scientifc Advisory Council of Osteoporosis Canada. 2010 clinical practice guidelines for the diagnosis and management of osteoporosis in Canada: summary. CMAJ. 2010;182(17):1864–1873.
5. Melton LJ, Thamer M, Ray NF, et al. Fractures attributable to osteoporosis: report from the National Osteoporosis Foundation. J Bone MinerRes. 1997;12(1):16–23.
6. O’Neill TW, Roy DK. How many people develop fractures with what outcome? Best Pract Res Clin Rheumatol. 2005;19(6):879–895.
7. Jones G, Nguyen T, Sambrook PN, Kelly PJ, Gilbert C, Eisman JA. Symptomatic fracture incidence in elderly men and women: the Dubbo Osteoporosis Epidemiology Study (DOES). Osteoporos Int. 1994;4(5):277–282.
8. Melton LJ, Crowson CS, O’Fallon WM. Fracture incidence in Olmsted County, Minnesota: comparison of urban with rural rates and changes in urban rates over time. Osteoporos Int. 1999;9(1):29–37.
9. Miller W. Survival and ambulation following hip fracture. J Bone Joint Surg Am.1978;60(7):930–934.
10. Cummings SR, Kelsey JL, Nevitt MC, O’Dowd KJ. Epidemiology of osteoporosis and osteoporotic fractures. Epidemiol Rev. 1985;7: 178–208.
11. Jensen JS, Bagger J. Long-term social prognosis after hip fractures. Acta Orthop Scand. 1982;53(1):97–101.
12. Johnell O, Kanis JA. An estimate of the worldwide prevalence and disability associated with osteoporotic fractures. Osteoporos Int. 2006; 17(12):1726–1733.
13. Old JL, Calvert M. Vertebral compression fractures in the elderly. Am Fam Physician. 2004;69(1):111–116.
14. Kanis JA, Johnell O, Oden A, et al. Long-term risk of osteoporotic fracture in Malmö. Osteoporos Int. 2000;11(8):669–674.
15. Sakuma M, Endo N, Oinuma T, et al. Incidence and outcome of osteo-porotic fractures in 2004 in Sado City, Niigata Prefecture, Japan. J Bone Miner Metab. 2008;26(4):373–378.
16. Majumdar SR, Kim N, Colman I, et al. Incidental vertebral fractures discovered with chest radiography in the emergency department: prevalence, recognition, and osteoporosis management in a cohort of elderly patients. Arch Intern Med. 2005;165(8):905–909.
17. Ross PD, Davis JW, Epstein RS, Wasnich RD. Pain and disability associated with new vertebral fractures and other spinal conditions. J Clin Epidemiol. 1994;47(3):231–239.
18. Leidig G, Minne HW, Sauer P, et al. A study of complaints and their relation to vertebral destruction in patients with osteoporosis. Bone Miner. 1990;8(3):217–229.
19. Greendale GA, Barrett-Connor E. Outcomes of osteoporotic fractures. In: Marcus R, Feldman D, Kelsey J, editors. Osteoporosis. 2nd ed. San Diego, CA: Academic Press. 2001;819–29.
20. Chrischilles EA, Butler CD, Davis CS, Wallace RB. A model of lifetime osteoporosis impact. Arch Intern Med. 1991;151(10):2026–2032.
21. Kaukonen JP, Karaharju EO, Porras M, Lüthje P, Jakobsson A. Functional recovery after fractures of the distal forearm. Analysis of radio-graphic and other factors affecting the outcome. Ann Chir Gynaecol. 1988;77(1):27–31.
22. Gold DT, Lyles KW, Shipp KM, Drezner MK. Osteoporosis and its nonskeletal consequences: their impact on treatment decisions. In: Marcus R, Feldman D, Kelsey J, editors. Osteoporosis. 2nd ed. San Diego, CA: Academic Press. 2001;479–84.
23. Cummings SR, Melton LJ. Epidemiology and outcomes of osteoporotic fractures. Lancet. 2002;359(9319):1761–1767.
24. Colón-Emeric CS, Saag KG. Osteoporotic fractures in older adults. Best Pract Res Clin Rheumatol. 2006;20(4):695–706.
25. Haentjens P, Lamraski G, Boonen S. Costs and consequences of hip fracture occurrence in old age: an economic perspective. Disabil Reha-bil. 2005;27(18–19):1129–1141.
26. Brainsky A, Glick H, Lydick E, et al. The economic cost of hip fractures in community-dwelling older adults: a prospective study. J Am Geriatr Soc. 1997;45(3):281–287.
27. Wiktorowicz ME, Goeree R, Papaioannou A, Adachi JD, Papadimitropoulos E. Economic implications of hip fracture: health service use, institutional care and cost in Canada. Osteoporos Int. 2001;12(4):271–278.
28. Bouee S, Lafuma A, Fagnani F, Meunier PJ, Reginster JY. Estimation of direct unit costs associated with non-vertebral osteoporotic fractures in fve European countries. Rheumatol Int. 2006;26(12):1063–1072.
29. Port L, Center J, Briffa NK, Nguyen T, Cumming R, Eisman J. Osteo-porotic fracture: missed opportunity for intervention. Osteoporos Int. 2003;14(9):780–784.
30. Eisman J, Clapham S, Kehoe L; Australian BoneCare Study. Osteoporosis prevalence and levels of treatment in primary care: the Australian BoneCare Study. J Bone Miner Res. 2004;19(12):1969–1975.
31. Majumdar SR, Rowe BH, Folk D, et al. A controlled trial to increase detection and treatment of osteoporosis in older patients with a wrist fracture. Ann Intern Med. 2004;141(5):366–373.
32. Lindsay R. The burden of osteoporosis: cost. Am J Med.1995;98(2A): 9S–11S.
33. Ioannidis G, Papaioannou A, Hopman WM, et al. Relation between fractures and mortality: results from the Canadian Multicentre Osteoporosis Study. CMAJ. 2009;181(5):265–271.
34. Kaffashian S, Raina P, Oremus M, et al; CaMos Research Group. The burden of osteoporotic fractures beyond acute care: the Canadian Multicentre Osteoporosis Study (CaMos). Age Ageing. 2011;40(5):602–607.
35. Siggeirsdottir K, Aspelund T, Jonsson BY, et al. Effect of vertebral fractures on function, quality of life and hospitalisation the AGES-Reykjavik study. Age Ageing. 2012;41(3):351–357.
36. Hallberg I, Rosenqvist AM, Kartous L, Löfman O, Wahlström O, Toss G. Health-related quality of life after osteoporotic fractures. Osteoporos Int. 2004;15(10):834–841.
37. Chen CW, Huang TL, Su LT, et al. Incidence of subsequent hip fractures is signifcantly increased within the frst month after distal radius fracture in patients older than 60 years. J Trauma Acute Care Surg. 2013;74(1):317–321.
38. Lih A, Nandapalan H, Kim M, et al. Targeted intervention reduces refracture rates in patients with incident non-vertebral osteoporotic fractures: a 4-year prospective controlled study. Osteoporos Int. 2011; 22(3):849–858.
39. Lyles KW, Schenck AP, Colón-Emeric CS. Hip and other osteoporotic fractures increase the risk of subsequent fractures in nursing home residents. Osteoporos Int. 2008;19(8):1225–1233.
40. Hodsman AB, Leslie WD, Tsang JF, Gamble GD. 10-year probability of recurrent fractures following wrist and other osteoporotic fractures in a large clinical cohort: an analysis from the Manitoba Bone Density Program. Arch Intern Med. 2008;168(20):2261–2267.
41. Center JR, Bliuc D, Nguyen TV, Eisman JA. Risk of subsequent fracture after low-trauma fracture in men and women. JAMA. 2007;297(4): 387–394.
42. Johnell O, Kanis JA, Odén A, et al. Fracture risk following an osteo-porotic fracture. Osteoporos Int. 2004;15(3):175–179.
43. Genant HK, Cooper C, Poor G, et al. Interim report and recommendations of the World Health Organization Task-Force for Osteoporosis. Osteoporos Int. 1999;10(4):259–264.
44. Roberts SE, Goldacre MJ. Time trends and demography of mortality after fractured neck of femur in an English population, 1968–1998: database study. BMJ. 2003;327(7418):771–775.
45. Vestergaard P, Rejnmark L, Mosekilde L. Has mortality after a hip fracture increased? J Am Geriatr Soc. 2007;55(11):1720–1726.
46. Bliuc D, Nguyen ND, Milch VE, Nguyen TV, Eisman JA, Center JR. Mortality risk associated with low-trauma osteoporotic fracture and subsequent fracture in men and women. JAMA. 2009;301(5):513–521.
47. Brauer CA, Coca-Perraillon M, Cutler DM, Rosen AB. Incidence and mortality of hip fractures in the United States. JAMA. 2009; 302(14):1573–1579.
48. Söderqvist A, Ekström W, Ponzer S, et al; Stockholm Hip Fracture Group. Prediction of mortality in elderly patients with hip fractures: a two-year prospective study of 1,944 patients. Gerontology. 2009;55(5):496–504.
49. Ziadé N, Jougla E, Coste J. Population-level impact of osteoporotic fractures on mortality and trends over time: a nationwide analysis of vital statistics for France, 1968–2004. Am J Epidemiol. 2010;172(8): 942–951.
50. Panula J, Pihlajamäki H, Mattila VM, et al. Mortality and cause of death in hip fracture patients aged 65 or older: a population-based study. BMC Musculoskelet Disord. 2011;12:105.
51. Kanis JA, Oden A, Johnell O, De Laet C, Jonsson B. Excess mortality after hospitalisation for vertebral fracture. Osteoporos Int. 2004; 15(2):108–112.
52. Laitinen P. Participation of caregivers in elderly-patient hospital care: informal caregiver approach. J Adv Nurs. 1993;18(9):1480–1487.
53. Sapountzi-Krepia D, Lavdaniti M, Psychogiou M, et al. Nursing staff shortage and in-hospital informal care in an oncology hospital in Greece: the nursing staff’s perceptions. Int J Nurs Pract. 2008;14(3): 256–263.
54. Ström O, Borgstrom F, Zethraeus N, et al. Long-term cost and effect on quality of life of osteoporosis-related fractures in Sweden. Acta Orthop. 2008;79(2):269–280.
55. Bouza C, López T, Palma M, Amate JM. Hospitalised osteoporotic vertebral fractures in Spain: analysis of the national hospital discharge registry. Osteoporos Int. 2007;18(5):649–657.
56. Braithwaite RS, Col NF, Wong JB. Estimating hip fracture morbidity, mortality and costs. J Am Geriatr Soc. 2003;51(3):364–370.
57. van den Berg B, Brouwer WB, Koopmanschap MA. Economic valuation of informal care. An overview of methods and applications. Eur J Health Econ. 2004;5(1):36–45.
58. Wilson D, Truman C. Comparing the health services utilization of long-term-care residents, home-care recipients, and the well elderly. Can J Nurs Res. 2005;37(4):138–154.
59. Keene GS, Parker MJ, Pryor GA. Mortality and morbidity after hip fractures. BMJ. 1993;307(6914):1248–1250.
60. Kenzora JE, McCarthy RE, Lowell JD, Sledge CB. Hip fracture mortality. Relation to age, treatment, preoperative illness, time of surgery, and complications. Clin Orthop Relat Res. 1984;(186):45–56.
61. Wehren LE, Hawkes WG, Orwig DL, Hebel JR, Zimmerman SI, Magaziner J. Gender differences in mortality after hip fracture: the role of infection. J Bone Miner Res. 2003;18(12):2231–2237.
62. Kannegaard PN, van der Mark S, Eiken P, Abrahamsen B. Excess mortality in men compared with women following a hip fracture. National analysis of comedications, comorbidity and survival. Age Ageing. 2010;39(2):203–209.