Stereospecific mechanism of DJ-1 glyoxalases inferred from their hemithioacetal-containing crystal structures

FEBS Journal

Volumn 281, Issue 24, 2014, Pages 5447-5462

  Choi, Dongwook ^a,b   Kim, Jihong ^b   Ha, Sura ^b   Kwon, Kyu ^b   Kim, Eun Hee ^a   Lee, Hee Yoon ^b   Ryu, Kyoung Seok ^a,c   Park, Chankyu ^b  

^a Korea Basic Science Institute (KBSI)   (South Korea)

^b Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

^c University of Science and Technology (UST)   (South Korea)

Author keywords

DJ 1; Enzyme mechanism; Glyoxalase; Glyoxylate; X ray crystallography

Indexed keywords

ACETAL; CYSTEINE; DJ 1 PROTEIN; GLUTAMIC ACID; GLYOXAL; GLYOXALASE; HISTIDINE; LACTIC ACID; METHYLGLYOXAL; ACETAL DERIVATIVE; LYASE;

ARABIDOPSIS THALIANA; ARTICLE; COVALENT BOND; CRYSTAL STRUCTURE; ENANTIOMER; ENZYME ACTIVE SITE; ENZYME MECHANISM; HUMAN; MOLECULAR MODEL; NONHUMAN; PROTEIN FAMILY; PROTEIN STRUCTURE; PROTON TRANSPORT; STEREOSPECIFICITY; X RAY DIFFRACTION; AMINO ACID SEQUENCE; CATALYSIS; CHEMISTRY; METABOLISM; MOLECULAR GENETICS; PROTEIN CONFORMATION; STEREOISOMERISM; X RAY CRYSTALLOGRAPHY;

ACETALS; AMINO ACID SEQUENCE; CARBON-SULFUR LYASES; CATALYSIS; CRYSTALLOGRAPHY, X-RAY; LACTIC ACID; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION; PYRUVALDEHYDE; STEREOISOMERISM;

EID: 84916631504     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/febs.13085     Document Type: Article

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