Nanogel-based immunologically stealth vaccine targets macrophages in the medulla of lymph node and induces potent antitumor immunity

ACS Nano

Volumn 8, Issue 9, 2014, Pages 9209-9218

  Muraoka, Daisuke ^a   Harada, Naozumi ^a,b   Hayashi, Tae ^a   Tahara, Yoshiro ^c,d   Momose, Fumiyasu ^a   Sawada, Shin Ichi ^c,d   Mukai, Sada Atsu ^c,d   Akiyoshi, Kazunari ^c,d   Shiku, Hiroshi ^a  

^a MIE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b ImmunoJapan Inc   (Japan)

^c KYOTO UNIVERSITY   (Japan)

^d JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

cancer vaccine; lymph node; macrophages; nanogel; T cells; vaccine delivery

Indexed keywords

BODY FLUIDS; CELLS; CYTOLOGY; DISEASES; MACROPHAGES; NANOSTRUCTURED MATERIALS; T-CELLS;

ANTITUMOR IMMUNITY; CANCER VACCINE; LYMPH NODE; NANOGELS; TOLL-LIKE RECEPTORS; VACCINATION STRATEGY; VACCINE DELIVERY; VACCINE EFFICACIES;

VACCINES;

CANCER VACCINE; DRUG CARRIER; GLUCAN; HYDROGEL; NANOPARTICLE; PULLULAN; TOLL LIKE RECEPTOR; TUMOR ANTIGEN;

AGONISTS; AMINO ACID SEQUENCE; ANIMAL; CD8+ T LYMPHOCYTE; CELL PROLIFERATION; CHEMISTRY; FEMALE; HYDROGEL; IMMUNOLOGY; LYMPH NODE; MACROPHAGE; MOLECULAR GENETICS; MOUSE; T LYMPHOCYTE; TUMOR CELL LINE;

AMINO ACID SEQUENCE; ANIMALS; ANTIGENS, NEOPLASM; CANCER VACCINES; CD8-POSITIVE T-LYMPHOCYTES; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG CARRIERS; FEMALE; GLUCANS; HYDROGELS; LYMPH NODES; MACROPHAGES; MICE; MOLECULAR SEQUENCE DATA; NANOPARTICLES; T-LYMPHOCYTES; TOLL-LIKE RECEPTORS;

EID: 84916895528     PISSN: 19360851     EISSN: 1936086X     Source Type: Journal    
DOI: 10.1021/nn502975r     Document Type: Article

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