Folate deficiency and FHIT hypermethylation and HPV 16 infection promote cervical cancerization

Asian Pacific Journal of Cancer Prevention

Volumn 15, Issue 21, 2014, Pages 9313-9317

  Bai, Li Xia ^a   Wang, Jin Tao ^a   Ding, Ling ^a   Jiang, Shi Wen ^b   Kang, Hui Jie ^a   Gao, Chen Fei ^a   Chen, Xiao ^a   Chen, Chen ^a   Zhou, Qin ^a  

^a SHANXI MEDICAL UNIVERSITY   (China)

^b MERCER UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cervical cancerization; FHIT; Folate; Methylation; Prevention

Indexed keywords

ACID ANHYDRIDE HYDROLASE; FOLIC ACID; FRAGILE HISTIDINE TRIAD PROTEIN; TUMOR PROTEIN;

ADULT; BLOOD; COHORT ANALYSIS; COMPARATIVE STUDY; CPG ISLAND; DISEASE COURSE; DNA METHYLATION; FEMALE; GENE EXPRESSION REGULATION; GENETICS; HUMAN; HUMAN PAPILLOMAVIRUS TYPE 16; MIDDLE AGED; PAPILLOMAVIRUS INFECTION; POLYMERASE CHAIN REACTION; PROCEDURES; SENSITIVITY AND SPECIFICITY; SQUAMOUS CELL CARCINOMA; UTERINE CERVIX TUMOR; VIROLOGY;

ACID ANHYDRIDE HYDROLASES; ADULT; CARCINOMA, SQUAMOUS CELL; COHORT STUDIES; CPG ISLANDS; DISEASE PROGRESSION; DNA METHYLATION; FEMALE; FOLIC ACID; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMAN PAPILLOMAVIRUS 16; HUMANS; MIDDLE AGED; NEOPLASM PROTEINS; PAPILLOMAVIRUS INFECTIONS; POLYMERASE CHAIN REACTION; SENSITIVITY AND SPECIFICITY; UTERINE CERVICAL NEOPLASMS;

EID: 84918560000     PISSN: 15137368     EISSN: None     Source Type: Journal    
DOI: 10.7314/APJCP.2014.15.21.9313     Document Type: Article

References (27)

1. Abike F, Engin AB, Dunder I, et al (2011). Human papilloma virus persistence and neopterin, folate and homocysteine levels in cervical dysplasias. Arch Gynecol Obstet, 284, 209-14.
2. Abouzeid HE, Kassem AM, Abdel Wahab AH, et al (2011). Promoter hypermethylation of RASSF1A, MGMT, and HIC-1 genes in benign and malignant colorectal tumors. Tumour Biol, 32, 845-52.
3. Al-Temaimi RA, Jacob S, Al-Ali W, et al (2013). Reduced FHIT expression is associated with mismatch repair deficient and high CpG island methylator phenotype colorectal cancer. J Histochem Cytochem, 61, 627-38.
4. Banzai C, Nishino K, Quan J, et al (2014). Promoter methylation of DAPK1, FHIT, MGMT, and CDKN2A genes in cervical carcinoma. Int J Clin Oncol, 19, 127-32.
5. Chen X, Li P, Yang Z, Mo WN (2013). Expression of fragile histidine triad (FHIT) and WW-domain oxidoreductase gene (WWOX) in nasopharyngealcarcinoma. Asian Pac J Cancer Prev, 14, 165-71.
6. Ding L, Ma J, Zhou Q, Wang J (2013). Effect of folate on the proliferation of human cervical cancer cell and relationship with HPV16. Wei Sheng Yan Jiu, 42, 748-53.
7. Flatley JE, McNeir K, Balasubramani L, et al (2009). Folate Status and Aberrant DNA Methylation Are Associated With HPV Infection and Cervical Pathogenesis. Cancer Epidemiol Biomarkers Prev, 18, 2782-9.
8. Han Y, Zhang Z, Zhang GJ, et al (2011). Aberrant FHIT expression is linked to bladder carcinogenesis and apoptosis. Asian Pac J Cancer Prev, 12, 2915-20.
9. Haroun RA, Zakhary NI, Mohamed MR, et al (2014). Assessment of the prognostic value of methylation status and expression levels of FHIT, GSTP1 and p16 in non-small cell lung cancer in Egyptian patients. Asian Pac J Cancer Prev, 15, 4281-7.
10. Jeong YJ, Jeong HY, Lee SM, et al (2013). Promoter methylation status of the FHIT gene and Fhit expression: association with HER2/neu status in breast cancer patients. Oncol Rep, 30, 2270-8.
11. Jin-Tao W, Ling D, Shi-Wen J, et al (2014). Folate Deficiency and Aberrant Expression of DNA Methyltransferase 1 were Associated with Cervical Cancerization. Curr Pharm Des, 20, 1639-46.
12. Li W, Deng J, Tang JX (2014). Combined effects methylation of FHIT, RASSF1A and RARß genes on non-small cell lung cancer in the Chinese population. Asian Pac J Cancer Prev, 15, 5233-7.
13. Neyaz MK, Kumar RS, Hussain S, et al (2008). Effect of aberrant promoter methylation of FHIT and RASSF1A genes on susceptibility to cervical cancer in a North Indian population. Biomarkers, 13, 597-606.
14. Pathak S, Bhatla N, Singh N (2012). Cervical cancer pathogenesis is associated with one-carbon metabolism. Mol Cell Biochem, 369, 1-7.
15. Piyathilake CJ, Henao OL, Macaluso M, et al (2004). Folate is associated with the natural history of high-risk human papillomaviruses. Cancer Res, 64, 8788-93.
16. Piyathilake CJ, Macaluso M, Brill I, et al (2007). Lower red blood cell folate enhances the HPV-16-associated risk of cervical intraepithelial neoplasia. Nutrition, 23, 203-10.
17. Piyathilake CJ, Badiga S, Paul P, et al (2010). Indian women with higher serum concentrations of folate and vitamin B12 are significantly less likely to be infected with carcinogenic or high-risk (HR) types of human papillomaviruses (HPVs). Int J Womens Health, 2, 7-12.
18. Piyathilake CJ, Macaluso M, Celedonio JE, et al (2010). Mandatory fortification with folic acid in the United States appears to have adverse effects on histone methylation in women with pre-cancer but not in women free of pre-cancer. Int J Womens Health, 9, 131-7.
19. Piyathilake CJ, Macaluso M, Alvarez RD, et al (2011). A higher degree of LINE-1 methylation in peripheral blood mononuclear cells, a one-carbon nutrient related epigenetic alteration, is associated with a lower risk of developing cervical intraepithelial neoplasia. Nutrition, 27, 513-9.
20. Ragasudha PN, Thulaseedharan JV, Wesley R, et al (2012). A case-control nutrigenomic study on the synergistic activity of folate and vitamin B12 in cervical cancer progression. Nutr Cancer, 64, 550-8.
21. Shi HR, Wu QH, Suo ZH, Nesland JM (2005). Correlation between methylation of 5'-CpG islands and inactivation of FHIT gene in cervical cancer. Ai Zheng, 24, 7-11.
22. Tan S, Sun C, Wei X, et al (2013). Quantitative assessment of lung cancer associated with genes methylation in the peripheral blood. Exp Lung Res, 39, 182-90.
23. Tomaszewski JJ, Cummings JL, Parwani AV, et al (2011). Increased cancer cell proliferation in prostate cancer patients with high levels of serum folate. Prostate, 71, 1287-93.
24. Tong SY, Kim MK, Lee JK, et al (2011). Common polymorphisms in methylenetetrahydrofolate reductase gene are associated with risks of cervical intraepithelial neoplasia and cervical cancer in women with low serum folate and vitamin B12. Cancer Causes Control, 22, 63-72.
25. Wang JT, Huo XX, Ding L, et al (2011). Effect of folic acid and DNA methyltransferase 1 on cervical cancer and its precancerous lesion. Zhonghua Liu Xing Bing Xue Za Zhi, 32, 617-21.
26. Wilke CM, Hall BK, Hoge A, et al (1996). FRA3B extends over a broad region and contains a spontaneous HPV16 integration site: direct evidence for the coincidence of viral integration sites and fragile sites. Hum Mol Genet, 5, 187-95.
27. Zhang Y, Chen FQ, Sun YH, et al (2011). Effects of DNMT1 silencing on malignant phenotype and methylated gene expression in cervical cancer cells. J Exp Clin Cancer Res, 17, 98.