IL-17/miR-192/IL-17Rs regulatory feedback loop facilitates multiple myeloma progression

PLoS ONE

Volumn 9, Issue 12, 2014, Pages

  Sun, Yuanyuan ^a   Pan, Jing ^a   Mao, Shudan ^a   Jin, Jieping ^a  

^a JINZHOU MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN TYPE 1; FIBRONECTIN; INTERLEUKIN 17; INTERLEUKIN 17 RECEPTOR; INTERLEUKIN 17 RECEPTOR A; INTERLEUKIN 17 RECEPTOR C; INTERLEUKIN 17 RECEPTOR E; KI 67 ANTIGEN; MICRORNA; MICRORNA 192; MICRORNA 215; RAC1 PROTEIN; RECOMBINANT CYTOKINE; RECOMBINANT INTERLEUKIN 17A; SCLEROPROTEIN; SYNAPTOTAGMIN I; TRANSCRIPTION FACTOR SLUG; TRANSCRIPTION FACTOR SNAIL; UNCLASSIFIED DRUG; UVOMORULIN; VIMENTIN; MIRN192 MICRORNA, HUMAN; MIRN215 MICRORNA, HUMAN; TRANSCRIPTION FACTOR RELA;

3' UNTRANSLATED REGION; APOPTOSIS; ARTICLE; BONE MARROW; CANCER CELL; CANCER PROGNOSIS; CARCINOGENESIS; CELL ADHESION; CELL MIGRATION; CELL MOTILITY; CELL PROLIFERATION; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE RESPONSE; DNA FRAGMENTATION; DOSE RESPONSE; DOWN REGULATION; EPITHELIAL MESENCHYMAL TRANSITION; FEEDBACK SYSTEM; FEMALE; GENE EXPRESSION; GENE LOSS; GENE REPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; METASTASIS; MULTIPLE MYELOMA; NICK END LABELING; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN TARGETING; UPREGULATION; CELL MOTION; DISEASE COURSE; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PATHOLOGY; PHYSIOLOGY; TUMOR CELL LINE; TUMOR MICROENVIRONMENT;

GASTROPODA;

APOPTOSIS; CELL ADHESION; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; DISEASE PROGRESSION; EPITHELIAL-MESENCHYMAL TRANSITION; FEEDBACK, PHYSIOLOGICAL; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INTERLEUKIN-17; MALE; MICRORNAS; MULTIPLE MYELOMA; TRANSCRIPTION FACTOR RELA; TUMOR MICROENVIRONMENT; VIMENTIN;

EID: 84916899060     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0114647     Document Type: Article

References (34)

1. Gupta GP, Massague J (2006) Cancer metastasis: building a framework. Cell 127: 679-695.
2. Ludwig H, Pohl G, Osterborg A (2004) Anemia in multiple myeloma. Clin Adv Hematol Oncol 2: 233-241.
3. Ribatti D, Vacca A (2014) The role of inflammatory cells in angiogenesis in multiple myeloma. Adv Exp Med Biol 816: 361-376.
4. Olechnowicz SW, Edwards CM (2014) Contributions of the host microenvironment to cancer-induced bone disease. Cancer Res 74: 1625-1631.
5. Kryczek I, Wei S, Zou L, Altuwaijri S, Szeliga W, et al. (2007) Cutting edge: Th17 and regulatory T cell dynamics and the regulation by IL-2 in the tumor microenvironment. J Immunol 178: 6730-6733.
6. Kirkham BW, Kavanaugh A, Reich K (2014) Interleukin-17A: a unique pathway in immune-mediated diseases: psoriasis, psoriatic arthritis and rheumatoid arthritis. Immunology 141: 133-142.
7. Iwakura Y, Nakae S, Saijo S, Ishigame H (2008) The roles of IL-17A in inflammatory immune responses and host defense against pathogens. Immunol Rev 226: 57-79.
8. Omrane I, Baroudi O, Bougatef K, Mezlini A, Abidi A, et al. (2014) Significant association between IL23R and IL17F polymorphisms and clinical features of colorectal cancer. Immunol Lett 158: 189-194.
9. Liu J, Duan Y, Cheng X, Chen X, Xie W, et al. (2011) IL-17 is associated with poor prognosis and promotes angiogenesis via stimulating VEGF production of cancer cells in colorectal carcinoma. Biochem Biophys Res Commun 407: 348-354.
10. Das Roy L, Pathangey LB, Tinder TL, Schettini JL, Gruber HE, et al. (2009) Breast-cancerassociated metastasis is significantly increased in a model of autoimmune arthritis. Breast Cancer Res 11: R56.
11. Song XN, Yang JZ, Sun LX, Meng JB, Zhang JQ, et al. (2013) Expression levels of IL-27 and IL-17 in multiple myeloma patients: a higher ratio of IL-27:IL-17 in bone marrow was associated with a superior progression-free survival. Leuk Res 37: 1094-1099.
12. Prabhala RH, Pelluru D, Fulciniti M, Prabhala HK, Nanjappa P, et al. (2010) Elevated IL-17 produced by TH17 cells promotes myeloma cell growth and inhibits immune function in multiple myeloma. Blood 115: 5385-5392.
13. Dogini DB, Pascoal VD, Avansini SH, Vieira AS, Pereira TC, et al. (2004) The new world of RNAs. Genet Mol Biol 37: 285-293.
14. Ambros V (2004) The functions of animal microRNAs. Nature 431: 350-355.
15. Khella HW, Bakhet M, Allo G, Jewett MA, Girgis AH, et al. (2013) miR-192, miR-194 and miR-215: a convergent microRNA network suppressing tumor progression in renal cell carcinoma. Carcinogenesis 34: 2231-2239.
16. Boni V, Bitarte N, Cristobal I, Zarate R, Rodriguez J, et al. (2010) miR-192/miR-215 influence 5-fluorouracil resistance through cell cycle-mediated mechanisms complementary to its posttranscriptional thymidilate synthase regulation. Mol Cancer Ther 9: 2265-2275.
17. Pichiorri F, Suh SS, Rocci A, De Luca L, Taccioli C, et al. (2010) Downregulation of p53-inducible microRNAs 192, 194, and 215 impairs the p53/MDM2 autoregulatory loop in multiple myeloma development. Cancer Cell 18: 367-381.
18. Heinemeyer T, Wingender E, Reuter I, Hermjakob H, Kel AE, et al. (1998) Databases on Transcriptional Regulation: TRANSFAC, TRRD, and COMPEL. Nucleic Acids Res 26: 364-370.
19. Umansky V, Sevko A (2013) Tumor microenvironment and myeloid-derived suppressor cells. Cancer Microenviron 6: 169-177.
20. Huston A, Roodman GD (2006) Role of the microenvironment in multiple myeloma bone disease. Future Oncol 2: 371-378.
21. Chang SH, Mirabolfathinejad SG, Katta H, Cumpian AM, Gong L, et al. (2014) T helper 17 cells play a critical pathogenic role in lung cancer. Proc Natl Acad Sci U S A 111: 5664-5669.
22. Li L, Boussiotis VA (2013) The role of IL-17-producing Foxp3+ CD4+ T cells in inflammatory bowel disease and colon cancer. Clin Immunol 148: 246-253.
23. Girardin A, McCall J, Black MA, Edwards F, Phillips V, et al. (2013) Inflammatory and regulatory T cells contribute to a unique immune microenvironment in tumor tissue of colorectal cancer patients. Int J Cancer 132: 1842-1850.
24. Gaffen SL (2009) Structure and signalling in the IL-17 receptor family. Nat Rev Immunol 9: 556-567.
25. Ruddy MJ, Wong GC, Liu XK, Yamamoto H, Kasayama S, et al. (2004) Functional cooperation between interleukin17 and tumor necrosis factora is mediated by CCAAT/enhancer binding protein family members. J Biol Chem 279: 2559-2567.
26. Shen F, Hu Z, Goswami J, Gaffen SL (2006) Identification of common transcriptional regulatory elements in interleukin-17 target genes. J Biol Chem 281: 24138-24148.
27. Huang F, Kao CY, Wachi S, Thai P, Ryu J, et al. (2007) Requirement for both JAK-mediated PI3K signaling and ACT1/TRAF6/TAK1-dependent NF-kB activation by IL-17A in enhancing cytokine expression in human airway epithelial cells. J Immunol 179: 6504-6513.
28. Calin GA, Croce CM (2006) MicroRNA signatures in human cancers. Nat Rev Cancer 6: 857-866.
29. Feng S, Cong S, Zhang X, Bao X, Wang W, et al. (2011) MicroRNA-192 targeting retinoblastoma 1 inhibits cell proliferation and induces cell apoptosis in lung cancer cells. Nucleic Acids Res 39: 6669-6678.
30. Song B, Wang Y, Kudo K, Gavin EJ, Xi Y, et al. (2008) miR-192 regulates dihydrofolate reductase and cellular proliferation through the p53-microRNA circuit. Clin Cancer Res 14: 8080-8086.
31. Harada M, Luo X, Murohara T, Yang B, Dobrev D, et al. (2014) MicroRNA regulation and cardiac calcium signaling: role in cardiac disease and therapeutic potential. Circ Res 114: 689-705.
32. Yu H, Jove R (2004) The STATs of cancer-new molecular targets come of age. Nature Reviews Cancer 4: 97-105.
33. Yu LL, Yu HG, Yu JP, Luo HS, Xu XM, et al. (2004) Nuclear factor-kappaB p65 (RelA) transcription factor is constitutively activated in human colorectal carcinoma tissue. World J Gastroenterol 10: 3255-3260.
34. Stathopoulos GT, Sherrill TP, Cheng DS, Scoggins RM, Han W, et al. (2007) Epithelial NF-kappaB activation promotes urethane-induced lung carcinogenesis. Proc Natl Acad Sci U S A 104: 18514-18519.