Molecular mechanisms of anti-hyperglycemic effects of Costus speciosus extract in streptozotocin-induced diabetic rats

Saudi Medical Journal

Volumn 35, Issue 12, 2014, Pages 1501-1506

  Ali, Haytham A ^a   Almaghrabi, Omar A ^b   Afifi, Mohamed E ^a,b  

^a Zagazig University   (Egypt)

^b KING ABDULAZIZ UNIVERSITY   (Saudi Arabia)

Author keywords

[No Author keywords available]

Indexed keywords

CHEILOCOSTUS SPECIOSUS EXTRACT; COMPLEMENTARY DNA; FRUCTOSE BISPHOSPHATE ALDOLASE; GLIBENCLAMIDE; GLUCOKINASE; GLUCOSE TRANSPORTER 2; GLYCOGEN SYNTHASE; INSULIN; INSULIN RECEPTOR; PLANT EXTRACT; PYRUVATE KINASE; SUCCINATE DEHYDROGENASE; UNCLASSIFIED DRUG; ANTIDIABETIC AGENT; GLUCOSE BLOOD LEVEL; MESSENGER RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIDIABETIC ACTIVITY; ARTICLE; CHEILOCOSTUS SPECIOSUS; CONTROLLED STUDY; DIABETES MELLITUS; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; GLUCOSE BLOOD LEVEL; GLYCOGEN ANALYSIS; INSULIN BLOOD LEVEL; MALE; NONHUMAN; POLYMERASE CHAIN REACTION; PROTEIN EXPRESSION; RAT; RNA PURIFICATION; SPECTROPHOTOMETRY; STREPTOZOTOCIN-INDUCED DIABETES MELLITUS; ANIMAL; COSTUS; DRUG EFFECTS; EXPERIMENTAL DIABETES MELLITUS; GENETICS; METABOLISM; PLANT ROOT;

ANIMALS; BLOOD GLUCOSE; COSTUS; DIABETES MELLITUS, EXPERIMENTAL; FRUCTOSE-BISPHOSPHATE ALDOLASE; GENE EXPRESSION; GLUCOKINASE; GLUCOSE TRANSPORTER TYPE 2; GLYCOGEN SYNTHASE; HYPOGLYCEMIC AGENTS; INSULIN; PLANT EXTRACTS; PLANT ROOTS; PYRUVATE KINASE; RATS; RECEPTOR, INSULIN; RNA, MESSENGER; SUCCINATE DEHYDROGENASE;

EID: 84918537321     PISSN: 03795284     EISSN: 16583175     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care 2010; 33: S62-S69
2. Ambady R, Chamukuttan S, Ananth S, Arun N. Trends in prevalence of diabetes in Asian countries. World J Diabetes 2012; 3: 110-117
3. Shamim IA. Diabetes an old disease, a new insight. Adv Exp Med Biol 2012; 771: 8-10
4. Awanish P, Poonam T, Rishabh P, Rashmi S, Shambaditya G. Alternative therapies useful in the management of diabetes: A systematic review. J Pharm Bioallied Sci 2011; 3: 504-512
5. Qari SH. DNA-RAPD fingerprinting and cytogenetic screening of genotoxic and antigenotoxic effects of aqueous extracts of Costus Speciosus (Koen.). Journal of King Abdulaziz University Science 2010; 22: 133-152
6. Vishalakshi DD, Asna U. Nutrient profile and antioxidant components of Costus Speciosus Sm, and Costus ignes Nak. Indian Journal of Natural Products and Resources 2010; 1: 116-118
7. Daisy P, Eliza J, Ignacimuthu S. Influence of Costus speciosus (Koen.) Sm. Rhizome extracts on biochemical parameters in Streptozotocin induced diabetic rats. J Health Sci 2008; 54: 675-681
8. Bavarva JH, Narasimhacharya AV. Antihyperglycemic and hypolipidemic effects of Costus Speciosus in alloxan induced diabetic rat. Phytotherapy Res 2008; 22: 620-626
9. Verma N, Khosa RL. Effect of Costus speciosus and Wedeliachinensis on brain neurotransmitters and enzyme monoamine oxidase following cold immobilization stress. J Pharm Sci Res 2009; 1: 22-25
10. Binny K, Kumar SG, Dennis T. Anti-inflammatory and antipyretic properties of the rhizome of Costus speciosus (Koen.) SM. J Basic Clin Pharm 2010; 1: 177-181
11. Verma N, Khosa RL. Evaluation of protective effect of ethanolic extract of Costus speciosus (Koen.) Sm. Rhizomes of carbon tetrachloride induced hepatotoxicity in rats. Nat Prod Radiance 2009; 8: 123-126
12. Liu H, Liu L, Li J, Mei D, Duan R, Hu N, et al. Combined contributions of impaired hepatic CYP2C11 and intestinal breast cancer resistance protein activities and expression to increased oral glibenclamide exposure in rats with streptozotocin-induced diabetes mellitus. Drug Metabolism and Disposition 2012; 40:1104-1112
13. Iwueke AV, Nwodo OFC. Antihyperglycaemic effect of aqueous extract of Daniella oliveri and Sarcocephalus latifolius roots on key carbohydrate metabolic enzymes and glycogen in experimental diabetes. Biokemistri 2008; 20: 63-70
14. Wu JL, Wu QP, Peng YP, Zhang JM. Effects of L-malate on mitochondrial oxidoreductases in liver of aged rats. Physiol Res 2011; 60: 329-336
15. Dawson NJ, Biggar KK, Storey KB. Characterization of fructose-1,6-bisphosphate aldolase during anoxia in the tolerant turtle, Trachemys scripta elegans: an assessment of enzyme activity, expression and structure. PLoS One 2013; 8: 68830
16. Nadal B, Barberà A, Fernández-Álvarez J, Crespo I, Muñoz MC, Guinovart JJ, et al. Treatment with sodium tungstate delays diabetes onset and lowers hyperglycemia in the NOD mouse. Avances en Diabetologia 2007; 23: 441-446
17. Ros S, García-Rocha M, Domínguez J, Ferrer JC, Guinovart JJ. Control of liver glycogen synthase activity and intracellular distribution by phosphorylation. J Biol Chem 2009; 284: 6370-6378
18. Metwally MA, El-Gellal AM. Use of some plant wastes for fish feeding with reference on its impact on growth performance and body composition. World Applied Sciences Journal 2009; 6: 1309-1313
19. Alkaladi A, Abdelazem A, Afifi M. Antidiabetic activity of zinc oxide and silver nanoparticles on streptozotocin-induced diabetic rats. Int J Mol Sci 2014; 15: 2015-2023
20. Tetsuya A, Naoko K, Koichiro Y, Reiko A, Ning G, Tetsuro M, et al. Fibre type distribution and gene expression levels of both succinate dehydrogenase and peroxisome proliferator-activated receptor-γ coactivator-1α of fibres in the soleus muscle of Zucker diabetic fatty rats. Exp Physiol 2007; 92: 449-455
21. Xu J, Christian B, Jump DB. Regulation of rat hepatic L-pyruvate kinase promoter composition and activity by glucose, n-3 polyunsaturated fatty acids, and peroxisome proliferator-activated receptor-alpha agonist. J Biol Chem 2006; 281: 18351-18362
22. Afifi MM, Abbas AM. Effects of reduced glutathione and vitamin C on cisplatin-induced hepatotoxicity in rats. Egyptian Journal of Biochemistry and Molecular Biology 2011; 29: 70-76
23. Ali H, Afifi M, Abdelazim A, Mosleh Y. Quercetin and omega 3 ameliorate oxidative stress induced by aluminium chloride in the brain. J Mol Neurosci 2014; 53: 654-660
24. Eliza J, Rajalakshmi M, Ignacimuthu SJ, Daisy P. Normalizing effects of Costus speciosus rhizome crude extracts and its fractions on diabetic complications in STZ-induced diabetic rats. Med Chem Res 2011; 20: 1111-1118
25. Eliza J, Daisy P, Ignacimuthub S, Duraipandiyan V. Antidiabetic and antilipidemic effect of eremanthin from Costus speciosus (Koen.) Sm. in STZ-induced diabetic rats. Chemico-Biological Interactions 2009; 182: 67-72
26. Metz E, Houghton A. Insulin receptor substrate regulation of phosphoinositide 3-kinase. Clin Cancer Res 2011; 17: 206-211
27. Zhang X, Wenbo L, Yiqing M, Hui L, Yang Y, Huanran T. Hepatic glucokinase activity is the primary defect in alloxaninduced diabetes of mice. Biomed Pharmacother 2009; 63: 180-186
28. Tahrani A, Milan K, Amy K, Anthony H. Glycaemic control in type 2 diabetes: Targets and new therapies. Pharmacol Ther 2010; 12: 328-361
29. Samir D, Abbas K, Djermoune M, Ben-Amara S, Zine K. The effects of copper supplement on zinc status, enzymes of zinc activities and antioxidant status in alloxan-induced diabetic rats fed on zinc over-dose diet. International Journal of Nutrition and Metabolism 2013; 5: 82-87
30. Rowe C, Jiang A, Arany Z. PGC-1 Coactivators in Cardiac Development and Disease. Circ Res 2010; 107: 825-838
31. Sadasivan S, Vasamsetti B, Singh J, Siddaraju N, Khan K, Oommen A, et al. Modulation of de novo purine biosynthesis leads to activation of AMPK and results in improved glucose handling and insulin sensitivity. J Diabetes Metab Disord 2014; 13: 1-9
32. El-Far AH, Abou-Ghanema I. Biochemical and hematological evaluation of Costus speciosus as a dietary supplement to Egyptian buffaloes. Afr J Pharm Pharmacol 2014; 7: 2774-2779.