Indian women with higher serum concentrations of folate and vitamin B12 are significantly less likely to be infected with carcinogenic or high-risk (HR) types of human papillomaviruses (HPVs)

International Journal of Women's Health

Volumn 2, Issue 1, 2010, Pages 7-12

  Piyathilake, Chandrika J ^a   Badiga, Suguna ^a   Paul, Proma ^b   Vijayaraghavan, K ^c   Vedantham, Haripriya ^c   Sudula, Mrudula ^c   Sowjanya, Pavani ^c   Ramakrishna, Gayatri ^d   Shah, Keerti V ^b   Partridge, Edward E ^e   Gravitt, Patti E ^b  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^c SHARE   (India)

^d Center for DNA Fingerprinting and Diagnostics   (India)

^e UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

Cervical cancer; Folate; Human papillomavirus; Vitamin B12

Indexed keywords

CYANOCOBALAMIN; FOLIC ACID;

ADULT; AGE; ARTICLE; CANCER PREVENTION; CANCER RISK; CIGARETTE SMOKING; CONTROLLED STUDY; COOKING; DISEASE ASSOCIATION; DISEASE CLASSIFICATION; EDUCATIONAL STATUS; FEMALE; FOLIC ACID BLOOD LEVEL; HUMAN; HUMAN PAPILLOMAVIRUS TYPE 11; INDIAN; INFECTION RISK; LOGISTIC REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; PAPILLOMAVIRUS INFECTION; PARITY; PREDICTION; SERODIAGNOSIS; UTERINE CERVIX CANCER; VIRUS ISOLATION; VIRUS STRAIN; VITAMIN BLOOD LEVEL;

EID: 77953382471     PISSN: None     EISSN: 11791411     Source Type: Journal    
DOI: 10.2147/ijwh.s6522     Document Type: Article

References (21)

1. Hughes JP, Garnett GP, Koutsky L. The theoretical population-level impact of a prophylactic human papillomavirus vaccine. Epidemiology. 2002;13:631-639.
2. Kulasingham SL, Myers ER. Potential health and economic impact of adding a human papillomavirus vaccine to screening programs. JAMA. 2003;290:781-789.
3. Trimble CL, Peng S, Kos F, Gravitt P, Viscidi R, Sugar E, et al. A phase I trial of a human papillomavirus DNA vaccine for HPV16+ cervical intraepithelial neoplasia 2/3. Clin Cancer Res. 2009;15: 361-367.
4. Chandra S, Chandra RK. Nutrition, immune response, and outcome. Prog Food Nutr Sci. 1986;10:1-65.
5. Dhur A, Galan P, Hercberg S. Folate status and the immune system. Prog Food Nutr Sci. 1991;15:43-60.
6. Ahluwalia N, Mastro AM, Ball R, Miles MP, Rajendra R, Handte G. Cytokine production by stimulated mononuclear cells did not change with aging in apparently healthy, well-nourished women. Mech Ageing Dev. 2001;122:1269-1279.
7. Kim YI, Hayek M, Mason JB, Meydani SM. Severe folate deficiency impairs natural killer cell-mediated cytotoxiccity in rats. J Nutr. 2002;132:1361-1367.
8. Piyathilake CJ, Henao OL, Macaluso M, Cornwell PE, Meleth M, Heimburger DC, et al. Folate is Associated with the Natural History of High-Risk Human Papillomaviruses. Cancer Res. 2004;64: 8788-8793.
9. Flatley JE, McNeir K, Balasubramani L, et al.Folate status and aberrant DNA methylation are associated with HPV infection and cervical pathogenesis. Cancer Epidemiol Biomarkers Prev. 2009;18:2782-2789.
10. Piyathilake CJ, Macaluso M, Brill I, Partridge EE, Heimburger DC. Lower red blood cell folate enhances the HPV 16-associated risk of cervical intraepithelial neoplasia. Nutrition. 2007;23:203-210.
11. Piyathilake CJ, Macaluso M, Alvarez RD, Bell WC, Heimburger DC, Partridge EE. Lower risk of cervical intraepithelial neoplasia in women with high plasma folate and sufficient vitamin B12 in the post-folic acid fortification era. Cancer Prev Res. 2009;2:658-664.
12. Sowjanya AP, Jain M, Poli UR, Padma S, Das M, Shah KV, et al. Prevalence and distribution of high-risk human papilloma virus (HPV) types in invasive squamous cell carcinoma of the cervix and in normal women in Andhra Pradesh, India. BMC Infect Dis. 2005;5:116.
13. Ferrera A, Velena JP, Figueroa M, Bulnes R, Toro LA, Claros JM, et al. Co-factors related the causal relationship between human papillomavirus and invasive cervical cancer in Honduras. Int J Epidemiol. 2000;29:817-825.
14. Refsum H, Yajnik CS, Gadkari M, Schneede J, Vollset SE, Orning L, et al. Hyperhomocystenemia and methylmalonic acid indicate a high prevalence of cobalamin deficiency in Asian Indians. Am J Clin Nut. 2001;74:233-241.
15. Khandhuri U, Sharma A, Joshi A. Occult cobalamin and folate deficiency in Indians. Natl Med J India. 2005;18:182-183.
16. Maggini S, Wintergerst ES, Beveridge S, Hornig DH. Selected vitamins and trace elements support immune function by strengthening epithelial barriers and cellular and humoral immune responses. Br J Nutr. 2007;98(Suppl 1):S29-S35.
17. Fenech M. Nutrition and genome health. Forum Nutr. 2007;60: 49-65.
18. Wilke CM, Hall BK, Hoge A, Paradee W, Smith DI, Glover TW. FRA3B extends over a broad region and contains a spontaneous HPV 16 integration site: direct evidence for the coincidence of viral integration sites and fragile sites. Hum Mol Genet. 1996;5:187-195.
19. Popescu NC, DiPaolo JA, Amsbaugh SC. Integration sites of human papillomavirus 18 DNA sequences on HeLa cell chromosomes. Cytogenet Cell Genet. 1987;44:58-62.
20. Butterworth CE. Effect of folate on cervical cancer: Synergism among risk factors. Ann NY Acad Sci. 1992;669:293-299.
21. Perluigi M, Giorgi A, Blarzino C, De Marco F, Foppoli C, Di Domenico F, et al. Proteomics analysis of protein expression and specific protein oxidation in human papillomavirus transformed keratinocytes upon UVB irradiation. J Cell Mol Med. 2008;13:1809-1822.