B12 deficiency increases with age in hospitalized patients: A study on 14,904 samples

Journals of Gerontology - Series A Biological Sciences and Medical Sciences

Volumn 69, Issue 12, 2014, Pages 1576-1585

  Mézière, Anthony ^a,b   Audureau, Etienne ^b,c   Vairelles, Stéphane ^b   Krypciak, Sébastien ^b   Dicko, Michèle ^b,d   Monié, Marguerite ^a   Giraudier, Stéphane ^b,d  

^a PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^b HENRI MONDOR HOSPITAL   (France)

^c UNIVERSITÉ PARIS EST CRÉTEIL   (France)

^d FACULTÉ DE MÉDECINE   (France)

Author keywords

Anemia; B12 deficiency; Folates; Hemotology; Nutrition

Indexed keywords

CYANOCOBALAMIN; HEMOGLOBIN; HOMOCYSTEINE;

ADOLESCENT; ADULT; AGE; AGE DISTRIBUTION; AGED; AGING; BLOOD; CLINICAL TRIAL; FEMALE; FOLLOW UP; FRANCE; HOSPITAL PATIENT; HUMAN; MALE; METABOLISM; MIDDLE AGED; MORBIDITY; MULTICENTER STUDY; RETROSPECTIVE STUDY; RISK FACTOR; TRENDS; VERY ELDERLY; VITAMIN B 12 DEFICIENCY; YOUNG ADULT;

ADOLESCENT; ADULT; AGE DISTRIBUTION; AGE FACTORS; AGED; AGED, 80 AND OVER; AGING; FEMALE; FOLLOW-UP STUDIES; HEMOGLOBINS; HOMOCYSTEINE; HUMANS; INPATIENTS; MALE; MIDDLE AGED; MORBIDITY; PARIS; RETROSPECTIVE STUDIES; RISK FACTORS; VITAMIN B 12; VITAMIN B 12 DEFICIENCY; YOUNG ADULT;

EID: 84918568826     PISSN: 10795006     EISSN: 1758535X     Source Type: Journal    
DOI: 10.1093/gerona/glu109     Document Type: Article

References (38)

1. Wolters M, Ströhle A, Hahn A. Cobalamin: a critical vitamin in the elderly. Prev Med. 2004;39:1256-1266. doi:10.1016/j. ypmed.2004.04.047
2. Leishear K, Ferrucci L, Lauretani F, et al. Vitamin B12 and homocysteine levels and 6-year change in peripheral nerve function and neurological signs. J Gerontol A Biol Sci Med Sci. 2012;67:537-543. doi:10.1093/gerona/glr202
3. Hin H, Clarke R, Sherliker P, et al. Clinical relevance of low serum vitamin B12 concentrations in older people: the Banbury B12 study. Age Ageing. 2006;35:416-422. doi:10.1093/ageing/afl033
4. Lachner C, Steinle NI, Regenold WT. The neuropsychiatry of vitamin B12 deficiency in elderly patients. J Neuropsychiatry Clin NeuroSci. 2012;24:5-15. doi:10.1093/ageing/afl033
5. Andrès E, Loukili NH, Noel E, et al. Vitamin B12 (cobalamin) deficiency in elderly patients. CMAJ. 2004;171:251-259. doi:10.1503/cmaj.1031155
6. Carmel R. How I treat cobalamin (vitamin B12) deficiency. Blood. 2008;112:2214-2221. doi:10.1182/blood-2008-03-040253
7. Stabler SP, Allen RH, Savage DG, Lindenbaum J. Clinical spectrum and diagnosis of cobalamin deficiency. Blood. 1990;76:871-881.
8. Clarke R, Daly L, Robinson K, et al. Hyperhomocysteinemia: an independent risk factor for vascular disease. N Engl J Med. 1991;324:1149-1155. doi:10.1056/NEJM199104253241701
9. Carmel R. Subclinical cobalamin deficiency. Curr Opin Gastroenterol. 2012;28:151-158. doi:10.1097/MOG.0b013e3283505852
10. Bailey RL, Carmel R, Green R, et al. Monitoring of vitamin B-12 nutritional status in the United States by using plasma methylmalonic acid and serum vitamin B-12. Am J Clin Nutr. 2011;94:552-561. doi:10.3945/ajcn. 111.015222
11. Institute of Medicine of the National Academies of Science. Dietary Reference Intake for Thiamine, Riboflavin, Niacin, Vitamin B 6, Folate, Vitamin B12, Panthotenic Acid, Biotine and Choline. Washington, DC: Nutritional Academies Press; 1998.
12. World Health Organization. Indicators and Strategies for Iron Deficiency and Anemia Programmes. Report of the WHO/UNICEF/UNU Consultation. Geneva, Switzerland: WHO; 1993.
13. Gibson, R. Income-Matched Black-White Hemoglobin Differences After Correction for Low Transferrin Saturation. New York, NY: Oxford University Press; 1993.
14. Loikas S, Koskinen P, Irjala K, et al. Vitamin B12 deficiency in the aged: a population-based study. Age Ageing. 2007;36:177-183. doi:10.1093/ageing/afl150
15. Haslam A, Hausman DB, Johnson MA, et al.; Georgia Centenarian Study. Prevalence and predictors of anemia in a population-based study of octogenarians and centenarians in Georgia. J Gerontol A Biol Sci Med Sci. 2012;67:100-106. doi:10.1093/gerona/glr151
16. Koenig V, Stanga Z, Zerlauth M, Bernasconi L, Risch M, Huber A. Prevalence of vitamin B12 depletion and deficiency in Liechtenstein. Public Health Nutr. 2012;14:1-7. doi:10.1017/S1368980012005289
17. Wang YH, Yan F, Zhang WB, et al. An investigation of vitamin B12 deficiency in elderly inpatients in neurology department. Neurosci Bull. 2009;25:209-215. doi:10.1007/s12264-009-0224-9
18. Vogiatzoglou A, Smith AD, Nurk E, et al. Dietary sources of vitamin B-12 and their association with plasma vitamin B-12 concentrations in the general population: the Hordaland homocysteine study. Am J Clin Nutr. 2009;89:1078-1087. doi:10.3945/ajcn. 2008.26598
19. Xavier JM, Costa FF, Annichino-Bizzacchi JM, Saad ST. High frequency of vitamin B12 deficiency in a Brazilian population. Public Health Nutr. 2010;13:1191-1197. doi:10.1017/S1368980009992205
20. Clarke R, Refsum H, Birks J, et al. Screening for vitamin B-12 and folate deficiency in older persons. Am J Clin Nutr. 2003;77:1241-1247.
21. Figlin E, Chetrit A, Shahar A, et al. High prevalences of vitamin B12 and folic acid deficiency in elderly subjects in Israel. Br J Haematol. 2003;123:696-701. doi:10.1046/j.1365-2141.2003.04658.x
22. Clarke R, Grimley Evans J, Schneede J, et al. Vitamin B12 and folate deficiency in later life. Age Ageing. 2004;33:34-41. doi:10.1093/ageing/afg109
23. Pautas E, Siguret V, Kim TM, et al. Anemia in the elderly: usefulness of an easy and comprehensive laboratory screen. Ann Biol Clin (Paris). 2012;70:643-647.
24. Wong YY, Almeida OP, McCaul KA, et al. Homcysteine, frailty, and all-cause mortality in older men: the health in men study. J Gerontol A Biol Sci Med Sci. 2013;685:590-598. doi:10.1093/gerona/gls211
25. Joosten E, Lesaffre E, Riezler R, et al. Is metabolic evidence for vitamin B-12 and folate deficiency more frequent in elderly patients with Alzheimer's disease? J Gerontol A Biol Sci Med Sci. 1997;52:M76-M79. doi:10.1093/gerona/52A.2. M76
26. Andreotti F, Burzotta F, Manzoli A, Robinson K. Homocysteine and risk of cardiovascular disease. J Thromb Thrombolysis. 2000;9:13-21. doi:10.1023/A:1018675624181
27. Selhub J, Jacques PF, Wilson PW, Rush D, Rosenberg IH. Vitamin status and intake as primary determinants of homocysteinemia in an elderly population. JAMA. 1993;270:2693-2698. doi:10.1001/jama.270.22.2693
28. Forster S, Gariballa S. Age as a determinant of nutritional status: a cross sectional study. Nutr J. 2005;4:28. doi:10.1186/1475-2891-4-28
29. Guralnik JM, Eisenstaedt RS, Ferrucci L, Klein HG, Woodman RC. Prevalence of anemia in persons 65 years and older in the United States: evidence for a high rate of unexplained anemia. Blood. 2004;104:2263-2268. doi:10.1182/blood-2004-05-1812
30. Takubo T, Tatsumi N. Reference values for hematologic laboratory tests and hematologic disorders in the aged. Rinsho Byori. 2000;48:207-216. doi:10804827
31. Giorno R, Clifford JH, Beverly S, Rossing RG. Hematology reference values. Analysis by different statistical technics and variations with age and sex. Am J Clin Pathol. 1980;74:765-770.
32. Norlund L, Grubb A, Fex G, et al. The increase of plasma homocysteine concentrations with age is partly due to the deterioration of renal function as determined by plasma cystatin C. Clin Chem Lab Med. 1998;36:175-178. doi:10.1515/CCLM.1998.032
33. Fakhrzadeh H, Ghotbi S, Pourebrahim R, et al. Total plasma homocysteine, folate, and vitamin B12 status in healthy Iranian adults: the Tehran homocysteine survey (2003-2004)/a cross-sectional population based study. BMC Public Health. 2006;6:29.
34. Tal S, Shavit Y, Stern F, Malnick S. Association between vitamin B12 levels and mortality in hospitalized older adults. J Am Geriatr Soc. 2010;58:523-526. doi:10.1111/j.1532-5415.2010.02721.x
35. Chatthanawaree W. Biomarkers of cobalamin (vitamin B12) deficiency and its application. J Nutr Health Aging. 2011;15:227-231. doi:10.1007/s12603-010-0280-x
36. Wang YH, Yan F, Zhang WB, et al. An investigation of vitamin B12 deficiency in elderly inpatients in neurology department. Neurosci Bull. 2009;25:209-215. doi:10.1007/s12264-009-0224-9
37. Gümürdülü Y, Serin E, Ozer B, et al. Predictors of vitamin B12 deficiency: age and Helicobacter pylori load of antral mucosa. Turk J Gastroenterol. 2003;14:44-49.
38. Obeid R, Herrmann W. Holotranscobalamin in laboratory diagnosis of cobalamin deficiency compared to total cobalamin and methylmalonic acid. Clin Chem Lab Med. 2007;45:1746-1750. doi:10.1515/CCLM.2007.361