Single diastereomer of a macrolactam core binds specifically to myeloid cell leukemia 1 (MCL1)

ACS Medicinal Chemistry Letters

Volumn 5, Issue 12, 2014, Pages 1308-1312

  Fang, Chao ^a   D'Souza, Brendan ^a   Thompson, Christopher F ^a   Clifton, Matthew C ^c   Fairman, James W ^c   Fulroth, Ben ^a   Leed, Alison ^a   McCarren, Patrick ^a   Wang, Lili ^a   Wang, Yikai ^a   Feau, Clementine ^a   Kaushik, Virendar K ^a   Palmer, Michelle ^a   Wei, Guo ^a   Golub, Todd R ^a,b   Hubbard, Brian K ^a   Serrano Wu, Michael H ^a  

^a BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^c Beryllium   (United States)

Author keywords

biophysical validation; MCL1; myeloid cell leukemia 1; sp3 rich

Indexed keywords

MACROLACTAM; MYELOID LEUKEMIA FACTOR 1; SULFONAMIDE; UNCLASSIFIED DRUG;

ARTICLE; DIASTEREOISOMER; HUMAN; HUMAN CELL; LEUKEMIA CELL; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

EID: 84918582325     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml500388q     Document Type: Article

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