Associations between variants in IL-33/st2 signaling pathway genes and coronary heart disease risk

International Journal of Molecular Sciences

Volumn 15, Issue 12, 2014, Pages 23227-23239

  Wu, Fangqin ^a   He, Mei’An ^a   Wen, Qiang ^a   Zhang, Wencai ^a   Yang, Jinhua ^a   Zhang, Xiaomin ^a   Wu, Tangchun ^a   Cheng, Longxian ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Coronary artery disease; Gene; IL 1RAcP; IL 33; Signaling pathway; ST2

Indexed keywords

ACYLGLYCEROL; CHOLESTEROL; INTERLEUKIN 1 RECEPTOR ACCESSORY PROTEIN; INTERLEUKIN 1 RECEPTOR TYPE I; INTERLEUKIN 33; CELL SURFACE RECEPTOR; IL1RL1 PROTEIN, HUMAN; IL33 PROTEIN, HUMAN; INTERLEUKIN DERIVATIVE;

ADULT; ARTICLE; BLOOD ANALYSIS; CARDIOVASCULAR RISK; CASE CONTROL STUDY; CONTROLLED STUDY; DNA ISOLATION; FEMALE; GENETIC ASSOCIATION; GENOTYPE; HUMAN; INTERVIEW; ISCHEMIC HEART DISEASE; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; QUESTIONNAIRE; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; AGED; CORONARY ARTERY DISEASE; GENETICS;

AGED; CASE-CONTROL STUDIES; CORONARY ARTERY DISEASE; FEMALE; HUMANS; INTERLEUKIN-1 RECEPTOR ACCESSORY PROTEIN; INTERLEUKIN-33; INTERLEUKINS; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, CELL SURFACE;

EID: 84918558034     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms151223227     Document Type: Article

References (39)

1. Profumo, E.; Buttari, B.; Saso, L.; Capoano, R.; Salvati, B.; Rigano, R. T lymphocyte autoreactivity in inflammatory mechanisms regulating atherosclerosis. Sci. World J. 2012, 2012, 157534.
2. Miller, A.M.; Xu, D.; Asquith, D.L.; Denby, L.; Li, Y.; Sattar, N.; Baker, A.H.; McInnes, I.B.; Liew, F.Y. IL-33 reduces the development of atherosclerosis. J. Exp. Med. 2008, 205, 339–346.
3. Weinberg, E.O.; Shimpo, M.; Hurwitz, S.; Tominaga, S.; Rouleau, J.L.; Lee, R.T. Identification of serum soluble ST2 receptor as a novel heart failure biomarker. Circulation2003, 107, 721–726.
4. Liew, F.Y.; Pitman, N.I.; McInnes, I.B. Disease-associated functions of IL-33: The new kid in the IL-1 family. Nat. Rev. Immunol. 2010, 10, 103–110.
5. Dhillon, O.S.; Narayan, H.K.; Quinn, P.A.; Squire, I.B.; Davies, J.E.; Ng, L.L. Interleukin 33 and ST2 in non-ST-elevation myocardial infarction: Comparison with global registry of acute coronary events risk scoring and NT-proBNP. Am. Heart J. 2011, 161, 1163–1170.
6. Miller, A.M.; Liew, F.Y. The IL-33/ST2 pathway—A new therapeutic target in cardiovascular disease. Pharmacol. Ther. 2011, 131, 179–186.
7. Milovanovic, M.; Volarevic, V.; Radosavljevic, G.; Jovanovic, I.; Pejnovic, N.; Arsenijevic, N.; Lukic, M.L. IL-33/ST2 axis in inflammation and immunopathology. Immunol. Res. 2012, 52, 89–99.
8. Schmitz, J.; Owyang, A.; Oldham, E.; Song, Y.; Murphy, E.; McClanahan, T.K.; Zurawski, G.; Moshrefi, M.; Qin, J.; Li, X.; et al. IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines. Immunity2005, 23, 479–490.
9. Chackerian, A.A.; Oldham, E.R.; Murphy, E.E.; Schmitz, J.; Pflanz, S.; Kastelein, R.A. IL-1 receptor accessory protein and ST2 comprise the IL-33 receptor complex. J. Immunol. 2007, 179, 2551–2555.
10. Liu, X.; Hammel, M.; He, Y.; Tainer, J.A.; Jeng, U.S.; Zhang, L.; Wang, S.; Wang, X. Structural insights into the interaction of IL-33 with its receptors. Proc. Natl. Acad. Sci. USA2013, 110, 14918–14923.
11. Choi, Y.S.; Choi, H.J.; Min, J.K.; Pyun, B.J.; Maeng, Y.S.; Park, H.; Kim, J.; Kim, Y.M.; Kwon, Y.G. Interleukin-33 induces angiogenesis and vascular permeability through ST2/TRAF6-mediated endothelial nitric oxide production. Blood2009, 114, 3117–3126.
12. Demyanets, S.; Konya, V.; Kastl, S.P.; Kaun, C.; Rauscher, S.; Niessner, A.; Pentz, R.; Pfaffenberger, S.; Rychli, K.; Lemberger, C.E.; et al. Interleukin-33 induces expression of adhesion molecules and inflammatory activation in human endothelial cells and in human atherosclerotic plaques. Arterioscler. Thromb. Vasc. Biol.2011, 31, 2080–2089.
13. Zhang, H.F.; Xie, S.L.; Chen, Y.X.; Mai, J.T.; Wang, J.F.; Zhu, W.L.; Zhu, L.G. Altered serum levels of IL-33 in patients with advanced systolic chronic heart failure: correlation with oxidative stress. J. Transl. Med. 2012, 10, 120.
14. Demyanets, S.; Tentzeris, I.; Jarai, R.; Katsaros, K.M.; Farhan, S.; Wonnerth, A.; Weiss, T.W.; Wojta, J.; Speidl, W.S.; Huber, K. An increase of interleukin-33 serum levels after coronary stent implantation is associated with coronary in-stent restenosis. Cytokine2014, 67, 65–70.
15. Dhillon, O.S.; Narayan, H.K.; Khan, S.Q.; Kelly, D.; Quinn, P.A.; Squire, I.B.; Davies, J.E.; Ng, L.L. Pre-discharge risk stratification in unselected STEMI: Is there a role for ST2 or its natural ligand IL-33 when compared with contemporary risk markers? Int. J. Cardiol. 2013, 167, 2182–2188.
16. Demyanets, S.; Speidl, W.S.; Tentzeris, I.; Jarai, R.; Katsaros, K.M.; Farhan, S.; Krychtiuk, K.A.; Wonnerth, A.; Weiss, T.W.; Huber, K.; et al. Soluble ST2 and interleukin-33 levels in coronary artery disease: Relation to disease activity and adverse outcome. PLoS One2014, 9, e95055.
17. Seki, K.; Sanada, S.; Kudinova, A.Y.; Steinhauser, M.L.; Handa, V.; Gannon, J.; Lee, R.T. Interleukin-33 prevents apoptosis and improves survival after experimental myocardial infarction through ST2 signaling. Circ. Heart Fail. 2009, 2, 684–691.
18. Dieplinger, B.; Egger, M.; Haltmayer, M.; Kleber, M.E.; Scharnagl, H.; Silbernagel, G.; de Boer, R.A.; Maerz, W.; Mueller, T. Increased soluble ST2 predicts long-term mortality in patients with stable coronary artery disease: Results from the Ludwigshafen risk and cardiovascular health study. Clin. Chem. 2014, 60, 530–540.
19. Wojtczak-Soska, K.; Pietrucha, T.; Sakowicz, A.; Lelonek, M. Soluble ST2 protein in chronic heart failure is independent of traditional factors. Arch. Med. Sci. 2013, 9, 21–26.
20. Tsapaki, A.; Zaravinos, A.; Apostolakis, S.; Voudris, K.; Vogiatzi, K.; Kochiadakis, G.E.; Spandidos, D.A. Genetic variability of the distal promoter of the ST2 gene is associated with angiographic severity of coronary artery disease. J. Thromb. Thrombolysis2010, 30, 365–371.
21. Yu, J.; Song, J.; Wang, N.; Wu, Z.; Zhang, Q.; Zhang, N.; Zhang, W.; Xuan, S.; Lan, T. Implication of IL-33 gene polymorphism in Chinese patients with Alzheimer’s disease. Neurobiol. Aging2012, 33, 1011–1014.
22. Ryckman, K.K.; Williams, S.M.; Krohn, M.A.; Simhan, H.N. Interaction between interleukin-1 receptor 2 and Toll-like receptor 4, and cervical cytokines. J. Reprod. Immunol. 2011, 90, 220–226.
23. Kim, J.J.; Hong, Y.M.; Sohn, S.; Jang, G.Y.; Ha, K.S.; Yun, S.W.; Han, M.K.; Lee, K.Y.; Song, M.S.; Lee, H.D.; et al. A genome-wide association analysis reveals 1p31 and 2p13.3 as susceptibility loci for Kawasaki disease. Hum. Genet. 2011, 129, 487–495.
24. Akhabir, L.; Sandford, A. Genetics of interleukin 1 receptor-like 1 in immune and inflammatory diseases. Curr. Genomics2010, 11, 591–606.
25. Buysschaert, I.D.; Grulois, V.; Eloy, P.; Jorissen, M.; Rombaux, P.; Bertrand, B.; Collet, S.; Bobic, S.; Vlaminck, S.; Hellings, P.W.; et al. Genetic evidence for a role of IL33 in nasal polyposis. Allergy2010, 65, 616–622.
26. Menon, R.; Fortunato, S.J.; Edwards, D.R.; Williams, S.M. Association of genetic variants, ethnicity and preterm birth with amniotic fluid cytokine concentrations. Ann. Hum. Genet. 2010, 74, 165–183.
27. Chapuis, J.; Hot, D.; Hansmannel, F.; Kerdraon, O.; Ferreira, S.; Hubans, C.; Maurage, C.; Huot, L.; Bensemain, F.; Laumet, G.; et al. Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer’s disease. Mol. Psychiatry2009, 14, 1004–1016.
28. Gudbjartsson, D.F.; Bjornsdottir, U.S.; Halapi, E.; Helgadottir, A.; Sulem, P.; Jonsdottir, G.M.; Thorleifsson, G.; Helgadottir, H.; Steinthorsdottir, V.; Stefansson, H.; et al. Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction. Clin. Exp. Allergy2008, 38, 1875–1881.
29. Sakashita, M.; Yoshimoto, T.; Hirota, T.; Harada, M.; Okubo, K.; Osawa, Y.; Fujieda, S.; Nakamura, Y.; Yasuda, K.; Nakanishi, K.; et al. Association of serum interleukin-33 level and the interleukin-33 genetic variant with Japanese cedar pollinosis. Clin. Exp. Allergy2008, 38, 1875–1881.
30. Zheng, S.L.; Liu, W.; Wiklund, F.; Dimitrov, L.; Balter, K.; Sun, J.; Adami, H.O.; Johansson, J.E.; Sun, J.; Chang, B.; et al. A comprehensive association study for genes in inflammation pathway provides support for their roles in prostate cancer risk in the CAPS study. Prostate2006, 66, 1556–1564.
31. Castano, R.; Bosse, Y.; Endam, L.M.; Desrosiers, M. Evidence of association of interleukin-1 receptor-like 1 gene polymorphisms with chronic rhinosinusitis. Am. J. Rhinol. Allergy2009, 23, 377–384.
32. Shimizu, M.; Matsuda, A.; Yanagisawa, K.; Hirota, T.; Akahoshi, M.; Inomata, N.; Ebe, K.; Tanaka, K.; Sugiura, H.; Nakashima, K.; et al. Functional SNPs in the distal promoter of the ST2 gene are associated with atopic dermatitis. Hum. Mol. Genet. 2005, 14, 2919–2927.
33. Kim, S.S.; Cheong, J.Y.; Lee, D.; Lee, S.K.; Kim, M.H.; Kwack, K.; Yang, S.J.; Lee, H.Y.; Cho, S.W. Interleukin-1β and interleukin-1 receptor accessory protein gene polymorphisms are associated with persistent hepatitis B virus infection. Hepato-Gastroenterology2012, 59, 190–197.
34. Ali, M.; Zhang, G.; Thomas, W.R.; McLean, C.J.; Bizzintino, J.A.; Laing, I.A.; Martin, A.C.; Goldblatt, J.; Le Souef, P.N.; Hayden, C.M. Investigations into the role of ST2 in acute asthma in children. Tissue Antigens2009, 73, 206–212.
35. He, M.; Guo, H.; Yang, X.; Zhou, L.; Zhang, X.; Cheng, L.; Zeng, H.; Hu, F.B.; Tanguay, R.M.; Wu, T. Genetic variations in HSPA8 gene associated with coronary heart disease risk in a Chinese population. PLoS One2010, 5, e9684.
36. Shi, Y.; Zhou, L.; Huang, L.H.; Lian, Y.T.; Zhang, X.M.; Guo, H.; Wu, T.C.; Cheng, L.X.; He, M.A. Plasma ferritin levels, genetic variations in HFE gene, and coronary heart disease in Chinese: A case-control study. Atherosclerosis2011, 218, 386–390.
37. Rapaport, E. Nomenclature and criteria for diagnosis of ischemic heart disease. Report of the Joint International Society and Federation of Cardiology/World Health Organization task force on standardization of clinical nomenclature. Circulation1979, 59, 607–609.
38. Savenije, O.E.; Kerkhof, M.; Reijmerink, N.E.; Brunekreef, B.; de Jongste, J.C.; Smit, H.A.; Wijga, A.H.; Postma, D.S.; Koppelman, G.H. Interleukin-1 receptor-like 1 polymorphisms are associated with serum IL1RL1-a, eosinophils, and asthma in childhood. J. Allergy Clin. Immunol. 2011, 127, 750–756.
39. Gauderman, W.J.; Morrison, J.M. Quanto 1.1: A computer program for power and sample size calculations for genetic—Epidemiology studies. Available online: http://hydra.Usc.Edu/gxe (accessed on 1 December 2008).