-
1
-
-
80053648778
-
Monoclonal antibodies and antibody fragments: State of the art and future perspectives in the treatment of nonhaematological tumors
-
Di Fede G, Bronte G, Rizzo S, et al. Monoclonal antibodies and antibody fragments: state of the art and future perspectives in the treatment of nonhaematological tumors. Expert Opin Biol Ther 2011;11(11):1433-45
-
(2011)
Expert Opin Biol Ther
, vol.11
, Issue.11
, pp. 1433-1445
-
-
Di Fede, G.1
Bronte, G.2
Rizzo, S.3
-
2
-
-
78649760112
-
Driver mutations and differential sensitivity to targeted therapies: A new approach to the treatment of lung adenocarcinoma
-
Bronte G, Rizzo S, La Paglia L, et al. Driver mutations and differential sensitivity to targeted therapies: a new approach to the treatment of lung adenocarcinoma. Cancer Treat Rev 2010;36(Suppl 3):S21-9
-
(2010)
Cancer Treat Rev
, vol.36
, pp. S21-S29
-
-
Bronte, G.1
Rizzo, S.2
La Paglia, L.3
-
3
-
-
84904790548
-
Novel therapeutic strategies for patients with NSCLC that do not respond to treatment with EGFR inhibitors
-
Rolfo C, Giovannetti E, Hong DS, et al. Novel therapeutic strategies for patients with NSCLC that do not respond to treatment with EGFR inhibitors. Cancer Treat Rev 2014;40(8):990-1004
-
(2014)
Cancer Treat Rev
, vol.40
, Issue.8
, pp. 990-1004
-
-
Rolfo, C.1
Giovannetti, E.2
Hong, D.S.3
-
4
-
-
84890249562
-
Immunotherapy for recurrent ovarian cancer: A further piece of the puzzle or a striking strategy?
-
Bronte G, Cicero G, Sortino G, et al. Immunotherapy for recurrent ovarian cancer: a further piece of the puzzle or a striking strategy? Expert Opin Biol Ther 2014;14(1):103-14
-
(2014)
Expert Opin Biol Ther
, vol.14
, Issue.1
, pp. 103-114
-
-
Bronte, G.1
Cicero, G.2
Sortino, G.3
-
5
-
-
84877909537
-
Monoclonal antibodies in gastrointestinal cancers
-
Bronte G, Cicero G, Cusenza S, et al. Monoclonal antibodies in gastrointestinal cancers. Expert Opin Biol Ther 2013;13(6):889-900
-
(2013)
Expert Opin Biol Ther
, vol.13
, Issue.6
, pp. 889-900
-
-
Bronte, G.1
Cicero, G.2
Cusenza, S.3
-
7
-
-
84887114555
-
The HER2 receptor in breast cancer: Pathophysiology, clinical use, and new advances in therapy
-
Mitri Z, Constantine T, O'Regan R. The HER2 receptor in breast cancer: pathophysiology, clinical use, and new advances in therapy. Chemother Res Pract 2012;2012:743193
-
(2012)
Chemother Res Pract
, vol.2012
, pp. 743193
-
-
Mitri, Z.1
Constantine, T.2
O'regan, R.3
-
8
-
-
34347395733
-
Trastuzumab-mechanism of action and use in clinical practice
-
Hudis CA. Trastuzumab-mechanism of action and use in clinical practice. Eng J Med 2007;357(1):39-51
-
(2007)
Eng J Med
, vol.357
, Issue.1
, pp. 39-51
-
-
Hudis, C.A.1
-
9
-
-
0035869407
-
Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2
-
Slamon DJ, Leyland-Jones B, Shak S, et al. Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. Eng J Med 2001;344(11):783-92
-
(2001)
Eng J Med
, vol.344
, Issue.11
, pp. 783-792
-
-
Slamon, D.J.1
Leyland-Jones, B.2
Shak, S.3
-
10
-
-
22344446208
-
Randomized phase II trial of the efficacy and safety of trastuzumab combined with docetaxel in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer administered as first-line treatment: The M77001 study group
-
Marty M, Cognetti F, Maraninchi D, et al. Randomized phase II trial of the efficacy and safety of trastuzumab combined with docetaxel in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer administered as first-line treatment: the M77001 study group. J Clin Oncol 2005;23(19):4265-74
-
(2005)
J Clin Oncol
, vol.23
, Issue.19
, pp. 4265-4274
-
-
Marty, M.1
Cognetti, F.2
Maraninchi, D.3
-
11
-
-
33846477245
-
Randomized Phase II Trial of weekly paclitaxel alone versus trastuzumab plus weekly paclitaxel as first-line therapy of patients with Her-2 positive advanced breast cancer
-
Gasparini G, Gion M, Mariani L, et al. Randomized Phase II Trial of weekly paclitaxel alone versus trastuzumab plus weekly paclitaxel as first-line therapy of patients with Her-2 positive advanced breast cancer. Breast Cancer Res Treat 2007;101(3):355-65
-
(2007)
Breast Cancer Res Treat
, vol.101
, Issue.3
, pp. 355-365
-
-
Gasparini, G.1
Gion, M.2
Mariani, L.3
-
12
-
-
0031903646
-
Phase II study of receptor-enhanced chemosensitivity using recombinant humanized anti-p185HER2/neu monoclonal antibody plus cisplatin in patients with HER2/neu-overexpressing metastatic breast cancer refractory to chemotherapy treatment
-
Pegram MD, Lipton A, Hayes DF, et al. Phase II study of receptor-enhanced chemosensitivity using recombinant humanized anti-p185HER2/neu monoclonal antibody plus cisplatin in patients with HER2/neu-overexpressing metastatic breast cancer refractory to chemotherapy treatment. J Clin Oncol 1998;16(8):2659-71
-
(1998)
J Clin Oncol
, vol.16
, Issue.8
, pp. 2659-2671
-
-
Pegram, M.D.1
Lipton, A.2
Hayes, D.F.3
-
13
-
-
2942691785
-
Results of two open-label, multicenter phase II studies of docetaxel, platinum salts, and trastuzumab in HER2-positive advanced breast cancer
-
Pegram MD, Pienkowski T, Northfelt DW, et al. Results of two open-label, multicenter phase II studies of docetaxel, platinum salts, and trastuzumab in HER2-positive advanced breast cancer. J Natl Cancer Inst 2004;96(10):759-69
-
(2004)
J Natl Cancer Inst
, vol.96
, Issue.10
, pp. 759-769
-
-
Pegram, M.D.1
Pienkowski, T.2
Northfelt, D.W.3
-
14
-
-
34548178720
-
Trastuzumab plus vinorelbine or taxane chemotherapy for HER2- overexpressing metastatic breast cancer: The trastuzumab and vinorelbine or taxane study
-
Burstein HJ, Keshaviah A, Baron AD, et al. Trastuzumab plus vinorelbine or taxane chemotherapy for HER2- overexpressing metastatic breast cancer: the trastuzumab and vinorelbine or taxane study. Cancer 2007;110(5):965-72
-
(2007)
Cancer
, vol.110
, Issue.5
, pp. 965-972
-
-
Burstein, H.J.1
Keshaviah, A.2
Baron, A.D.3
-
15
-
-
37249055069
-
A phase II study of trastuzumab and capecitabine for patients with HER2-overexpressing metastatic breast cancer: Japan Breast Cancer Research Network (JBCRN) 00 Trial
-
Yamamoto D, Iwase S, Kitamura K, et al. A phase II study of trastuzumab and capecitabine for patients with HER2-overexpressing metastatic breast cancer: Japan Breast Cancer Research Network (JBCRN) 00 Trial. Cancer Chemother Pharmacol 2008;61(3):509-14
-
(2008)
Cancer Chemother Pharmacol
, vol.61
, Issue.3
, pp. 509-514
-
-
Yamamoto, D.1
Iwase, S.2
Kitamura, K.3
-
16
-
-
58149250717
-
A phase II trial of gemcitabine/carboplatin with or without trastuzumab in the first-line treatment of patients with metastatic breast cancer
-
Yardley DA, Burris HA, Simons L, et al. A phase II trial of gemcitabine/carboplatin with or without trastuzumab in the first-line treatment of patients with metastatic breast cancer. Clin Breast Cancer 2008;8(5):425-31
-
(2008)
Clin Breast Cancer
, vol.8
, Issue.5
, pp. 425-431
-
-
Yardley, D.A.1
Burris, H.A.2
Simons, L.3
-
17
-
-
0036467826
-
Efficacy and safety of trastuzumab as a single agent in first-line treatment of HER2-overexpressing metastatic breast cancer
-
Vogel CL, Cobleigh MA, Tripathy D, et al. Efficacy and safety of trastuzumab as a single agent in first-line treatment of HER2-overexpressing metastatic breast cancer. J Clin Oncol 2002;20(3):719-26
-
(2002)
J Clin Oncol
, vol.20
, Issue.3
, pp. 719-726
-
-
Vogel, C.L.1
Cobleigh, M.A.2
Tripathy, D.3
-
18
-
-
33646712747
-
Mechanisms of disease: Understanding resistance to HER2-targeted therapy in human breast cancer
-
Nahta R, Yu D, Hung MC, et al. Mechanisms of disease: understanding resistance to HER2-targeted therapy in human breast cancer. Nat Clin Pract Oncol 2006;3(5):269-80
-
(2006)
Nat Clin Pract Oncol
, vol.3
, Issue.5
, pp. 269-280
-
-
Nahta, R.1
Yu, D.2
Hung, M.C.3
-
19
-
-
58149235344
-
Retrospective evaluation of clinical outcomes in patients with HER2-positive advanced breast cancer progressing on trastuzumab-based therapy in the prelapatinib era
-
Montemurro F, Redana S, Viale G, et al. Retrospective evaluation of clinical outcomes in patients with HER2-positive advanced breast cancer progressing on trastuzumab-based therapy in the prelapatinib era. Clin Breast Cancer 2008;8(5):436-42
-
(2008)
Clin Breast Cancer
, vol.8
, Issue.5
, pp. 436-442
-
-
Montemurro, F.1
Redana, S.2
Viale, G.3
-
20
-
-
56249109418
-
Trastuzumab improves the efficacy of chemotherapy in breast cancer treatment beyond progression
-
Pirvulescu C, Uhlig M, von Minckwitz G, GROUP GGB. Trastuzumab improves the efficacy of chemotherapy in breast cancer treatment beyond progression. breast care (Basel) 2008;3(5):364-5
-
(2008)
Breast Care (Basel)
, vol.3
, Issue.5
, pp. 364-365
-
-
Pirvulescu, C.1
Uhlig, M.2
Von Minckwitz, G.3
-
21
-
-
79958296638
-
Trastuzumab in the adjuvant treatment of HER2-positive early breast cancer patients: A meta-analysis of published randomized controlled trials
-
Yin W, Jiang Y, Shen Z, et al. Trastuzumab in the adjuvant treatment of HER2-positive early breast cancer patients: a meta-analysis of published randomized controlled trials. PLoS One 2011;6(6):e21030
-
(2011)
PLoS One
, vol.6
, Issue.6
, pp. e21030
-
-
Yin, W.1
Jiang, Y.2
Shen, Z.3
-
22
-
-
84884418164
-
2 years versus 1 year of adjuvant trastuzumab for HER2-positive breast cancer (HERA): An open-label, randomised controlled trial
-
Goldhirsch A, Gelber RD, Piccart-Gebhart MJ, et al. 2 years versus 1 year of adjuvant trastuzumab for HER2-positive breast cancer (HERA): an open-label, randomised controlled trial. Lancet 2013;382(9897):1021-8
-
(2013)
Lancet
, vol.382
, Issue.9897
, pp. 1021-1028
-
-
Goldhirsch, A.1
Gelber, R.D.2
Piccart-Gebhart, M.J.3
-
23
-
-
80053539103
-
Adjuvant trastuzumab in HER2- positive breast cancer
-
Slamon D, Eiermann W, Robert N, et al. Adjuvant trastuzumab in HER2- positive breast cancer. Eng J Med 2011;365(14):1273-83
-
(2011)
Eng J Med
, vol.365
, Issue.14
, pp. 1273-1283
-
-
Slamon, D.1
Eiermann, W.2
Robert, N.3
-
24
-
-
73349119689
-
High risk of recurrence for patients with breast cancer who have human epidermal growth factor receptor 2-positive, nodenegative tumors 1 cm or smaller
-
Gonzalez-Angulo AM, Litton JK, et al. High risk of recurrence for patients with breast cancer who have human epidermal growth factor receptor 2-positive, nodenegative tumors 1 cm or smaller. J Clin Oncol 2009;27(34):5700-6
-
(2009)
J Clin Oncol
, vol.27
, Issue.34
, pp. 5700-5706
-
-
Gonzalez-Angulo, A.M.1
Litton, J.K.2
-
25
-
-
73349142700
-
Clinical relevance of HER2 overexpression/amplification in patients with small tumor size and nodenegative breast cancer
-
Curigliano G, Viale G, Bagnardi V, et al. Clinical relevance of HER2 overexpression/amplification in patients with small tumor size and nodenegative breast cancer. J Clin Oncol 2009;27(34):5693-9
-
(2009)
J Clin Oncol
, vol.27
, Issue.34
, pp. 5693-5699
-
-
Curigliano, G.1
Viale, G.2
Bagnardi, V.3
-
26
-
-
82955233117
-
Adjuvant trastuzumab with chemotherapy is effective in women with small, node-negative, HER2-positive breast cancer
-
McArthur HL, Mahoney KM, Morris PG, et al. Adjuvant trastuzumab with chemotherapy is effective in women with small, node-negative, HER2-positive breast cancer. Cancer 2011;117(24):5461-8
-
(2011)
Cancer
, vol.117
, Issue.24
, pp. 5461-5468
-
-
McArthur, H.L.1
Mahoney, K.M.2
Morris, P.G.3
-
27
-
-
78049427459
-
Trastuzumab treatment in t1ab, node-negative, human epidermal growth factor receptor 2-overexpressing breast carcinomas
-
Rodrigues MJ, Wassermann J, Albiges L, et al. Trastuzumab treatment in t1ab, node-negative, human epidermal growth factor receptor 2-overexpressing breast carcinomas. J Clin Oncol 2010;28(28):e541-2
-
(2010)
J Clin Oncol
, vol.28
, Issue.28
, pp. e541-e542
-
-
Rodrigues, M.J.1
Wassermann, J.2
Albiges, L.3
-
28
-
-
84874645814
-
Effects of adjuvant chemotherapy in HER2-positive or triple-negative pT1ab breast cancers: A multiinstitutional retrospective study
-
Olszewski AJ, Migdady Y, Boolbol SK, et al. Effects of adjuvant chemotherapy in HER2-positive or triple-negative pT1ab breast cancers: a multiinstitutional retrospective study. Breast Cancer Res Treat 2013;138(1):215-23
-
(2013)
Breast Cancer Res Treat
, vol.138
, Issue.1
, pp. 215-223
-
-
Olszewski, A.J.1
Migdady, Y.2
Boolbol, S.K.3
-
29
-
-
26844536978
-
Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer
-
Romond EH, Perez EA, Bryant J, et al. Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer. Eng J Med 2005;353(16):1673-84
-
(2005)
Eng J Med
, vol.353
, Issue.16
, pp. 1673-1684
-
-
Romond, E.H.1
Perez, E.A.2
Bryant, J.3
-
30
-
-
83355163400
-
Sequential versus concurrent trastuzumab in adjuvant chemotherapy for breast cancer
-
Perez EA, Suman VJ, Davidson NE, et al. Sequential versus concurrent trastuzumab in adjuvant chemotherapy for breast cancer. J Clin Oncol 2011;29(34):4491-7
-
(2011)
J Clin Oncol
, vol.29
, Issue.34
, pp. 4491-4497
-
-
Perez, E.A.1
Suman, V.J.2
Davidson, N.E.3
-
31
-
-
84863294022
-
Effect of HER-2/neu over-expression on prognosis in gastric cancer: A meta-analysis
-
Wang S, Zheng G, Chen L, Xiong B. Effect of HER-2/neu over-expression on prognosis in gastric cancer: a meta-analysis. Asian Pac J Cancer Prev 2011;12(6):1417-23
-
(2011)
Asian Pac J Cancer Prev
, vol.12
, Issue.6
, pp. 1417-1423
-
-
Wang, S.1
Zheng, G.2
Chen, L.3
Xiong, B.4
-
32
-
-
77956262693
-
Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): A phase 3, open-label, randomised controlled trial
-
Bang YJ, Van Cutsem E, Feyereislova A, et al. Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial. Lancet 2010;376(9742):687-97
-
(2010)
Lancet
, vol.376
, Issue.9742
, pp. 687-697
-
-
Bang, Y.J.1
Van Cutsem, E.2
Feyereislova, A.3
-
34
-
-
50849096058
-
Anthracycline-trastuzumab regimens for HER2/neu-overexpressing breast cancer: Current experience and future strategies
-
Rayson D, Richel D, Chia S, et al. Anthracycline-trastuzumab regimens for HER2/neu-overexpressing breast cancer: current experience and future strategies. Ann Oncol 2008;19(9):1530-9
-
(2008)
Ann Oncol
, vol.19
, Issue.9
, pp. 1530-1539
-
-
Rayson, D.1
Richel, D.2
Chia, S.3
-
35
-
-
56449129810
-
Targeting HER2-positive breast cancer with trastuzumab-DM1, an antibody-cytotoxic drug conjugate
-
Lewis Phillips GD, Li G, Dugger DL, et al. Targeting HER2-positive breast cancer with trastuzumab-DM1, an antibody-cytotoxic drug conjugate. Cancer Res 2008;68(22):9280-90
-
(2008)
Cancer Res
, vol.68
, Issue.22
, pp. 9280-9290
-
-
Lewis Phillips, G.D.1
Li, G.2
Dugger, D.L.3
-
36
-
-
77954031486
-
Phase i study of trastuzumab-DM1, an HER2 antibody-drug conjugate, given every 3 weeks to patients with HER2- positive metastatic breast cancer
-
Krop IE, Beeram M, Modi S, et al. Phase I study of trastuzumab-DM1, an HER2 antibody-drug conjugate, given every 3 weeks to patients with HER2- positive metastatic breast cancer. J Clin Oncol 2010;28(16):2698-704
-
(2010)
J Clin Oncol
, vol.28
, Issue.16
, pp. 2698-2704
-
-
Krop, I.E.1
Beeram, M.2
Modi, S.3
-
37
-
-
79959700509
-
Trastuzumab-DM1 (T-DM1) retains all the mechanisms of action of trastuzumab and efficiently inhibits growth of lapatinib insensitive breast cancer
-
Junttila TT, Li G, Parsons K, et al. Trastuzumab-DM1 (T-DM1) retains all the mechanisms of action of trastuzumab and efficiently inhibits growth of lapatinib insensitive breast cancer. Breast Cancer Res Treat 2011;128(2):347-56
-
(2011)
Breast Cancer Res Treat
, vol.128
, Issue.2
, pp. 347-356
-
-
Junttila, T.T.1
Li, G.2
Parsons, K.3
-
38
-
-
84863688392
-
A phase II study of trastuzumab emtansine in patients with human epidermal growth factor receptor 2- positive metastatic breast cancer who were previously treated with trastuzumab, lapatinib, an anthracycline, a taxane, and capecitabine
-
Krop IE, LoRusso P, Miller KD, et al. A phase II study of trastuzumab emtansine in patients with human epidermal growth factor receptor 2- positive metastatic breast cancer who were previously treated with trastuzumab, lapatinib, an anthracycline, a taxane, and capecitabine. J Clin Oncol 2012;30(26):3234-41
-
(2012)
J Clin Oncol
, vol.30
, Issue.26
, pp. 3234-3241
-
-
Krop, I.E.1
Lorusso, P.2
Miller, K.D.3
-
39
-
-
84876011018
-
Phase II randomized study of trastuzumab emtansine versus trastuzumab plus docetaxel in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer
-
Hurvitz SA, Dirix L, Kocsis J, et al. Phase II randomized study of trastuzumab emtansine versus trastuzumab plus docetaxel in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer. J Clin Oncol 2013;31(9):1157-63
-
(2013)
J Clin Oncol
, vol.31
, Issue.9
, pp. 1157-1163
-
-
Hurvitz, S.A.1
Dirix, L.2
Kocsis, J.3
-
40
-
-
84902973417
-
Phase IIa trial of trastuzumab emtansine with pertuzumab for patients with human epidermal growth factor receptor 2-positive, locally advanced, or metastatic breast cancer
-
Miller KD, Dieras V, Harbeck N, et al. Phase IIa trial of trastuzumab emtansine with pertuzumab for patients with human epidermal growth factor receptor 2-positive, locally advanced, or metastatic breast cancer. J Clin Oncol 2014;32(14):1437-44
-
(2014)
J Clin Oncol
, vol.32
, Issue.14
, pp. 1437-1444
-
-
Miller, K.D.1
Dieras, V.2
Harbeck, N.3
-
41
-
-
84868520609
-
Trastuzumab emtansine for HER2- positive advanced breast cancer
-
Verma S, Miles D, Gianni L, et al. Trastuzumab emtansine for HER2- positive advanced breast cancer. Eng J Med 2012;367(19):1783-91
-
(2012)
Eng J Med
, vol.367
, Issue.19
, pp. 1783-1791
-
-
Verma, S.1
Miles, D.2
Gianni, L.3
-
42
-
-
84867842898
-
MARIANNE: A Phase III, randomized study of trastuzumab-DM1 (T-DM1) with or without pertuzumab (P) compared with trastuzumab (H) plus taxane for first-line treatment of HER2- positive, progressive, or recurrent locally advanced or metastatic breast cancer (MBC)
-
abstract TPS102
-
Ellis PA BC, Im Y, Patre M, et al. MARIANNE: a Phase III, randomized study of trastuzumab-DM1 (T-DM1) with or without pertuzumab (P) compared with trastuzumab (H) plus taxane for first-line treatment of HER2- positive, progressive, or recurrent locally advanced or metastatic breast cancer (MBC). J Clin Oncol 2011;29(Suppl 15):abstract TPS102
-
(2011)
J Clin Oncol
, vol.29
-
-
Ellis, P.A.B.C.1
Im, Y.2
Patre, M.3
-
43
-
-
84901639476
-
Trastuzumab emtansine versus treatment of physician's choice for pretreated HER2-positive advanced breast cancer (TH3RESA): A randomised, open-label, phase 3 trial
-
Krop IE, Kim SB, Gonzalez-Martin A, et al. Trastuzumab emtansine versus treatment of physician's choice for pretreated HER2-positive advanced breast cancer (TH3RESA): a randomised, open-label, phase 3 trial. Lancet Oncol 2014;15(7):689-99
-
(2014)
Lancet Oncol
, vol.15
, Issue.7
, pp. 689-699
-
-
Krop, I.E.1
Kim, S.B.2
Gonzalez-Martin, A.3
-
44
-
-
1842605531
-
Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex
-
Franklin MC, Carey KD, Vajdos FF, et al. Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex. Cancer Cell 2004;5(4):317-28
-
(2004)
Cancer Cell
, vol.5
, Issue.4
, pp. 317-328
-
-
Franklin, M.C.1
Carey, K.D.2
Vajdos, F.F.3
-
45
-
-
73649149433
-
Strongly enhanced antitumor activity of trastuzumab and pertuzumab combination treatment on HER2-positive human xenograft tumor models
-
Scheuer W, Friess T, Burtscher H, et al. Strongly enhanced antitumor activity of trastuzumab and pertuzumab combination treatment on HER2-positive human xenograft tumor models. Cancer Res 2009;69(24):9330-6
-
(2009)
Cancer Res
, vol.69
, Issue.24
, pp. 9330-9336
-
-
Scheuer, W.1
Friess, T.2
Burtscher, H.3
-
46
-
-
1942474587
-
The HER-2-targeting antibodies trastuzumab and pertuzumab synergistically inhibit the survival of breast cancer cells
-
Nahta R, Hung MC, Esteva FJ. The HER-2-targeting antibodies trastuzumab and pertuzumab synergistically inhibit the survival of breast cancer cells. Cancer Res 2004;64(7):2343-6
-
(2004)
Cancer Res
, vol.64
, Issue.7
, pp. 2343-2346
-
-
Nahta, R.1
Hung, M.C.2
Esteva, F.J.3
-
47
-
-
79952276644
-
CLEOPATRA: A phase III evaluation of pertuzumab and trastuzumab for HER2-positive metastatic breast cancer
-
Baselga J, Swain SM. CLEOPATRA: a phase III evaluation of pertuzumab and trastuzumab for HER2-positive metastatic breast cancer. Clin Breast Cancer 2010;10(6):489-91
-
(2010)
Clin Breast Cancer
, vol.10
, Issue.6
, pp. 489-491
-
-
Baselga, J.1
Swain, S.M.2
-
48
-
-
84862914692
-
Pertuzumab plus trastuzumab plus docetaxel for metastatic breast cancer
-
Baselga J, Cortes J, Kim SB, et al. Pertuzumab plus trastuzumab plus docetaxel for metastatic breast cancer. Eng J Med 2012;366(2):109-19
-
(2012)
Eng J Med
, vol.366
, Issue.2
, pp. 109-119
-
-
Baselga, J.1
Cortes, J.2
Kim, S.B.3
-
49
-
-
84876970810
-
Pertuzumab, trastuzumab, and docetaxel for HER2-positive metastatic breast cancer (CLEOPATRA study): Overall survival results from a randomised, double-blind, placebo-controlled, phase 3 study
-
Swain SM, Kim SB, Cortes J, et al. Pertuzumab, trastuzumab, and docetaxel for HER2-positive metastatic breast cancer (CLEOPATRA study): overall survival results from a randomised, double-blind, placebo-controlled, phase 3 study. Lancet Oncol 2013;14(6):461-71
-
(2013)
Lancet Oncol
, vol.14
, Issue.6
, pp. 461-471
-
-
Swain, S.M.1
Kim, S.B.2
Cortes, J.3
-
50
-
-
84855297353
-
Efficacy and safety of neoadjuvant pertuzumab and trastuzumab in women with locally advanced, inflammatory, or early HER2-positive breast cancer (NeoSphere): A randomised multicentre, open-label, phase 2 trial
-
Gianni L, Pienkowski T, Im YH, et al. Efficacy and safety of neoadjuvant pertuzumab and trastuzumab in women with locally advanced, inflammatory, or early HER2-positive breast cancer (NeoSphere): a randomised multicentre, open-label, phase 2 trial. Lancet Oncol 2012;13(1):25-32
-
(2012)
Lancet Oncol
, vol.13
, Issue.1
, pp. 25-32
-
-
Gianni, L.1
Pienkowski, T.2
Im, Y.H.3
-
51
-
-
84883359410
-
Pertuzumab plus trastuzumab in combination with standard neoadjuvant anthracycline-containing and anthracycline-free chemotherapy regimens in patients with HER2-positive early breast cancer: A randomized phase II cardiac safety study (TRYPHAENA)
-
Schneeweiss A, Chia S, Hickish T, et al. Pertuzumab plus trastuzumab in combination with standard neoadjuvant anthracycline-containing and anthracycline-free chemotherapy regimens in patients with HER2-positive early breast cancer: a randomized phase II cardiac safety study (TRYPHAENA). Annals Oncol 2013;24(9):2278-84
-
(2013)
Annals Oncol
, vol.24
, Issue.9
, pp. 2278-2284
-
-
Schneeweiss, A.1
Chia, S.2
Hickish, T.3
-
52
-
-
47149084688
-
Epidermal growth factor receptor monoclonal antibodies for the treatment of metastatic colorectal cancer
-
Jean GW, Shah SR. Epidermal growth factor receptor monoclonal antibodies for the treatment of metastatic colorectal cancer. Pharmacotherapy 2008;28(6):742-54
-
(2008)
Pharmacotherapy
, vol.28
, Issue.6
, pp. 742-754
-
-
Jean, G.W.1
Shah, S.R.2
-
53
-
-
79960370663
-
EGFR genomic alterations in cancer: Prognostic and predictive values
-
Bronte G, Terrasi M, Rizzo S, et al. EGFR genomic alterations in cancer: prognostic and predictive values. Front Biosci (Elite Ed) 2011;3:879-87
-
(2011)
Front Biosci (Elite Ed)
, vol.3
, pp. 879-887
-
-
Bronte, G.1
Terrasi, M.2
Rizzo, S.3
-
54
-
-
3242720345
-
Cetuximab monotherapy and cetuximab plus irinotecan in irinotecanrefractory metastatic colorectal cancer
-
Cunningham D, Humblet Y, Siena S, et al. Cetuximab monotherapy and cetuximab plus irinotecan in irinotecanrefractory metastatic colorectal cancer. Eng J Med 2004;351(4):337-45
-
(2004)
Eng J Med
, vol.351
, Issue.4
, pp. 337-345
-
-
Cunningham, D.1
Humblet, Y.2
Siena, S.3
-
55
-
-
44249111440
-
EPIC: Phase III trial of cetuximab plus irinotecan after fluoropyrimidine and oxaliplatin failure in patients with metastatic colorectal cancer
-
Sobrero AF, Maurel J, Fehrenbacher L, et al. EPIC: phase III trial of cetuximab plus irinotecan after fluoropyrimidine and oxaliplatin failure in patients with metastatic colorectal cancer. J Clin Oncol 2008;26(14):2311-19
-
(2008)
J Clin Oncol
, vol.26
, Issue.14
, pp. 2311-2319
-
-
Sobrero, A.F.1
Maurel, J.2
Fehrenbacher, L.3
-
56
-
-
79956298812
-
Cetuximab plus irinotecan, fluorouracil, and leucovorin as first-line treatment for metastatic colorectal cancer: Updated analysis of overall survival according to tumor KRAS and BRAF mutation status
-
Van Cutsem E, Köhne CH, Láng I, et al. Cetuximab plus irinotecan, fluorouracil, and leucovorin as first-line treatment for metastatic colorectal cancer: updated analysis of overall survival according to tumor KRAS and BRAF mutation status. J Clin Oncol 2011;29(15):2011-19
-
(2011)
J Clin Oncol
, vol.29
, Issue.15
, pp. 2011-2019
-
-
Van Cutsem, E.1
Köhne, C.H.2
Láng, I.3
-
57
-
-
77949883874
-
The long and winding road to useful predictive factors for anti-EGFR therapy in metastatic colorectal carcinoma: The KRAS/BRAF pathway
-
Russo A, Rizzo S, Bronte G, et al. The long and winding road to useful predictive factors for anti-EGFR therapy in metastatic colorectal carcinoma: the KRAS/BRAF pathway. Oncology 2009;77(Suppl 1):57-68
-
(2009)
Oncology
, vol.77
, pp. 57-68
-
-
Russo, A.1
Rizzo, S.2
Bronte, G.3
-
58
-
-
78649744892
-
Prognostic vs predictive molecular biomarkers in colorectal cancer: Is KRAS and BRAF wild type status required for anti-EGFR therapy?
-
Rizzo S, Bronte G, Fanale D, et al. Prognostic vs predictive molecular biomarkers in colorectal cancer: is KRAS and BRAF wild type status required for anti-EGFR therapy? Cancer Treat Rev 2010;36(Suppl 3):S56-61
-
(2010)
Cancer Treat Rev
, vol.36
, pp. S56-61
-
-
Rizzo, S.1
Bronte, G.2
Fanale, D.3
-
59
-
-
36749067866
-
Phase II trial of cetuximab in combination with fluorouracil, leucovorin, and oxaliplatin in the first-line treatment of metastatic colorectal cancer
-
Tabernero J, Van Cutsem E, Díaz-Rubio E, et al. Phase II trial of cetuximab in combination with fluorouracil, leucovorin, and oxaliplatin in the first-line treatment of metastatic colorectal cancer. J Clin Oncol 2007;25(33):5225-32
-
(2007)
J Clin Oncol
, vol.25
, Issue.33
, pp. 5225-5232
-
-
Tabernero, J.1
Van Cutsem, E.2
Díaz-Rubio, E.3
-
60
-
-
79959337678
-
Addition of cetuximab to oxaliplatin-based first-line combination chemotherapy for treatment of advanced colorectal cancer: Results of the randomised phase 3 MRC COIN trial
-
Maughan TS, Adams RA, Smith CG, et al. Addition of cetuximab to oxaliplatin-based first-line combination chemotherapy for treatment of advanced colorectal cancer: results of the randomised phase 3 MRC COIN trial. Lancet 2011;377(9783):2103-14
-
(2011)
Lancet
, vol.377
, Issue.9783
, pp. 2103-2114
-
-
Maughan, T.S.1
Adams, R.A.2
Smith, C.G.3
-
61
-
-
84861432557
-
Phase III trial of cetuximab with continuous or intermittent fluorouracil, leucovorin, and oxaliplatin (Nordic FLOX) versus FLOX alone in first-line treatment of metastatic colorectal cancer: The NORDIC-VII study
-
Tveit KM, Guren T, Glimelius B, et al. Phase III trial of cetuximab with continuous or intermittent fluorouracil, leucovorin, and oxaliplatin (Nordic FLOX) versus FLOX alone in first-line treatment of metastatic colorectal cancer: the NORDIC-VII study. J Clin Oncol 2012;30(15):1755-62
-
(2012)
J Clin Oncol
, vol.30
, Issue.15
, pp. 1755-1762
-
-
Tveit, K.M.1
Guren, T.2
Glimelius, B.3
-
62
-
-
84865553918
-
Cetuximab rechallenge in metastatic colorectal cancer patients: How to come away from acquired resistance?
-
Santini D, Vincenzi B, Addeo R, et al. Cetuximab rechallenge in metastatic colorectal cancer patients: how to come away from acquired resistance? Ann Oncol 2012;23(9):2313-18
-
(2012)
Ann Oncol
, vol.23
, Issue.9
, pp. 2313-2318
-
-
Santini, D.1
Vincenzi, B.2
Addeo, R.3
-
63
-
-
73249143536
-
Radiotherapy plus cetuximab for locoregionally advanced head and neck cancer: 5-year survival data from a phase 3 randomised trial, and relation between cetuximab-induced rash and survival
-
Bonner JA, Harari PM, Giralt J, et al. Radiotherapy plus cetuximab for locoregionally advanced head and neck cancer: 5-year survival data from a phase 3 randomised trial, and relation between cetuximab-induced rash and survival. Lancet Oncol 2010;11(1):21-8
-
(2010)
Lancet Oncol
, vol.11
, Issue.1
, pp. 21-28
-
-
Bonner, J.A.1
Harari, P.M.2
Giralt, J.3
-
64
-
-
51649085865
-
Platinum-based chemotherapy plus cetuximab in head and neck cancer
-
Vermorken JB, Mesia R, Rivera F, et al. Platinum-based chemotherapy plus cetuximab in head and neck cancer. Eng J Med 2008;359(11):1116-27
-
(2008)
Eng J Med
, vol.359
, Issue.11
, pp. 1116-1127
-
-
Vermorken, J.B.1
Mesia, R.2
Rivera, F.3
-
65
-
-
40949091368
-
U.S. Food and Drug Administration approval: Panitumumab for epidermal growth factor receptor-expressing metastatic colorectal carcinoma with progression following fluoropyrimidine-, oxaliplatin-, and irinotecan-containing chemotherapy regimens
-
Giusti RM, Shastri K, Pilaro AM, et al. U.S. Food and Drug Administration approval: panitumumab for epidermal growth factor receptor-expressing metastatic colorectal carcinoma with progression following fluoropyrimidine-, oxaliplatin-, and irinotecan-containing chemotherapy regimens. Clin Cancer Res 2008;14(5):1296-302
-
(2008)
Clin Cancer Res
, vol.14
, Issue.5
, pp. 1296-1302
-
-
Giusti, R.M.1
Shastri, K.2
Pilaro, A.M.3
-
66
-
-
42649145667
-
Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer
-
Amado RG, Wolf M, Peeters M, et al. Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer. J Clin Oncol 2008;26(10):1626-34
-
(2008)
J Clin Oncol
, vol.26
, Issue.10
, pp. 1626-1634
-
-
Amado, R.G.1
Wolf, M.2
Peeters, M.3
-
67
-
-
84903694472
-
Final results from PRIME: Randomized phase 3 study of panitumumab with FOLFOX4 for first-line treatment of metastatic colorectal cancer
-
Douillard JY, Siena S, Cassidy J, et al. Final results from PRIME: randomized phase 3 study of panitumumab with FOLFOX4 for first-line treatment of metastatic colorectal cancer. Annals Oncol 2014;25(7):1346-55
-
(2014)
Annals Oncol
, vol.25
, Issue.7
, pp. 1346-1355
-
-
Douillard, J.Y.1
Siena, S.2
Cassidy, J.3
-
68
-
-
84883680951
-
Panitumumab-FOLFOX4 treatment and RAS mutations in colorectal cancer
-
Douillard JY, Oliner KS, Siena S, et al. Panitumumab-FOLFOX4 treatment and RAS mutations in colorectal cancer. Eng J Med 2013;369(11):1023-34
-
(2013)
Eng J Med
, vol.369
, Issue.11
, pp. 1023-1034
-
-
Douillard, J.Y.1
Oliner, K.S.2
Siena, S.3
-
69
-
-
84899940235
-
Final results from a randomized phase 3 study of FOLFIRI {+/-} panitumumab for second-line treatment of metastatic colorectal cancer
-
Peeters M, Price TJ, Cervantes A, et al. Final results from a randomized phase 3 study of FOLFIRI {+/-} panitumumab for second-line treatment of metastatic colorectal cancer. Annals Oncol 2014;25(1):107-16
-
(2014)
Annals Oncol
, vol.25
, Issue.1
, pp. 107-116
-
-
Peeters, M.1
Price, T.J.2
Cervantes, A.3
-
70
-
-
84861318872
-
FOLFIRI plus cetuximab versus FOLFIRI plus bevacizumab as first-line treatment for patients with metastatic colorectal cancersubgroup analysis of patients with KRAS: Mutated tumours in the randomised German AIO study KRK-0306
-
Stintzing S, Fischer von Weikersthal L, Decker T, et al. FOLFIRI plus cetuximab versus FOLFIRI plus bevacizumab as first-line treatment for patients with metastatic colorectal cancersubgroup analysis of patients with KRAS: mutated tumours in the randomised German AIO study KRK-0306. Annals Oncol 2012;23(7):1693-9
-
(2012)
Annals Oncol
, vol.23
, Issue.7
, pp. 1693-1699
-
-
Stintzing, S.1
Fischer Von Weikersthal, L.2
Decker, T.3
-
71
-
-
84917737759
-
Treatment outcome according to tumor RAS mutation status in CRYSTAL study patients with metastatic colorectal cancer (mCRC) randomized to FOLFIRI with/without cetuximab
-
abstract 3506
-
Fortunato Ciardiello H-JL, et al. Treatment outcome according to tumor RAS mutation status in CRYSTAL study patients with metastatic colorectal cancer (mCRC) randomized to FOLFIRI with/without cetuximab. J Clin Oncol 2014;32(Suppl 5s):abstract 3506
-
(2014)
J Clin Oncol
, vol.32
-
-
Fortunato Ciardiello, H.-J.L.1
-
72
-
-
27544477748
-
The von Hippel-Lindau protein, HIF hydroxylation, and oxygen sensing
-
Kaelin WG. The von Hippel-Lindau protein, HIF hydroxylation, and oxygen sensing. Biochem Biophys Res Commun 2005;338(1):627-38
-
(2005)
Biochem Biophys Res Commun
, vol.338
, Issue.1
, pp. 627-638
-
-
Kaelin, W.G.1
-
73
-
-
85013312416
-
Tumor angiogenesis: Therapeutic implications
-
Folkman J. Tumor angiogenesis: therapeutic implications. Eng J Med 1971;285(21):1182-6
-
(1971)
Eng J Med
, vol.285
, Issue.21
, pp. 1182-1186
-
-
Folkman, J.1
-
74
-
-
0037699954
-
The biology of VEGF and its receptors
-
Ferrara N, Gerber HP, LeCouter J. The biology of VEGF and its receptors. Nat Med 2003;9(6):669-76
-
(2003)
Nat Med
, vol.9
, Issue.6
, pp. 669-676
-
-
Ferrara, N.1
Gerber, H.P.2
Lecouter, J.3
-
76
-
-
2442621619
-
Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer
-
Ferrara N, Hillan KJ, Gerber HP, Novotny W. Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer. Nat Rev Drug Discov 2004;3(5):391-400
-
(2004)
Nat Rev Drug Discov
, vol.3
, Issue.5
, pp. 391-400
-
-
Ferrara, N.1
Hillan, K.J.2
Gerber, H.P.3
Novotny, W.4
-
77
-
-
11844254414
-
Normalization of tumor vasculature: An emerging concept in antiangiogenic therapy
-
Jain RK. Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Science 2005;307(5706):58-62
-
(2005)
Science
, vol.307
, Issue.5706
, pp. 58-62
-
-
Jain, R.K.1
-
78
-
-
20544478429
-
Addition of bevacizumab to bolus fluorouracil and leucovorin in first-line metastatic colorectal cancer: Results of a randomized phase II trial
-
Kabbinavar FF, Schulz J, McCleod M, et al. Addition of bevacizumab to bolus fluorouracil and leucovorin in first-line metastatic colorectal cancer: results of a randomized phase II trial. J Clin Oncol 2005;23(16):3697-705
-
(2005)
J Clin Oncol
, vol.23
, Issue.16
, pp. 3697-3705
-
-
Kabbinavar, F.F.1
Schulz, J.2
McCleod, M.3
-
79
-
-
2542561964
-
Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
-
Hurwitz H, Fehrenbacher L, Novotny W, et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. Eng J Med 2004;350(23):2335-42
-
(2004)
Eng J Med
, vol.350
, Issue.23
, pp. 2335-2342
-
-
Hurwitz, H.1
Fehrenbacher, L.2
Novotny, W.3
-
80
-
-
42949149159
-
Bevacizumab in combination with oxaliplatin-based chemotherapy as firstline therapy in metastatic colorectal cancer: A randomized phase III study
-
Saltz LB, Clarke S, Díaz-Rubio E, et al. Bevacizumab in combination with oxaliplatin-based chemotherapy as firstline therapy in metastatic colorectal cancer: a randomized phase III study. J Clin Oncol 2008;26(12):2013-19
-
(2008)
J Clin Oncol
, vol.26
, Issue.12
, pp. 2013-2019
-
-
Saltz, L.B.1
Clarke, S.2
Díaz-Rubio, E.3
-
81
-
-
82255173970
-
Predicting efficacy and toxicity in the era of targeted therapy: Focus on anti-EGFR and anti-VEGF molecules
-
Caraglia M, Santini D, Bronte G, et al. Predicting efficacy and toxicity in the era of targeted therapy: focus on anti-EGFR and anti-VEGF molecules. Curr Drug Metab 2011;12(10):944-55
-
(2011)
Curr Drug Metab
, vol.12
, Issue.10
, pp. 944-955
-
-
Caraglia, M.1
Santini, D.2
Bronte, G.3
-
82
-
-
84880338271
-
Dilemma in metastatic colorectal cancer: VEGF versus EGRF targeting
-
Rolfo C, Russo A, Santini D, et al. Dilemma in metastatic colorectal cancer: VEGF versus EGRF targeting. Expert Opin Ther Targets 2013;17(8):869-71
-
(2013)
Expert Opin Ther Targets
, vol.17
, Issue.8
, pp. 869-871
-
-
Rolfo, C.1
Russo, A.2
Santini, D.3
-
83
-
-
84900826629
-
How to find the Ariadne's thread in the labyrinth of salvage treatment options for metastatic colorectal cancer?
-
Bronte G, Rolfo C, Peeters M, Russo A. How to find the Ariadne's thread in the labyrinth of salvage treatment options for metastatic colorectal cancer? Expert Opin Biol Ther 2014;14(6):743-8
-
(2014)
Expert Opin Biol Ther
, vol.14
, Issue.6
, pp. 743-748
-
-
Bronte, G.1
Rolfo, C.2
Peeters, M.3
Russo, A.4
-
84
-
-
84871720057
-
Continuation of bevacizumab after first progression in metastatic colorectal cancer (ML18147): A randomised phase 3 trial
-
Bennouna J, Sastre J, Arnold D, et al. Continuation of bevacizumab after first progression in metastatic colorectal cancer (ML18147): a randomised phase 3 trial. Lancet Oncol 2013;14(1):29-37
-
(2013)
Lancet Oncol
, vol.14
, Issue.1
, pp. 29-37
-
-
Bennouna, J.1
Sastre, J.2
Arnold, D.3
-
85
-
-
84883381780
-
Bevacizumab plus chemotherapy continued beyond first progression in patients with metastatic colorectal cancer previously treated with bevacizumab plus chemotherapy: ML18147 study KRAS subgroup findings
-
Kubicka S, Greil R, Andre T, et al. Bevacizumab plus chemotherapy continued beyond first progression in patients with metastatic colorectal cancer previously treated with bevacizumab plus chemotherapy: ML18147 study KRAS subgroup findings. Annals Oncol 2013;24(9):2342-9
-
(2013)
Annals Oncol
, vol.24
, Issue.9
, pp. 2342-2349
-
-
Kubicka, S.1
Greil, R.2
Andre, T.3
-
86
-
-
84917711557
-
Subgroup analyses in RAS mutant, BRAF mutant and all-wt mCRC pts treated with FOLFOXIRI plus bevacizumab (bev) or FOLFIRI plus bev in the TRIBE study
-
abstract 3519
-
Fotios Loupakis CC, Lonardi S, et al. Subgroup analyses in RAS mutant, BRAF mutant and all-wt mCRC pts treated with FOLFOXIRI plus bevacizumab (bev) or FOLFIRI plus bev in the TRIBE study. J Clin Oncol 2014;32(Suppl 5):abstract 3519
-
(2014)
J Clin Oncol
, vol.32
-
-
Fotios Loupakis, C.C.1
Lonardi, S.2
-
87
-
-
33845490014
-
Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer
-
Sandler A, Gray R, Perry MC, et al. Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer. Eng J Med 2006;355(24):2542-50
-
(2006)
Eng J Med
, vol.355
, Issue.24
, pp. 2542-2550
-
-
Sandler, A.1
Gray, R.2
Perry, M.C.3
-
88
-
-
2942657615
-
Randomized phase II trial comparing bevacizumab plus carboplatin and paclitaxel with carboplatin and paclitaxel alone in previously untreated locally advanced or metastatic non-small-cell lung cancer
-
Johnson DH, Fehrenbacher L, Novotny WF, et al. Randomized phase II trial comparing bevacizumab plus carboplatin and paclitaxel with carboplatin and paclitaxel alone in previously untreated locally advanced or metastatic non-small-cell lung cancer. J Clin Oncol 2004;22(11):2184-91
-
(2004)
J Clin Oncol
, vol.22
, Issue.11
, pp. 2184-2191
-
-
Johnson, D.H.1
Fehrenbacher, L.2
Novotny, W.F.3
-
89
-
-
62449124416
-
Phase III trial of cisplatin plus gemcitabine with either placebo or bevacizumab as first-line therapy for nonsquamous non-small-cell lung cancer: AVAil
-
Reck M, von Pawel J, Zatloukal P, et al. Phase III trial of cisplatin plus gemcitabine with either placebo or bevacizumab as first-line therapy for nonsquamous non-small-cell lung cancer: AVAil. J Clin Oncol 2009;27(8):1227-34
-
(2009)
J Clin Oncol
, vol.27
, Issue.8
, pp. 1227-1234
-
-
Reck, M.1
Von Pawel, J.2
Zatloukal, P.3
-
90
-
-
37549040613
-
Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancer
-
Miller K, Wang M, Gralow J, et al. Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancer. Eng J Med 2007;357(26):2666-76
-
(2007)
Eng J Med
, vol.357
, Issue.26
, pp. 2666-2676
-
-
Miller, K.1
Wang, M.2
Gralow, J.3
-
91
-
-
77954700380
-
Phase III study of bevacizumab plus docetaxel compared with placebo plus docetaxel for the first-line treatment of human epidermal growth factor receptor 2-negative metastatic breast cancer
-
Miles DW, Chan A, Dirix LY, et al. Phase III study of bevacizumab plus docetaxel compared with placebo plus docetaxel for the first-line treatment of human epidermal growth factor receptor 2-negative metastatic breast cancer. J Clin Oncol 2010;28(20):3239-47
-
(2010)
J Clin Oncol
, vol.28
, Issue.20
, pp. 3239-3247
-
-
Miles, D.W.1
Chan, A.2
Dirix, L.Y.3
-
92
-
-
79953874259
-
RIBBON-1: Randomized, double-blind, placebo-controlled, phase III trial of chemotherapy with or without bevacizumab for first-line treatment of human epidermal growth factor receptor 2-negative, locally recurrent or metastatic breast cancer
-
Robert NJ, Dieras V, Glaspy J, et al. RIBBON-1: randomized, double-blind, placebo-controlled, phase III trial of chemotherapy with or without bevacizumab for first-line treatment of human epidermal growth factor receptor 2-negative, locally recurrent or metastatic breast cancer. J Clin Oncol 2011;29(10):1252-60
-
(2011)
J Clin Oncol
, vol.29
, Issue.10
, pp. 1252-1260
-
-
Robert, N.J.1
Dieras, V.2
Glaspy, J.3
-
93
-
-
37349080670
-
Bevacizumab plus interferon alfa-2a for treatment of metastatic renal cell carcinoma: A randomised, double-blind phase III trial
-
Escudier B, Pluzanska A, Koralewski P, et al. Bevacizumab plus interferon alfa-2a for treatment of metastatic renal cell carcinoma: a randomised, double-blind phase III trial. Lancet 2007;370(9605):2103-11
-
(2007)
Lancet
, vol.370
, Issue.9605
, pp. 2103-2111
-
-
Escudier, B.1
Pluzanska, A.2
Koralewski, P.3
-
94
-
-
77952300540
-
Phase III trial of bevacizumab plus interferon alfa-2a in patients with metastatic renal cell carcinoma (AVOREN): Final analysis of overall survival
-
Escudier B, Bellmunt J, Negrier S, et al. Phase III trial of bevacizumab plus interferon alfa-2a in patients with metastatic renal cell carcinoma (AVOREN): final analysis of overall survival. J Clin Oncol 2010;28(13):2144-50
-
(2010)
J Clin Oncol
, vol.28
, Issue.13
, pp. 2144-2150
-
-
Escudier, B.1
Bellmunt, J.2
Negrier, S.3
-
95
-
-
77952318310
-
Phase III trial of bevacizumab plus interferon alfa versus interferon alfa monotherapy in patients with metastatic renal cell carcinoma: Final results of CALGB 90206
-
Rini BI, Halabi S, Rosenberg JE, et al. Phase III trial of bevacizumab plus interferon alfa versus interferon alfa monotherapy in patients with metastatic renal cell carcinoma: final results of CALGB 90206. J Clin Oncol 2010;28(13):2137-43
-
(2010)
J Clin Oncol
, vol.28
, Issue.13
, pp. 2137-2143
-
-
Rini, B.I.1
Halabi, S.2
Rosenberg, J.E.3
-
96
-
-
70350461699
-
Bevacizumab alone and in combination with irinotecan in recurrent glioblastoma
-
Friedman HS, Prados MD, Wen PY, et al. Bevacizumab alone and in combination with irinotecan in recurrent glioblastoma. J Clin Oncol 2009;27(28):4733-40
-
(2009)
J Clin Oncol
, vol.27
, Issue.28
, pp. 4733-4740
-
-
Friedman, H.S.1
Prados, M.D.2
Wen, P.Y.3
-
97
-
-
59949083263
-
Phase II trial of single-agent bevacizumab followed by bevacizumab plus irinotecan at tumor progression in recurrent glioblastoma
-
Kreisl TN, Kim L, Moore K, et al. Phase II trial of single-agent bevacizumab followed by bevacizumab plus irinotecan at tumor progression in recurrent glioblastoma. J Clin Oncol 2009;27(5):740-5
-
(2009)
J Clin Oncol
, vol.27
, Issue.5
, pp. 740-745
-
-
Kreisl, T.N.1
Kim, L.2
Moore, K.3
-
98
-
-
84855425106
-
Incorporation of bevacizumab in the primary treatment of ovarian cancer
-
Burger RA, Brady MF, Bookman MA, et al. Incorporation of bevacizumab in the primary treatment of ovarian cancer. Eng J Med 2011;365(26):2473-83
-
(2011)
Eng J Med
, vol.365
, Issue.26
, pp. 2473-2483
-
-
Burger, R.A.1
Brady, M.F.2
Bookman, M.A.3
-
99
-
-
84906076585
-
LATE BREAKING ABSTRACT: ICON7: Final overall survival results in the GCIG phase III randomized trial of bevacizumab in women with newly diagnosed ovarian cancer
-
29 September[abstract 6]
-
Oza AM, Perren TJ, Swart AM, et al. LATE BREAKING ABSTRACT: ICON7: Final overall survival results in the GCIG phase III randomized trial of bevacizumab in women with newly diagnosed ovarian cancer [abstract 6]. European Cancer Congress; 29 September 2013
-
(2013)
European Cancer Congress
-
-
Oza, A.M.1
Perren, T.J.2
Swart, A.M.3
-
100
-
-
84892852372
-
Ramucirumab monotherapy for previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (REGARD): An international, randomised, multicentre, placebo-controlled, phase 3 trial
-
Fuchs CS, Tomasek J, Yong CJ, et al. Ramucirumab monotherapy for previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (REGARD): an international, randomised, multicentre, placebo-controlled, phase 3 trial. Lancet 2014;383(9911):31-9
-
(2014)
Lancet
, vol.383
, Issue.9911
, pp. 31-39
-
-
Fuchs, C.S.1
Tomasek, J.2
Yong, C.J.3
-
101
-
-
84893395110
-
RAINBOW: A global, phase III, randomized, double-blind study of ramucirumab plus paclitaxel versus placebo plus paclitaxel in the treatment of metastatic gastroesophageal junction (GEJ) and gastric adenocarcinoma following disease progression on first-line platinum- and fluoropyrimidinecontaining combination therapy rainbow IMCL CP12-0922 (I4T-IE-JVBE)
-
abstract LBA7
-
Wilke H, Van Cutsem E, Cheul Oh S, et al. RAINBOW: a global, phase III, randomized, double-blind study of ramucirumab plus paclitaxel versus placebo plus paclitaxel in the treatment of metastatic gastroesophageal junction (GEJ) and gastric adenocarcinoma following disease progression on first-line platinum- and fluoropyrimidinecontaining combination therapy rainbow IMCL CP12-0922 (I4T-IE-JVBE). J Clin Oncol 2014;32(Suppl 3):abstract LBA7
-
(2014)
J Clin Oncol
, vol.32
-
-
Wilke, H.1
Van Cutsem, E.2
Cheul Oh, S.3
-
102
-
-
84867047384
-
Addition of aflibercept to fluorouracil, leucovorin, and irinotecan improves survival in a phase III randomized trial in patients with metastatic colorectal cancer previously treated with an oxaliplatin-based regimen
-
Van Cutsem E, Tabernero J, Lakomy R, et al. Addition of aflibercept to fluorouracil, leucovorin, and irinotecan improves survival in a phase III randomized trial in patients with metastatic colorectal cancer previously treated with an oxaliplatin-based regimen. J Clin Oncol 2012;30(28):3499-506
-
(2012)
J Clin Oncol
, vol.30
, Issue.28
, pp. 3499-3506
-
-
Van Cutsem, E.1
Tabernero, J.2
Lakomy, R.3
-
103
-
-
28244492012
-
Analysis of the cellular mechanism of antitumor responses and autoimmunity in patients treated with CTLA-4 blockade
-
Maker AV, Attia P, Rosenberg SA. Analysis of the cellular mechanism of antitumor responses and autoimmunity in patients treated with CTLA-4 blockade. J Immunol (Baltimore, MD : 1950) 2005;175(11):7746-54
-
(2005)
J Immunol (Baltimore, MD : 1950)
, vol.175
, Issue.11
, pp. 7746-7754
-
-
Maker, A.V.1
Attia, P.2
Rosenberg, S.A.3
-
104
-
-
77954801079
-
Improved survival with ipilimumab in patients with metastatic melanoma
-
Hodi FS, O'Day SJ, McDermott DF, et al. Improved survival with ipilimumab in patients with metastatic melanoma. Eng J Med 2010;363(8):711-23
-
(2010)
Eng J Med
, vol.363
, Issue.8
, pp. 711-723
-
-
Hodi, F.S.1
O'day, S.J.2
McDermott, D.F.3
-
105
-
-
79959772576
-
Ipilimumab plus dacarbazine for previously untreated metastatic melanoma
-
Robert C, Thomas L, Bondarenko I, et al. Ipilimumab plus dacarbazine for previously untreated metastatic melanoma. Eng J Med 2011;364(26):2517-26
-
(2011)
Eng J Med
, vol.364
, Issue.26
, pp. 2517-2526
-
-
Robert, C.1
Thomas, L.2
Bondarenko, I.3
-
106
-
-
84863911486
-
Ipilimumab in combination with paclitaxel and carboplatin as first-line treatment in stage IIIB/IV non-small-cell lung cancer: Results from a randomized, double-blind, multicenter phase II study
-
Lynch TJ, Bondarenko I, Luft A, et al. Ipilimumab in combination with paclitaxel and carboplatin as first-line treatment in stage IIIB/IV non-small-cell lung cancer: results from a randomized, double-blind, multicenter phase II study. J Clin Oncol 2012;30(17):2046-54
-
(2012)
J Clin Oncol
, vol.30
, Issue.17
, pp. 2046-2054
-
-
Lynch, T.J.1
Bondarenko, I.2
Luft, A.3
-
107
-
-
84871532643
-
Ipilimumab in combination with paclitaxel and carboplatin as first-line therapy in extensive-disease-small-cell lung cancer: Results from a randomized, double-blind, multicenter phase 2 trial
-
Reck M, Bondarenko I, Luft A, et al. Ipilimumab in combination with paclitaxel and carboplatin as first-line therapy in extensive-disease-small-cell lung cancer: results from a randomized, double-blind, multicenter phase 2 trial. Ann Oncol 2013;24(1):75-83
-
(2013)
Ann Oncol
, vol.24
, Issue.1
, pp. 75-83
-
-
Reck, M.1
Bondarenko, I.2
Luft, A.3
-
108
-
-
84877743151
-
CA184-104: Randomized, multicenter, double-blind, phase III trial comparing the efficacy of ipilimumab (Ipi) with paclitaxel/carboplatin (PC) versus placebo with PC in patients (pts) with stage IV/recurrent non-small cell lung cancer (NSCLC) of squamous histology
-
abstract TPS7611
-
Reck M, Lu H, Gribkoff G, et al. CA184-104: Randomized, multicenter, double-blind, phase III trial comparing the efficacy of ipilimumab (Ipi) with paclitaxel/carboplatin (PC) versus placebo with PC in patients (pts) with stage IV/recurrent non-small cell lung cancer (NSCLC) of squamous histology. J Clin Oncol 2012;30(Suppl):abstract TPS7611
-
(2012)
J Clin Oncol
, vol.30
-
-
Reck, M.1
Lu, H.2
Gribkoff, G.3
-
109
-
-
84894469146
-
CA184-156: Randomized, multicenter, double-blind, phase III trial comparing the efficacy of ipilimumab (Ipi) plus etoposide/platinum (EP) versus placebo plus EP in patients (Pts) with newly diagnosed extensive-stage disease small cell lung cancer (ED-SCLC)
-
abstract TPS7608
-
Von Pawel J, Kim SW, Spigel DR, et al. CA184-156: Randomized, multicenter, double-blind, phase III trial comparing the efficacy of ipilimumab (Ipi) plus etoposide/platinum (EP) versus placebo plus EP in patients (Pts) with newly diagnosed extensive-stage disease small cell lung cancer (ED-SCLC). J Clin Oncol 2013;31(Suppl):abstract TPS7608
-
(2013)
J Clin Oncol
, vol.31
-
-
Von Pawel, J.1
Kim, S.W.2
Spigel, D.R.3
-
111
-
-
84867582660
-
Superiority of denosumab to zoledronic acid for prevention of skeletal-related events: A combined analysis of 3 pivotal, randomised, phase 3 trials
-
Lipton A, Fizazi K, Stopeck AT, et al. Superiority of denosumab to zoledronic acid for prevention of skeletal-related events: a combined analysis of 3 pivotal, randomised, phase 3 trials. Eur J Cancer 2012;48(16):3082-92
-
(2012)
Eur J Cancer
, vol.48
, Issue.16
, pp. 3082-3092
-
-
Lipton, A.1
Fizazi, K.2
Stopeck, A.T.3
-
112
-
-
84855516339
-
Denosumab and bone-metastasis-free survival in men with castration-resistant prostate cancer: Results of a phase 3, randomised, placebo-controlled trial
-
Smith MR, Saad F, Coleman R, et al. Denosumab and bone-metastasis-free survival in men with castration-resistant prostate cancer: results of a phase 3, randomised, placebo-controlled trial. Lancet 2012;379(9810):39-46
-
(2012)
Lancet
, vol.379
, Issue.9810
, pp. 39-46
-
-
Smith, M.R.1
Saad, F.2
Coleman, R.3
-
113
-
-
84911488148
-
A randomized, multicenter, openlabel, phase III study of gemcitabinecisplatin (GC) chemotherapy plus necitumumab (IMC-11F8/LY3012211) versus GC alone in the first-line treatment of patients (pts) with stage IV squamous non-small cell lung cancer (sq- NSCLC)
-
abstract 8008
-
Thatcher N, Hirsch FR, Szczesna A, et al. A randomized, multicenter, openlabel, phase III study of gemcitabinecisplatin (GC) chemotherapy plus necitumumab (IMC-11F8/LY3012211) versus GC alone in the first-line treatment of patients (pts) with stage IV squamous non-small cell lung cancer (sq- NSCLC). J Clin Oncol 2014;32(Suppl 5s):abstract 8008
-
(2014)
J Clin Oncol
, vol.32
-
-
Thatcher, N.1
Hirsch, F.R.2
Szczesna, A.3
-
114
-
-
84917737757
-
Randomized phase-3 trial (INSPIRE) of necitumumab plus cisplatin-pemetrexed versus cisplatinpemetrexed alone as first-line therapy in stage IV non-squamous NSCLC
-
Luis Paz-Ares JM, Mezger J, Ciuleanu T, et al. Randomized phase-3 trial (INSPIRE) of necitumumab plus cisplatin-pemetrexed versus cisplatinpemetrexed alone as first-line therapy in stage IV non-squamous NSCLC. J Thorac Oncol 2013;8(Suppl 2):S1-S1410
-
(2013)
J Thorac Oncol
, vol.8
, pp. S1-S1410
-
-
Luis Paz-Ares, J.M.1
Mezger, J.2
Ciuleanu, T.3
-
115
-
-
84874605864
-
Phase III randomized clinical trial comparing tremelimumab with standard-of-care chemotherapy in patients with advanced melanoma
-
Ribas A, Kefford R, Marshall MA, et al. Phase III randomized clinical trial comparing tremelimumab with standard-of-care chemotherapy in patients with advanced melanoma. J Clin Oncol 2013;31(5):616-22
-
(2013)
J Clin Oncol
, vol.31
, Issue.5
, pp. 616-622
-
-
Ribas, A.1
Kefford, R.2
Marshall, M.A.3
-
116
-
-
84862859820
-
Safety, activity, and immune correlates of anti-PD-1 antibody in cancer
-
Topalian SL, Hodi FS, Brahmer JR, et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. Eng J Med 2012;366(26):2443-54
-
(2012)
Eng J Med
, vol.366
, Issue.26
, pp. 2443-2454
-
-
Topalian, S.L.1
Hodi, F.S.2
Brahmer, J.R.3
-
117
-
-
84887262315
-
A study of MPDL3280A, an engineered PD-L1 antibody in patients with locally advanced or metastatic tumors
-
abstract 3000
-
Herbst RS, Gordon MS, Fine GD, et al. A study of MPDL3280A, an engineered PD-L1 antibody in patients with locally advanced or metastatic tumors. J Clin Oncol 2013;31(Suppl):abstract 3000
-
(2013)
J Clin Oncol
, vol.31
-
-
Herbst, R.S.1
Gordon, M.S.2
Fine, G.D.3
-
118
-
-
84890108571
-
Randomized phase II trial of Onartuzumab in combination with erlotinib in patients with advanced non-small-cell lung cancer
-
Spigel DR, Ervin TJ, Ramlau RA, et al. Randomized phase II trial of Onartuzumab in combination with erlotinib in patients with advanced non-small-cell lung cancer. J Clin Oncol 2013;31(32):4105-14
-
(2013)
J Clin Oncol
, vol.31
, Issue.32
, pp. 4105-4114
-
-
Spigel, D.R.1
Ervin, T.J.2
Ramlau, R.A.3
-
119
-
-
84904679830
-
Onartuzumab plus erlotinib versus erlotinib in previously treated stage IIIb or IV NSCLC: Results from the pivotal phase III randomized, multicenter, placebo-controlled METLung (OAM4971g) global trial
-
abstract 8000
-
Spigel DR. Onartuzumab plus erlotinib versus erlotinib in previously treated stage IIIb or IV NSCLC: Results from the pivotal phase III randomized, multicenter, placebo-controlled METLung (OAM4971g) global trial. J Clin Oncol 2014;32(Suppl 5s):abstract 8000
-
(2014)
J Clin Oncol
, vol.32
-
-
Spigel, D.R.1
|