Anti inflammatory and anti angiogenic effect of black raspberry extract on human esophageal and intestinal microvascular endothelial cells

Microvascular Research

Volumn 97, Issue , 2015, Pages 167-180

  Medda, Rituparna ^a   Lyros, Orestis ^a   Schmidt, Jamie L ^a   Jovanovic, Nebojsa ^a   Nie, Linghui ^a   Link, Benjamin J ^a   Otterson, Mary F ^a   Stoner, Gary D ^a   Shaker, Reza ^a   Rafiee, Parvaneh ^a  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

Angiogenesis; Black raspberry; HEMEC; HIMEC; Inflammation

Indexed keywords

ANGIOGENESIS INHIBITOR; ANTIINFLAMMATORY AGENT; BLACK RASPBERRY EXTRACT; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 1BETA; MITOGEN ACTIVATED PROTEIN KINASE; PLANT EXTRACT; PROTEIN KINASE B; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1; AUTACOID;

ANTIANGIOGENIC ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL ADHESION; CELL ISOLATION; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; COX 2 GENE; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; ESOPHAGUS MUCOSA; GENE; GENE EXPRESSION; HUMAN; HUMAN CELL; ICAM 1 GENE; IN VITRO STUDY; INTESTINE MUCOSA; LEUKOCYTE; MICROVASCULATURE; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; UPREGULATION; VCAM 1 GENE; ANGIOGENESIS; ANIMAL; CELL MOTION; CELL SURVIVAL; COMPARATIVE STUDY; DRUG EFFECTS; ENDOTHELIUM CELL; ESOPHAGUS; FRUIT; INTESTINE; MEDICINAL PLANT; METABOLISM; PHOSPHORYLATION; PHYTOTHERAPY; RUBUS; TIME FACTOR; VASCULARIZATION;

RATTUS; RUBUS OCCIDENTALIS;

ANGIOGENESIS INHIBITORS; ANIMALS; ANTI-INFLAMMATORY AGENTS; CELL MOVEMENT; CELL PROLIFERATION; CELL SURVIVAL; ENDOTHELIAL CELLS; ESOPHAGUS; FRUIT; HUMANS; INFLAMMATION MEDIATORS; INTESTINES; MICROVESSELS; MITOGEN-ACTIVATED PROTEIN KINASES; NEOVASCULARIZATION, PHYSIOLOGIC; PHOSPHORYLATION; PHYTOTHERAPY; PLANT EXTRACTS; PLANTS, MEDICINAL; PROTO-ONCOGENE PROTEINS C-AKT; RUBUS; SIGNAL TRANSDUCTION; TIME FACTORS;

EID: 84918496923     PISSN: 00262862     EISSN: 10959319     Source Type: Journal    
DOI: 10.1016/j.mvr.2014.10.008     Document Type: Article

References (62)

1. Aird W.C. Phenotypic heterogeneity of the endothelium: I. Structure, function, and mechanisms. Circ. Res. 2007, 100:158-173.
2. Andoh A., et al. Mucosal cytokine network in inflammatory bowel disease. World J. Gastroenterol. 2008, 14:5154-5161.
3. Baek J.Y., et al. Selective COX-2 inhibitor, NS-398, suppresses cellular proliferation in human hepatocellular carcinoma cell lines via cell cycle arrest. World J. Gastroenterol. 2007, 13:1175-1181.
4. Bi X., et al. Black raspberries inhibit intestinal tumorigenesis in apc1638+/- and Muc2-/- mouse models of colorectal cancer. Cancer Prev. Res. (Phila.) 2010, 3:1443-1450.
5. Binion D.G., Rafiee P. Is inflammatory bowel disease a vascular disease? Targeting angiogenesis improves chronic inflammation in inflammatory bowel disease. Gastroenterology 2009, 136:400-403.
6. Binion D.G., et al. Enhanced leukocyte binding by intestinal microvascular endothelial cells in inflammatory bowel disease. Gastroenterology 1997, 112:1895-1907.
7. Binion D.G., et al. Curcumin inhibits VEGF-mediated angiogenesis in human intestinal microvascular endothelial cells through COX-2 and MAPK inhibition. Gut 2008, 57:1509-1517.
8. Binion D.G., et al. Vascular cell adhesion molecule-1 expression in human intestinal microvascular endothelial cells is regulated by PI 3-kinase/Akt/MAPK/NF-kappaB: inhibitory role of curcumin. Am. J. Physiol. Gastrointest. Liver Physiol. 2009, 297:G259-G268.
9. Borsum T., et al. Alterations in the protein composition and surface structure of human endothelial cells during growth in primary culture. Atherosclerosis 1982, 44:367-378.
10. Bouma G., Strober W. The immunological and genetic basis of inflammatory bowel disease. Nat. Rev. Immunol. 2003, 3:521-533.
11. Butler J.M., et al. Endothelial cells are essential for the self-renewal and repopulation of Notch-dependent hematopoietic stem cells. Cell Stem Cell 2010, 6:251-264.
12. Chen T., et al. Chemopreventive properties of black raspberries in N-nitrosomethylbenzylamine-induced rat esophageal tumorigenesis: down-regulation of cyclooxygenase-2, inducible nitric oxide synthase, and c-Jun. Cancer Res. 2006, 66:2853-2859.
13. Chen T., et al. Black raspberries inhibit N-nitrosomethylbenzylamine (NMBA)-induced angiogenesis in rat esophagus parallel to the suppression of COX-2 and iNOS. Carcinogenesis 2006, 27:2301-2307.
14. Choo B.K., Roh S.S. Berberine protects against esophageal mucosal damage in reflux esophagitis by suppressing proinflammatory cytokines. Exp. Ther. Med. 2013, 6:663-670.
15. Danese S., et al. Angiogenesis as a novel component of inflammatory bowel disease pathogenesis. Gastroenterology 2006, 130:2060-2073.
16. Danese S., et al. Angiogenesis blockade as a new therapeutic approach to experimental colitis. Gut 2007, 56:855-862.
17. Ding L., et al. Endothelial and perivascular cells maintain haematopoietic stem cells. Nature 2012, 481:457-462.
18. Doan P.L., et al. Epidermal growth factor regulates hematopoietic regeneration after radiation injury. Nat. Med. 2013, 19:295-304.
19. Duncan F.J., et al. Topical treatment with black raspberry extract reduces cutaneous UVB-induced carcinogenesis and inflammation. Cancer Prev. Res. (Phila.) 2009, 2:665-672.
20. Fodde R., et al. A targeted chain-termination mutation in the mouse Apc gene results in multiple intestinal tumors. Proc. Natl. Acad. Sci. U. S. A. 1994, 91:8969-8973.
21. Furuno K., et al. The contribution of the pyrogallol moiety to the superoxide radical scavenging activity of flavonoids. Biol. Pharm. Bull. 2002, 25:19-23.
22. Grassi D., et al. Flavonoids, vascular function and cardiovascular protection. Curr. Pharm. Des. 2009, 15:1072-1084.
23. Hecht S.S., et al. Identification of cyanidin glycosides as constituents of freeze-dried black raspberries which inhibit anti-benzo[a]pyrene-7,8-diol-9,10-epoxide induced NFkappaB and AP-1 activity. Carcinogenesis 2006, 27:1617-1626.
24. Heidemann J., et al. Angiogenic effects of interleukin 8 (CXCL8) in human intestinal microvascular endothelial cells are mediated by CXCR2. J. Biol. Chem. 2003, 278:8508-8515.
25. Himburg H.A., et al. Pleiotrophin regulates the retention and self-renewal of hematopoietic stem cells in the bone marrow vascular niche. Cell Rep. 2012, 2:964-975.
26. Hooper A.T., et al. Engraftment and reconstitution of hematopoiesis is dependent on VEGFR2-mediated regeneration of sinusoidal endothelial cells. Cell Stem Cell 2009, 4:263-274.
27. Hussain S.P., Harris C.C. Inflammation and cancer: an ancient link with novel potentials. Int. J. Cancer 2007, 121:2373-2380.
28. Jayakumar T., et al. Brazilin ameliorates high glucose-induced vascular inflammation via inhibiting ROS and CAMs production in human umbilical vein endothelial cells. Biomed. Res. Int. 2014, 2014:403703.
29. Kahkonen M.P., Heinonen M. Antioxidant activity of anthocyanins and their aglycons. J. Agric. Food Chem. 2003, 51:628-633.
30. La Vecchia C., Tavani A. Fruit and vegetables, and human cancer. Eur. J. Cancer Prev. 1998, 7:3-8.
31. Lechner J.F., et al. Effects of a black raspberry diet on gene expression in the rat esophagus. Nutr. Cancer 2008, 60(Suppl. 1):61-69.
32. Liu Z., et al. Black raspberry extract and fractions contain angiogenesis inhibitors. J. Agric. Food Chem. 2005, 53:3909-3915.
33. Madhusoodhanan R., et al. Effect of black raspberry extract in inhibiting NFkappa B dependent radioprotection in human breast cancer cells. Nutr. Cancer 2010, 62:93-104.
34. Mallery S.R., et al. Topical application of a bioadhesive black raspberry gel modulates gene expression and reduces cyclooxygenase 2 protein in human premalignant oral lesions. Cancer Res. 2008, 68:4945-4957.
35. Molema G. Heterogeneity in endothelial responsiveness to cytokines, molecular causes, and pharmacological consequences. Semin. Thromb. Hemost. 2010, 36:246-264.
36. Montrose D.C., et al. Anti-inflammatory effects of freeze-dried black raspberry powder in ulcerative colitis. Carcinogenesis 2011, 32:343-350.
37. Morales-Ruiz M., et al. Vascular endothelial growth factor-stimulated actin reorganization and migration of endothelial cells is regulated via the serine/threonine kinase Akt. Circ. Res. 2000, 86:892-896.
38. Muller A.M., et al. Comparative study of adhesion molecule expression in cultured human macro- and microvascular endothelial cells. Exp. Mol. Pathol. 2002, 73:171-180.
39. Noda Y., et al. Antioxidant activities of pomegranate fruit extract and its anthocyanidins: delphinidin, cyanidin, and pelargonidin. J. Agric. Food Chem. 2002, 50:166-171.
40. Nolan D.J., et al. Molecular signatures of tissue-specific microvascular endothelial cell heterogeneity in organ maintenance and regeneration. Dev. Cell 2013, 26:204-219.
41. Ogawa H., et al. Sodium butyrate inhibits angiogenesis of human intestinal microvascular endothelial cells through COX-2 inhibition. FEBS Lett. 2003, 554:88-94.
42. Ogawa H., et al. Mechanisms of MAdCAM-1 gene expression in human intestinal microvascular endothelial cells. Am. J. Physiol. Cell Physiol. 2005, 288:C272-C281.
43. Otterson M.F., et al. EUK-207 protects human intestinal microvascular endothelial cells (HIMEC) against irradiation-induced apoptosis through the Bcl2 pathway. Life Sci. 2012, 91:771-782.
44. Rafiee P., et al. Isolation and characterization of human esophageal microvascular endothelial cells: mechanisms of inflammatory activation. Am. J. Physiol. Gastrointest. Liver Physiol. 2003, 285:G1277-G1292.
45. Rafiee P., et al. Cyclosporin A differentially inhibits multiple steps in VEGF induced angiogenesis in human microvascular endothelial cells through altered intracellular signaling. Cell Commun. Signal. 2004, 2:3.
46. Rafiee P., et al. Modulatory effect of curcumin on survival of irradiated human intestinal microvascular endothelial cells: role of Akt/mTOR and NF-{kappa}B. Am. J. Physiol. Gastrointest. Liver Physiol. 2010, 298:G865-G877.
47. Rafiee P., et al. Thalidomide inhibits inflammatory and angiogenic activation of human intestinal microvascular endothelial cells (HIMEC). Am. J. Physiol. Gastrointest. Liver Physiol. 2010, 298:G167-G176.
48. Seaman S., et al. Genes that distinguish physiological and pathological angiogenesis. Cancer Cell 2007, 11:539-554.
49. Seeram N.P., et al. Cyclooxygenase inhibitory and antioxidant cyanidin glycosides in cherries and berries. Phytomedicine 2001, 8:362-369.
50. Slattery M.L., et al. Dietary influence on MAPK-signaling pathways and risk of colon and rectal cancer. Nutr. Cancer 2013, 65:729-738.
51. Stoner G.D., Wang L.S. Chemoprevention of esophageal squamous cell carcinoma with berries. Top. Curr. Chem. 2013, 329:1-20.
52. Stoner G.D., et al. Protection against esophageal cancer in rodents with lyophilized berries: potential mechanisms. Nutr. Cancer 2006, 54:33-46.
53. Turini M.E., DuBois R.N. Cyclooxygenase-2: a therapeutic target. Annu. Rev. Med. 2002, 53:35-57.
54. Velcich A., et al. Colorectal cancer in mice genetically deficient in the mucin Muc2. Science 2002, 295:1726-1729.
55. Wang L.S., Stoner G.D. Anthocyanins and their role in cancer prevention. Cancer Lett. 2008, 269:281-290.
56. Wang L.S., et al. Anthocyanins in black raspberries prevent esophageal tumors in rats. Cancer Prev. Res. (Phila.) 2009, 2:84-93.
57. Wang L.S., et al. Gene-diet interactions on colorectal cancer risk. Curr. Nutr. Rep. 2012, 1:132-141.
58. Xue H., et al. Inhibition of cellular transformation by berry extracts. Carcinogenesis 2001, 22:351-356.
59. Yang L., et al. Akt/protein kinase B signaling inhibitor-2, a selective small molecule inhibitor of Akt signaling with antitumor activity in cancer cells overexpressing Akt. Cancer Res. 2004, 64:4394-4399.
60. Yi L., et al. Structural requirements of anthocyanins in relation to inhibition of endothelial injury induced by oxidized low-density lipoprotein and correlation with radical scavenging activity. FEBS Lett. 2010, 584:583-590.
61. Zhang H.M., et al. Akt kinase activation blocks apoptosis in intestinal epithelial cells by inhibiting caspase-3 after polyamine depletion. J. Biol. Chem. 2004, 279:22539-22547.
62. Zikri N.N., et al. Black raspberry components inhibit proliferation, induce apoptosis, and modulate gene expression in rat esophageal epithelial cells. Nutr. Cancer 2009, 61:816-826.