The respiratory microbiome and innate immunity in asthma

Current Opinion in Pulmonary Medicine

Volumn 21, Issue 1, 2015, Pages 27-32

  Huang, Yvonne J ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Airway; Asthma; Immune; Lung; Microbiota

Indexed keywords

CATHELICIDIN ANTIMICROBIAL PEPTIDE LL 37; CIGARETTE SMOKE; CLARITHROMYCIN; CORTICOSTEROID; INTERLEUKIN 8; LACTOFERRIN; SECRETORY LEUKOCYTE PROTEINASE INHIBITOR; TOLL LIKE RECEPTOR; TRANSFORMING GROWTH FACTOR BETA;

AIRWAY; ASTHMA; CORTICOSTEROID THERAPY; CYSTIC FIBROSIS; DENDRITIC CELL; DISEASE SEVERITY; GENE EXPRESSION; HOST RESISTANCE; HUMAN; IMMUNOCOMPETENT CELL; INFECTION; INNATE IMMUNITY; LOWER RESPIRATORY TRACT; MICROBIAL COMMUNITY; MICROBIOME; MICROFLORA; MUCOSAL IMMUNITY; NONHUMAN; PHENOTYPE; PROTEOBACTERIA; PSEUDOMONAS AERUGINOSA; RESPIRATORY EPITHELIUM; RESPIRATORY TRACT INFECTION; REVIEW; T LYMPHOCYTE; ADVERSE EFFECTS; ENVIRONMENTAL EXPOSURE; EVIDENCE BASED MEDICINE; IMMUNOLOGY; INFLAMMATION; MICROBIOLOGY; PATHOPHYSIOLOGY; RESPIRATORY SYSTEM;

ASTHMA; ENVIRONMENTAL EXPOSURE; EVIDENCE-BASED MEDICINE; HUMANS; IMMUNITY, INNATE; IMMUNITY, MUCOSAL; INFLAMMATION; MICROBIOTA; PHENOTYPE; RESPIRATORY SYSTEM;

EID: 84918493756     PISSN: 10705287     EISSN: 15316971     Source Type: Journal    
DOI: 10.1097/MCP.0000000000000124     Document Type: Review

References (39)

1. Strachan DP. Hay fever, hygiene, and household size. BMJ 1989; 299:1259-1260.
2. Lynch SV, Wood RA, Boushey H, et al. Effects of early-life exposure to allergens and bacteria on recurrent wheeze and atopy in urban children. J Allergy Clin Immunol 2014; 134:59312-60112.
3. Heederik D, von Mutius E. Does diversity of environmental microbial exposure matter for the occurrence of allergy and asthma? J Allergy Clin Immunol 2012; 130:44-50.
4. Brar T, Nagaraj S, Mohapatra S. Microbes and asthma in the elderly: The missing cellular and molecular links. Curr Opin Pulm Med 2012; 18:14-22.
5. Huang YJ, Boushey HA. The microbiome and asthma. Ann Am Thorac Soc 2014; 11 (Suppl 1):S48-S51.
6. Essilfie AT, Simpson JL, Dunkley ML, et al. Combined Haemophilus influenzae respiratory infection and allergic airways disease drives chronic infection and features of neutrophilic asthma. Thorax 2012; 67:588-599.
7. Larsen JM, Steen-Jensen DB, Laursen JM, et al. Divergent proinflammatory profile of human dendritic cells in response to commensal and pathogenic bacteria associated with the airway microbiota. PLoS One 2012; 7:e31976.
8. Fujimura KE, Demoor T, Rauch M, et al. House dust exposure mediates gut microbiome Lactobacillus enrichment and airway immune defense against allergens and virus infection. Proc Natl Acad Sci U S A 2014; 111:805-810.
9. Dulek DE, Newcomb DC, Goleniewska K, et al. Allergic airway inflammation decreases lung bacterial burden following acute Klebsiella pneumoniae infection in a neutrophil and CCL8-dependent manner. Infect Immun 2014; 82:3723-3739.
10. Liang Z, Zhang Q, Thomas CM, et al. Impaired macrophage phagocytosis of bacteria in severe asthma. Respir Res 2014; 15:72.
11. Sagar S, Morgan ME, Chen S, et al. Bifidobacterium breve and Lactobacillus rhamnosus treatment is as effective as budesonide at reducing inflammation in a murine model for chronic asthma. Respir Res 2014; 15:46.
12. Hilty M, Burke C, Pedro H, et al. Disordered microbial communities in asthmatic airways. PLoS One 2010; 5:e8578.
13. Huang YJ, Nelson CE, Brodie EL, et al. Airway microbiota and bronchial hyperresponsiveness in patients with suboptimally controlled asthma. J Allergy Clin Immunol 2011; 127:372-381.
14. Marri PR, Stern DA, Wright AL, et al. Asthma-associated differences in microbial composition of induced sputum. J Allergy Clin Immunol 2013; 131:346-352.
15. Huang YJ, Nariya S, Lynch SV, et al. The airway microbiome in severe asthma. Ann Am Thorac Soc 2014; Suppl 11:S78.
16. Huang YJ. Asthma microbiome studies and the potential for new therapeutic strategies. Curr Allergy Asthma Rep 2013; 13:453-461.
17. Gollwitzer ES, Saglani S, Trompette A, et al. Lung microbiota promotes tolerance to allergens in neonates via PD-L1. Nat Med 2014; 20:642-647.
18. Green BJ, Wiriyachaiporn S, Grainge C, et al. Potentially pathogenic airway bacteria and neutrophilic inflammation in treatment resistant severe asthma. PLoS One 2014; 9:e100645.
19. Segal LN, Alekseyenko AV, Clemente JC, et al. Enrichment of lung microbiome with supraglottic taxa is associated with increased pulmonary inflammation. Microbiome 2013; 1:19.
20. Morris A, Beck JM, Schloss PD, et al. Lung HIV Microbiome Project. Comparison of the respiratory microbiome in healthy nonsmokers and smokers. Am J Respir Crit Care Med 2013; 187:1067-1075.
21. Jaspers I. Cigarette smoke effects on innate immune mechanisms in the nasal mucosa. Potential effects on the microbiome. Ann Am Thorac Soc 2014; 11 (Suppl 1):S38-S42.
22. Philip NH, Artis D. New friendships and old feuds: relationships between innate lymphoid cells and microbial communities. Immunol Cell Biol 2013; 91:225-231.
23. Hansel TT, Johnston SL, Openshaw PJ. Microbes and mucosal immune responses in asthma. Lancet 2013; 381:861-873.
24. Lambrecht BN, Hammad H. Asthma: The importance of dysregulated barrier immunity. Eur J Immunol 2013; 43:3125-3137.
25. Hallstrand TS, Hackett TL, Altemeier WA, et al. Airway epithelial regulation of pulmonary immune homeostasis and inflammation. Clin Immunol 2014; 151:1-15.
26. Fahy JV, Dickey BF. Airway mucus function and dysfunction. N Engl J Med 2010; 363:2233-2247.
27. Gauvreau GM, O'Byrne PM, Boulet LP, et al. Effects of an anti-TSLP antibody on allergen-induced asthmatic responses. N Engl J Med 2014; 370:2102-2110.
28. Roy MG, Livraghi-Butrico A, Fletcher AA, et al. Muc5b is required for airway defence. Nature 2014; 505:412-416.
29. Staudinger BJ, Muller JF, Halldórsson S, et al. Conditions associated with the cystic fibrosis defect promote chronic Pseudomonas aeruginosa infection. Am J Respir Crit Care Med 2014; 189:812-824.
30. Barr JJ, Auro R, Furlan M, et al. Bacteriophage adhering to mucus provide a nonhost-derived immunity. Proc Natl Acad Sci U S A 2013; 110:10771-10776.
31. van Helden MJ, Lambrecht BN. Dendritic cells in asthma. Curr Opin Immunol 2013; 25:745-754.
32. Kim TH, Lee HK. Differential roles of lung dendritic cell subsets against respiratory virus infection. Immune Netw 2014; 14:128-137.
33. McGrath KW, Icitovic N, Boushey HA, et al. Asthma Clinical Research Network of the National Heart, Lung, and Blood Institute. A large subgroup of mild-to-moderate asthma is persistently noneosinophilic. Am J Respir Crit Care Med 2012; 185:612-619.
34. Wenzel SE. Asthma phenotypes: The evolution from clinical to molecular approaches. Nat Med 2012; 18:716-725.
35. Chung KF, Adcock IM. How variability in clinical phenotypes should guide research into disease mechanisms in asthma. Ann Am Thorac Soc 2013; 10 (Suppl):S109-S117.
36. Dickson RP, Erb-Downward JR, Huffnagle GB. Towards an ecology of the lung: new conceptual models of pulmonary microbiology and pneumonia pathogenesis. Lancet Respir Med 2014; 2:238-246.
37. West CE, Jenmalm MC, Prescott SL. The gut microbiota and its role in the development of allergic disease: A wider perspective. Clin Exp Allergy 2014. [Epub ahead of print].
38. Wang J, Li F, Sun R, et al. Bacterial colonization dampens influenza-mediated acute lung injury via induction of M2 alveolar macrophages. Nat Commun 2013; 4:2106.
39. Holt PG, Strickland DH, Hales BJ, Sly PD. Defective respiratory tract immune surveillance in asthma: A primary causal factor in disease onset and progression. Chest 2014; 145:370-378.