Apigenin inhibits the self-renewal capacity of human ovarian cancer SKOV3-derived sphere-forming cells

Molecular Medicine Reports

Volumn 11, Issue 3, 2015, Pages 2221-2226

  Tang, Ai Qiong ^a   Cao, Xiao Cheng ^b   Tian, Li ^b   He, Lihua ^b   Liu, Fei ^b  

^a Maternal and Child Health Hospital of Hunan Province   (China)

^b HUNAN NORMAL UNIVERSITY   (China)

Author keywords

Apigenin; Cancer stem cells; Casein kinase 2 ; Glioma associated oncogene 1; Ovarian cancer; Self renewal

Indexed keywords

APIGENIN; CASEIN KINASE II; CASEIN KINASE IIALPHA; TRANSCRIPTION FACTOR GLI1; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; GLI PROTEIN; ONCOPROTEIN; TRANSACTIVATOR PROTEIN;

ARTICLE; CANCER INHIBITION; CANCER STEM CELL; CELL RENEWAL; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; ENZYME INHIBITION; FEMALE; HUMAN; HUMAN CELL; OVARY CANCER; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; SPHERE FORMING CELL; UPREGULATION; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MULTICELLULAR SPHEROID; OVARY TUMOR; TUMOR CELL CULTURE; TUMOR CELL LINE;

ERINACEIDAE;

ANTINEOPLASTIC AGENTS; APIGENIN; CASEIN KINASE II; CELL LINE, TUMOR; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; NEOPLASTIC STEM CELLS; ONCOGENE PROTEINS; OVARIAN NEOPLASMS; SPHEROIDS, CELLULAR; TRANS-ACTIVATORS; TUMOR CELLS, CULTURED;

EID: 84916613631     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2014.2974     Document Type: Article

References (35)

1. Meggio F and Pinna LA: One-thousand-and-one substrates of protein kinase CK2-. FASEB J 17: 349-368, 2003.
2. Raaf J, Bischoff N, Klopffleisch K, et al: Interaction between CK2alpha and CK2beta, the subunits of protein kinase CK2: thermodynamic contributions of key residues on the CK2alpha surface. Biochemistry 50: 512-522, 2011.
3. Buchou T, Vernet M, Blond O, et al: Disruption of the regulatory beta subunit of protein kinase CK2 in mice leads to a cell-autonomous defect and early embryonic lethality. Mol Cell Biol 23: 908-915, 2003.
4. Ahmad KA, Wang G, Unger G, Slaton J and Ahmed K: Protein kinase CK2 ? a key suppressor of apoptosis. Adv Enzyme Regul 48: 179-187, 2008.
5. Piazza FA, Ruzzene M, Gurrieri C, et al: Multiple myeloma cell survival relies on high activity of protein kinase CK2. Blood 108: 1698-1707, 2006.
6. Prudent R, Moucadel V, Nguyen CH, et al: Antitumor activity of pyridocarbazole and benzopyridoindole derivatives that inhibit protein kinase CK2. Cancer Res 70: 9865-9874, 2010.
7. Dominguez I, Sonenshein GE and Seldin DC: Protein kinase CK2 in health and disease: CK2 and its role in Wnt and NF-kappaB signaling: linking development and cancer. Cell Mol Life Sci 66: 1850-1857, 2009.
8. Duncan JS and Litchfield DW: Too much of a good thing: the role of protein kinase CK2 in tumorigenesis and prospects for therapeutic inhibition of CK2. Biochim Biophys Acta 1784: 33-47, 2008.
9. Guerra B: Protein kinase CK2 subunits are positive regulators of AKT kinase. Int J Oncol 28: 685-693, 2006.
10. Zhang S, Wang Y, Mao JH, et al: Inhibition of CK2α down-regulates Hedgehog/Gli signaling leading to a reduction of a stem-like side population in human lung cancer cells. PLoS One 7: e38996, 2012.
11. Varjosalo M and Taipale J: Hedgehog: functions and mechanisms. Genes Dev 22: 2454-2472, 2008.
12. Ingham PW, Nakano Y and Seger C: Mechanisms and functions of Hedgehog signalling across the metazoa. Nat Rev Genet 12: 393-406, 2011.
13. Ng JM and Curran T: The Hedgehog's tale: developing strategies for targeting cancer. Nat Rev Cancer 11: 493-501, 2011.
14. Takebe N, Harris PJ, Warren RQ and Ivy SP: Targeting cancer stem cells by inhibiting Wnt, Notch, and Hedgehog pathways. Nature Rev Clin Oncol 8: 97-106, 2011.
15. Ruiz i Altaba A: Therapeutic inhibition of Hedgehog-GLI signaling in cancer: epithelial, stromal, or stem cell targets? Cancer Cell 14: 281-283, 2008.
16. Kinzler KW, Bigner SH, Bigner DD, et al: Identification of an amplified, highly expressed gene in a human glioma. Science 236: 70-73, 1987.
17. Epstein EH: Basal cell carcinomas: attack of the hedgehog. Nature Rev Cancer 8: 743-754, 2008.
18. Ciucci A, De Stefano I, Vellone VG, et al: Expression of the glioma-associated oncogene homolog 1 (gli1) in advanced serous ovarian cancer is associated with unfavorable overall survival. PloS One 8: e60145, 2013.
19. Shukla S and Gupta S: Apigenin-induced cell cycle arrest is mediated by modulation of MAPK, PI3K-Akt, and loss of cyclin D1 associated retinoblastoma dephosphorylation in human prostate cancer cells. Cell Cycle 6: 1102-1114, 2007.
20. Shukla S and Gupta S: Suppression of constitutive and tumor necrosis factor alpha-induced nuclear factor (NF)-kappaB activation and induction of apoptosis by apigenin in human prostate carcinoma PC-3 cells: correlation with down-regulation of NF-kappaB-responsive genes. Clin Cancer Res 10: 3169-3178, 2004.
21. Chen D, Landis-Piwowar KR, Chen MS and Dou QP: Inhibition of proteasome activity by the dietary flavonoid apigenin is associated with growth inhibition in cultured breast cancer cells and xenografts. Breast Cancer Res 9: R80, 2007.
22. Way TD, Kao MC and Lin JK: Degradation of HER2/neu by apigenin induces apoptosis through cytochrome c release and caspase-3 activation in HER2/neu-overexpressing breast cancer cells. FEBS Lett 579: 145-152, 2005.
23. Feng X, Zhou Q, Liu C and Tao ML: Drug screening study using glioma stem-like cells. Mol Med Rep 6: 1117-1120, 2012.
24. Castellanos JA, Merchant NB and Nagathihalli NS: Emerging targets in pancreatic cancer: epithelial-mesenchymal transition and cancer stem cells. Onco Targets Ther 6: 1261-1267, 2013.
25. Bae KM, Su Z, Frye C, et al: Expression of pluripotent stem cell reprogramming factors by prostate tumor initiating cells. J Urol 183: 2045-2053, 2010.
26. Jia H, Liu Y, Xia R, et al: Casein kinase 2 promotes Hedgehog signaling by regulating both smoothened and Cubitus interruptus. J Biol Chem 285: 37218-37226, 2010.
27. Varjosalo M, Li SP and Taipale J: Divergence of hedgehog signal transduction mechanism between Drosophila and mammals. Dev Cell 10: 177-186, 2006.
28. Huangfu D and Anderson KV: Signaling from Smo to Ci/Gli: conservation and divergence of Hedgehog pathways from Drosophila to vertebrates. Development 133: 3-14, 2006.
29. Chen Y, Sasai N, Ma G, et al: Sonic Hedgehog dependent phosphorylation by CK1alpha and GRK2 is required for ciliary accumulation and activation of smoothened. PLoS Biol 9: e1001083, 2011.
30. Sarno S and Pinna LA: Protein kinase CK2 as a druggable target. Mol Biosyst 4: 889-894, 2008.
31. Gao Y and Wang HY: Casein kinase 2 is activated and essential for Wnt/beta-catenin signaling. J Biol Chem 281: 18394-18400, 2006.
32. Cozza G, Meggio F and Moro S: The dark side of protein kinase CK2 inhibition. Curr Med Chem 18: 2867-2884, 2011.
33. Cozza G, Bortolato A and Moro S: How druggable is protein kinase CK2-. Med Res Rev 30: 419-462, 2010.
34. Pierre F, Chua PC, O'Brien SE, et al: Pre-clinical characterization of CX-4945, a potent and selective small molecule inhibitor of CK2 for the treatment of cancer. Mol Cell Biochem 356: 37-43, 2011.
35. Perea SE, Baladron I, Garcia Y, et al: CIGB-300, a synthetic peptide-based drug that targets the CK2 phosphoaceptor domain. Translational and clinical research. Mol Cell Biochem 356: 45-50, 2011.