Antiproliferative activity of aqueous leaf extract of Annona muricata L. on the prostate, BPH-1 cells, and some target genes

Integrative Cancer Therapies

Volumn 14, Issue 1, 2015, Pages 65-74

  Asare, George Awuku ^a   Afriyie, Dan ^a   Ngala, Robert A ^b   Abutiate, Harry ^c   Doku, Derek ^a,b   Mahmood, Seidu A ^a   Rahman, Habibur ^a,d  

^a UNIVERSITY OF GHANA   (Ghana)

^b KWAME NKRUMAH UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Ghana)

^c West Africa Postgraduate College of Pharmacists   (Ghana)

^d BANGLADESH AGRICULTURAL UNIVERSITY   (Bangladesh)

Author keywords

Annona muricata; Apoptosis; BPH 1; Proliferation; Prostate; Rats

Indexed keywords

ANNONA MURICATA EXTRACT; ANTINEOPLASTIC AGENT; MESSENGER RNA; PROTEIN BAX; PROTEIN BCL 2; BAX PROTEIN, RAT; PLANT EXTRACT;

ACINAR CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANNONA MURICATA; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CELL COUNT; CELL MEMBRANE; CELL NUCLEUS MEMBRANE; CELL PROLIFERATION; CELL STRUCTURE; CELL VACUOLE; CELL VIABILITY; CHROMATIN; CONTROLLED STUDY; CYTOPLASM; DOWN REGULATION; EPITHELIUM; EPITHELIUM CELL; GENE TARGETING; HISTOLOGY; HUMAN; HUMAN CELL; IC50; IN VITRO STUDY; LEYDIG CELL; MALE; MTT ASSAY; NONHUMAN; PROSTATE; PROSTATE EPITHELIUM; PROSTATE FLUID; PROSTATE HYPERTROPHY; PROSTATE SECRETION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SECRETION (PROCESS); SEMINAL VESICLE; SEMINIFEROUS TUBULE; SERTOLI CELL; SPERMATID; SPERMATOCYTE; SPERMATOGENESIS; SPERMATOGONIUM; SPERMATOZOON; UPREGULATION; ANIMAL; ANNONA; CELL LINE; CHEMISTRY; DRUG EFFECTS; DRUG SCREENING; FISCHER 344 RAT; GENETICS; METABOLISM; PATHOLOGY; PHYTOTHERAPY; PLANT LEAF; PROCEDURES; PROSTATIC HYPERPLASIA;

ANIMALS; ANNONA; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CELL LINE; CELL PROLIFERATION; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MALE; PHYTOTHERAPY; PLANT EXTRACTS; PLANT LEAVES; PROSTATE; PROSTATIC HYPERPLASIA; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; RATS, INBRED F344; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 84918565751     PISSN: 15347354     EISSN: 1552695X     Source Type: Journal    
DOI: 10.1177/1534735414550198     Document Type: Article

References (41)

1. American Cancer Society. Cancer Facts & Figures. Atlanta, GA: American Cancer Society;2012.
2. Won YJ, Sung S, Lee JS. Nationwide cancer incidence in Korea, 2003-2005. Cancer Res Treat. 2009;41:122-131.
3. Johansson JE, Andren O, Andersson SO, et al. Natural history of early, localized prostate cancer. JAMA. 2004;291:2713-2719.
4. Wiredu EK, Armah HB. Cancer mortality patterns in Ghana: a 10-year review of autopsies and hospital mortality. BMC Public Health. 2006;20:159.
5. Steineck G, Bergmark K, Henningsohn L, al-Abany M, Dickman PW, Helgason AR. Symptom documentation in cancer survivors as a basis for therapy modifications. Acta Oncol. 2002;41:244-252.
6. Albertsen PC, Hanley JA, Fine J. 20-Year outcomes following conservative management of clinically localized prostate cancer. JAMA. 2005;293:2095-2101.
7. Liaw CC, Chang FR, Lin CY, et al. New cytotoxic monotetra-hydrofuran annonaceous acetogenins from A. muricata. J Nat Prod. 2002;65:470-475.
8. Ragasa C, Soriano G, Torres OB, Ming-Jaw D, Chien-Chang S. Acetogenins from A. muricata. Phcog J. 2012;32:32-37.
9. Kim GS, Zeng L, Alali F, et al. Muricoreacin and murihexocin C, mono-tetrahydrofuran acetogenins, from the leaves of A. muricata. Phytochemistry. 1998;49:565-571.
10. Astirin OP, Artanti AN, Fitria MS, Perwitasari EA, Prayitno A. Annonaa muricata Linn leaf induce apoptosis in cancer cause virus. J Cancer Ther. 2013;4:1244-1250.
11. Arthur FKN, Woode E, Terlabi EO, Larbie C. Evaluation of acute and subchronic toxicity of Annona muricata (Linn.) aqueous extract in animals. Eur J Exp Biol. 2011;1:115-124.
12. Champy P, Melot A, Guerineau Eng V, et al. Quantification of acetogenins in Annona muricata linked to atypical parkinsonism in guadeloupe. Mov Disord. 2005;20:1629-1633.
13. Gupta RK, Kesari AN, Watal G, et al. Hypoglycaemic and antidiabetic effect of aqueous extract of leaves of Annona squamosa (L.) in experimental animal. Curr Sci. 2005;88:1244-1254.
14. Adewole SO, Ojewole JAO. Protective effects of Annona muricata Linn. (Annonaceae) leaf aqueous extract on serum lipid profiles and oxidative stress in hepatocytes of strep-tozontocin-treated rats. Afr J Tradit Complement Altern Med. 2009;6:30-41.
15. OECD. Test No. 408: Repeated Dose 90-Day Oral Toxicity Study in Rodents; OECD Guidelines for the Testing of Chemicals, Section 4: Health Effects. Paris, France: OECD Publishing; 1998.
16. Adewole SO, Caxton-Martins EA. Morphological changes and hypoglycemic effects of A. muricata (Annonaceae) leaf aqueous extract on pancreatic B-cells of streptozotocin-treated diabetic rats. Afr J Biomed Res. 2006;9:173-187.
17. George VC, Kumar DRN, Rajkumar V, Suresh PK, Kumar RA. Quantitative assessment of the relative antineoplastic potential of the n-butanolic leaf extract of A. muricata in normal and immortalized human cell lines. Asian Pac J Cancer Prev. 2012;13:699-704.
18. Tormo JR, Royo I, Gallardo T, et al. In vitro antitumor structure activity relationships of threo/trans/three mono-tetrahydrofuranic acetogenins: correlations with their inhibition of mitochondial complex 1. Oncol Res. 2003;14:147-154.
19. Kojima N. Systemic synthesis of antitumor Annonaceous acetogenins. Yakugaku Zasshi. 2004;124:673-681.
20. Oberlies NH, Jones JL, Corbett TH, Fotopoulos SS, McLaughlin JL. Tumor cell growth inhibition by several Annonaceous acetogenins in an in vitro disk diffusion assay. Cancer Lett. 1995;96:55-62.
21. Chatterjee S, Srivastava S, Khalid A, et al. Comprehensive metabolic fingerprinting of Withania somnifera leaf and root extracts. Phytochemistry. 2010;71:1085-1094.
22. Maier TS, Kuhn J, Müller C. Proposal for field sampling of plants and processing in the lab for environmental metabolic fingerprinting. Plant Methods. 2010;6:6.
23. Abhishek SL, Vd Goray Namrata P. Pharmacognostical studies on the leaf of Annona squamosa Linn. Phcog J. 2009;1:1.
24. Ahmad I, Bhagat S, Sharma TVRS, Krishna K, Simachalam P, Srivastava RC. ISSR and RAPD marker based DNA fingerprinting and diversity assessment of Annona spp. in South Andaman. Ind J Horticulture. 2010;67:147-151.
25. Elhawary SS, El Tantawy ME, Rabeh MA, Fawaz NE. DNA fingerprinting, chemical composition, antitumor and antimicrobial activities of the essential oils and extractives of four Annona species from Egypt. J Natural Sci Res. 2013;3:59-68.
26. Nawab A, Yunus M, Mahdi AA, Gupta S. Evaluation of anticancer properties of medicinal plants from the Indian subcontinent. Mol Cell Pharmacol. 2011;3:21-29.
27. Lopez LM, Martin CC, Bermejo A, Cortes D, Ayuso MJ. Cytotoxic compounds from annonaceous species as DNA topoisomerase I poisons. Anticancer Res. 2001;21:3493-3497.
28. Yuan SS, Chang HL, Chen HW, et al. Annonacin, a monotetrahydrofuran acetogenin, arrests cancer cells at the G1 phase and causes cytotoxicity in a bax- and caspase-3-related pathway. Life Sci. 2003;72:2853-2861.
29. Kojima N, Morioka T, Urabe D, et al. Convergent synthesis of fluorescence-labeled probes of annonaceous acetogenins and visualization of their cell distribution. Bioorg Med Chem. 2010;18:8630-8641.
30. Olamide AA, Olayemi OO, Demetrius OO, Olatoye OJ, Kehinde AA. Effects of methanolic extract of Citrullus lanatus seed on experimentally induced prostatic hyperplasia. Eur J Med Plants. 2011;1:171-179.
31. Dhanotiya R, Chauhan NS, Saraf DK, Dixit VK. Effect of Citrullus colocynthis Schard on testosterone-induced benign prostatic hyperplasia. J Comp Integr Med. 2009;6:29.
32. Torres MP, Rachagani S, Purohit V, et al. Graviola: a novel promising natural-derived drug that inhibits tumorigenicity and metastasis of pancreatic cancer cells in vitro and in vivo through altering cell metabolism. Cancer Lett. 2012;323:29-40.
33. Harsh R, Overholser MD, Wells LJ. Effects of estrogen and androgen injections on reproductive organs in male rats and mice. J Endocrinol. 1939;1:261-267.
34. Clegg EJ. Postnatal changes in the histology of the seminal vesicle and coagulating gland in the rat. J Anatomy. 1953;93:361-367.
35. Bøe R, Gjertsen BT, Vintermyr OK, Houge G, Lanotte M, Døskeland SO. The protein phosphatase inhibitor okadaic acid induces morphological changes typical of apoptosis in mammalian cells. Exp Cell Res. 1991;195:237-246.
36. Mancini M, Nicholson DW, Roy S, et al. The caspase-3 precursor has a cytosolic and mitochondrial distribution: implications for apoptotic signaling. J Cell Biol. 1998;140:1485-1495.
37. Nicholson DW, Thornberry NA. Caspases: killer proteases. Trends Biochem Sci. 1997;22:299-306.
38. Higgins SJ, Burchell JM. Effects of testosterone on messenger ribonucleic acid and protein synthesis in rat seminal vesicle. Biochem J. 1978;174:543-551.
39. Zanato VF, Martins MP, Anselmo-Franci JA. Sexual development of male Wistar rats. Braz J Med Biol Res. 1994;27:1273-1280.
40. Bartsch G, Rittmaster RS, Klocker H. Dihydrotestosterone and the concept of 5-alpha-reductase inhibition in human benign prostatic hyperplasia. World J Urol. 2002;19:413-425.
41. Andriole G, Bruchovsky N, Chung LW, et al. Dihydrotestosterone and the prostate: the scientific rationale for 5-alphareductase inhibitors in the treatment of benign prostatic hyperplasia. J Urol. 2004;172:1399-403.