Folate deficiency and aberrant expression of DNA methyltransferase 1 were associated with cervical cancerization

Current Pharmaceutical Design

Volumn 20, Issue 11, 2014, Pages 1639-1646

  Wang, Jin tao ^a   Ding, Ling ^a   Jiang, Shi Wen ^b   Hao, Junxia ^a   Zhao, Wei min ^a   Zhou, Qin ^a   Yang, Zuo kai ^a   Zhang, Li ^a  

^a SHANXI MEDICAL UNIVERSITY   (China)

^b MERCER UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cervical cancer cells; Cervical cancerization; DNA methyltransferase 1 (DNMT1); Folate

Indexed keywords

DNA METHYLTRANSFERASE 1; FOLIC ACID; DNA (CYTOSINE 5) METHYLTRANSFERASE; DNA (CYTOSINE-5-)-METHYLTRANSFERASE 1; MESSENGER RNA;

ADULT; AGED; ARTICLE; CANCER GROWTH; CANCER INHIBITION; CARCINOGENESIS; CELL VIABILITY; CERVICAL CANCER CELL LINE; CLINICAL EVALUATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DISEASE ASSOCIATION; DISEASE SEVERITY; DNA METHYLATION; EXPERIMENTAL STUDY; FEMALE; FOLIC ACID BLOOD LEVEL; FOLIC ACID DEFICIENCY; HUMAN; HUMAN CELL; IN VITRO STUDY; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROTEIN EXPRESSION; SQUAMOUS CELL CARCINOMA; UTERINE CERVIX CARCINOMA IN SITU; BLOOD; CARCINOMA, SQUAMOUS CELL; CERVICAL INTRAEPITHELIAL NEOPLASIA; COMPLICATION; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MIDDLE AGED; PATHOLOGY; SEVERITY OF ILLNESS INDEX; UTERINE CERVICAL NEOPLASMS;

ADULT; AGED; CARCINOMA, SQUAMOUS CELL; CERVICAL INTRAEPITHELIAL NEOPLASIA; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; DNA METHYLATION; FEMALE; FOLIC ACID; FOLIC ACID DEFICIENCY; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MIDDLE AGED; RNA, MESSENGER; SEVERITY OF ILLNESS INDEX; UTERINE CERVICAL NEOPLASMS;

EID: 84903711045     PISSN: 13816128     EISSN: 18734286     Source Type: Journal    
DOI: 10.2174/13816128113199990543     Document Type: Article

References (31)

1. Arbyn M, Castellsagué X, de Sanjosé S, et al. Worldwide burden of cervical cancer in 2008. Ann Oncol 2011; 22: 2675-86.
2. International Collaboration of Epidemiological Studies of Cervical Cancer. Comparison of risk factors for invasive squamous cell carcinoma and adenocarcinoma of the cervix: collaborative reanalysis of individual data on 8,097 women with squamous cell carcinoma and 1,374 women with adenocarcinoma from 12 epidemiological studies. Int J Cancer 2007; 120: 885-91.
3. Guan P, Howell-Jones R, Li N, et al.Human papillomavirus (HPV) types in 115789 HPV-positive women: A meta-analysis from cervical infection to cancer. Int J Cancer 2012; 131: 2349-59.
4. Kanai Y, Hirohashi S. Alterations of DNA methylation associated with abnormalities of DNA methyltransferases in human cancers during transition from a precancerous to a malignant state. Carcinogenesis 2007; 28: 2434-42.
5. Jones PA. DNA methylation errors and cancer. Cancer Res 1996; 56: 2463-7.
6. Zhang A, Månér S, Betz R, et al. Genetic alterations in cervical carcinomas: frequent low-level amplifications of oncogenes are associated with human papillomavirus infection. Int J Cancer 2002; 101: 427-33.
7. Robert MF, Morin S, Beaulieu N, et al. DNMT1 is required to maintain CpG methylation and aberrant gene silencing in human cancer cells. Nat Genet 2003; 33: 61-5.
8. Cheung HH, Lee TL, Rennert OM, Chan WY. DNA methylation of cancer genome. Birth Defects Res C Embryo Today 2009; 87: 335-50.
9. Humeniuk R, Mishra PJ, Bertino JR, Banerjee D. Molecular targets for epigenetic therapy of cancer. Curr Pharm Biotechnol 2009; 10: 161-5.
10. Blount BC, Mack MM, Wehr CM, et al. Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: implications for cancer and neuronal damage. Proc Natl Acad Sci USA 1997; 94: 3290-5.
11. Duthie SJ. Folic acid deficiency and cancer: mechanisms of DNA instability. Br Med Bull 1999; 55: 578-92.
12. Pufulete M, Al-Ghnaniem R, Leather AJ, et al. Folate status, genomic DNA hypomethylation, and risk of colorectal adenoma and cancer: a case control study. Gastroenterology 2003; 124: 1240-8.
13. Wang JT, Ma XC, Cheng YY, Ding L, Zhou Q. A case-control study on the association between folate and cervical cancer. Zhonghua Liu Xing Bing Xue Za Zhi 2006; 27: 424-7. [Article in Chinese]
14. Weinstein SJ, Ziegler RG, Frongillo EA Jr, et al. Low serum and red blood cell folate are moderately, but nonsignificantly associated with increased risk of invasive cervical cancer in U.S. women. J Nutr 2001; 131: 2040-8.
15. Wang JT, Ding L, Gao ES, Cheng YY. Analysis on the expression of human papillomavirus type 16 E2 and E6 oncogenes and disruption of E2 in cervical cancer. Zhonghua Liu Xing Bing Xue Za Zhi 2007; 28: 968-71.
16. zur Hausen H. Human papillomavirus & cervical cancer. Indian J Med Res 2009; 130: 209.
17. zur Hausen H. The search for infectious causes of human cancers: where and why (Nobel lecture). Angew Chem Int Ed Engl 2009; 48: 5798-808.
18. Petry KU, Luyten A, Justus A, et al. Prevalence of high-risk HPV types and associated genital diseases in women born in 1988/89 or 1983/84--results of WOLVES, a population-based epidemiological study in Wolfsburg, Germany. BMC Infect Dis 2013; 13: 135, [Epub ahead of print].
19. Ferrera A, Velema JP, Figueroa M, et al. Co-factors related to the causal relationship between human papillomavirus and invasive cervical cancer in Honduras. Int J Epidemiol 2000; 29: 817-25.
20. Louie KS, de Sanjose S, Diaz M, et al. International Agency for Research on Cancer Multicenter Cervical Cancer Study Group. Early age at first sexual intercourse and early pregnancy are risk factors for cervical cancer in developing countries. Br J Cancer 2009; 100: 1191-7.
21. Pathak S, Bhatla N, Singh N. Cervical cancer pathogenesis is associated with one-carbon metabolism. Mol Cell Biochem 2012; 369: 1-7.
22. Goll MG, Bestor TH. Eukaryotic cytosine methyltransferases. Annu Rev Biochem 2005; 74: 481-514.
23. Sowińska A, Jagodzinski PP. RNA interference-mediated knockdown of DNMT1 and DNMT3B induces CXCL12 expression in MCF-7 breast cancer and AsPC1 pancreatic carcinoma cell lines. Cancer Lett 2007; 255: 153-9.
24. Jones PA, Takai D. The role of DNA methylation in mammalian epigenetics. Science 2001; 293: 1068-70.
25. Hermann A, Gowher H, Jeltsch A. Biochemistry and biology of mammalian DNA methyltransferases. Cell Mol Life Sci 2004; 61: 2571-87.
26. Jones PA, Baylin SB. The epigenomics of cancer. Cell 2007; 128: 683-92.
27. Taby R, Issa JP. Cancer epigenetics. CA Cancer J Clin 2010; 60: 376-92.
28. Sawada M, Kanai Y, Arai E, Ushijima S, Ojima H, Hirohashi S. Increased expression of DNA methyltransferase 1 (DNMT1) protein in uterine cervix squamous cell carcinoma and its precursor lesion. Cancer Lett 2007; 251: 211-19.
29. Kim KC, Friso S, Choi SW. DNA methylation, an epigenetic mechanism connecting folate to healthy embryonic development and aging. J Nutr Biochem 2009; 20: 917-26.
30. Trasler J, Deng L, Melnyk S, et al. Impact of Dnmt1 deficiency, with and without low folate diets, on tumor numbers and DNA methylation in Min mice. Carcinogenesis 2003; 24: 39-45.
31. Ghoshal K, Li X, Datta J, et al. A folate-and methyl-deficient diet alters the expression of DNA methyltransferases and methyl CpG binding proteins involved in epigenetic gene silencing in livers of F344 rats. J Nutr 2006; 136: 1522-7.