Why regenerative medicine needs an extracellular matrix

Expert Opinion on Biological Therapy

Volumn 15, Issue 1, 2015, Pages 3-7

  Prestwich, Glenn D ^a   Healy, Kevin E ^b,c  

^a UNIVERSITY OF UTAH   (United States)

^b University of California   (United States)

^c University of California Berkeley   (United States)

Author keywords

Cell delivery; Cell differentiation; Cell retention; Cell therapy; Clinical biomaterial; Extracellular matrix; Regulatory barriers; Stem cell transplantation; Tissue engineering; Translational medicine

Indexed keywords

CELL ADHESION; CELL ENCAPSULATION; CELL INFILTRATION; CELL MOTION; CELL THERAPY; CROSS LINKING; ENZYMATIC DEGRADATION; EXTRACELLULAR MATRIX; GENE EXPRESSION; HUMAN; HYDROGEL; HYDROLYSIS; INTRACELLULAR SIGNALING; REGENERATIVE MEDICINE; REVIEW; SIGNAL TRANSDUCTION; SOLID; STEM CELL; STEM CELL TRANSPLANTATION; TISSUE REGENERATION; CHEMISTRY; PHYSIOLOGY; PROCEDURES; SYNTHESIS; TISSUE ENGINEERING; TISSUE SCAFFOLD; TRANSLATIONAL RESEARCH;

BIOMATERIAL;

BIOCOMPATIBLE MATERIALS; EXTRACELLULAR MATRIX; HUMANS; REGENERATIVE MEDICINE; TISSUE ENGINEERING; TISSUE SCAFFOLDS; TRANSLATIONAL MEDICAL RESEARCH;

EID: 84917690902     PISSN: 14712598     EISSN: 17447682     Source Type: Journal    
DOI: 10.1517/14712598.2015.975200     Document Type: Review

References (24)

1. Prestwich GD. Engineering a clinicallyuseful matrix for cell therapy. Organogenesis 2008;4:42-7
2. Prestwich GD. Hyaluronic acid-based clinical biomaterials derived for cell and molecule delivery in regenerative medicine. J Control Release 2011;155:193-9
3. Prestwich GD, Erickson I, Zarembinski TI, et al. The translational imperative: making cell therapy simple and effective. Acta Biomater 2012;8:4200-7
4. Prestwich GD, Bhatia S, Breuer CK, et al. Insider views: what is the greatest regulatory challenge in the translation of biomaterials to the clinic? Sci Transl Med 2012;4(160):160cm14
5. Williams DF. The biomaterials conundrum in tissue engineering. Tissue Eng Part A 2014;20:1129-31
6. Saha K, Pollock JF, Schaffer DV, Healy KE. Designing synthetic materials to control stem cell phenotype. Curr Opin Chem Biol 2007;11:381-7
7. Engler AJ, Sen S, Sweeney HL, Discher DE. Matrix elasticity directs stem cell lineage specification. Cell 2006;126:677-89
8. Saha K, Keung AJ, Irwin EF, et al. Substrate modulus directs neural stem cell behavior. Biophys J 2008;95:4426-38
9. Sakiyama-Elbert SE, Hubbell JA. Controlled release of nerve growth factor from a heparin-containing fibrin-based cell ingrowth matrix. J Control Release 2000;69:149-58
10. Kim S, Healy KE. Synthesis and characterization of injectable poly(Nisopropylacrylamide- co-acrylic acid) hydrogels with proteolytically degradable cross-links. Biomacromolecules 2003;4:1214-23
11. West JL, Hubbell JA. Polymeric biomaterials with degradation sites for proteases involved in cell migration. Macromolecules 1999;32:241-4
12. Lutolf MR, Weber FE, Schmoekel HG, et al. Repair of bone defects using synthetic mimetics of collagenous extracellular matrices. Nat Biotechnol 2003;21:513-18
13. Chung EH, Gilbert M, Virdi AS, et al. Biomimetic artificial ECMs stimulate bone regeneration. J Biomed Mater Res A 2006;79:815-26
14. Li YJ, Chung EH, Rodriguez RT, et al. Hydrogels as artificial matrices for human embryonic stem cell self-renewal. J Biomed Mater Res A 2006;79:1-5
15. Pollock JF, Healy KE. Biomimetic and bio-responsive materials in regenerative medicine: intelligent materials for healing living tissues. In: Santin M, editor. Strategies in regenerative medicine. Springer; New York: 2009
16. Burdick JA, Prestwich GD. Hyaluronic acid hydrogels for biomedical applications. Adv Mater 2011;23:H41-56
17. Anderson DG, Levenberg S, Langer R. Nanoliter-scale synthesis of arrayed biomaterials and application to human embryonic stem cells. Nat Biotechnol 2004;22:863-6
18. Harbers GA, Gamble LJ, Irwin EF, et al. Development and characterization of a high-throughput system for assessing cellsurface receptor-ligand engagement. Langmuir 2005;21:8374-84
19. Little LE, Dane KY, Daugherty PS, et al. Exploiting bacterial peptide display technology to engineer biomaterials for neural stem cell culture. Biomaterials 2011;32:1484-94
20. Seliktar D, Zisch AH, Lutolf MP, et al. MMP-2 sensitive, VEGF-bearing bioactive hydrogels for promotion of vascular healing. J Biomed Mater Res A 2004;68:704-16
21. Martino MM, Briquez PS, Guc E, et al. Growth factors engineered for superaffinity to the extracellular matrix enhance tissue healing. Science 2014;343:885-8
22. Prestwich GD. Simplifying the extracellular matrix for 3-D cell culture and tissue engineering: a pragmatic approach. J Cell Biochem 2007;101:1370-83
23. Prestwich GD. Evaluating drug toxicity and efficacy in three dimensions: using synthetic extracellular matrices in drug discovery. Acc Chem Res 2008;41:139-48
24. Prestwich GD. Clinical biomaterials for scar-free healing and localized delivery of cells and growth factors. Adv Wound Care 2010;1:394-9