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Volumn 2, Issue 1, 2014, Pages

Overcoming multiple drug resistance mechanisms in medulloblastoma

Author keywords

ABCB1; Etoposide; Medulloblastoma; MGMT; Obatoclax; Temozolomide

Indexed keywords

ABCB1 PROTEIN, HUMAN; ALKYLATING AGENT; BCL2-RELATED PROTEIN A1; DACARBAZINE; DNA METHYLTRANSFERASE; ENZYME INHIBITOR; MCL1 PROTEIN, HUMAN; MGMT PROTEIN, HUMAN; MULTIDRUG RESISTANCE PROTEIN; OBATOCLAX; POLYDEOXYRIBONUCLEOTIDE SYNTHASE; PROTEIN BCL 2; PROTEIN MCL 1; PYRROLE DERIVATIVE; TEMOZOLOMIDE; TUMOR SUPPRESSOR PROTEIN;

EID: 84918767508     PISSN: None     EISSN: 20515960     Source Type: Journal    
DOI: 10.1186/2051-5960-2-57     Document Type: Article
Times cited : (54)

References (79)
  • 1
    • 68849120875 scopus 로고    scopus 로고
    • The potential impact of tumour biology on improved clinical practice for medulloblastoma: progress towards biologically driven clinical trials
    • Pizer BL, Clifford SC: The potential impact of tumour biology on improved clinical practice for medulloblastoma: progress towards biologically driven clinical trials. Br J Neurosurg 2009, 23(4):364-375. 10.1080/02688690903121807
    • (2009) Br J Neurosurg , vol.23 , Issue.4 , pp. 364-375
    • Pizer, B.L.1    Clifford, S.C.2
  • 2
    • 84867869131 scopus 로고    scopus 로고
    • Concurrent cyclophosphamide and craniospinal radiotherapy for pediatric high-risk embryonal brain tumors
    • Campen CJ, Dearlove J, Partap S, Murphy P, Gibbs IC, Dahl GV, Fisher PG: Concurrent cyclophosphamide and craniospinal radiotherapy for pediatric high-risk embryonal brain tumors. J Neurooncol 2012, 110(2):287-291. 10.1007/s11060-012-0969-2
    • (2012) J Neurooncol , vol.110 , Issue.2 , pp. 287-291
    • Campen, C.J.1    Dearlove, J.2    Partap, S.3    Murphy, P.4    Gibbs, I.C.5    Dahl, G.V.6    Fisher, P.G.7
  • 3
    • 84866532813 scopus 로고    scopus 로고
    • Hyperfractionated Versus Conventional Radiotherapy Followed by Chemotherapy in Standard-Risk Medulloblastoma: Results From the Randomized Multicenter HIT-SIOP PNET 4 Trial
    • Lannering B, Rutkowski S, Doz F, Pizer B, Gustafsson G, Navajas A, Massimino M, Reddingius R, Benesch M, Carrie C: Hyperfractionated Versus Conventional Radiotherapy Followed by Chemotherapy in Standard-Risk Medulloblastoma: Results From the Randomized Multicenter HIT-SIOP PNET 4 Trial. J Clin Oncol 2012, 30(26):3187-3193. 10.1200/JCO.2011.39.8719
    • (2012) J Clin Oncol , vol.30 , Issue.26 , pp. 3187-3193
    • Lannering, B.1    Rutkowski, S.2    Doz, F.3    Pizer, B.4    Gustafsson, G.5    Navajas, A.6    Massimino, M.7    Reddingius, R.8    Benesch, M.9    Carrie, C.10
  • 4
    • 0031680298 scopus 로고    scopus 로고
    • Atypical teratoid/rhabdoid tumor of the central nervous system: a highly malignant tumor of infancy and childhood frequently mistaken for medulloblastoma: a Pediatric Oncology Group study
    • Burger PC, Yu I, Tihan T, Friedman HS, Strother DR, Kepner JL, Duffner PK, Kun LE, Perlman EJ: Atypical teratoid/rhabdoid tumor of the central nervous system: a highly malignant tumor of infancy and childhood frequently mistaken for medulloblastoma: a Pediatric Oncology Group study. Am J Surg Pathol 1998, 22(9):1083-1092. 10.1097/00000478-199809000-00007
    • (1998) Am J Surg Pathol , vol.22 , Issue.9 , pp. 1083-1092
    • Burger, P.C.1    Yu, I.2    Tihan, T.3    Friedman, H.S.4    Strother, D.R.5    Kepner, J.L.6    Duffner, P.K.7    Kun, L.E.8    Perlman, E.J.9
  • 5
    • 33745431175 scopus 로고    scopus 로고
    • Current therapy for medulloblastoma
    • Gottardo NG, Gajjar A: Current therapy for medulloblastoma. Curr Treat Options Neurol 2006, 8(4):319-334. 10.1007/s11940-006-0022-x
    • (2006) Curr Treat Options Neurol , vol.8 , Issue.4 , pp. 319-334
    • Gottardo, N.G.1    Gajjar, A.2
  • 7
    • 0033050817 scopus 로고    scopus 로고
    • Metastasis stage, adjuvant treatment, and residual tumor are prognostic factors for medulloblastoma in children: conclusions from the Children's Cancer Group 921 randomized phase III study
    • Zeltzer PM, Boyett JM, Finlay JL, Albright AL, Rorke LB, Milstein JM, Allen JC, Stevens KR, Stanley P, Li H: Metastasis stage, adjuvant treatment, and residual tumor are prognostic factors for medulloblastoma in children: conclusions from the Children's Cancer Group 921 randomized phase III study. J Clin Oncol 1999, 17(3):832-832.
    • (1999) J Clin Oncol , vol.17 , Issue.3 , pp. 832-832
    • Zeltzer, P.M.1    Boyett, J.M.2    Finlay, J.L.3    Albright, A.L.4    Rorke, L.B.5    Milstein, J.M.6    Allen, J.C.7    Stevens, K.R.8    Stanley, P.9    Li, H.10
  • 9
    • 84871996797 scopus 로고    scopus 로고
    • Survival and secondary tumors in children with medulloblastoma receiving radiotherapy and adjuvant chemotherapy: results of Children's Oncology Group trial A9961
    • Packer RJ, Zhou T, Holmes E, Vezina G, Gajjar A: Survival and secondary tumors in children with medulloblastoma receiving radiotherapy and adjuvant chemotherapy: results of Children's Oncology Group trial A9961. Neuro Oncol 2013, 15(1):97-103. 10.1093/neuonc/nos267
    • (2013) Neuro Oncol , vol.15 , Issue.1 , pp. 97-103
    • Packer, R.J.1    Zhou, T.2    Holmes, E.3    Vezina, G.4    Gajjar, A.5
  • 10
    • 0037842140 scopus 로고    scopus 로고
    • Results of a randomized study of preradiation chemotherapy versus radiotherapy alone for nonmetastatic medulloblastoma: The International Society of Paediatric Oncology/United Kingdom Children's Cancer Study Group PNET-3 Study
    • Taylor RE, Bailey CC, Robinson K, Weston CL, Ellison D, Ironside J, Lucraft H, Gilbertson R, Tait DM, Walker DA: Results of a randomized study of preradiation chemotherapy versus radiotherapy alone for nonmetastatic medulloblastoma: The International Society of Paediatric Oncology/United Kingdom Children's Cancer Study Group PNET-3 Study. J Clin Oncol 2003, 21(8):1581-1591. 10.1200/JCO.2003.05.116
    • (2003) J Clin Oncol , vol.21 , Issue.8 , pp. 1581-1591
    • Taylor, R.E.1    Bailey, C.C.2    Robinson, K.3    Weston, C.L.4    Ellison, D.5    Ironside, J.6    Lucraft, H.7    Gilbertson, R.8    Tait, D.M.9    Walker, D.A.10
  • 11
    • 0342614892 scopus 로고    scopus 로고
    • Postoperative neoadjuvant chemotherapy before radiotherapy as compared to immediate radiotherapy followed by maintenance chemotherapy in the treatment of medulloblastoma in childhood: results of the German prospective randomized trial HIT'91
    • Kortmann RD, Kühl J, Timmermann B, Mittler U, Urban C, Budach V, Richter E, Willich N, Flentje M, Berthold F: Postoperative neoadjuvant chemotherapy before radiotherapy as compared to immediate radiotherapy followed by maintenance chemotherapy in the treatment of medulloblastoma in childhood: results of the German prospective randomized trial HIT'91. Int J Radiat Oncol Biol Phys 2000, 46(2):269-279. 10.1016/S0360-3016(99)00369-7
    • (2000) Int J Radiat Oncol Biol Phys , vol.46 , Issue.2 , pp. 269-279
    • Kortmann, R.D.1    Kühl, J.2    Timmermann, B.3    Mittler, U.4    Urban, C.5    Budach, V.6    Richter, E.7    Willich, N.8    Flentje, M.9    Berthold, F.10
  • 12
    • 84886726351 scopus 로고    scopus 로고
    • High-risk medulloblastoma: a Pediatric Oncology Group randomized trial of chemotherapy Before or after radiation therapy (POG 9031)
    • Tarbell NJ, Friedman H, Polkinghorn WR, Yock T, Zhou T, Chen Z, Burger P, Barnes P, Kun L: High-risk medulloblastoma: a Pediatric Oncology Group randomized trial of chemotherapy Before or after radiation therapy (POG 9031). J Clin Oncol 2013, 31(23):2936-2941. 10.1200/JCO.2012.43.9984
    • (2013) J Clin Oncol , vol.31 , Issue.23 , pp. 2936-2941
    • Tarbell, N.J.1    Friedman, H.2    Polkinghorn, W.R.3    Yock, T.4    Zhou, T.5    Chen, Z.6    Burger, P.7    Barnes, P.8    Kun, L.9
  • 13
    • 31544446902 scopus 로고    scopus 로고
    • Outcome of medulloblastoma in children: long-term complications and quality of life
    • Ribi K, Relly C, Landolt M, Alber F, Boltshauser E, Grotzer M: Outcome of medulloblastoma in children: long-term complications and quality of life. Neuropediatrics 2005, 36(6):357-365. 10.1055/s-2005-872880
    • (2005) Neuropediatrics , vol.36 , Issue.6 , pp. 357-365
    • Ribi, K.1    Relly, C.2    Landolt, M.3    Alber, F.4    Boltshauser, E.5    Grotzer, M.6
  • 14
    • 64049087816 scopus 로고    scopus 로고
    • Long-term outcome and clinical prognostic factors in children with medulloblastoma treated in the prospective randomised multicentre trial HIT '91
    • HoffK, Hinkes B, Gerber NU, Deinlein F, Mittler U, Urban C, Benesch M, Warmuth-Metz M, Soerensen N, Zwiener I: Long-term outcome and clinical prognostic factors in children with medulloblastoma treated in the prospective randomised multicentre trial HIT '91. Eur J Cancer 2009, 45(7):1209-1217. 10.1016/j.ejca.2009.01.015
    • (2009) Eur J Cancer , vol.45 , Issue.7 , pp. 1209-1217
    • Hoff, K.1    Hinkes, B.2    Gerber, N.U.3    Deinlein, F.4    Mittler, U.5    Urban, C.6    Benesch, M.7    Warmuth-Metz, M.8    Soerensen, N.9    Zwiener, I.10
  • 16
    • 71249117569 scopus 로고    scopus 로고
    • Primary postoperative chemotherapy without radiotherapy for treatment of brain tumours other than ependymoma in children under 3 years: results of the first UKCCSG/SIOP CNS 9204 trial
    • Grundy R, Wilne S, Robinson K, Ironside J, Cox T, Chong W, Michalski A, Campbell R, Bailey C, Thorp N: Primary postoperative chemotherapy without radiotherapy for treatment of brain tumours other than ependymoma in children under 3 years: results of the first UKCCSG/SIOP CNS 9204 trial. Eur J Cancer 2010, 46(1):120-133. 10.1016/j.ejca.2009.09.013
    • (2010) Eur J Cancer , vol.46 , Issue.1 , pp. 120-133
    • Grundy, R.1    Wilne, S.2    Robinson, K.3    Ironside, J.4    Cox, T.5    Chong, W.6    Michalski, A.7    Campbell, R.8    Bailey, C.9    Thorp, N.10
  • 17
    • 53549111626 scopus 로고    scopus 로고
    • Medulloblastoma: new insights into biology and treatment
    • Pizer B, Clifford S: Medulloblastoma: new insights into biology and treatment. Arch Dis Child Educ Pract Ed 2008, 93(5):137-144. 10.1136/adc.2007.136655
    • (2008) Arch Dis Child Educ Pract Ed , vol.93 , Issue.5 , pp. 137-144
    • Pizer, B.1    Clifford, S.2
  • 18
    • 33749044182 scopus 로고    scopus 로고
    • Risk-adapted craniospinal radiotherapy followed by high-dose chemotherapy and stem-cell rescue in children with newly diagnosed medulloblastoma (St Jude Medulloblastoma-96): long-term results from a prospective, multicentre trial
    • Gajjar A, Chintagumpala M, Ashley D, Kellie S, Kun LE, Merchant TE, Woo S, Wheeler G, Ahern V, Krasin MJ: Risk-adapted craniospinal radiotherapy followed by high-dose chemotherapy and stem-cell rescue in children with newly diagnosed medulloblastoma (St Jude Medulloblastoma-96): long-term results from a prospective, multicentre trial. Lancet Oncol 2006, 7(10):813-820. 10.1016/S1470-2045(06)70867-1
    • (2006) Lancet Oncol , vol.7 , Issue.10 , pp. 813-820
    • Gajjar, A.1    Chintagumpala, M.2    Ashley, D.3    Kellie, S.4    Kun, L.E.5    Merchant, T.E.6    Woo, S.7    Wheeler, G.8    Ahern, V.9    Krasin, M.J.10
  • 19
    • 67649116468 scopus 로고    scopus 로고
    • Outcome for metastatic (M+) medulloblastoma (MB) treated with carboplatin during craniospinal radiotherapy (CSRT) followed by cyclophosphamide (CPM) and vincristine (VCR): Preliminary results of COG 99701
    • Jakacki R, Burger P, Zhou T, Holmes E, Packer R, Goldwein J, Mehta M, Pollack I: Outcome for metastatic (M+) medulloblastoma (MB) treated with carboplatin during craniospinal radiotherapy (CSRT) followed by cyclophosphamide (CPM) and vincristine (VCR): Preliminary results of COG 99701. J Clin Oncol 2007, 25(18S):2017.
    • (2007) J Clin Oncol , vol.25 , Issue.18 , pp. 2017
    • Jakacki, R.1    Burger, P.2    Zhou, T.3    Holmes, E.4    Packer, R.5    Goldwein, J.6    Mehta, M.7    Pollack, I.8
  • 20
    • 84876693211 scopus 로고    scopus 로고
    • Response to bevacizumab, irinotecan, and temozolomide in children with relapsed medulloblastoma: a multi-institutional experience
    • Aguilera D, Mazewski C, Fangusaro J, MacDonald TJ, McNall-Knapp RY, Hayes LL, Kim S, Castellino RC: Response to bevacizumab, irinotecan, and temozolomide in children with relapsed medulloblastoma: a multi-institutional experience. Childs Nerv Syst 2013, 29(4):589-596. doi:10.1007/s00381-012-2013-4 10.1007/s00381-012-2013-4
    • (2013) Childs Nerv Syst , vol.29 , Issue.4 , pp. 589-596
    • Aguilera, D.1    Mazewski, C.2    Fangusaro, J.3    MacDonald, T.J.4    McNall-Knapp, R.Y.5    Hayes, L.L.6    Kim, S.7    Castellino, R.C.8
  • 21
    • 84856698901 scopus 로고    scopus 로고
    • Temozolomide in relapsed pediatric brain tumors: 14 cases from a single center
    • Akyüz C, Demir HA, Varan A, Yalçin B, Kutluk T, Büyükpamukçu M: Temozolomide in relapsed pediatric brain tumors: 14 cases from a single center. Childs Nerv Syst 2012, 28(1):111-115. 10.1007/s00381-011-1561-3
    • (2012) Childs Nerv Syst , vol.28 , Issue.1 , pp. 111-115
    • Akyüz, C.1    Demir, H.A.2    Varan, A.3    Yalçin, B.4    Kutluk, T.5    Büyükpamukçu, M.6
  • 23
    • 62449200068 scopus 로고    scopus 로고
    • Embryonal neural tumours and cell death
    • Johnsen JI, Kogner P, Albihn A, Henriksson MA: Embryonal neural tumours and cell death. Apoptosis 2009, 14(4):424-438. doi:10.1007/s10495-009-0325-y 10.1007/s10495-009-0325-y
    • (2009) Apoptosis , vol.14 , Issue.4 , pp. 424-438
    • Johnsen, J.I.1    Kogner, P.2    Albihn, A.3    Henriksson, M.A.4
  • 28
    • 0029552544 scopus 로고
    • Multidrug resistance gene expression in childhood medulloblastoma: correlation with clinical outcome and DNA ploidy in 29 patients
    • Chou PM, Reyes-Mugica M, Barquin N, Yasuda T, Tan X, Tomita T: Multidrug resistance gene expression in childhood medulloblastoma: correlation with clinical outcome and DNA ploidy in 29 patients. Pediatr Neurosurg 1995, 23(6):283-292. 10.1159/000120984
    • (1995) Pediatr Neurosurg , vol.23 , Issue.6 , pp. 283-292
    • Chou, P.M.1    Reyes-Mugica, M.2    Barquin, N.3    Yasuda, T.4    Tan, X.5    Tomita, T.6
  • 29
    • 0030810103 scopus 로고    scopus 로고
    • Immunohistochemical expression of P-glycoprotein and glutathione S-transferases in cerebral gliomas and response to chemotherapy
    • von Bossanyi P, Diete S, Dietzmann K, Warich-Kirches M, Kirches E: Immunohistochemical expression of P-glycoprotein and glutathione S-transferases in cerebral gliomas and response to chemotherapy. Acta Neuropathol 1997, 94(6):605-611. 10.1007/s004010050756
    • (1997) Acta Neuropathol , vol.94 , Issue.6 , pp. 605-611
    • von Bossanyi, P.1    Diete, S.2    Dietzmann, K.3    Warich-Kirches, M.4    Kirches, E.5
  • 31
    • 84862925785 scopus 로고    scopus 로고
    • Temozolomide: mechanisms of action, repair and resistance
    • Zhang J, Stevens M, Bradshaw T: Temozolomide: mechanisms of action, repair and resistance. Curr Mol Pharmacol 2012, 5(1):102. 10.2174/1874467211205010102
    • (2012) Curr Mol Pharmacol , vol.5 , Issue.1 , pp. 102
    • Zhang, J.1    Stevens, M.2    Bradshaw, T.3
  • 34
    • 0023160388 scopus 로고
    • Antitumour imidazotetrazines-XV: Role of guanine O6 alkylation in the mechanism of cytotoxicity of imidazotetrazinones
    • Tisdale MJ: Antitumour imidazotetrazines-XV: Role of guanine O6 alkylation in the mechanism of cytotoxicity of imidazotetrazinones. Biochem Pharmacol 1987, 36(4):457-462. 10.1016/0006-2952(87)90351-0
    • (1987) Biochem Pharmacol , vol.36 , Issue.4 , pp. 457-462
    • Tisdale, M.J.1
  • 35
    • 78149469318 scopus 로고    scopus 로고
    • Central nervous system penetration and enhancement of temozolomide activity in childhood medulloblastoma models by poly (ADP-ribose) polymerase inhibitor AG-014699
    • Daniel R, Rozanska A, Mulligan E, Drew Y, Thomas H, Castelbuono D, Hostomsky Z, Plummer E, Tweddle D, Boddy A: Central nervous system penetration and enhancement of temozolomide activity in childhood medulloblastoma models by poly (ADP-ribose) polymerase inhibitor AG-014699. Br J Cancer 2010, 103(10):1588-1596. 10.1038/sj.bjc.6605946
    • (2010) Br J Cancer , vol.103 , Issue.10 , pp. 1588-1596
    • Daniel, R.1    Rozanska, A.2    Mulligan, E.3    Drew, Y.4    Thomas, H.5    Castelbuono, D.6    Hostomsky, Z.7    Plummer, E.8    Tweddle, D.9    Boddy, A.10
  • 37
    • 79959682172 scopus 로고    scopus 로고
    • Certain imidazotetrazines escape O6-methylguanine-DNA methyltransferase and mismatch repair
    • Zhang J, Stevens MF, Hummersone M, Madhusudan S, Laughton CA, Bradshaw TD: Certain imidazotetrazines escape O6-methylguanine-DNA methyltransferase and mismatch repair. Oncology 2011, 80(3-4):195-207.
    • (2011) Oncology , vol.80 , Issue.3-4 , pp. 195-207
    • Zhang, J.1    Stevens, M.F.2    Hummersone, M.3    Madhusudan, S.4    Laughton, C.A.5    Bradshaw, T.D.6
  • 39
    • 65849378710 scopus 로고    scopus 로고
    • Unleashing the power of inhibitors of oncogenic kinases through BH3 mimetics
    • Cragg MS, Harris C, Strasser A, Scott CL: Unleashing the power of inhibitors of oncogenic kinases through BH3 mimetics. Nat Rev Cancer 2009, 9(5):321-326. 10.1038/nrc2615
    • (2009) Nat Rev Cancer , vol.9 , Issue.5 , pp. 321-326
    • Cragg, M.S.1    Harris, C.2    Strasser, A.3    Scott, C.L.4
  • 40
    • 42349098051 scopus 로고    scopus 로고
    • BH3 mimetic ABT-737 potentiates TRAIL-mediated apoptotic signaling by unsequestering Bim and Bak in human pancreatic cancer cells
    • Huang S, Sinicrope FA: BH3 mimetic ABT-737 potentiates TRAIL-mediated apoptotic signaling by unsequestering Bim and Bak in human pancreatic cancer cells. Cancer Res 2008, 68(8):2944-2951. 10.1158/0008-5472.CAN-07-2508
    • (2008) Cancer Res , vol.68 , Issue.8 , pp. 2944-2951
    • Huang, S.1    Sinicrope, F.A.2
  • 41
    • 7044246306 scopus 로고    scopus 로고
    • Bcl2 expression inversely correlates with tumour cell differentiation in medulloblastoma
    • Schüller U, Schober F, Kretzschmar H, Herms J: Bcl2 expression inversely correlates with tumour cell differentiation in medulloblastoma. Neuropathol Appl Neurobiol 2004, 30(5):513-521. 10.1111/j.1365-2990.2004.00553.x
    • (2004) Neuropathol Appl Neurobiol , vol.30 , Issue.5 , pp. 513-521
    • Schüller, U.1    Schober, F.2    Kretzschmar, H.3    Herms, J.4
  • 45
    • 58849164097 scopus 로고    scopus 로고
    • Phase I study of obatoclax mesylate (GX15-070), a small molecule pan-Bcl-2 family antagonist, in patients with advanced chronic lymphocytic leukemia
    • O'Brien SM, Claxton DF, Crump M, Faderl S, Kipps T, Keating MJ, Viallet J, Cheson BD: Phase I study of obatoclax mesylate (GX15-070), a small molecule pan-Bcl-2 family antagonist, in patients with advanced chronic lymphocytic leukemia. Blood 2009, 113(2):299-305.
    • (2009) Blood , vol.113 , Issue.2 , pp. 299-305
    • O'Brien, S.M.1    Claxton, D.F.2    Crump, M.3    Faderl, S.4    Kipps, T.5    Keating, M.J.6    Viallet, J.7    Cheson, B.D.8
  • 46
    • 84856239462 scopus 로고    scopus 로고
    • RASSF1A and the BH3-only mimetic ABT-737 promote apoptosis in pediatric medulloblastoma cell lines
    • Levesley J, Lusher ME, Lindsey JC, Clifford SC, Grundy R, Coyle B: RASSF1A and the BH3-only mimetic ABT-737 promote apoptosis in pediatric medulloblastoma cell lines. Neuro Oncol 2011, 13(12):1265-1276. 10.1093/neuonc/nor129
    • (2011) Neuro Oncol , vol.13 , Issue.12 , pp. 1265-1276
    • Levesley, J.1    Lusher, M.E.2    Lindsey, J.C.3    Clifford, S.C.4    Grundy, R.5    Coyle, B.6
  • 47
    • 79955668070 scopus 로고    scopus 로고
    • The B-cell lymphoma 2 (BCL2)-inhibitors, ABT-737 and ABT-263, are substrates for P-glycoprotein
    • Vogler M, Dickens D, Dyer MJS, Owen A, Pirmohamed M, Cohen GM: The B-cell lymphoma 2 (BCL2)-inhibitors, ABT-737 and ABT-263, are substrates for P-glycoprotein. Biochem Biophys Res Commun 2011, 408(2):344-349. 10.1016/j.bbrc.2011.04.043
    • (2011) Biochem Biophys Res Commun , vol.408 , Issue.2 , pp. 344-349
    • Vogler, M.1    Dickens, D.2    Dyer, M.J.S.3    Owen, A.4    Pirmohamed, M.5    Cohen, G.M.6
  • 54
    • 84871556659 scopus 로고    scopus 로고
    • Expression of Wnt 3a, β-Catenin, Cyclin D1 and PCNA in Mouse Dentate Gyrus Subgranular Zone (SGZ): a Possible Role of Wnt Pathway in SGZ Neural Stem Cell Proliferation
    • Kumar D, Devaraj H: Expression of Wnt 3a, β-Catenin, Cyclin D1 and PCNA in Mouse Dentate Gyrus Subgranular Zone (SGZ): a Possible Role of Wnt Pathway in SGZ Neural Stem Cell Proliferation. Folia Biol (Praha) 2012, 58: 115-120.
    • (2012) Folia Biol (Praha) , vol.58 , pp. 115-120
    • Kumar, D.1    Devaraj, H.2
  • 55
    • 84860378325 scopus 로고    scopus 로고
    • Global gene expression profiling confirms the molecular fidelity of primary tumor-based orthotopic xenograft mouse models of medulloblastoma
    • Zhao X, Liu Z, Yu L, Zhang Y, Baxter P, Voicu H, Gurusiddappa S, Luan J, Su JM, Leung H-cE: Global gene expression profiling confirms the molecular fidelity of primary tumor-based orthotopic xenograft mouse models of medulloblastoma. Neuro Oncol 2012, 14(5):574-583. 10.1093/neuonc/nos061
    • (2012) Neuro Oncol , vol.14 , Issue.5 , pp. 574-583
    • Zhao, X.1    Liu, Z.2    Yu, L.3    Zhang, Y.4    Baxter, P.5    Voicu, H.6    Gurusiddappa, S.7    Luan, J.8    Su, J.M.9    Leung, H.-C.10
  • 56
    • 9144266455 scopus 로고    scopus 로고
    • Multiple drug resistance protein (MDR-1), multidrug resistance-related protein (MRP) and lung resistance protein (LRP) gene expression in childhood acute lymphoblastic leukemia
    • Valera ET, Scrideli CA, Queiroz R, Mori B, Tone LG: Multiple drug resistance protein (MDR-1), multidrug resistance-related protein (MRP) and lung resistance protein (LRP) gene expression in childhood acute lymphoblastic leukemia. Sao Paulo Med J 2004, 122(4):166-171. 10.1590/S1516-31802004000400007
    • (2004) Sao Paulo Med J , vol.122 , Issue.4 , pp. 166-171
    • Valera, E.T.1    Scrideli, C.A.2    Queiroz, R.3    Mori, B.4    Tone, L.G.5
  • 57
    • 17344392308 scopus 로고    scopus 로고
    • A new mathematical model for relative quantification in real-time RT-PCR
    • PfafflMW: A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 2001, 29(9):e45-e45. 10.1093/nar/29.9.e45
    • (2001) Nucleic Acids Res , vol.29 , Issue.9 , pp. 45
    • Pfaffl, M.W.1
  • 63
    • 79952993517 scopus 로고    scopus 로고
    • Multidrug efflux pumps and cancer stem cells: insights into multidrug resistance and therapeutic development
    • Moitra K, Lou H, Dean M: Multidrug efflux pumps and cancer stem cells: insights into multidrug resistance and therapeutic development. Basic Clin Pharmacol Toxicol 2011, 89(4):491-502.
    • (2011) Basic Clin Pharmacol Toxicol , vol.89 , Issue.4 , pp. 491-502
    • Moitra, K.1    Lou, H.2    Dean, M.3
  • 64
    • 0018595465 scopus 로고
    • Therapeutic trials with VP-16-213 and VM-26: active agents in small cell lung cancer, non-Hodgkin's lymphomas, and other malignancies
    • Radice P, Bunn P Jr, Ihde D: Therapeutic trials with VP-16-213 and VM-26: active agents in small cell lung cancer, non-Hodgkin's lymphomas, and other malignancies. Cancer Treat Rep 1979, 63(8):1231-1239.
    • (1979) Cancer Treat Rep , vol.63 , Issue.8 , pp. 1231-1239
    • Radice, P.1    Bunn, P.2    Ihde, D.3
  • 66
    • 33644912648 scopus 로고    scopus 로고
    • Effect of vardenafil, an inhibitor of phosphodiesterase5, on portal haemodynamics in normal and cirrhotic liver-results of a pilot study
    • Deibert P, SCHUMACHER YO, Ruecker G, Opitz O, Blum H, Rössle M, Kreisel W: Effect of vardenafil, an inhibitor of phosphodiesterase5, on portal haemodynamics in normal and cirrhotic liver-results of a pilot study. Aliment Pharmacol Ther 2006, 23(1):121-128. 10.1111/j.1365-2036.2006.02735.x
    • (2006) Aliment Pharmacol Ther , vol.23 , Issue.1 , pp. 121-128
    • Deibert, P.1    SCHUMACHER, Y.O.2    Ruecker, G.3    Opitz, O.4    Blum, H.5    Rössle, M.6    Kreisel, W.7
  • 67
    • 84894630218 scopus 로고    scopus 로고
    • Paediatric pulmonary hypertension and sildenafil: current practice and controversies
    • Wardle AJ, Tulloh RM: Paediatric pulmonary hypertension and sildenafil: current practice and controversies. Arch Dis Child Educ Pract Ed 2013, 98(4):141-147. doi:10.1136/archdischild-2013-303981 10.1136/archdischild-2013-303981
    • (2013) Arch Dis Child Educ Pract Ed , vol.98 , Issue.4 , pp. 141-147
    • Wardle, A.J.1    Tulloh, R.M.2
  • 68
    • 77956326618 scopus 로고    scopus 로고
    • Phosphodiesterase type 5 inhibitors increase Herceptin transport and treatment efficacy in mouse metastatic brain tumor models
    • Hu J, Ljubimova JY, Inoue S, Konda B, Patil R, Ding H, Espinoza A, Wawrowsky KA, Patil C, Ljubimov AV: Phosphodiesterase type 5 inhibitors increase Herceptin transport and treatment efficacy in mouse metastatic brain tumor models. PLoS One 2010, 5(4):e10108. 10.1371/journal.pone.0010108
    • (2010) PLoS One , vol.5 , Issue.4
    • Hu, J.1    Ljubimova, J.Y.2    Inoue, S.3    Konda, B.4    Patil, R.5    Ding, H.6    Espinoza, A.7    Wawrowsky, K.A.8    Patil, C.9    Ljubimov, A.V.10
  • 72
    • 33646354381 scopus 로고    scopus 로고
    • Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members
    • Certo M, Del Gaizo MV, Nishino M, Wei G, Korsmeyer S, Armstrong SA, Letai A: Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members. Cancer Cell 2006, 9(5):351-365. 10.1016/j.ccr.2006.03.027
    • (2006) Cancer Cell , vol.9 , Issue.5 , pp. 351-365
    • Certo, M.1    Del Gaizo, M.V.2    Nishino, M.3    Wei, G.4    Korsmeyer, S.5    Armstrong, S.A.6    Letai, A.7
  • 74
    • 77951442337 scopus 로고    scopus 로고
    • Acquired resistance to ABT-737 in lymphoma cells that up-regulate MCL-1 and BFL-1
    • Yecies D, Carlson NE, Deng J, Letai A: Acquired resistance to ABT-737 in lymphoma cells that up-regulate MCL-1 and BFL-1. Blood 2010, 115(16):3304-3313. 10.1182/blood-2009-07-233304
    • (2010) Blood , vol.115 , Issue.16 , pp. 3304-3313
    • Yecies, D.1    Carlson, N.E.2    Deng, J.3    Letai, A.4
  • 75
    • 66149147044 scopus 로고    scopus 로고
    • Concurrent up-regulation of BCL-XL and BCL2A1 induces approximately 1000-fold resistance to ABT-737 in chronic lymphocytic leukemia
    • Vogler M, Butterworth M, Majid A, Walewska RJ, Sun XM, Dyer MJS, Cohen GM: Concurrent up-regulation of BCL-XL and BCL2A1 induces approximately 1000-fold resistance to ABT-737 in chronic lymphocytic leukemia. Blood 2009, 113(18):4403-4413. 10.1182/blood-2008-08-173310
    • (2009) Blood , vol.113 , Issue.18 , pp. 4403-4413
    • Vogler, M.1    Butterworth, M.2    Majid, A.3    Walewska, R.J.4    Sun, X.M.5    Dyer, M.J.S.6    Cohen, G.M.7
  • 76
    • 77956257700 scopus 로고    scopus 로고
    • Actinomycin D decreases Mcl-1 expression and acts synergistically with ABT-737 against small cell lung cancer cell lines
    • Xu H, Krystal GW: Actinomycin D decreases Mcl-1 expression and acts synergistically with ABT-737 against small cell lung cancer cell lines. Clin Cancer Res 2010, 16(17):4392-4400. 10.1158/1078-0432.CCR-10-0640
    • (2010) Clin Cancer Res , vol.16 , Issue.17 , pp. 4392-4400
    • Xu, H.1    Krystal, G.W.2


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