Understanding the HPA response to critical illness: novel insights with clinical implications

Intensive Care Medicine

Volumn 41, Issue 1, 2015, Pages 131-133

  Boonen, Eva ^a   Van den Berghe, Greet ^a  

^a LABORATORY OF MOLECULAR AND CELLULAR SIGNALING   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOTROPIN; HYDROCORTISONE; MELANOCORTIN 2 RECEPTOR; NITRIC OXIDE;

ACTH SECRETING CELL; ADRENAL CORTEX; ADRENAL CORTEX ATROPHY; ADRENAL CORTEX CELL; ADRENAL INSUFFICIENCY; ARTICLE; CHOLESTEROL SYNTHESIS; CHOLESTEROL TRANSPORT; CORTICOTROPIN BLOOD LEVEL; CRITICAL ILLNESS; CRITICALLY ILL PATIENT; GENE EXPRESSION; HUMAN; HYDROCORTISONE BLOOD LEVEL; HYDROCORTISONE RELEASE; HYPERCORTISOLISM; HYPOTHALAMUS HYPOPHYSIS SYSTEM; INTENSIVE CARE UNIT; NEGATIVE FEEDBACK; PLASMA CLEARANCE; SEPTIC SHOCK; STEROIDOGENESIS; ANIMAL; HYPOPHYSIS ADRENAL SYSTEM; PHYSIOLOGY; SECRETION (PROCESS); SIGNAL TRANSDUCTION;

ADRENOCORTICOTROPIC HORMONE; ANIMALS; CRITICAL ILLNESS; HUMANS; HYDROCORTISONE; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; PITUITARY-ADRENAL SYSTEM; SIGNAL TRANSDUCTION;

EID: 84918565848     PISSN: 03424642     EISSN: 14321238     Source Type: Journal    
DOI: 10.1007/s00134-014-3545-8     Document Type: Article

References (16)

1. Lebrethon MC, Naville D, Begeot M, Saez JM (1994) Regulation of corticotropin receptor number and messenger RNA in cultured human adrenocortical cells by corticotropin and angiotensin II. J Clin Invest 93:1828–1833
2. Lehoux JG, Lefebvre A, Belisle S, Bellabarba D (1989) Hormonal regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase mRNA in the rat adrenal gland. J Steroid Biochem 34:379–384
3. Lehoux JG, Fleury A, Ducharme L (1998) The acute and chronic effects of adrenocorticotropin on the levels of messenger ribonucleic acid and protein of steroidogenic enzymes in rat adrenal in vivo. Endocrinology 139:3913–3922
4. Liu J, Heikkila P, Meng QH, Kahri AI, Tikkanen MJ, Voutilainen R (2000) Expression of low and high density lipoprotein receptor genes in human adrenals. Eur J Endocrinol 142:677–682
5. Stocco DM, Clark BJ (1996) Regulation of the acute production of steroids in steroidogenic cells. Endocr Rev 17:221–244
6. Annane D, Maxime V, Ibrahim F, Alvarez JC, Abe E, Boudou P (2006) Diagnosis of adrenal insufficiency in severe sepsis and septic shock. Am J Respir Crit Care Med 174:1319–1326
7. Vermes I, Beishuizen A, Hampsink RM, Haanen C (1995) Dissociation of plasma adrenocorticotropin and cortisol levels in critically ill patients: possible role of endothelin and atrial natriuretic hormone. J Clin Endocrinol Metab 80:1238–1242
8. Boonen E, Vervenne H, Meersseman P et al (2013) Reduced cortisol metabolism during critical illness. N Engl J Med 368:1477–1488
9. Polito A, Sonneville R, Guidoux C et al (2011) Changes in CRH and ACTH synthesis during experimental and human septic shock. PLoS One 6:e25905
10. Gibbison B, Angelini GD, Lightman SL (2013) Dynamic output and control of the hypothalamic-pituitary-adrenal axis in critical illness and major surgery. Br J Anaesth 111:347–360
11. Deutschman CS, Raj NR, McGuire EO, Kelz MB (2013) Orexinergic activity modulates altered vital signs and pituitary hormone secretion in experimental sepsis. Crit Care Med 41:e368–e375
12. Boonen E, Meersseman P, Vervenne H et al (2014) Reduced nocturnal ACTH-driven cortisol secretion during critical illness. Am J Physiol Endocrinol Metab 306:E883–E892
13. Boonen E, Langouche L, Janssens T, Meersseman P, Vervenne H, De Samblanx E, Pironet Z, Van Dyck L, Vander Perre S, Derese I, Van den Berghe G (2014) Impact of duration of critical illness on the adrenal glands of human intensive care patients. J Clin Endocrinol Metab. doi:10.1210/jc.2014-2429
14. Boonen E, Bornstein SR, Van den Berghe G (2014) On the controversy of adrenal (dys)function during critical illness: new insights. Lancet Diabetes Endocrinol (in press)
15. Annane D, Sebille V, Troche G, Raphael JC, Gajdos P, Bellissant E (2000) A 3-level prognostic classification in septic shock based on cortisol levels and cortisol response to corticotropin. JAMA 283:1038–1045
16. Venkatesh B, Cohen J (2011) Adrenocortical (dys)function in septic shock—a sick euadrenal state. Best Pract Res Clin Endocrinol Metab 25:719–733